John Kane, MD, PhD

Professor of Medicine
Medicine
+1 415 476-2241
Publications: 

Loss-of-Function CREB3L3 Variants in Patients With Severe Hypertriglyceridemia.

Arteriosclerosis, thrombosis, and vascular biology

Dron JS, Dilliott AA, Lawson A, McIntyre AD, Davis BD, Wang J, Cao H, Movsesyan I, Malloy MJ, Pullinger CR, Kane JP, Hegele RA

Separation of postprandial lipoproteins: improved purification of chylomicrons using an ApoB100 immunoaffinity method.

Journal of lipid research

Jones GM, Caccavello R, Palii SP, Pullinger CR, Kane JP, Mulligan K, Gugliucci A, Schwarz JM

Three patients with homozygous familial hypercholesterolemia: Genomic sequencing and kindred analysis.

Molecular genetics & genomic medicine

Wong KHY, Levy-Sakin M, Ma W, Gonzaludo N, Mak ACY, Vaka D, Poon A, Chu C, Lao R, Balamir M, Grenville Z, Wong N, Kane JP, Kwok PY, Malloy MJ, Pullinger CR

Partial LPL deletions: rare copy-number variants contributing towards severe hypertriglyceridemia.

Journal of lipid research

Dron JS, Wang J, McIntyre AD, Cao H, Robinson JF, Duell PB, Manjoo P, Feng J, Movsesyan I, Malloy MJ, Pullinger CR, Kane JP, Hegele RA

Emerging roles of HDL in immune function.

Current opinion in lipidology

Creasy KT, Kane JP, Malloy MJ

Severe hypertriglyceridemia is primarily polygenic.

Journal of clinical lipidology

Dron JS, Wang J, Cao H, McIntyre AD, Iacocca MA, Menard JR, Movsesyan I, Malloy MJ, Pullinger CR, Kane JP, Hegele RA

Multi-ethnic genome-wide association study for atrial fibrillation.

Nature genetics

Roselli C, Chaffin MD, Weng LC, Aeschbacher S, Ahlberg G, Albert CM, Almgren P, Alonso A, Anderson CD, Aragam KG, Arking DE, Barnard J, Bartz TM, Benjamin EJ, Bihlmeyer NA, Bis JC, Bloom HL, Boerwinkle E, Bottinger EB, Brody JA, Calkins H, Campbell A, Cappola TP, Carlquist J, Chasman DI, Chen LY, Chen YI, Choi EK, Choi SH, Christophersen IE, Chung MK, Cole JW, Conen D, Cook J, Crijns HJ, Cutler MJ, Damrauer SM, Daniels BR, Darbar D, Delgado G, Denny JC, Dichgans M, Dörr M, Dudink EA, Dudley SC, Esa N, Esko T, Eskola M, Fatkin D, Felix SB, Ford I, Franco OH, Geelhoed B, Grewal RP, Gudnason V, Guo X, Gupta N, Gustafsson S, Gutmann R, Hamsten A, Harris TB, Hayward C, Heckbert SR, Hernesniemi J, Hocking LJ, Hofman A, Horimoto ARVR, Huang J, Huang PL, Huffman J, Ingelsson E, Ipek EG, Ito K, Jimenez-Conde J, Johnson R, Jukema JW, Kääb S, Kähönen M, Kamatani Y, Kane JP, Kastrati A, Kathiresan S, Katschnig-Winter P, Kavousi M, Kessler T, Kietselaer BL, Kirchhof P, Kleber ME, Knight S, Krieger JE, Kubo M, Launer LJ, Laurikka J, Lehtimäki T, Leineweber K, Lemaitre RN, Li M, Lim HE, Lin HJ, Lin H, Lind L, Lindgren CM, Lokki ML, London B, Loos RJF, Low SK, Lu Y, Lyytikäinen LP, Macfarlane PW, Magnusson PK, Mahajan A, Malik R, Mansur AJ, Marcus GM, Margolin L, Margulies KB, März W, McManus DD, Melander O, Mohanty S, Montgomery JA, Morley MP, Morris AP, Müller-Nurasyid M, Natale A, Nazarian S, Neumann B, Newton-Cheh C, Niemeijer MN, Nikus K, Nilsson P, Noordam R, Oellers H, Olesen MS, Orho-Melander M, Padmanabhan S, Pak HN, Paré G, Pedersen NL, Pera J, Pereira A, Porteous D, Psaty BM, Pulit SL, Pullinger CR, Rader DJ, Refsgaard L, Ribasés M, Ridker PM, Rienstra M, Risch L, Roden DM, Rosand J, Rosenberg MA, Rost N, Rotter JI, Saba S, Sandhu RK, Schnabel RB, Schramm K, Schunkert H, Schurman C, Scott SA, Seppälä I, Shaffer C, Shah S, Shalaby AA, Shim J, Shoemaker MB, Siland JE, Sinisalo J, Sinner MF, Slowik A, Smith AV, Smith BH, Smith JG, Smith JD, Smith NL, Soliman EZ, Sotoodehnia N, Stricker BH, Sun A, Sun H, Svendsen JH, Tanaka T, Tanriverdi K, Taylor KD, Teder-Laving M, Teumer A, Thériault S, Trompet S, Tucker NR, Tveit A, Uitterlinden AG, Van Der Harst P, Van Gelder IC, Van Wagoner DR, Verweij N, Vlachopoulou E, Völker U, Wang B, Weeke PE, Weijs B, Weiss R, Weiss S, Wells QS, Wiggins KL, Wong JA, Woo D, Worrall BB, Yang PS, Yao J, Yoneda ZT, Zeller T, Zeng L, Lubitz SA, Lunetta KL, Ellinor PT

Levels of prebeta-1 high-density lipoprotein are elevated in 3 phenotypes of dyslipidemia.

Journal of clinical lipidology

Stock EO, Ferrara CT, O'Connor PM, Naya-Vigne JM, Frost PH, Malloy MJ, Kane JP, Pullinger CR

Moderate statin treatment reduces prebeta-1 high-density lipoprotein levels in dyslipidemic patients.

Journal of clinical lipidology

Quinn AG, Schwemberger R, Stock EO, Movsesyan I, Axtell A, Chang S, Ishida BY, Malloy MJ, Kane JP, Pullinger CR

Lipoproteins and amyloid vascular disease.

Current opinion in lipidology

Kane JP, Malloy MJ

Familial hypercholesterolaemia: cholesterol efflux and coronary disease.

European journal of clinical investigation

Versmissen J, Vongpromek R, Yahya R, van der Net JB, van Vark-van der Zee L, Blommesteijn-Touw J, Wattimena D, Rietveld T, Pullinger CR, Christoffersen C, Dahlbäck B, Kane JP, Mulder M, Sijbrands EJ

Infectious basophilia?

American journal of hematology

Kane JP

Emerging molecular strategies for management of dyslipidemias.

Current opinion in lipidology

Kane JP, Malloy MJ

Cholesterol Efflux Capacity and Pre-Beta-1 HDL Concentrations Are Increased in Dyslipidemic Patients Treated With Evacetrapib.

Journal of the American College of Cardiology

Nicholls SJ, Ruotolo G, Brewer HB, Kane JP, Wang MD, Krueger KA, Adelman SJ, Nissen SE, Rader DJ

An internal promoter underlies the difference in disease severity between N- and C-terminal truncation mutations of Titin in zebrafish.

eLife

Zou J, Tran D, Baalbaki M, Tang LF, Poon A, Pelonero A, Titus EW, Yuan C, Shi C, Patchava S, Halper E, Garg J, Movsesyan I, Yin C, Wu R, Wilsbacher LD, Liu J, Hager RL, Coughlin SR, Jinek M, Pullinger CR, Kane JP, Hart DO, Kwok PY, Deo RC

Identification and metabolic profiling of patients with lysosomal acid lipase deficiency.

Journal of clinical lipidology

Pullinger CR, Stock EO, Movsesyan I, Malloy MJ, Frost PH, Tripuraneni R, Quinn AG, Ishida BY, Schaefer EJ, Asztalos BF, Kane JP

HDL cholesterol efflux capacity and cardiovascular events.

The New England journal of medicine

Kane JP, Malloy MJ, Pullinger CR

Exome sequencing in suspected monogenic dyslipidemias.

Circulation. Cardiovascular genetics

Stitziel NO, Peloso GM, Abifadel M, Cefalu AB, Fouchier S, Motazacker MM, Tada H, Larach DB, Awan Z, Haller JF, Pullinger CR, Varret M, Rabès JP, Noto D, Tarugi P, Kawashiri MA, Nohara A, Yamagishi M, Risman M, Deo R, Ruel I, Shendure J, Nickerson DA, Wilson JG, Rich SS, Gupta N, Farlow DN, Neale BM, Daly MJ, Kane JP, Freeman MW, Genest J, Rader DJ, Mabuchi H, Kastelein JJ, Hovingh GK, Averna MR, Gabriel S, Boileau C, Kathiresan S

Effects of the absence of apolipoprotein e on lipoproteins, neurocognitive function, and retinal function.

JAMA neurology

Mak AC, Pullinger CR, Tang LF, Wong JS, Deo RC, Schwarz JM, Gugliucci A, Movsesyan I, Ishida BY, Chu C, Poon A, Kim P, Stock EO, Schaefer EJ, Asztalos BF, Castellano JM, Wyss-Coray T, Duncan JL, Miller BL, Kane JP, Kwok PY, Malloy MJ

Aberrant hetero-disulfide bond formation by the hypertriglyceridemia-associated p.Gly185Cys APOA5 variant (rs2075291).

Arteriosclerosis, thrombosis, and vascular biology

Sharma V, Witkowski A, Witkowska HE, Dykstra A, Simonsen JB, Nelbach L, Beckstead JA, Pullinger CR, Kane JP, Malloy MJ, Watson G, Forte TM, Ryan RO

Sebelipase alfa over 52 weeks reduces serum transaminases, liver volume and improves serum lipids in patients with lysosomal acid lipase deficiency.

Journal of hepatology

Valayannopoulos V, Malinova V, Honzík T, Balwani M, Breen C, Deegan PB, Enns GM, Jones SA, Kane JP, Stock EO, Tripuraneni R, Eckert S, Schneider E, Hamilton G, Middleton MS, Sirlin C, Kessler B, Bourdon C, Boyadjiev SA, Sharma R, Twelves C, Whitley CB, Quinn AG

Association of endothelial lipase Thr111Ile polymorphism with proliferative retinopathy in type 2 diabetes patients.

Diabetes & metabolism

Arndt C, Leclercq I, Nazeyrollas P, Durlach A, Ducasse A, Movesayan I, Socquard E, Clavel C, Malloy MM, Pullinger CR, Kane JP, Durlach V

Lipoprotein (a), LPA Ile4399Met, and fibrin clot properties.

Thrombosis research

Rowland CM, Pullinger CR, Luke MM, Shiffman D, Green L, Movsesyan I, Devlin JJ, Malloy MJ, Kane JP, Undas A

Impact of a 4q25 genetic variant in atrial flutter and on the risk of atrial fibrillation after cavotricuspid isthmus ablation.

Journal of cardiovascular electrophysiology

Roberts JD, Hsu JC, Aouizerat BE, Pullinger CR, Malloy MJ, Kane JP, Olgin JE, Marcus GM

Evidence that an HMGA1 gene variant associates with type 2 diabetes, body mass index, and high-density lipoprotein cholesterol in a Hispanic-American population.

Metabolic syndrome and related disorders

Pullinger CR, Goldfine ID, Tanyolaç S, Movsesyan I, Faynboym M, Durlach V, Chiefari E, Foti DP, Frost PH, Malloy MJ, Brunetti A, Kane JP

Needed: a better understanding of the antiatherogenic properties of HDL.

Current opinion in lipidology

Kane JP, Malloy MJ

New horizons in lipid management.

Journal of the American College of Cardiology

Kane JP

Deficiency of TDAG51 protects against atherosclerosis by modulating apoptosis, cholesterol efflux, and peroxiredoxin-1 expression.

Journal of the American Heart Association

Hossain GS, Lynn EG, Maclean KN, Zhou J, Dickhout JG, Lhoták S, Trigatti B, Capone J, Rho J, Tang D, McCulloch CA, Al-Bondokji I, Malloy MJ, Pullinger CR, Kane JP, Li Y, Shiffman D, Austin RC

Clinical effect and safety profile of recombinant human lysosomal acid lipase in patients with cholesteryl ester storage disease.

Hepatology (Baltimore, Md.)

Balwani M, Breen C, Enns GM, Deegan PB, Honzík T, Jones S, Kane JP, Malinova V, Sharma R, Stock EO, Valayannopoulos V, Wraith JE, Burg J, Eckert S, Schneider E, Quinn AG

Hyperlipidemia and cardiovascular disease.

Current opinion in lipidology

Malloy MJ, Kane JP

Prebeta-1 HDL and coronary heart disease.

Current opinion in lipidology

Kane JP, Malloy MJ

New molecular insights into CETP structure and function: a review.

Journal of lipid research

Charles MA, Kane JP

Rare and common variants in CARD14, encoding an epidermal regulator of NF-kappaB, in psoriasis.

American journal of human genetics

Jordan CT, Cao L, Roberson ED, Duan S, Helms CA, Nair RP, Duffin KC, Stuart PE, Goldgar D, Hayashi G, Olfson EH, Feng BJ, Pullinger CR, Kane JP, Wise CA, Goldbach-Mansky R, Lowes MA, Peddle L, Chandran V, Liao W, Rahman P, Krueger GG, Gladman D, Elder JT, Menter A, Bowcock AM

Plasma BIN1 correlates with heart failure and predicts arrhythmia in patients with arrhythmogenic right ventricular cardiomyopathy.

Heart rhythm

Hong TT, Cogswell R, James CA, Kang G, Pullinger CR, Malloy MJ, Kane JP, Wojciak J, Calkins H, Scheinman MM, Tseng ZH, Ganz P, De Marco T, Judge DP, Shaw RM

Polymorphisms and noncardioembolic stroke in three case-control studies.

Cerebrovascular diseases (Basel, Switzerland)

Luke MM, Berger K, Rowland CM, Catanese JJ, Tong CH, Ross DA, Garcia V, Kuhlenbaeumer G, Ringelstein EB, Pullinger CR, Malloy MJ, Deedwania P, Ellis SG, Kane JP, Devlin JJ, Lalouschek W, Mannhalter C

Association between regulator of G protein signaling 9-2 and body weight.

PloS one

Waugh JL, Celver J, Sharma M, Dufresne RL, Terzi D, Risch SC, Fairbrother WG, Neve RL, Kane JP, Malloy MJ, Pullinger CR, Gu HF, Tsatsanis C, Hamilton SP, Gold SJ, Zachariou V, Kovoor A

Relation of increased prebeta-1 high-density lipoprotein levels to risk of coronary heart disease.

The American journal of cardiology

Guey LT, Pullinger CR, Ishida BY, O'Connor PM, Zellner C, Francone OL, Laramie JM, Naya-Vigne JM, Siradze KA, Deedwania P, Redberg RF, Frost PH, Seymour AB, Kane JP, Malloy MJ

Evaluation of polymorphisms in EWSR1 and risk of Ewing sarcoma: a report from the Childhood Cancer Survivor Study.

Pediatric blood & cancer

DuBois SG, Goldsby R, Segal M, Woo J, Copren K, Kane JP, Pullinger CR, Matthay KK, Witte J, Lessnick SL, Robison LL, Bhatia S, Strong LC

Mechanisms of statin-induced myalgia assessed by physiogenomic associations.

Atherosclerosis

Ruaño G, Windemuth A, Wu AH, Kane JP, Malloy MJ, Pullinger CR, Kocherla M, Bogaard K, Gordon BR, Holford TR, Gupta A, Seip RL, Thompson PD

Disruption of the murine procollagen C-proteinase enhancer 2 gene causes accumulation of pro-apoA-I and increased HDL levels.

Journal of lipid research

Francone OL, Ishida BY, de la Llera-Moya M, Royer L, Happe C, Zhu J, Chalkey RJ, Schaefer P, Cox C, Burlingame A, Kane JP, Rothblat GH

Functional variants of the HMGA1 gene and type 2 diabetes mellitus.

JAMA

Chiefari E, Tanyolaç S, Paonessa F, Pullinger CR, Capula C, Iiritano S, Mazza T, Forlin M, Fusco A, Durlach V, Durlach A, Malloy MJ, Kane JP, Heiner SW, Filocamo M, Foti DP, Goldfine ID, Brunetti A

Association of endothelial lipase Thr111Ile polymorphism with lipid metabolism and microvascular complications in type 2 diabetic patients.

Diabetes & metabolism

Durlach V, Durlach A, Movesayan I, Socquard E, Zellner C, Clavel C, Nazeyrollas P, Malloy MJ, Pullinger CR, Kane JP, Ducasse A, Aouizerat BE

Morphology and structure of lipoproteins revealed by an optimized negative-staining protocol of electron microscopy.

Journal of lipid research

Zhang L, Song J, Cavigiolio G, Ishida BY, Zhang S, Kane JP, Weisgraber KH, Oda MN, Rye KA, Pownall HJ, Ren G

Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?

Pharmacogenomics

Ruaño G, Thompson PD, Kane JP, Pullinger CR, Windemuth A, Seip RL, Kocherla M, Holford TR, Wu AH

Metabolic abnormalities and coronary heart disease risk in human immunodeficiency virus-infected adults.

Metabolic syndrome and related disorders

Pullinger CR, Aouizerat BE, Gay C, Coggins T, Movsesyan I, Davis H, Kane JP, Portillo C, Lee KA

Single variants can explain the association between coronary heart disease and haplotypes in the apolipoprotein(a) locus.

Atherosclerosis

Shiffman D, Louie JZ, Rowland CM, Malloy MJ, Kane JP, Devlin JJ

Effect of niacin on preß-1 high-density lipoprotein levels in diabetes.

Metabolism: clinical and experimental

Pan J, Shilian P, Ishida B, Wu X, Kane JP, Malloy MJ, Charles MA

High-density lipoprotein metabolism and the human embryo.

Human reproduction update

Fujimoto VY, Kane JP, Ishida BY, Bloom MS, Browne RW

Genetic variants of the ENPP1/PC-1 gene are associated with hypertriglyceridemia in male subjects.

Metabolic syndrome and related disorders

Tanyolaç S, Bremer AA, Hodoglugil U, Movsesyan I, Pullinger CR, Heiner SW, Malloy MJ, Kane JP, Goldfine ID

The I4399M variant of apolipoprotein(a) is associated with increased oxidized phospholipids on apolipoprotein B-100 particles.

Atherosclerosis

Arai K, Luke MM, Koschinsky ML, Miller ER, Pullinger CR, Witztum JL, Kane JP, Tsimikas S

HDL antielastase activity prevents smooth muscle cell anoikis, a potential new antiatherogenic property.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Ortiz-Muñoz G, Houard X, Martín-Ventura JL, Ishida BY, Loyau S, Rossignol P, Moreno JA, Kane JP, Chalkley RJ, Burlingame AL, Michel JB, Meilhac O

Expression of reverse cholesterol transport proteins ATP-binding cassette A1 (ABCA1) and scavenger receptor BI (SR-BI) in the retina and retinal pigment epithelium.

The British journal of ophthalmology

Duncan KG, Hosseini K, Bailey KR, Yang H, Lowe RJ, Matthes MT, Kane JP, LaVail MM, Schwartz DM, Duncan JL

Regulation of apoAI processing by procollagen C-proteinase enhancer-2 and bone morphogenetic protein-1.

Journal of lipid research

Zhu J, Gardner J, Pullinger CR, Kane JP, Thompson JF, Francone OL

Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case-control study.

Human molecular genetics

Calton MA, Ersoy BA, Zhang S, Kane JP, Malloy MJ, Pullinger CR, Bromberg Y, Pennacchio LA, Dent R, McPherson R, Ahituv N, Vaisse C

GOSR2 Lys67Arg is associated with hypertension in whites.

American journal of hypertension

Meyer TE, Shiffman D, Morrison AC, Rowland CM, Louie JZ, Bare LA, Ross DA, Arellano AR, Chasman DI, Ridker PM, Pankow JS, Coresh J, Malloy MJ, Kane JP, Ellis SG, Devlin JJ, Boerwinkle E

Galanin preproprotein is associated with elevated plasma triglycerides.

Arteriosclerosis, thrombosis, and vascular biology

Plaisier CL, Kyttälä M, Weissglas-Volkov D, Sinsheimer JS, Huertas-Vazquez A, Riba L, Ramírez-Jiménez S, de Bruin TW, Tusié-Luna T, Aouizerat BE, Pullinger CR, Malloy MJ, Kane JP, Cruz-Bautista I, Herrera MF, Aguilar-Salinas C, Kuusisto J, Laakso M, Taskinen MR, van der Kallen CJ, Pajukanta P

Analysis of 17,576 potentially functional SNPs in three case-control studies of myocardial infarction.

PloS one

Shiffman D, Kane JP, Louie JZ, Arellano AR, Ross DA, Catanese JJ, Malloy MJ, Ellis SG, Devlin JJ

Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and coronary heart disease risk in familial hypercholesterolemia.

Atherosclerosis

van der Net JB, Versmissen J, Oosterveer DM, Defesche JC, Yazdanpanah M, Aouizerat BE, Steyerberg EW, Malloy MJ, Pullinger CR, Kane JP, Kastelein JJ, Sijbrands EJ

WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels.

American journal of human genetics

Lee JC, Weissglas-Volkov D, Kyttälä M, Dastani Z, Cantor RM, Sobel EM, Plaisier CL, Engert JC, van Greevenbroek MM, Kane JP, Malloy MJ, Pullinger CR, Huertas-Vazquez A, Aguilar-Salinas CA, Tusie-Luna T, de Bruin TW, Aouizerat BE, van der Kallen CC, Croce CM, Aqeilan RI, Marcil M, Viikari JS, Lehtimäki T, Raitakari OT, Kuusisto J, Laakso M, Taskinen MR, Genest J, Pajukanta P

Replication study of 10 genetic polymorphisms associated with coronary heart disease in a specific high-risk population with familial hypercholesterolemia.

European heart journal

van der Net JB, Oosterveer DM, Versmissen J, Defesche JC, Yazdanpanah M, Aouizerat BE, Steyerberg EW, Malloy MJ, Pullinger CR, Kastelein JJ, Kane JP, Sijbrands EJ

An apolipoprotein A-V gene SNP is associated with marked hypertriglyceridemia among Asian-American patients.

Journal of lipid research

Pullinger CR, Aouizerat BE, Movsesyan I, Durlach V, Sijbrands EJ, Nakajima K, Poon A, Dallinga-Thie GM, Hattori H, Green LL, Kwok PY, Havel RJ, Frost PH, Malloy MJ, Kane JP

A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci.

PLoS genetics

Liu Y, Helms C, Liao W, Zaba LC, Duan S, Gardner J, Wise C, Miner A, Malloy MJ, Pullinger CR, Kane JP, Saccone S, Worthington J, Bruce I, Kwok PY, Menter A, Krueger J, Barton A, Saccone NL, Bowcock AM

Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia.

Nature genetics

Péterfy M, Ben-Zeev O, Mao HZ, Weissglas-Volkov D, Aouizerat BE, Pullinger CR, Frost PH, Kane JP, Malloy MJ, Reue K, Pajukanta P, Doolittle MH

Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.

Arteriosclerosis, thrombosis, and vascular biology

Shiffman D, O'Meara ES, Bare LA, Rowland CM, Louie JZ, Arellano AR, Lumley T, Rice K, Iakoubova O, Luke MM, Young BA, Malloy MJ, Kane JP, Ellis SG, Tracy RP, Devlin JJ, Psaty BM

Five common gene variants identify elevated genetic risk for coronary heart disease.

Genetics in medicine : official journal of the American College of Medical Genetics

Bare LA, Morrison AC, Rowland CM, Shiffman D, Luke MM, Iakoubova OA, Kane JP, Malloy MJ, Ellis SG, Pankow JS, Willerson JT, Devlin JJ, Boerwinkle E

Assessment of lipoprotein profiles study (ALPS) and antioxidant activity in healthy subjects treated with AGI-1067.

Journal of clinical lipidology

Davidson MH, Smith J, Scott R, Small R, Choi J, Ishida BY, Kane JP

A polymorphism in the protease-like domain of apolipoprotein(a) is associated with severe coronary artery disease.

Arteriosclerosis, thrombosis, and vascular biology

Luke MM, Kane JP, Liu DM, Rowland CM, Shiffman D, Cassano J, Catanese JJ, Pullinger CR, Leong DU, Arellano AR, Tong CH, Movsesyan I, Naya-Vigne J, Noordhof C, Feric NT, Malloy MJ, Topol EJ, Koschinsky ML, Devlin JJ, Ellis SG

Prediction of coronary heart disease risk using a genetic risk score: the Atherosclerosis Risk in Communities Study.

American journal of epidemiology

Morrison AC, Bare LA, Chambless LE, Ellis SG, Malloy M, Kane JP, Pankow JS, Devlin JJ, Willerson JT, Boerwinkle E

The lipoprotein lipase gene in combined hyperlipidemia: evidence of a protective allele depletion.

Lipids in health and disease

Wung SF, Kulkarni MV, Pullinger CR, Malloy MJ, Kane JP, Aouizerat BE

Gene variants of VAMP8 and HNRPUL1 are associated with early-onset myocardial infarction.

Arteriosclerosis, thrombosis, and vascular biology

Shiffman D, Rowland CM, Louie JZ, Luke MM, Bare LA, Bolonick JI, Young BA, Catanese JJ, Stiggins CF, Pullinger CR, Topol EJ, Malloy MJ, Kane JP, Ellis SG, Devlin JJ

High density lipoprotein mediated lipid efflux from retinal pigment epithelial cells in culture.

The British journal of ophthalmology

Ishida BY, Duncan KG, Bailey KR, Kane JP, Schwartz DM

Lack of support for the association between GAD2 polymorphisms and severe human obesity.

PLoS biology

Swarbrick MM, Waldenmaier B, Pennacchio LA, Lind DL, Cavazos MM, Geller F, Merriman R, Ustaszewska A, Malloy M, Scherag A, Hsueh WC, Rief W, Mauvais-Jarvis F, Pullinger CR, Kane JP, Dent R, McPherson R, Kwok PY, Hinney A, Hebebrand J, Vaisse C

Identification of four gene variants associated with myocardial infarction.

American journal of human genetics

Shiffman D, Ellis SG, Rowland CM, Malloy MJ, Luke MM, Iakoubova OA, Pullinger CR, Cassano J, Aouizerat BE, Fenwick RG, Reitz RE, Catanese JJ, Leong DU, Zellner C, Sninsky JJ, Topol EJ, Devlin JJ, Kane JP

Parotid secretory protein is an HDL-associated protein with anticandidal activity.

American journal of physiology. Regulatory, integrative and comparative physiology

Khovidhunkit W, Hachem JP, Medzihradszky KF, Duchateau PN, Shigenaga JK, Moser AH, Movsesyan I, Naya-Vigne J, Kane JP, Feingold KR, Grunfeld C

Variations in human HM74 (GPR109B) and HM74A (GPR109A) niacin receptors.

Human mutation

Zellner C, Pullinger CR, Aouizerat BE, Frost PH, Kwok PY, Malloy MJ, Kane JP

Apolipoprotein L-I is positively associated with hyperglycemia and plasma triglycerides in CAD patients with low HDL.

Journal of lipid research

Albert TS, Duchateau PN, Deeb SS, Pullinger CR, Cho MH, Heilbron DC, Malloy MJ, Kane JP, Brown BG

Apolipoproteins A-IV and A-V are acute-phase proteins in mouse HDL.

Atherosclerosis

Khovidhunkit W, Duchateau PN, Medzihradszky KF, Moser AH, Naya-Vigne J, Shigenaga JK, Kane JP, Grunfeld C, Feingold KR

The primary stone event: a new hypothesis involving a vascular etiology.

The Journal of urology

Stoller ML, Meng MV, Abrahams HM, Kane JP

Regulated expression of apolipoprotein E by human retinal pigment epithelial cells.

Journal of lipid research

Ishida BY, Bailey KR, Duncan KG, Chalkley RJ, Burlingame AL, Kane JP, Schwartz DM

Dynamic regulation of alternative ATP-binding cassette transporter A1 transcripts.

Biochemical and biophysical research communications

Huuskonen J, Abedin M, Vishnu M, Pullinger CR, Baranzini SE, Kane JP, Fielding PE, Fielding CJ

Primary hypercholesterolemia: genetic causes and treatment of five monogenic disorders.

Expert review of cardiovascular therapy

Pullinger CR, Kane JP, Malloy MJ

Genetic analysis of a polymorphism in the human apoA-V gene: effect on plasma lipids.

Journal of lipid research

Aouizerat BE, Kulkarni M, Heilbron D, Drown D, Raskin S, Pullinger CR, Malloy MJ, Kane JP

The effects of physical exercise on plasma prebeta-1 high-density lipoprotein.

Metabolism: clinical and experimental

Jafari M, Leaf DA, Macrae H, Kasem J, O'conner P, Pullinger C, Malloy M, Kane JP

Apolipoprotein L-I is the trypanosome lytic factor of human serum.

Nature

Vanhamme L, Paturiaux-Hanocq F, Poelvoorde P, Nolan DP, Lins L, Van Den Abbeele J, Pays A, Tebabi P, Van Xong H, Jacquet A, Moguilevsky N, Dieu M, Kane JP, De Baetselier P, Brasseur R, Pays E

Human cholesterol 7alpha-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype.

The Journal of clinical investigation

Pullinger CR, Eng C, Salen G, Shefer S, Batta AK, Erickson SK, Verhagen A, Rivera CR, Mulvihill SJ, Malloy MJ, Kane JP

Influence of an asparagine to lysine mutation at amino acid 3516 of apolipoprotein B on low-density lipoprotein receptor binding.

Clinica chimica acta; international journal of clinical chemistry

Gaffney D, Pullinger CR, O'Reilly DS, Hoffs MS, Cameron I, Vass JK, Kulkarni MV, Kane JP, Schumaker VN, Watts GF, Packard CJ

Human retinal pigment epithelial cells express scavenger receptors BI and BII.

Biochemical and biophysical research communications

Duncan KG, Bailey KR, Kane JP, Schwartz DM

Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene.

Journal of lipid research

Duchateau PN, Pullinger CR, Cho MH, Eng C, Kane JP

A risk factor for atherosclerosis: triglyceride-rich lipoproteins.

Advances in internal medicine

Malloy MJ, Kane JP

Elevated baseline triglyceride levels modulate effects of HMGCoA reductase inhibitors on plasma lipoproteins.

Journal of cardiovascular pharmacology and therapeutics

Drmanac S, Heilbron DC, Pullinger CR, Jafari M, Gietzen D, Ukrainczyk T, Cho MH, Frost PH, Siradze K, Drmanac RT, Kane JP, Malloy MJ

Haplotypes of the human renin gene associated with essential hypertension and stroke.

Journal of human hypertension

Frossard PM, Malloy MJ, Lestringant GG, Kane JP

Plasma apolipoprotein L concentrations correlate with plasma triglycerides and cholesterol levels in normolipidemic, hyperlipidemic, and diabetic subjects.

Journal of lipid research

Duchateau PN, Movsesyan I, Yamashita S, Sakai N, Hirano K, Schoenhaus SA, O'Connor-Kearns PM, Spencer SJ, Jaffe RB, Redberg RF, Ishida BY, Matsuzawa Y, Kane JP, Malloy MJ

Analysis of hABC1 gene 5' end: additional peptide sequence, promoter region, and four polymorphisms.

Biochemical and biophysical research communications

Pullinger CR, Hakamata H, Duchateau PN, Eng C, Aouizerat BE, Cho MH, Fielding CJ, Kane JP

Lack of association of lipoprotein(a) levels with coronary calcium deposits in asymptomatic postmenopausal women.

Journal of the American College of Cardiology

Nishino M, Malloy MJ, Naya-Vigne J, Russell J, Kane JP, Redberg RF

Human renin gene BglI dimorphism associated with hypertension in two independent populations.

Clinical genetics

Frossard PM, Lestringant GG, Malloy MJ, Kane JP

Renin gene MboI dimorphism is a discriminator for hypertension in hyperlipidaemic subjects.

Hypertension research : official journal of the Japanese Society of Hypertension

Frossard PM, Kane JP, Malloy MJ, Bener A

A multilocus genotyping assay for candidate markers of cardiovascular disease risk.

Genome research

Cheng S, Grow MA, Pallaud C, Klitz W, Erlich HA, Visvikis S, Chen JJ, Pullinger CR, Malloy MJ, Siest G, Kane JP

The apolipoprotein B R3531C mutation. Characteristics of 24 subjects from 9 kindreds.

Journal of lipid research

Pullinger CR, Gaffney D, Gutierrez MM, Malloy MJ, Schumaker VN, Packard CJ, Kane JP

A multilocus genotyping assay for cardiovascular disease.

Clinical chemistry and laboratory medicine

Cheng S, Pallaud C, Grow MA, Scharf SJ, Erlich HA, Klitz W, Pullinger CR, Malloy MJ, Kane JP, Siest G, Visvikis S

Prebeta-1 HDL in plasma of normolipidemic individuals: influences of plasma lipoproteins, age, and gender.

Journal of lipid research

O'Connor PM, Zysow BR, Schoenhaus SA, Ishida BY, Kunitake ST, Naya-Vigne JM, Duchateau PN, Redberg RF, Spencer SJ, Mark S, Mazur M, Heilbron DC, Jaffe RB, Malloy MJ, Kane JP

Rationale and design of the Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) study that evaluates atorvastatin in unstable angina pectoris and in non-Q-wave acute myocardial infarction.

The American journal of cardiology

Schwartz GG, Oliver MF, Ezekowitz MD, Ganz P, Waters D, Kane JP, Texter M, Pressler ML, Black D, Chaitman BR, Olsson AG

Premature coronary artery disease associated with a disruptive mutation in the estrogen receptor gene in a man.

Circulation

Sudhir K, Chou TM, Chatterjee K, Smith EP, Williams TC, Kane JP, Malloy MJ, Korach KS, Rubanyi GM

Apolipoprotein L, a new human high density lipoprotein apolipoprotein expressed by the pancreas. Identification, cloning, characterization, and plasma distribution of apolipoprotein L.

The Journal of biological chemistry

Duchateau PN, Pullinger CR, Orellana RE, Kunitake ST, Naya-Vigne J, O'Connor PM, Malloy MJ, Kane JP

Measurement of prebeta-1 HDL in human plasma by an ultrafiltration-isotope dilution technique.

Analytical biochemistry

O'Connor PM, Naya-Vigne JM, Duchateau PN, Ishida BY, Mazur M, Schoenhaus SA, Zysow BR, Malloy MJ, Kunitake ST, Kane JP

A novel apolipoprotein C-III variant, apoC-III(Gln38-->Lys), associated with moderate hypertriglyceridemia in a large kindred of Mexican origin.

Journal of lipid research

Pullinger CR, Malloy MJ, Shahidi AK, Ghassemzadeh M, Duchateau P, Villagomez J, Allaart J, Kane JP

Isolation of subpopulations of high density lipoproteins: three particle species containing apoE and two species devoid of apoE that have affinity for heparin.

Journal of lipid research

Hennessy LK, Kunitake ST, Jarvis M, Hamilton RL, Endeman G, Protter A, Kane JP

A single copy of apolipoprotein B-48 is present on the human chylomicron remnant.

Journal of lipid research

Phillips ML, Pullinger C, Kroes I, Kroes J, Hardman DA, Chen G, Curtiss LK, Gutierrez MM, Kane JP, Schumaker VN

Cryo-electron microscopy of low density lipoprotein and reconstituted discoidal high density lipoprotein: imaging of the apolipoprotein moiety.

Journal of lipid research

van Antwerpen R, Chen GC, Pullinger CR, Kane JP, LaBelle M, Krauss RM, Luna-Chavez C, Forte TM, Gilkey JC

The apolipoprotein B Q3405E polymorphism has no effect on its low-density-lipoprotein receptor binding affinity.

Human genetics

Pullinger CR, Love JA, Liu W, Hennessy LK, Ghassemzadeh M, Newcomb KC, Illingworth DR, Kane JP

Angiographically silent atherosclerosis detected by intravascular ultrasound in patients with familial hypercholesterolemia and familial combined hyperlipidemia: correlation with high density lipoproteins.

Journal of the American College of Cardiology

Hausmann D, Johnson JA, Sudhir K, Mullen WL, Friedrich G, Fitzgerald PJ, Chou TM, Ports TA, Kane JP, Malloy MJ, Yock PG

Identification of apolipoprotein B100 polymorphisms that affect low-density lipoprotein metabolism: description of a new approach involving monoclonal antibodies and dynamic light scattering.

Biochemistry

Chatterton JE, Schlapfer P, Bütler E, Gutierrez MM, Puppione DL, Pullinger CR, Kane JP, Curtiss LK, Schumaker VN

Triglyceride-rich lipoproteins prevent septic death in rats.

The Journal of experimental medicine

Read TE, Grunfeld C, Kumwenda ZL, Calhoun MC, Kane JP, Feingold KR, Rapp JH

Familial ligand-defective apolipoprotein B. Identification of a new mutation that decreases LDL receptor binding affinity.

The Journal of clinical investigation

Pullinger CR, Hennessy LK, Chatterton JE, Liu W, Love JA, Mendel CM, Frost PH, Malloy MJ, Schumaker VN, Kane JP

Increased prevalence of coronary ectasia in heterozygous familial hypercholesterolemia.

Circulation

Sudhir K, Ports TA, Amidon TM, Goldberger JJ, Bhushan V, Kane JP, Yock P, Malloy MJ

The effects of colestipol tablets compared with colestipol granules on plasma cholesterol and other lipids in moderately hypercholesterolemic patients.

Atherosclerosis

Insull W, Davidson MH, Demke DM, Dujovne CA, Eckert SM, Ginsberg D, Goldberg AC, Hodis HN, Hughes TA, Kane JP

Triglyceride-rich lipoproteins improve survival when given after endotoxin in rats.

Surgery

Read TE, Grunfeld C, Kumwenda Z, Calhoun MC, Kane JP, Feingold KR, Rapp JH

Triglyceride-rich lipoproteins isolated by selected-affinity anti-apolipoprotein B immunosorption from human atherosclerotic plaque.

Arteriosclerosis and thrombosis : a journal of vascular biology

Rapp JH, Lespine A, Hamilton RL, Colyvas N, Chaumeton AH, Tweedie-Hardman J, Kotite L, Kunitake ST, Havel RJ, Kane JP

Lipopolysaccharide (LPS)-binding protein is carried on lipoproteins and acts as a cofactor in the neutralization of LPS.

The Journal of experimental medicine

Wurfel MM, Kunitake ST, Lichenstein H, Kane JP, Wright SD

The apolipoprotein C-II variant apoC-IILys19-->Thr is not associated with dyslipidemia in an affected kindred.

Clinical genetics

Zysow BR, Pullinger CR, Hennessy LK, Farese RV, Ghassemzadeh M, Kane JP

Medical management of hyperlipidemic states.

Advances in internal medicine

Malloy MJ, Kane JP

The protective effect of serum lipoproteins against bacterial lipopolysaccharide.

European heart journal

Read TE, Harris HW, Grunfeld C, Feingold KR, Kane JP, Rapp JH

Chylomicrons enhance endotoxin excretion in bile.

Infection and immunity

Read TE, Harris HW, Grunfeld C, Feingold KR, Calhoun MC, Kane JP, Rapp JH

Chylomicrons alter the fate of endotoxin, decreasing tumor necrosis factor release and preventing death.

The Journal of clinical investigation

Harris HW, Grunfeld C, Feingold KR, Read TE, Kane JP, Jones AL, Eichbaum EB, Bland GF, Rapp JH

Binding of transition metals by apolipoprotein A-I-containing plasma lipoproteins: inhibition of oxidation of low density lipoproteins.

Proceedings of the National Academy of Sciences of the United States of America

Kunitake ST, Jarvis MR, Hamilton RL, Kane JP

Two apolipoprotein B gene defects in a kindred with hypobetalipoproteinemia, one of which results in a truncated variant, apoB-61, in VLDL and LDL.

Journal of lipid research

Pullinger CR, Hillas E, Hardman DA, Chen GC, Naya-Vigne JM, Iwasa JA, Hamilton RL, Lalouel JM, Williams RR, Kane JP

Relation of plasma lipid and apoprotein levels to progressive intimal hyperplasia after arterial endarterectomy.

Circulation

Colyvas N, Rapp JH, Phillips NR, Stoney R, Perez S, Kane JP, Havel RJ

Drs malloy and kane respond.

The Western journal of medicine

Malloy MJ, Kane JP

Chylomicrons can inhibit endotoxin activity in vitro.

The Journal of surgical research

Eichbaum EB, Harris HW, Kane JP, Rapp JH

Molecular and metabolic basis for the metabolic disorder normotriglyceridemic abetalipoproteinemia.

The Journal of clinical investigation

Hardman DA, Pullinger CR, Hamilton RL, Kane JP, Malloy MJ

Niacin--the long and the short of it.

The Western journal of medicine

Malloy MJ, Frost PH, Kane JP

Detection of endotoxin in triglyceride-rich lipoproteins in vitro.

The Journal of laboratory and clinical medicine

Harris HW, Eichbaum EB, Kane JP, Rapp JH

Familial chylomicronemia (type I hyperlipoproteinemia) due to a single missense mutation in the lipoprotein lipase gene.

The Journal of clinical investigation

Ameis D, Kobayashi J, Davis RC, Ben-Zeev O, Malloy MJ, Kane JP, Lee G, Wong H, Havel RJ, Schotz MC

Conformation of apolipoprotein B-100 in the low density lipoproteins of tangier disease. Identification of localized conformational response to triglyceride content.

The Journal of biological chemistry

Kunitake ST, Young SG, Chen GC, Pullinger CR, Zhu S, Pease RJ, Scott J, Hass P, Schilling J, Kane JP

Pre-beta high density lipoprotein. Unique disposition of apolipoprotein A-I increases susceptibility to proteolysis.

Arteriosclerosis (Dallas, Tex.)

Kunitake ST, Chen GC, Kung SF, Schilling JW, Hardman DA, Kane JP

Treatment of hyperlipidemia.

Annual review of medicine

Kane JP, Malloy MJ

Distribution of lipid-binding regions in human apolipoprotein B-100.

Biochemistry

Chen GC, Hardman DA, Hamilton RL, Mendel CM, Schilling JW, Zhu S, Lau K, Wong JS, Kane JP

Particle size distribution of lipoproteins from human atherosclerotic plaque: a preliminary report.

Journal of vascular surgery

Rapp JH, Harris HW, Hamilton RL, Krupski WC, Reilly LM, Ehrenfeld WK, Stoney RJ, Goldstone J, Kane JP

Neutralization of mouse xenotropic virus by lipoproteins involves binding to the virions.

The Journal of general virology

Sernatinger J, Hoffman A, Hardman D, Kane JP, Levy JA

Radiation inactivation of binding sites for high-density lipoproteins in human liver membranes.

Biochimica et biophysica acta

Mendel CM, Kunitake ST, Hong K, Erickson SK, Kane JP, Kempner ES

Bsm I RFLP at the human apolipoprotein AI-CIII gene complex locus.

Nucleic acids research

Coleman RT, Cawthon RM, Malloy MJ, Kane JP, Nakashima PF, Frossard PM

NcoI dimorphic site located 8kb 3' to the human apolipoprotein AIV (APOA4) gene.

Nucleic acids research

Coleman RT, Malloy MJ, Kane JP, Frossard PM

Determinants of kallikrein proteolysis of apolipoprotein B-100 in human blood plasma.

European journal of clinical investigation

Gustafson A, Kane JP, Havel RJ

Radiation inactivation of binding sites for high density lipoproteins in human fibroblast membranes.

The Journal of biological chemistry

Mendel CM, Kunitake ST, Kane JP, Kempner ES

When to treat hyperlipidemia.

Advances in internal medicine

Kane JP, Malloy MJ

Carboxyl terminal analysis of human B-48 protein confirms the novel mechanism proposed for chain termination.

Biochemical and biophysical research communications

Hardman DA, Protter AA, Schilling JW, Kane JP

Human apolipoprotein CI (apoC1) gene locus: DraI dimorphic site.

Nucleic acids research

Frossard PM, Coleman RT, Malloy MJ, Kane JP, Levy-Wilson B, Appleby VA

Human apolipoprotein CI (ApoC1) gene locus: BglI dimorphic site.

Nucleic acids research

Frossard PM, Lim DW, Coleman RT, Funke H, Assmann G, Malloy MJ, Kane JP

DraI RFLP in the human apolipoprotein AI-CIII-AIV gene complex.

Nucleic acids research

Frossard PM, Coleman RT, Dillan NA, Lim DW, Malloy MJ, Kane JP, Funke H, Assmann G

TaqI and XbaI RFLPs detected with a human apo IV (Apo4) cDNA probe.

Nucleic acids research

Coleman RT, Dillan NA, Lim DW, Malloy MJ, Kane JP, Frossard PM

Analysis of cDNA clones encoding the entire B-26 region of human apolipoprotein B.

Proceedings of the National Academy of Sciences of the United States of America

Protter AA, Hardman DA, Sato KY, Schilling JW, Yamanaka M, Hort YJ, Hjerrild KA, Chen GC, Kane JP

Scission of human apolipoprotein B-100 by kallikrein: characterization of the cleavage site.

Biochemical and biophysical research communications

Hardman DA, Gustafson A, Schilling JW, Donaldson VH, Kane JP

Isolation of a cDNA clone encoding the amino-terminal region of human apolipoprotein B.

Proceedings of the National Academy of Sciences of the United States of America

Protter AA, Hardman DA, Schilling JW, Miller J, Appleby V, Chen GC, Kirsher SW, McEnroe G, Kane JP

A variant primary structure of apolipoprotein C-II in individuals of African descent.

The Journal of clinical investigation

Menzel HJ, Kane JP, Malloy MJ, Havel RJ

Speciation of HDL.

Advances in experimental medicine and biology

Kane JP

Treatment of hypercholesterolemia.

Annual review of medicine

Kane JP, Havel RJ

Apolipoprotein A-I-containing lipoproteins with pre-beta electrophoretic mobility.

Journal of lipid research

Kunitake ST, La Sala KJ, Kane JP

Characteristics of human lipoproteins isolated by selected-affinity immunosorption of apolipoprotein A-I.

Proceedings of the National Academy of Sciences of the United States of America

McVicar JP, Kunitake ST, Hamilton RL, Kane JP

Metabolism of apolipoproteins B-48 and B-100 of triglyceride-rich lipoproteins in normal and lipoprotein lipase-deficient humans.

Proceedings of the National Academy of Sciences of the United States of America

Stalenhoef AF, Malloy MJ, Kane JP, Havel RJ

Secretion of lipoproteins from the liver of normal and Watanabe heritable hyperlipidemic rabbits.

Proceedings of the National Academy of Sciences of the United States of America

Hornick CA, Kita T, Hamilton RL, Kane JP, Havel RJ

Apolipoprotein and size heterogeneity in human umbilical cord blood low density lipoproteins.

Biochimica et biophysica acta

Davis PA, Forte TM, Kane JP, Hardman DA, Krauss RM, Blum CB

Atypical familial dysbetalipoproteinemia associated with apolipoprotein phenotype E3/3.

The Journal of clinical investigation

Havel RJ, Kotite L, Kane JP, Tun P, Bersot T

Cholesterol net transport, esterification, and transfer in human hyperlipidemic plasma.

The Journal of clinical investigation

Fielding PE, Fielding CJ, Havel RJ, Kane JP, Tun P

Remnants of lipoproteins of intestinal and hepatic origin in familial dysbetalipoproteinemia.

Arteriosclerosis (Dallas, Tex.)

Kane JP, Chen GC, Hamilton RL, Hardman DA, Malloy MJ, Havel RJ

Concentration and composition of lipoproteins in blood plasma of the WHHL rabbit. An animal model of human familial hypercholesterolemia.

Arteriosclerosis (Dallas, Tex.)

Havel RJ, Kita T, Kotite L, Kane JP, Hamilton RL, Goldstein JL, Brown MS

Characterization and quantitation of apolipoproteins A-I and E of normal and cholesterol-fed guinea pigs.

Journal of lipid research

Guo LS, Hamilton RL, Kane JP, Fielding CJ, Chen GC

Transfer of mouse anti-xenotropic virus neutralizing factor to human lipoproteins.

Journal of virology

Levy JA, Dimpfl J, Hardman D, Kane JP

Hypolipidemia.

The Medical clinics of North America

Malloy MJ, Kane JP

Treatment of hypercholesterolemia.

The Medical clinics of North America

Kane JP, Malloy MJ

Apolipoprotein B (B-48) of rat chylomicrons is not a precursor of the apolipoprotein of low density lipoproteins.

Proceedings of the National Academy of Sciences of the United States of America

Van't Hooft FM, Hardman DA, Kane JP, Havel RJ

Therapy of hyperlipidemic states.

Annual review of medicine

Havel RJ, Kane JP

Familial dysbetalipoproteinemia. Abnormal binding of mutant apoprotein E to low density lipoprotein receptors of human fibroblasts and membranes from liver and adrenal of rats, rabbits, and cows.

The Journal of clinical investigation

Schneider WJ, Kovanen PT, Brown MS, Goldstein JL, Utermann G, Weber W, Havel RJ, Kotite L, Kane JP, Innerarity TL, Mahley RW

Normotriglyceridemic abetalipoproteinemia. absence of the B-100 apolipoprotein.

The Journal of clinical investigation

Malloy MJ, Kane JP, Hardman DA, Hamilton RL, Dalal KB

Normalization of low-density-lipoprotein levels in heterozygous familial hypercholesterolemia with a combined drug regimen.

The New England journal of medicine

Kane JP, Malloy MJ, Tun P, Phillips NR, Freedman DD, Williams ML, Rowe JS, Havel RJ

Human apolipoprotein C-I: concentration in blood serum and lipoproteins.

Biochemical medicine

Polz E, Kotite L, Havel RJ, Kane JP, Sata T

Pancreatic alpha and beta cell function in familial dysbetalipoproteinemia.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme

Tan MH, Havel RJ, Gerich JE, Soeldner JS, Kane JP

Heterogeneity of apolipoprotein B: isolation of a new species from human chylomicrons.

Proceedings of the National Academy of Sciences of the United States of America

Kane JP, Hardman DA, Paulus HE

Apolipoprotein is responsible for neutralization of xenotropic type C virus by mouse serum.

Proceedings of the National Academy of Sciences of the United States of America

Kane JP, Hardman DA, Dimpfl JC, Levy JA

Normocholesterolemic dysbetalipoproteinemia with xanthomatosis.

Metabolism: clinical and experimental

Abrams JJ, Grundy SM, Kane JP, Chang CM

Heterogeneity of hemoglobin gamma chains in normal newborns and in cases of alpha and beta thalassemia.

American journal of hematology

Lie-Injo LE, Randhawa ZI, Kane JP, Ganesan J, George R

Molecular weight distributions of polydisperse systems: application to very low density lipoproteins.

Biochemistry

Kunitake ST, Loh E, Schumaker VN, Ma SK, Knobler CM, Kane JP, Hamilton RL

Bladder cancer and squamous metaplasia in spinal cord injury patients.

The Journal of urology

Kaufman JM, Fam B, Jacobs SC, Gabilondo F, Yalla S, Kane JP, Rossier AB

Hb Leiden-beta (0) thalassemia in a Chinese with severe hemolytic anemia.

American journal of hematology

Lie-Injo LE, Ganesan J, Randhawa ZI, Peterson D, Kane JP

New protein in human blood plasma, rich in proline, with lipid-binding properties.

Proceedings of the National Academy of Sciences of the United States of America

Sata T, Havel RJ, Kotite L, Kane JP

Effects of a 3-day fast and of ethanol on splanchnic metabolism of FFA, amino acids, and carbohydrates in healthy young men.

The Journal of clinical investigation

Wolfe BM, Havel JR, Marliss EB, Kane JP, Seymour J, Ahuja SP

Apoprotein composition of very low density lipoproteins of human serum.

The Journal of clinical investigation

Kane JP, Sata T, Hamilton RL, Havel RJ

Metabolism of apoprotein B of plasma very low density lipoproteins in the rat.

The Journal of clinical investigation

Faergeman O, Sata T, Kane JP, Havel RJ

Editorial: Early prevention of atherosclerosis.

The Western journal of medicine

Kane JP, Malloy MJ

Mechanism of the hypolipemic effect of clofibrate in postabsorptive man.

The Journal of clinical investigation

Wolfe BM, Kane JP, Havel RJ, Brewster HP

Primary dysbetalipoproteinemia: predominance of a specific apoprotein species in triglyceride-rich lipoproteins.

Proceedings of the National Academy of Sciences of the United States of America

Havel RJ, Kane JP

Drugs and lipid metabolism.

Annual review of pharmacology

Havel RJ, Kane JP

Cholestasis: lamellar structure of the abnormal human serum lipoprotein.

Science (New York, N.Y.)

Hamilton RL, Havel RJ, Kane JP, Blaurock AE, Sata T

Subunit heterogeneity in human serum beta lipoprotein.

Proceedings of the National Academy of Sciences of the United States of America

Kane JP, Richards EG, Havel RJ

Splanchnic metabolism in von Gierke's disease (glycogenosis type I).

Transactions of the Association of American Physicians

Havel RJ, Balasse EO, Williams HE, Kane JP, Segel N

STUDIES OF CARBOHYDRATE METABOLISM IN IDIOPATHIC HYPERTRIGLYCERIDEMIA.

Metabolism: clinical and experimental

KANE JP, LONGCOPE C, PAVLATOS FC, GRODSKY GM