Dieter Meyerhoff, PhD

Professor in Residence
Radiology
+1 415 221-4810 ext. 24803

Dieter Meyerhoff, PhD, is a Professor in Residence in the Department of Radiology at the University of California, San Francisco and at the San Francisco Veterans Affairs Medical Center. He is also Co-Director of the Treatment Research Center in the Department of Psychiatry at UCSF. Dr. Meyerhoff completed his undergraduate degree in Chemistry from Westphälische Wilhelms Universität in Münster, Germany, and he obtained his PhD in Chemistry at Westphälische Wilhelms Universität, followed by a postdoctoral fellowship from the University of California, Berkeley Department of Chemistry.

Dr. Meyerhoff’s research goal is to better understand the neurodegenerative processes associated with specific insults to the human brain and repair process after removal of these insults. At the VA, Dr. Meyerhoff studies insults exceedingly common in the brain of veterans with substance dependence (alcohol, cocaine, and nicotine), post-traumatic stress disorder (PTSD), Gulf War Syndrome, and HIV infection. As senior scientist at the CIND, he primarily uses 1H MR to study mechanisms of neurodegenerative insults and recovery from them under special consideration of behavioral and cognitive correlations as well as genetic determinants.

Dr. Meyerhoff serves as Principal Investigator, Co-Principal Investigator, and Co-Investigator on numerous NIH- and DoD-funded research projects. Dr. Meyerhoff has published more than 120 peer-reviewed research articles, has written and co-authored about 15 book chapters and presented more than 250 abstracts at national and international scientific meetings.

Expertise:
nuclear magnetic resonance, neuroimaging

Specialty:
Neurodegenerative processes, structural MRI, metabolic imaging via MR spectroscopy, perfusion, and diffusion tensor imaging

Professional Interests:
Magnetic resonance, cognition, brain, substance use disorders (alcohol, cocaine, tobacco, heroin, polysubstances), addiction, obesity, HIV/AIDS, posttraumatic stress disorder (PTSD), neurogenetics

Education and Training:
• Undergraduate: Westphälische Wilhelms Universität, Münster, Germany - Chemistry
• Dr. Rer. Nat.: Westphälische Wilhelms Universität, Münster, Germany - Chemistry
• Postdoctoral Fellowship: University of California, Berkeley, Department of Chemistry - NMR

Publications: 

Longitudinal Trajectories of Brain Volume and Cortical Thickness in Treated and Untreated Primary HIV Infection.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Sanford R, Ances BM, Meyerhoff DJ, Price RW, Fuchs D, Zetterberg H, Spudich S, Collins DL

Regional Brain Volume Changes in Alcohol-dependent Individuals during Short-term and Long-term Abstinence.

Alcoholism, clinical and experimental research

Zou X, Durazzo TC, Meyerhoff DJ

Regional cerebral blood flow in opiate dependence relates to substance use and neuropsychological performance.

Addiction biology

Murray DE, Durazzo TC, Schmidt TP, Murray TA, Abé C, Guydish J, Meyerhoff DJ

Cigarette smoking is associated with amplified age-related volume loss in subcortical brain regions.

Drug and alcohol dependence

Durazzo TC, Meyerhoff DJ, Yoder KK, Murray DE

Blood-Brain Barrier Disruption Is Initiated During Primary HIV Infection and Not Rapidly Altered by Antiretroviral Therapy.

The Journal of infectious diseases

Rahimy E, Li FY, Hagberg L, Fuchs D, Robertson K, Meyerhoff DJ, Zetterberg H, Price RW, Gisslén M, Spudich S

Effects of abstinence and chronic cigarette smoking on white matter microstructure in alcohol dependence: Diffusion tensor imaging at 4T.

Drug and alcohol dependence

Zou Y, Murray DE, Durazzo TC, Schmidt TP, Murray TA, Meyerhoff DJ

Structural Neuroimaging in Polysubstance Users.

Current opinion in behavioral sciences

Meyerhoff DJ

Neurocognition and inhibitory control in polysubstance use disorders: Comparison with alcohol use disorders and changes with abstinence.

Journal of clinical and experimental neuropsychology

Schmidt TP, Pennington DL, Cardoos SL, Durazzo TC, Meyerhoff DJ

Association of Superoxide Dismutase 2 (SOD2) Genotype with Gray Matter Volume Shrinkage in Chronic Alcohol Users: Replication and Further Evaluation of an Addiction Gene Panel.

The international journal of neuropsychopharmacology

Gitik M, Srivastava V, Hodgkinson CA, Shen PH, Goldman D, Meyerhoff DJ

Putamen volume and its clinical and neurological correlates in primary HIV infection.

AIDS (London, England)

Wright PW, Pyakurel A, Vaida FF, Price RW, Lee E, Peterson J, Fuchs D, Zetterberg H, Robertson KR, Walter R, Meyerhoff DJ, Spudich SS, Ances BM

Frontal Metabolite Concentration Deficits in Opiate Dependence Relate to Substance Use, Cognition, and Self-Regulation.

Journal of addiction research & therapy

Murray DE, Durazzo TC, Schmidt TP, Abé C, Guydish J, Meyerhoff DJ

Time for Cigarette Smoke Exposure Chambers?

Alcoholism, clinical and experimental research

Meyerhoff DJ

Fat may affect magnetic resonance signal intensity and brain tissue volumes.

Obesity research & clinical practice

Mon A, Abé C, Durazzo TC, Meyerhoff DJ

Comparison of Regional Brain Perfusion Levels in Chronically Smoking and Non-Smoking Adults.

International journal of environmental research and public health

Durazzo TC, Meyerhoff DJ, Murray DE

Brain pathways to recovery from alcohol dependence.

Alcohol (Fayetteville, N.Y.)

Cui C, Noronha A, Warren KR, Koob GF, Sinha R, Thakkar M, Matochik J, Crews FT, Chandler LJ, Pfefferbaum A, Becker HC, Lovinger D, Everitt BJ, Egli M, Mandyam CD, Fein G, Potenza MN, Harris RA, Grant KA, Roberto M, Meyerhoff DJ, Sullivan EV

Brain perfusion in polysubstance users: relationship to substance and tobacco use, cognition, and self-regulation.

Drug and alcohol dependence

Murray DE, Durazzo TC, Mon A, Schmidt TP, Meyerhoff DJ

Cerebral white matter integrity during primary HIV infection.

AIDS (London, England)

Wright PW, Vaida FF, Fernández RJ, Rutlin J, Price RW, Lee E, Peterson J, Fuchs D, Shimony JS, Robertson KR, Walter R, Meyerhoff DJ, Spudich S, Ances BM

Effects of cigarette smoking history on neurocognitive recovery over 8 months of abstinence in alcohol-dependent individuals.

Alcoholism, clinical and experimental research

Durazzo TC, Pennington DL, Schmidt TP, Meyerhoff DJ

Cerebral metabolite changes prior to and after antiretroviral therapy in primary HIV infection.

Neurology

Young AC, Yiannoutsos CT, Hegde M, Lee E, Peterson J, Walter R, Price RW, Meyerhoff DJ, Spudich S

Structural brain differences in alcohol-dependent individuals with and without comorbid substance dependence.

Drug and alcohol dependence

Mon A, Durazzo TC, Abe C, Gazdzinski S, Pennington D, Schmidt T, Meyerhoff DJ

Genetic and behavioral determinants of hippocampal volume recovery during abstinence from alcohol.

Alcohol (Fayetteville, N.Y.)

Hoefer ME, Pennington DL, Durazzo TC, Mon A, Abé C, Truran D, Hutchison KE, Meyerhoff DJ

Postural stability in cigarette smokers and during abstinence from alcohol.

Alcoholism, clinical and experimental research

Schmidt TP, Pennington DL, Durazzo TC, Meyerhoff DJ

Clinical proton MR spectroscopy in central nervous system disorders.

Radiology

Oz G, Alger JR, Barker PB, Bartha R, Bizzi A, Boesch C, Bolan PJ, Brindle KM, Cudalbu C, Dinçer A, Dydak U, Emir UE, Frahm J, González RG, Gruber S, Gruetter R, Gupta RK, Heerschap A, Henning A, Hetherington HP, Howe FA, Hüppi PS, Hurd RE, Kantarci K, Klomp DW, Kreis R, Kruiskamp MJ, Leach MO, Lin AP, Luijten PR, Marjanska M, Maudsley AA, Meyerhoff DJ, Mountford CE, Nelson SJ, Pamir MN, Pan JW, Peet AC, Poptani H, Posse S, Pouwels PJ, Ratai EM, Ross BD, Scheenen TW, Schuster C, Smith IC, Soher BJ, Tkác I, Vigneron DB, Kauppinen RA

Interactive effects of chronic cigarette smoking and age on hippocampal volumes.

Drug and alcohol dependence

Durazzo TC, Meyerhoff DJ, Nixon SJ

Human linear growth trajectory defined.

American journal of human biology : the official journal of the Human Biology Council

Mon A, Cabana M, Halpern-Felsher B, Meyerhoff DJ

Metabolic abnormalities in lobar and subcortical brain regions of abstinent polysubstance users: magnetic resonance spectroscopic imaging.

Alcohol and alcoholism (Oxford, Oxfordshire)

Abé C, Mon A, Hoefer ME, Durazzo TC, Pennington DL, Schmidt TP, Meyerhoff DJ

Neurocognition in 1-month-abstinent treatment-seeking alcohol-dependent individuals: interactive effects of age and chronic cigarette smoking.

Alcoholism, clinical and experimental research

Durazzo TC, Pennington DL, Schmidt TP, Mon A, Abé C, Meyerhoff DJ

Cerebrospinal fluid and neuroimaging biomarker abnormalities suggest early neurological injury in a subset of individuals during primary HIV infection.

The Journal of infectious diseases

Peluso MJ, Meyerhoff DJ, Price RW, Peterson J, Lee E, Young AC, Walter R, Fuchs D, Brew BJ, Cinque P, Robertson K, Hagberg L, Zetterberg H, Gisslén M, Spudich S

The effects of chronic cigarette smoking on cognitive recovery during early abstinence from alcohol.

Alcoholism, clinical and experimental research

Pennington DL, Durazzo TC, Schmidt TP, Mon A, Abé C, Meyerhoff DJ

Polysubstance and alcohol dependence: unique abnormalities of magnetic resonance-derived brain metabolite levels.

Drug and alcohol dependence

Abé C, Mon A, Durazzo TC, Pennington DL, Schmidt TP, Meyerhoff DJ

Loss in connectivity among regions of the brain reward system in alcohol dependence.

Human brain mapping

Kuceyeski A, Meyerhoff DJ, Durazzo TC, Raj A

How acute and chronic alcohol consumption affects brain networks: insights from multimodal neuroimaging.

Alcoholism, clinical and experimental research

Schulte T, Oberlin BG, Kareken DA, Marinkovic K, Müller-Oehring EM, Meyerhoff DJ, Tapert S

A comprehensive assessment of neurocognition in middle-aged chronic cigarette smokers.

Drug and alcohol dependence

Durazzo TC, Meyerhoff DJ, Nixon SJ

The relationship between Gulf War illness, brain N-acetylaspartate, and post-traumatic stress disorder.

Military medicine

Weiner MW, Meyerhoff DJ, Neylan TC, Hlavin J, Ramage ER, McCoy D, Studholme C, Cardenas V, Marmar C, Truran D, Chu PW, Kornak J, Furlong CE, McCarthy C

Brain morphology at entry into treatment for alcohol dependence is related to relapse propensity.

Biological psychiatry

Cardenas VA, Durazzo TC, Gazdzinski S, Mon A, Studholme C, Meyerhoff DJ

Cortical thickness, surface area, and volume of the brain reward system in alcohol dependence: relationships to relapse and extended abstinence.

Alcoholism, clinical and experimental research

Durazzo TC, Tosun D, Buckley S, Gazdzinski S, Mon A, Fryer SL, Meyerhoff DJ

Hippocampal volume differences in Gulf War veterans with current versus lifetime posttraumatic stress disorder symptoms.

Biological psychiatry

Apfel BA, Ross J, Hlavin J, Meyerhoff DJ, Metzler TJ, Marmar CR, Weiner MW, Schuff N, Neylan TC

Chronic cigarette smoking: implications for neurocognition and brain neurobiology.

International journal of environmental research and public health

Durazzo TC, Meyerhoff DJ, Nixon SJ

Measures of learning, memory and processing speed accurately predict smoking status in short-term abstinent treatment-seeking alcohol-dependent individuals.

Alcohol and alcoholism (Oxford, Oxfordshire)

Durazzo TC, Fryer SL, Rothlind JC, Vertinski M, Gazdzinski S, Mon A, Meyerhoff DJ

Body mass index is associated with brain metabolite levels in alcohol dependence--a multimodal magnetic resonance study.

Alcoholism, clinical and experimental research

Gazdzinski S, Durazzo TC, Mon A, Meyerhoff DJ

Cerebral white matter recovery in abstinent alcoholics--a multimodality magnetic resonance study.

Brain : a journal of neurology

Gazdzinski S, Durazzo TC, Mon A, Yeh PH, Meyerhoff DJ

BMI and neuronal integrity in healthy, cognitively normal elderly: a proton magnetic resonance spectroscopy study.

Obesity (Silver Spring, Md.)

Gazdzinski S, Millin R, Kaiser LG, Durazzo TC, Mueller SG, Weiner MW, Meyerhoff DJ

In-vivo investigation of the human cingulum bundle using the optimization of MR diffusion spectrum imaging.

European journal of radiology

Nezamzadeh M, Wedeen VJ, Wang R, Zhang Y, Zhan W, Young K, Meyerhoff DJ, Weiner MW, Schuff N

MRSI and DTI: a multimodal approach for improved detection of white matter abnormalities in alcohol and nicotine dependence.

NMR in biomedicine

Wang JJ, Durazzo TC, Gazdzinski S, Yeh PH, Mon A, Meyerhoff DJ

Combined neuroimaging, neurocognitive and psychiatric factors to predict alcohol consumption following treatment for alcohol dependence.

Alcohol and alcoholism (Oxford, Oxfordshire)

Durazzo TC, Gazdzinski S, Yeh PH, Meyerhoff DJ

Proton magnetic resonance spectroscopy in alcohol use disorders: a potential new endophenotype?

Alcoholism, clinical and experimental research

Meyerhoff DJ, Durazzo TC

Body mass index and magnetic resonance markers of brain integrity in adults.

Annals of neurology

Gazdzinski S, Kornak J, Weiner MW, Meyerhoff DJ

Chronic cigarette smoking modulates injury and short-term recovery of the medial temporal lobe in alcoholics.

Psychiatry Research

Gazdzinski S, Durazzo TC, Yeh PH, Hardin D, Banys P, Meyerhoff DJ

Chronic cigarette smoking and heavy drinking in human immunodeficiency virus: consequences for neurocognition and brain morphology.

Alcohol (Fayetteville, N.Y.)

Durazzo TC, Rothlind JC, Cardenas VA, Studholme C, Weiner MW, Meyerhoff DJ

Neurobiological and neurocognitive effects of chronic cigarette smoking and alcoholism.

Frontiers in bioscience : a journal and virtual library

Durazzo TC, Meyerhoff DJ

The neurobiological and neurocognitive consequences of chronic cigarette smoking in alcohol use disorders.

Alcohol and alcoholism (Oxford, Oxfordshire)

Durazzo TC, Gazdzinski S, Meyerhoff DJ

Chronic smoking is associated with differential neurocognitive recovery in abstinent alcoholic patients: a preliminary investigation.

Alcoholism, clinical and experimental research

Durazzo TC, Rothlind JC, Gazdzinski S, Banys P, Meyerhoff DJ

Proton MRS and neuropsychological correlates in AIDS dementia complex: evidence of subcortical specificity.

The Journal of neuropsychiatry and clinical neurosciences

Paul RH, Yiannoutsos CT, Miller EN, Chang L, Marra CM, Schifitto G, Ernst T, Singer E, Richards T, Jarvik GJ, Price R, Meyerhoff DJ, Kolson D, Ellis RJ, Gonzalez G, Lenkinski RE, Cohen RA, Navia BA

Deformation-based morphometry of brain changes in alcohol dependence and abstinence.

NeuroImage

Cardenas VA, Studholme C, Gazdzinski S, Durazzo TC, Meyerhoff DJ

Non-treatment-seeking heavy drinkers: effects of chronic cigarette smoking on brain structure.

Drug and alcohol dependence

Durazzo TC, Cardenas VA, Studholme C, Weiner MW, Meyerhoff DJ

A comparison of neurocognitive function in nonsmoking and chronically smoking short-term abstinent alcoholics.

Alcohol (Fayetteville, N.Y.)

Durazzo TC, Rothlind JC, Gazdzinski S, Banys P, Meyerhoff DJ

Effects of chronic alcohol dependence and chronic cigarette smoking on cerebral perfusion: a preliminary magnetic resonance study.

Alcoholism, clinical and experimental research

Gazdzinski S, Durazzo T, Jahng GH, Ezekiel F, Banys P, Meyerhoff D

Smoking comorbidity in alcoholism: neurobiological and neurocognitive consequences.

Alcoholism, clinical and experimental research

Meyerhoff DJ, Tizabi Y, Staley JK, Durazzo TC, Glass JM, Nixon SJ

N-acetylaspartate as a marker of neuronal injury in neurodegenerative disease.

Advances in experimental medicine and biology

Schuff N, Meyerhoff DJ, Mueller S, Chao L, Sacrey DT, Laxer K, Weiner MW

Health risks of chronic moderate and heavy alcohol consumption: how much is too much?

Alcoholism, clinical and experimental research

Meyerhoff DJ, Bode C, Nixon SJ, de Bruin EA, Bode JC, Seitz HK

Using automated morphometry to detect associations between ERP latency and structural brain MRI in normal adults.

Human brain mapping

Cardenas VA, Chao LL, Blumenfeld R, Song E, Meyerhoff DJ, Weiner MW, Studholme C

Sensitive and fast T1 mapping based on two inversion recovery images and a reference image.

Medical physics

Jahng GH, Stables L, Ebel A, Matson GB, Meyerhoff DJ, Weiner MW, Schuff N

Chronic active heavy drinking and family history of problem drinking modulate regional brain tissue volumes.

Psychiatry Research

Cardenas VA, Studholme C, Meyerhoff DJ, Song E, Weiner MW

Heavy alcohol consumption in individuals with HIV infection: effects on neuropsychological performance.

Journal of the International Neuropsychological Society : JINS

Rothlind JC, Greenfield TM, Bruce AV, Meyerhoff DJ, Flenniken DL, Lindgren JA, Weiner MW

Magnetic resonance detects brainstem changes in chronic, active heavy drinkers.

Psychiatry Research

Bloomer CW, Langleben DD, Meyerhoff DJ

Cigarette smoking exacerbates chronic alcohol-induced brain damage: a preliminary metabolite imaging study.

Alcoholism, clinical and experimental research

Durazzo TC, Gazdzinski S, Banys P, Meyerhoff DJ

Regional patterns of brain metabolites in AIDS dementia complex.

NeuroImage

Yiannoutsos CT, Ernst T, Chang L, Lee PL, Richards T, Marra CM, Meyerhoff DJ, Jarvik JG, Kolson D, Schifitto G, Ellis RJ, Swindells S, Simpson DM, Miller EN, Gonzalez RG, Navia BA

Abnormal contingent negative variation in HIV patients receiving antiretroviral therapy.

Neuroreport

Chao LL, Cardenas VA, Meyerhoff DJ, Rothlind JC, Flenniken DL, Lindgren JA, Weiner MW

Abnormal CNV in chronic heavy drinkers.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

Chao LL, Meyerhoff DJ, Cardenas VA, Rothlind JC, Weiner MW

A multi-center 1H MRS study of the AIDS dementia complex: validation and preliminary analysis.

Journal of magnetic resonance imaging : JMRI

Lee PL, Yiannoutsos CT, Ernst T, Chang L, Marra CM, Jarvik JG, Richards TL, Kwok EW, Kolson DL, Simpson D, Tang CY, Schifitto G, Ketonen LM, Meyerhoff DJ, Lenkinski RE, Gonzalez RG, Navia BA

Indirect imaging of ethanol via magnetization transfer at high and low magnetic fields.

Magnetic resonance in medicine

Estilaei MR, Matson GB, Meyerhoff DJ