- FAMRI Center
Carolyn Calfee, MD
Assistant Professor of Medicine
Research focuses on the effects of active and passive smoking on susceptibility to acute lung injury, a major cause of respiratory failure in critically ill patients. In addition, she is interested in the use of biomarkers to measure cigarette smoke exposure.
Acute lung injury (ALI) is a common and frequently fatal cause of acute respiratory failure, with an estimated U.S. incidence of 190,600 cases/year and a mortality of 30-40%; no specific therapies beyond supportive measures have been demonstrated to be beneficial. Despite advances in both basic and clinical research on ALI, we still do not understand why only some of the many critically ill patients at risk for ALI progress to develop the syndrome. Our research is focused on both improving our understanding of the pathogenesis of ALI and on developing novel biomarker-based strategies for diagnostic and prognostic purposes, all with the ultimate goal of developing new preventative and therapeutic strategies for this devastating syndrome.
Yale University, BA, 1991-1995, English
University of Pennsylvania, MD, 1995-1999, Medicine
University of California, San Francisco Internship/Residency, 1999-2002, Internal Medicine
University of California, San Francisco Chief Residency, 2002-2003, Internal Medicine
University of California, San Francisco Fellowship, 2003-2007, Pulmonary/Critical Care
1. Calfee CS, Matthay MA. Recent advances in mechanical ventilation. American Journal of Medicine. 2005; 118: 584-91.
2. Calfee CS, Shah SJ, Wolters PJ, Saint S, King TE. Clinical problem-solving. Anchors away. New England Journal of Medicine 2007, 356: 504-9.
3. Calfee CS, Matthay MA. Non-ventilatory treatments for acute lung injury and the acute respiratory distress syndrome. Chest 2007; 131: 913-20.
4. Calfee CS, Eisner MD, Ware LB, Thompson BT, Parsons PE, Wheeler AP, Korpak A, Matthay MA. Trauma-associated lung injury differs clinically and biologically from acute lung injury due to other clinical disorders. Critical Care Medicine 2007; 35(10): 2243-50. (Feature Article) PMCID: PMC2790376.
5. Calfee CS, Ware LB, Eisner MD, Parsons PE, Thompson BT, Wickersham N, Matthay MA. Plasma receptor for advanced glycation end-products and clinical outcomes in acute lung injury. Thorax 2008; 63(12): 1083-9. PMCID: PMC2764528.
6. Calfee CS, Eisner MD, Parsons PE, Thompson BT, Matthay MA, Ware LB. Soluble intercellular adhesion molecule-1 and clinical outcomes in patients with acute lung injury. Intensive Care Medicine 2009; 35(2): 248-57. PMCID: PMC2790376.
7. Suratt BT, Eisner MD, Calfee CS, Allard JB, Whittaker LA, Engelken DT, Petty JM, Trimarchi T, Gauthier L, Parsons PE. Plasma G-CSF levels and clinical outcomes in patients with acute lung injury. Critical Care Medicine 2009; 37(4): 1322-8. PMCID: PMC2827851.
8. Levitt JE, Bedi H, Calfee CS, Gould MK, Matthay MA. Identification of Early Acute Lung Injury at Initial Evaluation in an Acute Care Setting Prior to the Onset of Respiratory Failure. Chest 2009; 135(4): 936-43. PMCID: PMC2758305.
9. Kropski JA, Fremont RD, Calfee CS, Ware LB. Clara cell protein (CC16), a marker of lung epithelial injury, is decreased in plasma and pulmonary edema fluid from critically ill patients with acute lung injury and the acute respiratory distress syndrome. Chest 2009; 135(6): 1440-7. PMCID: PMC2716712.
10. Cohen MJ, Brohi K, Calfee CS, Rahn P, Cheseboro BB, Christiaans SC, Carles M, Howard M, Pittet JF. Early release of HMGB1 after severe trauma in humans: role of injury severity and tissue hypoperfusion. Critical Care 2009; 13(6): R174 (Epub ahead of print). PMCID: PMC2811903.
11. Ware LB, Fremont RD, Bastarache JA, Calfee CS, Matthay MA. Non-invasive diagnosis of the etiology of acute pulmonary edema using the edema fluid-to-plasma protein ratio. Eur Resp Jl 2010; 35(2): 331-7. PMCID: PMC2819058.
12. Fremont RD, Koyama T, Calfee CS, Wu W, Dossett LA, Bossert FR, Mitchell D, Wickersham N, Bernard GR, Matthay MA, May AK, Ware LB. Acute Lung Injury in Patients with Traumatic Injuries Using a Panel of Biomarkers for Diagnosis and Pathogenesis. J Trauma 2009 Dec 24 (Epub ahead of print).
13. Cohen MJ, Carles M, Brohi K, Calfee CS, Rahn P, Call MS, Cheseboro BB, West MA, Pittet JF. Early release of soluble RAGE after severe trauma in humans. Critical Care, in press.
14. Calfee CS, Thompson BT, Parsons PE, Ware LB, Matthay MA, Wong HR. Plasma IL-8 is not an effective risk stratification tool for adults with vasopressor-dependent septic shock. Critical Care Medicine, in press.
15. Calfee CS, Matthay MA. Culprits with Evolutionary Ties. Nature 2010; 464(4), 41-2.