Carolyn Hendrickson, MD, MPH

Assistant Professor
Medicine
+1 415 476-0735

Dr. Hendrickson is an Assistant Professor of Medicine in the Division of Pulmonary, Critical Care, Allergy, Immunology, and Sleep Medicine at UCSF.  She is an attending physician at Zuckerberg San Francisco General Hospital and Trauma Center.  Her research focuses on understanding the biology driving the acute respiratory distress syndrome (ARDS) after severe traumatic injury.  ARDS is a form of acute lung injury marked by low oxygen levels and associated with significant morbidity and mortality among patients with critical illness.  This project studies how environmental exposures, including tobacco smoke, air pollution, and alcohol use effect the risk of developing ARDS after trauma.  This work uses biomarkers to measure exposures to cigarette smoke and alcohol and to understand how these exposures may interact with exposure to ambient air pollution.  Dr. Hendrickson is implementing a prospective cohort study in Fresno, California, a region with very poor air quality, to measure plasma proteins associated with inflammation and the regulation of the vascular endothelium among patients who have suffered acute traumatic injuries. She will compare these protein levels between people who have varying degrees of exposure to air pollution, tobacco smoke, and alcohol use.  This research may improve our understanding of the pathogenesis of ARDS with the ultimate goal of developing new preventative strategies for this syndrome perhaps through regulation of environmental exposures or public health campaigns.

Publications: 

Perhaps It's Not the Platelet: Ristocetin Uncovers the Potential Role of von Willebrand Factor in Impaired Platelet Aggregation Following Traumatic Brain Injury.

The journal of trauma and acute care surgery

Kornblith LZ, Robles AJ, Conroy AS, Hendrickson CM, Calfee CS, Fields AT, Callcut RA, Cohen MJ

Health care utilization and the cost of posttraumatic acute respiratory distress syndrome care.

The journal of trauma and acute care surgery

Robles AJ, Kornblith LZ, Hendrickson CM, Howard BM, Conroy AS, Moazed F, Calfee CS, Cohen MJ, Callcut RA

Elevated plasma levels of TIMP-3 are associated with a higher risk of acute respiratory distress syndrome and death following severe isolated traumatic brain injury.

Trauma surgery & acute care open

Hendrickson CM, Gibb SL, Miyazawa BY, Keating SM, Ross E, Conroy AS, Calfee CS, Pati S, Cohen MJ

Platelet aggregation after blunt trauma is associated with the acute respiratory distress syndrome and altered by cigarette smoke exposure.

The journal of trauma and acute care surgery

Moazed F, Hendrickson C, Nelson M, Conroy A, Cohen MJ, Calfee CS

Characterization of distinct coagulopathic phenotypes in injury: Pathway-specific drivers and implications for individualized treatment.

The journal of trauma and acute care surgery

Christie SA, Kornblith LZ, Howard BM, Conroy AS, Kunitake RC, Nelson MF, Hendrickson CM, Calfee CS, Callcut RA, Cohen MJ

Higher mini-BAL total protein concentration in early ARDS predicts faster resolution of lung injury measured by more ventilator-free days.

American journal of physiology. Lung cellular and molecular physiology

Hendrickson CM, Abbott J, Zhuo H, Liu KD, Calfee CS, Matthay MA

The acute respiratory distress syndrome following isolated severe traumatic brain injury.

The journal of trauma and acute care surgery

Hendrickson CM, Howard BM, Kornblith LZ, Conroy AS, Nelson MF, Zhuo H, Liu KD, Manley GT, Matthay MA, Calfee CS, Cohen MJ

Misclassification of acute respiratory distress syndrome after traumatic injury: The cost of less rigorous approaches.

The journal of trauma and acute care surgery

Hendrickson CM, Dobbins S, Redick BJ, Greenberg MD, Calfee CS, Cohen MJ

Differences in degree, differences in kind: characterizing lung injury in trauma.

The journal of trauma and acute care surgery

Howard BM, Kornblith LZ, Hendrickson CM, Redick BJ, Conroy AS, Nelson MF, Callcut RA, Calfee CS, Cohen MJ

Biology and pathology of fibroproliferation following the acute respiratory distress syndrome.

Intensive care medicine

Hendrickson CM, Crestani B, Matthay MA

Differences in biofilm formation and antimicrobial resistance of Pseudomonas aeruginosa isolated from airways of mechanically ventilated patients and cystic fibrosis patients.

International journal of antimicrobial agents

Fricks-Lima J, Hendrickson CM, Allgaier M, Zhuo H, Wiener-Kronish JP, Lynch SV, Yang K