Mark Rubinstein, MD

Professor
Pediatrics
+1 415 476-5763

My research program centers on the development of nicotine dependence in adolescents and young adults. My primary research interest is investigating factors which mediate nicotine addiction in adolescence.  If we can understand the pathways to addiction, it may be possible to find ways to prevent nicotine addiction before it occurs. My current projects focus on electronic cigarette (e-cig) use and the co-use of tobacco and cannabis in adolescents.

The Teen Vaping Study investigates the effect of nicotine metabolism on adolescent smoking behaviors including e-cigs.  The study participants are adolescent e-cig only users.  The rate of nicotine metabolism (how fast the body breaks down nicotine) for each participant is assessed at baseline.  Then we follow the participants to evaluate the effect on dependence and the potential uptake of traditional cigarette smoking.  We are also examining the urine from subjects to look for potential toxicants.  I have also developed studies to look at the co-use of cannabis in adolescent light tobacco users and the effect on nicotine addiction.

Publications: 

Author Response.

Pediatrics

Rubinstein ML

Prevalence and correlates of adolescents' e-cigarette use frequency and dependence.

Drug and alcohol dependence

Vogel EA, Ramo DE, Rubinstein ML

Adolescent Exposure to Toxic Volatile Organic Chemicals From E-Cigarettes.

Pediatrics

Rubinstein ML, Delucchi K, Benowitz NL, Ramo DE

Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products.

Neuroscience and biobehavioral reviews

England LJ, Aagaard K, Bloch M, Conway K, Cosgrove K, Grana R, Gould TJ, Hatsukami D, Jensen F, Kandel D, Lanphear B, Leslie F, Pauly JR, Neiderhiser J, Rubinstein M, Slotkin TA, Spindel E, Stroud L, Wakschlag L

Polydrug use among urban adolescent cigarette smokers.

Addictive behaviors

McKelvey KL, Ramo DE, Delucchi K, Rubinstein ML

Eating Disorders in Adolescent and Young Adult Males: Presenting Characteristics.

The Journal of adolescent health : official publication of the Society for Adolescent Medicine

Vo M, Lau J, Rubinstein M

Recruitment of adolescents for a smoking study: use of traditional strategies and social media.

Translational behavioral medicine

Rait MA, Prochaska JJ, Rubinstein ML

Reporting of cigar use among adolescent tobacco smokers.

Addictive behaviors

Rait MA, Prochaska JJ, Rubinstein ML

Exploration of the Effect of Tobacco Smoking on Metabolic Measures in Young People Living with HIV.

AIDS research and treatment

Rubinstein ML, Harris DR, Rudy BJ, Kapogiannis BG, Aldrovandi GM, Mulligan K

Frequent marijuana use is associated with greater nicotine addiction in adolescent smokers.

Drug and alcohol dependence

Rubinstein ML, Rait MA, Prochaska JJ

Characteristics of adolescent intermittent and daily smokers.

Addictive behaviors

Rubinstein ML, Rait MA, Sen S, Shiffman S

Race, gender, and nicotine metabolism in adolescent smokers.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

Rubinstein ML, Shiffman S, Rait MA, Benowitz NL

Nicotine metabolism and addiction among adolescent smokers.

Addiction (Abingdon, England)

Rubinstein ML, Shiffman S, Moscicki AB, Rait MA, Sen S, Benowitz NL

Adolescent smokers show decreased brain responses to pleasurable food images compared with nonsmokers.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

Rubinstein ML, Luks TL, Dryden WY, Rait MA, Simpson GV

Smoking-related cue-induced brain activation in adolescent light smokers.

The Journal of adolescent health : official publication of the Society for Adolescent Medicine

Rubinstein ML, Luks TL, Moscicki AB, Dryden W, Rait MA, Simpson GV

Withdrawal in adolescent light smokers following 24-hour abstinence.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

Rubinstein ML, Benowitz NL, Auerback GM, Moscicki AB

A randomized trial of nicotine nasal spray in adolescent smokers.

Pediatrics

Rubinstein ML, Benowitz NL, Auerback GM, Moscicki AB

Rate of nicotine metabolism and withdrawal symptoms in adolescent light smokers.

Pediatrics

Rubinstein ML, Benowitz NL, Auerback GM, Moscicki AB

Who's Smoking? Cotinine versus self-report in adolescent populations.

The Journal of adolescent health : official publication of the Society for Adolescent Medicine

Rubinstein ML

Cotinine levels in relation to smoking behavior and addiction in young adolescent smokers.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

Rubinstein ML, Thompson PJ, Benowitz NL, Shiffman S, Moscicki AB

An evaluation of the use of the transdermal contraceptive patch in adolescents.

The Journal of adolescent health : official publication of the Society for Adolescent Medicine

Rubinstein ML, Halpern-Felsher BL, Irwin CE