Carolyn Calfee, MD, MAS

Assistant Professor of Medicine
Medicine

Research focuses on the effects of active and passive smoking on susceptibility to acute lung injury, a major cause of respiratory failure in critically ill patients. In addition, she is interested in the use of biomarkers to measure cigarette smoke exposure.

Acute lung injury (ALI) is a common and frequently fatal cause of acute respiratory failure, with an estimated U.S. incidence of 190,600 cases/year and a mortality of 30-40%; no specific therapies beyond supportive measures have been demonstrated to be beneficial.  Despite advances in both basic and clinical research on ALI, we still do not understand why only some of the many critically ill patients at risk for ALI progress to develop the syndrome.  Our research is focused on both improving our understanding of the pathogenesis of ALI and on developing novel biomarker-based strategies for diagnostic and prognostic purposes, all with the ultimate goal of developing new preventative and therapeutic strategies for this devastating syndrome.

Publications: 

Assessment of industry data on pulmonary and immunosuppressive effects of IQOS.

Tobacco control

Moazed F, Chun L, Matthay MA, Calfee CS, Gotts J

Possible hepatotoxicity of IQOS.

Tobacco control

Chun L, Moazed F, Matthay M, Calfee C, Gotts J

Early Plasma Matrix Metalloproteinase Profiles: A Novel Pathway in Pediatric Acute Respiratory Distress Syndrome.

American journal of respiratory and critical care medicine

Zinter MS, Delucchi KL, Kong MY, Orwoll BE, Spicer AS, Lim MJ, Alkhouli MF, Ratiu AE, McKenzie AV, McQuillen PS, Dvorak CC, Calfee CS, Matthay MA, Sapru A

Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial.

The Lancet. Respiratory medicine

Calfee CS, Delucchi KL, Sinha P, Matthay MA, Hackett J, Shankar-Hari M, McDowell C, Laffey JG, O'Kane CM, McAuley DF

Low to Moderate Air Pollutant Exposure and Acute Respiratory Distress Syndrome after Severe Trauma.

American journal of respiratory and critical care medicine

Reilly JP, Zhao Z, Shashaty MGS, Koyama T, Christie JD, Lanken PN, Wang C, Balmes JR, Matthay MA, Calfee CS, Ware LB

Plasma sRAGE is independently associated with increased mortality in ARDS: a meta-analysis of individual patient data.

Intensive care medicine

Jabaudon M, Blondonnet R, Pereira B, Cartin-Ceba R, Lichtenstern C, Mauri T, Determann RM, Drabek T, Hubmayr RD, Gajic O, Uhle F, Coppadoro A, Pesenti A, Schultz MJ, Ranieri MV, Brodska H, Mrozek S, Sapin V, Matthay MA, Constantin JM, Calfee CS

Human pulmonary endothelial cell permeability after exposure to LPS-stimulated leukocyte supernatants derived from patients with early sepsis.

American journal of physiology. Lung cellular and molecular physiology

Leligdowicz A, Chun LF, Jauregui A, Vessel K, Liu KD, Calfee CS, Matthay MA

Perhaps It's Not the Platelet: Ristocetin Uncovers the Potential Role of von Willebrand Factor in Impaired Platelet Aggregation Following Traumatic Brain Injury.

The journal of trauma and acute care surgery

Kornblith LZ, Robles AJ, Conroy AS, Hendrickson CM, Calfee CS, Fields AT, Callcut RA, Cohen MJ

Health care utilization and the cost of posttraumatic acute respiratory distress syndrome care.

The journal of trauma and acute care surgery

Robles AJ, Kornblith LZ, Hendrickson CM, Howard BM, Conroy AS, Moazed F, Calfee CS, Cohen MJ, Callcut RA

Association between pre-operative biological phenotypes and postoperative pulmonary complications: An unbiased cluster analysis.

European journal of anaesthesiology

Serpa Neto A, Bos LD, Campos PPZA, Hemmes SNT, Bluth T, Calfee CS, Ferner M, Güldner A, Hollmann MW, India I, Kiss T, Laufenberg-Feldmann R, Sprung J, Sulemanji D, Unzueta C, Vidal Melo MF, Weingarten TN, Tuip-de Boer AM, Pelosi P, Gama de Abreu M, Schultz MJ

Elevated plasma levels of TIMP-3 are associated with a higher risk of acute respiratory distress syndrome and death following severe isolated traumatic brain injury.

Trauma surgery & acute care open

Hendrickson CM, Gibb SL, Miyazawa BY, Keating SM, Ross E, Conroy AS, Calfee CS, Pati S, Cohen MJ

Severity scoring of lung oedema on the chest radiograph is associated with clinical outcomes in ARDS.

Thorax

Warren MA, Zhao Z, Koyama T, Bastarache JA, Shaver CM, Semler MW, Rice TW, Matthay MA, Calfee CS, Ware LB

Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice.

American journal of physiology. Lung cellular and molecular physiology

Gotts JE, Chun LF, Abbott J, Fang X, Takasaki N, Nishimura SL, Springer ML, Schick SF, Calfee CS, Matthay MA

Stability of ARDS subphenotypes over time in two randomised controlled trials.

Thorax

Delucchi K, Famous KR, Ware LB, Parsons PE, Thompson BT, Calfee CS

Maladaptive role of neutrophil extracellular traps in pathogen-induced lung injury.

JCI insight

Lefrançais E, Mallavia B, Zhuo H, Calfee CS, Looney MR

Platelet aggregation after blunt trauma is associated with the acute respiratory distress syndrome and altered by cigarette smoke exposure.

The journal of trauma and acute care surgery

Moazed F, Hendrickson C, Nelson M, Conroy A, Cohen MJ, Calfee CS

Exposing the bidirectional effects of alcohol on coagulation in trauma: Impaired clot formation and decreased fibrinolysis in rotational thromboelastometry.

The journal of trauma and acute care surgery

Howard BM, Kornblith LZ, Redick BJ, Conroy AS, Nelson MF, Calfee CS, Callcut RA, Cohen MJ

Reply to "Letter to the Editor: Pulmonary toxicity of electronic cigarettes: more doubts than certainties".

American journal of physiology. Lung cellular and molecular physiology

Chun LF, Moazed F, Calfee CS, Matthay MA, Gotts JE

Characterizing the gut microbiome in trauma: significant changes in microbial diversity occur early after severe injury.

Trauma surgery & acute care open

Howard BM, Kornblith LZ, Christie SA, Conroy AS, Nelson MF, Campion EM, Callcut RA, Calfee CS, Lamere BJ, Fadrosh DW, Lynch S, Cohen MJ

Lung Microbiota is Related to Smoking Status and to Development of ARDS in Critically Ill Trauma Patients.

American journal of respiratory and critical care medicine

Panzer AR, Lynch SV, Langelier C, Christie JD, McCauley K, Nelson M, Cheung CK, Benowitz NL, Cohen MJ, Calfee CS

Reply: Next Step to Understanding Subphenotypes of Acute Respiratory Distress Syndrome.

American journal of respiratory and critical care medicine

Calfee CS, Delucchi K, Famous KR

Cigarette Smoke Exposure Worsens Endotoxin-Induced Lung Injury and Pulmonary Edema in Mice.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

Gotts JE, Abbott J, Fang X, Yanagisawa H, Takasaka N, Nishimura SL, Calfee CS, Matthay MA

Derivation and validation of a two-biomarker panel for diagnosis of ARDS in patients with severe traumatic injuries.

Trauma surgery & acute care open

Ware LB, Zhao Z, Koyama T, Brown RM, Semler MW, Janz DR, May AK, Fremont RD, Matthay MA, Cohen MJ, Calfee CS

Gender Parity in Critical Care Medicine.

American journal of respiratory and critical care medicine

Mehta S, Burns KEA, Machado FR, Fox-Robichaud AE, Cook DJ, Calfee CS, Ware LB, Burnham EL, Kissoon N, Marshall JC, Mancebo J, Finfer S, Hartog C, Reinhart K, Maitland K, Stapleton RD, Kwizera A, Amin P, Abroug F, Smith O, Laake JH, Shrestha GS, Herridge MS

External validation of a biomarker and clinical prediction model for hospital mortality in acute respiratory distress syndrome.

Intensive care medicine

Zhao Z, Wickersham N, Kangelaris KN, May AK, Bernard GR, Matthay MA, Calfee CS, Koyama T, Ware LB

Characterization of distinct coagulopathic phenotypes in injury: Pathway-specific drivers and implications for individualized treatment.

The journal of trauma and acute care surgery

Christie SA, Kornblith LZ, Howard BM, Conroy AS, Kunitake RC, Nelson MF, Hendrickson CM, Calfee CS, Callcut RA, Cohen MJ

Pulmonary toxicity of e-cigarettes.

American journal of physiology. Lung cellular and molecular physiology

Chun LF, Moazed F, Calfee CS, Matthay MA, Gotts JE

Incorporating Inflammation into Mortality Risk in Pediatric Acute Respiratory Distress Syndrome.

Critical care medicine

Zinter MS, Orwoll BE, Spicer AC, Alkhouli MF, Calfee CS, Matthay MA, Sapru A

Identification and validation of distinct biological phenotypes in patients with acute respiratory distress syndrome by cluster analysis.

Thorax

Bos LD, Schouten LR, van Vught LA, Wiewel MA, Ong DSY, Cremer O, Artigas A, Martin-Loeches I, Hoogendijk AJ, van der Poll T, Horn J, Juffermans N, Calfee CS, Schultz MJ

The Canary in the Coal Mine Is Coughing: Electronic Cigarettes and Respiratory Symptoms in Adolescents.

American journal of respiratory and critical care medicine

Moazed F, Calfee CS

Higher mini-BAL total protein concentration in early ARDS predicts faster resolution of lung injury measured by more ventilator-free days.

American journal of physiology. Lung cellular and molecular physiology

Hendrickson CM, Abbott J, Zhuo H, Liu KD, Calfee CS, Matthay MA

Acute Respiratory Distress Syndrome Subphenotypes Respond Differently to Randomized Fluid Management Strategy.

American journal of respiratory and critical care medicine

Famous KR, Delucchi K, Ware LB, Kangelaris KN, Liu KD, Thompson BT, Calfee CS

Acute kidney injury subphenotypes based on creatinine trajectory identifies patients at increased risk of death.

Critical care (London, England)

Bhatraju PK, Mukherjee P, Robinson-Cohen C, O'Keefe GE, Frank AJ, Christie JD, Meyer NJ, Liu KD, Matthay MA, Calfee CS, Christiani DC, Himmelfarb J, Wurfel MM

A Simple and Robust Bedside Model for Mortality Risk in Pediatric Patients With Acute Respiratory Distress Syndrome.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Spicer AC, Calfee CS, Zinter MS, Khemani RG, Lo VP, Alkhouli MF, Orwoll BE, Graciano AL, Boriosi JP, Howard JP, Flori HR, Matthay MA, Sapru A

Clinical Predictors of Hospital Mortality Differ Between Direct and Indirect ARDS.

Chest

Luo L, Shaver CM, Zhao Z, Koyama T, Calfee CS, Bastarache JA, Ware LB

The authors reply.

Critical care medicine

Kangelaris KN, Ware LB, Matthay MA, Calfee CS

The authors reply.

Critical care medicine

Kangelaris KN, Ware LB, Matthay MA, Calfee CS

Toward Smarter Lumping and Smarter Splitting: Rethinking Strategies for Sepsis and Acute Respiratory Distress Syndrome Clinical Trial Design.

American journal of respiratory and critical care medicine

Prescott HC, Calfee CS, Thompson BT, Angus DC, Liu VX

The acute respiratory distress syndrome following isolated severe traumatic brain injury.

The journal of trauma and acute care surgery

Hendrickson CM, Howard BM, Kornblith LZ, Conroy AS, Nelson MF, Zhuo H, Liu KD, Manley GT, Matthay MA, Calfee CS, Cohen MJ

Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome.

Critical care (London, England)

Sapru A, Liu KD, Wiemels J, Hansen H, Pawlikowska L, Poon A, Jorgenson E, Witte JS, Calfee CS, Ware LB, Matthay MA

Long-Term Ozone Exposure Increases the Risk of Developing the Acute Respiratory Distress Syndrome.

American journal of respiratory and critical care medicine

Ware LB, Zhao Z, Koyama T, May AK, Matthay MA, Lurmann FW, Balmes JR, Calfee CS

Personalized medicine for ARDS: the 2035 research agenda.

Intensive care medicine

Beitler JR, Goligher EC, Schmidt M, Spieth PM, Zanella A, Martin-Loeches I, Calfee CS, Cavalcanti AB

Diagnostic workup for ARDS patients.

Intensive care medicine

Papazian L, Calfee CS, Chiumello D, Luyt CE, Meyer NJ, Sekiguchi H, Matthay MA, Meduri GU

Cigarette smokers have exaggerated alveolar barrier disruption in response to lipopolysaccharide inhalation.

Thorax

Moazed F, Burnham EL, Vandivier RW, O'Kane CM, Shyamsundar M, Hamid U, Abbott J, Thickett DR, Matthay MA, McAuley DF, Calfee CS

The relationship between plasma lipid peroxidation products and primary graft dysfunction after lung transplantation is modified by donor smoking and reperfusion hyperoxia.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

Diamond JM, Porteous MK, Roberts LJ, Wickersham N, Rushefski M, Kawut SM, Shah RJ, Cantu E, Lederer DJ, Chatterjee S, Lama VN, Bhorade S, Crespo M, McDyer J, Wille K, Orens J, Weinacker A, Arcasoy S, Shah PD, Wilkes DS, Hage C, Palmer SM, Snyder L, Calfee CS, Ware LB, Christie JD

Timing of Intubation and Clinical Outcomes in Adults With Acute Respiratory Distress Syndrome.

Critical care medicine

Kangelaris KN, Ware LB, Wang CY, Janz DR, Zhuo H, Matthay MA, Calfee CS

Elevated soluble thrombomodulin is associated with organ failure and mortality in children with acute respiratory distress syndrome (ARDS): a prospective observational cohort study.

Critical care (London, England)

Orwoll BE, Spicer AC, Zinter MS, Alkhouli MF, Khemani RG, Flori HR, Neuhaus JM, Calfee CS, Matthay MA, Sapru A

Plasma angiopoietin-2 outperforms other markers of endothelial injury in prognosticating pediatric ARDS mortality.

American journal of physiology. Lung cellular and molecular physiology

Zinter MS, Spicer A, Orwoll BO, Alkhouli M, Dvorak CC, Calfee CS, Matthay MA, Sapru A

ARDS in 2015: new clinical directions, new biological insights.

The Lancet. Respiratory medicine

Calfee CS

Interstitial lung diseases in the hospitalized patient.

BMC medicine

Disayabutr S, Calfee CS, Collard HR, Wolters PJ

Cigarette Smoke Exposure and the Acute Respiratory Distress Syndrome.

Critical care medicine

Calfee CS, Matthay MA, Kangelaris KN, Siew ED, Janz DR, Bernard GR, May AK, Jacob P, Havel C, Benowitz NL, Ware LB

Misclassification of acute respiratory distress syndrome after traumatic injury: The cost of less rigorous approaches.

The journal of trauma and acute care surgery

Hendrickson CM, Dobbins S, Redick BJ, Greenberg MD, Calfee CS, Cohen MJ

Biomarkers of ARDS: what's new?

Intensive care medicine

Ware LB, Calfee CS

Distinct molecular phenotypes of direct vs indirect ARDS in single-center and multicenter studies.

Chest

Calfee CS, Janz DR, Bernard GR, May AK, Kangelaris KN, Matthay MA, Ware LB

Differences in degree, differences in kind: characterizing lung injury in trauma.

The journal of trauma and acute care surgery

Howard BM, Kornblith LZ, Hendrickson CM, Redick BJ, Conroy AS, Nelson MF, Callcut RA, Calfee CS, Cohen MJ

Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS.

American journal of physiology. Lung cellular and molecular physiology

Kangelaris KN, Prakash A, Liu KD, Aouizerat B, Woodruff PG, Erle DJ, Rogers A, Seeley EJ, Chu J, Liu T, Osterberg-Deiss T, Zhuo H, Matthay MA, Calfee CS

Erratum to: plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome.

Intensive care medicine

Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbott J, Matthay MA

Plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome.

Intensive care medicine

Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbott J, Abbot J, Matthay MA

Clearing the air. Smoking and incident asthma in adults.

American journal of respiratory and critical care medicine

Moazed F, Calfee CS

Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial.

The Lancet. Respiratory medicine

Wilson JG, Liu KD, Zhuo H, Caballero L, McMillan M, Fang X, Cosgrove K, Vojnik R, Calfee CS, Lee JW, Rogers AJ, Levitt J, Wiener-Kronish J, Bajwa EK, Leavitt A, McKenna D, Thompson BT, Matthay MA

ARDS: new mechanistic insights, new therapeutic directions.

Clinics in chest medicine

Ware LB, Bastarache JA, Calfee CS

Environmental risk factors for acute respiratory distress syndrome.

Clinics in chest medicine

Moazed F, Calfee CS

Prevalence and impact of active and passive cigarette smoking in acute respiratory distress syndrome.

Critical care medicine

Hsieh SJ, Zhuo H, Benowitz NL, Thompson BT, Liu KD, Matthay MA, Calfee CS

Donor smoking is associated with pulmonary edema, inflammation and epithelial dysfunction in ex vivo human donor lungs.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Ware LB, Lee JW, Wickersham N, Nguyen J, Matthay MA, Calfee CS

Silencing Bruton's tyrosine kinase in alveolar neutrophils protects mice from LPS/immune complex-induced acute lung injury.

American journal of physiology. Lung cellular and molecular physiology

Krupa A, Fol M, Rahman M, Stokes KY, Florence JM, Leskov IL, Khoretonenko MV, Matthay MA, Liu KD, Calfee CS, Tvinnereim A, Rosenfield GR, Kurdowska AK

Design and implementation of the START (STem cells for ARDS Treatment) trial, a phase 1/2 trial of human mesenchymal stem/stromal cells for the treatment of moderate-severe acute respiratory distress syndrome.

Annals of intensive care

Liu KD, Wilson JG, Zhuo H, Caballero L, McMillan ML, Fang X, Cosgrove K, Calfee CS, Lee JW, Kangelaris KN, Gotts JE, Rogers AJ, Levitt JE, Wiener-Kronish JP, Delucchi KL, Leavitt AD, McKenna DH, Thompson BT, Matthay MA

Keratinocyte growth factor promotes epithelial survival and resolution in a human model of lung injury.

American journal of respiratory and critical care medicine

Shyamsundar M, McAuley DF, Ingram RJ, Gibson DS, O'Kane D, McKeown ST, Edwards A, Taggart C, Elborn JS, Calfee CS, Matthay MA, O'Kane CM

Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials.

The Lancet. Respiratory medicine

Calfee CS, Delucchi K, Parsons PE, Thompson BT, Ware LB, Matthay MA

Performance of interleukin-27 as a sepsis diagnostic biomarker in critically ill adults.

Journal of critical care

Wong HR, Liu KD, Kangelaris KN, Lahni P, Calfee CS

Is there still a role for the lung injury score in the era of the Berlin definition ARDS?

Annals of intensive care

Kangelaris KN, Calfee CS, May AK, Zhuo H, Matthay MA, Ware LB

Fibrinogen and platelet contributions to clot formation: implications for trauma resuscitation and thromboprophylaxis.

The journal of trauma and acute care surgery

Kornblith LZ, Kutcher ME, Redick BJ, Calfee CS, Vilardi RF, Cohen MJ

One-year mortality and predictors of death among hospital survivors of acute respiratory distress syndrome.

Intensive care medicine

Wang CY, Calfee CS, Paul DW, Janz DR, May AK, Zhuo H, Bernard GR, Matthay MA, Ware LB, Kangelaris KN

Effect of simvastatin on physiological and biological outcomes in patients undergoing esophagectomy: a randomized placebo-controlled trial.

Annals of surgery

Shyamsundar M, McAuley DF, Shields MO, MacSweeney R, Duffy MJ, Johnston JR, McGuigan J, Backman JT, Calfee CS, Matthay MM, Griffiths MJ, McDowell C, Elborn SJ, O'Kane CM

Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome.

Critical care (London, England)

Ware LB, Koyama T, Zhao Z, Janz DR, Wickersham N, Bernard GR, May AK, Calfee CS, Matthay MA

Early acute lung injury: criteria for identifying lung injury prior to the need for positive pressure ventilation*.

Critical care medicine

Levitt JE, Calfee CS, Goldstein BA, Vojnik R, Matthay MA

Plasma angiopoietin-2 predicts the onset of acute lung injury in critically ill patients.

American journal of respiratory and critical care medicine

Agrawal A, Matthay MA, Kangelaris KN, Stein J, Chu JC, Imp BM, Cortez A, Abbott J, Liu KD, Calfee CS

Fixing the leak: targeting the vascular endothelium in sepsis.

Critical care (London, England)

Spicer A, Calfee CS

The search for diagnostic markers in sepsis: many miles yet to go.

American journal of respiratory and critical care medicine

Calfee CS, Pugin J

Clinical evidence of early acute lung injury often precedes the diagnosis of ALI.

Journal of intensive care medicine

Rackley CR, Levitt JE, Zhuo H, Matthay MA, Calfee CS

Plasma angiopoietin-2 in clinical acute lung injury: prognostic and pathogenetic significance.

Critical care medicine

Calfee CS, Gallagher D, Abbott J, Thompson BT, Matthay MA

Comparison of chest radiograph scoring to lung weight as a quantitative index of pulmonary edema in organ donors.

Clinical transplantation

Ware LB, Neyrinck A, O'Neal HR, Lee JW, Landeck M, Johnson E, Calfee CS, Matthay MA

Critical role of activated protein C in early coagulopathy and later organ failure, infection and death in trauma patients.

Annals of surgery

Cohen MJ, Call M, Nelson M, Calfee CS, Esmon CT, Brohi K, Pittet JF

Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma.

PloS one

Christie JD, Wurfel MM, Feng R, O'Keefe GE, Bradfield J, Ware LB, Christiani DC, Calfee CS, Cohen MJ, Matthay M, Meyer NJ, Kim C, Li M, Akey J, Barnes KC, Sevransky J, Lanken PN, May AK, Aplenc R, Maloney JP, Hakonarson H

The association between a Darc gene polymorphism and clinical outcomes in African American patients with acute lung injury.

Chest

Kangelaris KN, Sapru A, Calfee CS, Liu KD, Pawlikowska L, Witte JS, Vittinghoff E, Zhuo H, Auerbach AD, Ziv E, Matthay MA

A simple classification model for hospital mortality in patients with acute lung injury managed with lung protective ventilation.

Critical care medicine

Brown LM, Calfee CS, Matthay MA, Brower RG, Thompson BT, Checkley W

FGF-23 and PTH levels in patients with acute kidney injury: A cross-sectional case series study.

Annals of intensive care

Zhang M, Hsu R, Hsu CY, Kordesch K, Nicasio E, Cortez A, McAlpine I, Brady S, Zhuo H, Kangelaris KN, Stein J, Calfee CS, Liu KD

Use of risk reclassification with multiple biomarkers improves mortality prediction in acute lung injury.

Critical care medicine

Calfee CS, Ware LB, Glidden DV, Eisner MD, Parsons PE, Thompson BT, Matthay MA

Active and passive cigarette smoking and acute lung injury after severe blunt trauma.

American journal of respiratory and critical care medicine

Calfee CS, Matthay MA, Eisner MD, Benowitz N, Call M, Pittet JF, Cohen MJ

ANGPT2 genetic variant is associated with trauma-associated acute lung injury and altered plasma angiopoietin-2 isoform ratio.

American journal of respiratory and critical care medicine

Meyer NJ, Li M, Feng R, Bradfield J, Gallop R, Bellamy S, Fuchs BD, Lanken PN, Albelda SM, Rushefski M, Aplenc R, Abramova H, Atochina-Vasserman EN, Beers MF, Calfee CS, Cohen MJ, Pittet JF, Christiani DC, O'Keefe GE, Ware LB, May AK, Wurfel MM, Hakonarson H, Christie JD

Biomarkers increase detection of active smoking and secondhand smoke exposure in critically ill patients.

Critical care medicine

Hsieh SJ, Ware LB, Eisner MD, Yu L, Jacob P, Havel C, Goniewicz ML, Matthay MA, Benowitz NL, Calfee CS

Therapeutic potential of mesenchymal stem cells for severe acute lung injury.

Chest

Matthay MA, Thompson BT, Read EJ, McKenna DH, Liu KD, Calfee CS, Lee JW

Therapeutic strategies for severe acute lung injury.

Critical care medicine

Diaz JV, Brower R, Calfee CS, Matthay MA

Early release of soluble receptor for advanced glycation endproducts after severe trauma in humans.

The Journal of trauma

Cohen MJ, Carles M, Brohi K, Calfee CS, Rahn P, Call MS, Chesebro BB, West MA, Pittet JF

Plasma interleukin-8 is not an effective risk stratification tool for adults with vasopressor-dependent septic shock.

Critical care medicine

Calfee CS, Thompson BT, Parsons PE, Ware LB, Matthay MA, Wong HR

Acute lung injury in patients with traumatic injuries: utility of a panel of biomarkers for diagnosis and pathogenesis.

The Journal of trauma

Fremont RD, Koyama T, Calfee CS, Wu W, Dossett LA, Bossert FR, Mitchell D, Wickersham N, Bernard GR, Matthay MA, May AK, Ware LB

Plasma biomarker profiles in acute exacerbation of idiopathic pulmonary fibrosis.

American journal of physiology. Lung cellular and molecular physiology

Collard HR, Calfee CS, Wolters PJ, Song JW, Hong SB, Brady S, Ishizaka A, Jones KD, King TE, Matthay MA, Kim DS

Early release of high mobility group box nuclear protein 1 after severe trauma in humans: role of injury severity and tissue hypoperfusion.

Critical care (London, England)

Cohen MJ, Brohi K, Calfee CS, Rahn P, Chesebro BB, Christiaans SC, Carles M, Howard M, Pittet JF

Determining the aetiology of pulmonary oedema by the oedema fluid-to-plasma protein ratio.

The European respiratory journal

Ware LB, Fremont RD, Bastarache JA, Calfee CS, Matthay MA

Plasma granulocyte colony-stimulating factor levels correlate with clinical outcomes in patients with acute lung injury.

Critical care medicine

Suratt BT, Eisner MD, Calfee CS, Allard JB, Whittaker LA, Engelken DT, Petty JM, Trimarchi T, Gauthier L, Parsons PE

Soluble intercellular adhesion molecule-1 and clinical outcomes in patients with acute lung injury.

Intensive care medicine

Calfee CS, Eisner MD, Parsons PE, Thompson BT, Conner ER, Matthay MA, Ware LB

Plasma receptor for advanced glycation end products and clinical outcomes in acute lung injury.

Thorax

Calfee CS, Ware LB, Eisner MD, Parsons PE, Thompson BT, Wickersham N, Matthay MA

Trauma-associated lung injury differs clinically and biologically from acute lung injury due to other clinical disorders.

Critical care medicine

Calfee CS, Eisner MD, Ware LB, Thompson BT, Parsons PE, Wheeler AP, Korpak A, Matthay MA

Plasma receptor for advanced glycation end-products predicts duration of ICU stay and mechanical ventilation in patients after lung transplantation.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

Calfee CS, Budev MM, Matthay MA, Church G, Brady S, Uchida T, Ishizaka A, Lara A, Ranes JL, deCamp MM, Arroliga AC

Clinical problem-solving. Anchors away.

The New England journal of medicine

Calfee CS, Shah SJ, Wolters PJ, Saint S, King TE

The influence of perceived control of asthma on health outcomes.

Chest

Calfee CS, Katz PP, Yelin EH, Iribarren C, Eisner MD

Recent advances in mechanical ventilation.

The American journal of medicine

Calfee CS, Matthay MA