November 15, 2019
The paper “Short-term e-cigarette vapour exposure causes vascular oxidative stress and dysfunction: evidence for a close connection to brain damage and a key role of the phagocytic NADPH oxidase (NOX-2)” recently published by Marin Kuntic and colleagues in the European Heart Journal is a real-tour de force that includes human, mouse, and isolated cell studies to not only show that e-cigarette use has adverse effects on blood vessels (in several places throughout the body), but defines the cellular and molecular pathways responsible for these effects.
Consistent with earlier studies, they founds that e-cigarette smoking immediately compromised the ability of arteries to dilate (expand) in response to increases in the need for blood flow (called flow-mediated dilation). Significantly, they found this effect in smokers, which is consistent with our (paper 1, paper 2) and others’ epidemiological findings that e-cigarettes pose an independent risk of having had a heart attack (myocardial infarction) in smokers.
November 12, 2019
Despite the continuing happy talk coming out of our colleagues in England that the epidemic of serious lung illness in e-cigarette users is a US-phenomenon, BMJ’s Archives of Disease in Childhood just published a case report, “Life-threatening hypersensitivity pneumonitis secondary to e-cigarettes.” The youth used nicotine e-cigarettes.
Here is the abstract:
November 10, 2019
Despite the fact that surveys show broad support among both Republicans and Democrats favor getting rid of menthol and mint e-cigarettes (along with other flavors), the Trump Administration has signalled that they will give in to industry pressure to continue to allow these important flavors in e-cigarettes?
What makes me say this? They announced that they are supporting raising the purchase age to 21.
Increasing the legal age to sell tobacco products to 21 is a good idea, but it has been co-opted by the tobacco (including e-cig) companies as an alternative to getting rid of flavors. And menthol/mint is the most important flavor for attracting kids.
(Many people have asked me the difference between menthol and mint. Menthol is a specific chemical extracted from mint, so all mint tobacco products include menthol.)
November 10, 2019
Earlier this week CDC released data showing that vitamin E acetate, a chemical used in THC and nicotine e-cigarettes, was present deep in the lungs of all 29 patients they studied. This is important because many people have suspected that vitamin E acetate was contributing to the epidemic of serous lung injury in vapers.
Nicotine e-cigarette advocates have seized on this observation to blame the serious lung disease on THC vapes. But, it is important to pay attention to what CDC actually said:
Vitamin E acetate was detected in all 29 patient BAL [bronchial alveoliar lavage, which yields information of what is deep in the tiny air sacks in the lungs] samples.. Among 23 patients for whom self-reported THC use information was available, 20 reported using THC-containing products. THC or its metabolites were detected in 23 of 28 patient BAL samples, including in those of three patients who said they did not use THC products. Nicotine metabolites were detected in 16 of 26 patient BAL specimens. [emphasis added]
November 10, 2019
Several people have emailed me asking what I thought of the analysis “Epidemic of youth nicotine addiction? What does the National Youth Tobacco Survey reveal about high school e-cigarette use in the USA? (Preprint)” that Robert West, Jamie Brown, and Martin Jarvis posted to a non-peer reviewed preprint server. They did this analysis to debunk concerns expressed by FDA and others that e-cigarettes are expanding the nicotine epidemic based on the huge increase in e-cig use by youth last year. West et al’s bottom line is: “Data from the NYTS do not support claims of a new epidemic of nicotine addiction stemming from use of e-cigarettes, nor concerns that declines in youth tobacco addiction stand to be reversed after years of progress.”