Jeffrey Gotts, MD, PhD

Assistant Professor
Medicine
+1 415 443-9263

Research focuses on the effects of cigarette smoke and e-cigarette aerosols on susceptibility to acute respiratory distress syndrome (ARDS), a major cause of respiratory failure in critically ill patients.

ARDS remains a frequently fatal cause of acute respiratory failure, with an estimated U.S. incidence of nearly 200,000 cases per year and a mortality of 30%; no specific therapies beyond supportive measures have been demonstrated to be beneficial.  Our research is focused on both improving our understanding of the pathogenesis of ALI and on developing novel biomarker-based strategies for diagnostic and prognostic purposes, with the ultimate goal of developing new preventative and therapeutic strategies for this devastating syndrome. To this end we have developed animal models of how smoke exposure affects the trajectory of viral and bacterial lung injury. More recently we have begun studying e-cigarette aerosols and their toxicity to human lung cells, exposing cultures of alveolar and airway epithelia (derived from human lungs declined for transplantation) in a novel aerosol generating machine. 

Publications: 

What are the respiratory effects of e-cigarettes?

BMJ (Clinical research ed.)

Gotts JE, Jordt SE, McConnell R, Tarran R

Clinically Relevant Model of Pneumococcal Pneumonia, ARDS, and Non-Pulmonary Organ Dysfunction in Mice.

American journal of physiology. Lung cellular and molecular physiology

Gotts JE, Bernard O, Chun L, Croze RH, Ross JT, Nesseler N, Wu X, Abbott J, Fang X, Calfee CS, Matthay MA

Precision medicine for cell therapy in acute respiratory distress syndrome - Authors' reply.

The Lancet. Respiratory medicine

Matthay MA, Zhuo H, Gotts JE, Liu KD, Calfee CS

High Power Vaping Injures the Human Lung.

American journal of physiology. Lung cellular and molecular physiology

Gotts JE

Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial.

The Lancet. Respiratory medicine

Matthay MA, Calfee CS, Zhuo H, Thompson BT, Wilson JG, Levitt JE, Rogers AJ, Gotts JE, Wiener-Kronish JP, Bajwa EK, Donahoe MP, McVerry BJ, Ortiz LA, Exline M, Christman JW, Abbott J, Delucchi KL, Caballero L, McMillan M, McKenna DH, Liu KD

Assessment of industry data on pulmonary and immunosuppressive effects of IQOS.

Tobacco control

Moazed F, Chun L, Matthay MA, Calfee CS, Gotts J

Possible hepatotoxicity of IQOS.

Tobacco control

Chun L, Moazed F, Matthay M, Calfee C, Gotts J

Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice.

American journal of physiology. Lung cellular and molecular physiology

Gotts JE, Chun LF, Abbott J, Fang X, Takasaki N, Nishimura SL, Springer ML, Schick SF, Calfee CS, Matthay MA

Cell-based Therapy in Sepsis. A Step Closer.

American journal of respiratory and critical care medicine

Gotts JE, Matthay MA

Reply to "Letter to the Editor: Pulmonary toxicity of electronic cigarettes: more doubts than certainties".

American journal of physiology. Lung cellular and molecular physiology

Chun LF, Moazed F, Calfee CS, Matthay MA, Gotts JE

Cigarette Smoke Exposure Worsens Endotoxin-Induced Lung Injury and Pulmonary Edema in Mice.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

Gotts JE, Abbott J, Fang X, Yanagisawa H, Takasaka N, Nishimura SL, Calfee CS, Matthay MA

Local lung hypoxia determines epithelial fate decisions during alveolar regeneration.

Nature cell biology

Xi Y, Kim T, Brumwell AN, Driver IH, Wei Y, Tan V, Jackson JR, Xu J, Lee DK, Gotts JE, Matthay MA, Shannon JM, Chapman HA, Vaughan AE

Pulmonary toxicity of e-cigarettes.

American journal of physiology. Lung cellular and molecular physiology

Chun LF, Moazed F, Calfee CS, Matthay MA, Gotts JE

Cathepsin L Helps to Defend Mice from Infection with Influenza A.

PloS one

Xu X, Greenland JR, Gotts JE, Matthay MA, Caughey GH

Persistent Pathology in Influenza-Infected Mouse Lungs.

American journal of respiratory cell and molecular biology

Kanegai CM, Xi Y, Donne ML, Gotts JE, Driver IH, Amidzic G, Lechner AJ, Jones KD, Vaughan AE, Chapman HA, Rock JR

Sepsis: pathophysiology and clinical management.

BMJ (Clinical research ed.)

Gotts JE, Matthay MA

Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury.

Nature

Vaughan AE, Brumwell AN, Xi Y, Gotts JE, Brownfield DG, Treutlein B, Tan K, Tan V, Liu FC, Looney MR, Matthay MA, Rock JR, Chapman HA

Influenza causes prolonged disruption of the alveolar-capillary barrier in mice unresponsive to mesenchymal stem cell therapy.

American journal of physiology. Lung cellular and molecular physiology

Gotts JE, Abbott J, Matthay MA

Design and implementation of the START (STem cells for ARDS Treatment) trial, a phase 1/2 trial of human mesenchymal stem/stromal cells for the treatment of moderate-severe acute respiratory distress syndrome.

Annals of intensive care

Liu KD, Wilson JG, Zhuo H, Caballero L, McMillan ML, Fang X, Cosgrove K, Calfee CS, Lee JW, Kangelaris KN, Gotts JE, Rogers AJ, Levitt JE, Wiener-Kronish JP, Delucchi KL, Leavitt AD, McKenna DH, Thompson BT, Matthay MA

Treating ARDS: new hope for a tough problem.

The Lancet. Respiratory medicine

Gotts JE, Matthay MA

Mesenchymal stem cells and the stem cell niche: a new chapter.

American journal of physiology. Lung cellular and molecular physiology

Gotts JE, Matthay MA

Mesenchymal stem cells and acute lung injury.

Critical care clinics

Gotts JE, Matthay MA

Mechanisms of subventricular zone expansion after focal cortical ischemic injury.

The Journal of comparative neurology

Gotts JE, Chesselet MF

Migration and fate of newly born cells after focal cortical ischemia in adult rats.

Journal of neuroscience research

Gotts JE, Chesselet MF

Noninvasive, repetitive, quantitative measurement of gene expression from a bicistronic message by positron emission tomography, following gene transfer with adenovirus.

Molecular therapy : the journal of the American Society of Gene Therapy

Liang Q, Gotts J, Satyamurthy N, Barrio J, Phelps ME, Gambhir SS, Herschman HR

Intracisternal basic fibroblast growth factor enhances functional recovery and up-regulates the expression of a molecular marker of neuronal sprouting following focal cerebral infarction.

Proceedings of the National Academy of Sciences of the United States of America

Kawamata T, Dietrich WD, Schallert T, Gotts JE, Cocke RR, Benowitz LI, Finklestein SP