- FAMRI Center
Neal Benowitz, MD
Professor of Medicine, Bioengineering and Therapeutic Sciences
Neal Benowitz has been conducting research at UCSF/SFGH since 1973. His research focus is on the human pharmacology of nicotine in relation to addiction and the pathogenesis of and individual differences in vulnerability to tobacco-related disease, and the use of pharmacologic data as a basis for public health policies to prevent and reduce such disease. He has served on a number of national and international committees addressing issues in tobacco-related diseases and smoking cessation, including several sponsored by the Institute of Medicine. He has authored over 600 publications, and has contributed to a number of Reports of the U.S.Surgeon General on Smoking and Health. He has served as president of the American Society for Clinical Pharmacology and Therapeutics and of the Society for Research on Nicotine and Tobacco and was the Second UCSF Annual Distinguished Clinical Research Lecturer.
Rensselaer Polytechnic Institute BS Physics University of Rochester MD Bronx Municipal Hospital Center Intern/Resident Medicine University of California, San Francisco Res. Fellow Clinical Pharmacology
Neuropsychiatric safety and efficacy of varenicline, bupropion, and nicotine patch in smokers with and without psychiatric disorders (EAGLES): a double-blind, randomised, placebo-controlled clinical trial.
Anthenelli RM, Benowitz NL, West R, St Aubin L, McRae T, Lawrence D, Ascher J, Russ C, Krishen A, Evins AE. Lancet. 2016 Apr 22. pii: S0140-6736(16)30272-0. doi: 10.1016/S0140-6736(16)30272-0. [Epub ahead of print] PMID: 27116918
Cardiovascular toxicity of nicotine: Implications for electronic cigarette use.
Benowitz NL, Burbank AD. Trends Cardiovasc Med. 2016 Mar 10. pii: S1050-1738(16)00053-0. doi: 10.1016/j.tcm.2016.03.001. [Epub ahead of print] Review.
Disposition kinetics and metabolism of nicotine and cotinine in African American smokers: impact of CYP2A6 genetic variation and enzymatic activity.
Benowitz NL, St Helen G, Dempsey DA, Jacob P 3rd, Tyndale RF. Pharmacogenet Genomics. 2016 Jul;26(7):340-50. doi: 10.1097/FPC.0000000000000222. PMID: 27035242
Nicotine delivery, retention and pharmacokinetics from various electronic cigarettes.
St Helen G, Havel C, Dempsey DA, Jacob P 3rd, Benowitz NL.
Addiction. 2016 Mar;111(3):535-44. doi: 10.1111/add.13183. Epub 2015 Nov 11.
Randomized Trial of Reduced-Nicotine Standards for Cigarettes.
Donny EC, Denlinger RL, Tidey JW, Koopmeiners JS, Benowitz NL, Vandrey RG, al'Absi M, Carmella SG, Cinciripini PM, Dermody SS, Drobes DJ, Hecht SS, Jensen J, Lane T, Le CT, McClernon FJ, Montoya ID, Murphy SE, Robinson JD, Stitzer ML, Strasser AA, Tindle H, Hatsukami DK. N Engl J Med. 2015 Oct;373(14):1340-9. doi: 10.1056/NEJMsa1502403. PMID: 26422724
Cardiovascular Effects of Exposure to Cigarette Smoke and Electronic Cigarettes: Clinical Perspectives From the Prevention of Cardiovascular Disease Section Leadership Council and Early Career Councils of the American College of Cardiology.
Morris PB, Ference BA, Jahangir E, Feldman DN, Ryan JJ, Bahrami H, El-Chami MF, Bhakta S, Winchester DE, Al-Mallah MH, Sanchez Shields M, Deedwania P, Mehta LS, Phan BA, Benowitz NL. J Am Coll Cardiol. 2015 Sep 22;66(12):1378-91. doi: 10.1016/j.jacc.2015.07.037. Review. PMID: 26383726
Effect of reducing the nicotine content of cigarettes on cigarette smoking behavior and tobacco smoke toxicant exposure: 2-year follow up.
Benowitz NL, Nardone N, Dains KM, Hall SM, Stewart S, Dempsey D, Jacob P 3rd. Addiction. 2015 Oct;110(10):1667-75. doi: 10.1111/add.12978. Epub 2015 Jul 21. PMID: 26198394
Use of the nicotine metabolite ratio as a genetically informed biomarker of response to nicotine patch or varenicline for smoking cessation: a randomised, double-blind placebo-controlled trial.
Lerman C, Schnoll RA, Hawk LW Jr, Cinciripini P, George TP, Wileyto EP, Swan GE, Benowitz NL, Heitjan DF, Tyndale RF; PGRN-PNAT Research Group. Lancet Respir Med. 2015 Feb;3(2):131-8. doi: 10.1016/S2213-2600(14)70294-2. Epub 2015 Jan 12. PMID: 25588294
Electronic cigarettes: review of use, content, safety, effects on smokers and potential for harm and benefit.
Hajek P, Etter JF, Benowitz N, Eissenberg T, McRobbie H. Addiction. 2014 Nov;109(11):1801-10. doi: 10.1111/add.12659. Epub 2014 Jul 31. PMID: 25078252
E-cigarettes: a scientific review.
Grana R, Benowitz N, Glantz SA. Circulation. 2014 May 13;129(19):1972-86. doi: 10.1161/CIRCULATIONAHA.114.007667. Review. No abstract available. PMID: 24821826