Mehrdad Arjomandi, MD

Professor
Medicine
+1 415 221-4810 ext. 24393

Dr. Arjomandi is Professor of Medicine in the Division of Pulmonary, Critical Care, Allergy, Immunology, and Sleep Medicine at UCSF with a joint appointment at San Francisco Veterans Affairs Medical Center. He is Director of the UCSF Human Exposure Laboratory at San Francisco General Hospital, Director of Environmental Medicine Clinic at San Francisco VA Medical Center, and an investigator at the UCSF Center for Tobacco Control Research and Education.

Dr. Arjomandi received his bachelor degree in molecular biology from University of California San Diego in 1991, and his MD degree from Stanford University School of Medicine in 1996. He completed his residency in Internal Medicine at UCLA Medical Center (1999) and his fellowship in Pulmonary and Critical Care Medicine at UCSF (2003) before obtaining an NIH/NHLBI Mentored Patient-oriented Career Development Award (K23) and joining the faculty at UCSF. He currently is the PI on several large investigator-initiated industry-funded grants. In addition, he is the PI on two foundation grants [the Flight Attendant Medical Research Institute (FAMRI), and the Health Effect Institute (HEI)].

Research Interests

The lung is constantly exposed to various environmental pollutants, allergens, and toxins, which interact with airways and alveoli and result in inflammation, injury, and disease. Exposure-related pulmonary diseases are increasingly recognized as a growing global problem.

My laboratory primary research interest has been centered on the paradigm that respiratory exposures to pollutants and toxicants contribute to development and progression of chronic lung disease, and may further yield systemic effects well beyond lungs. Under this paradigm, my research activities have focused on understanding the physiologic and immunologic mechanisms via which environmental exposures contribute to chronic lung disease and how knowledge of these mechanisms could be translated to ways to better define, prognosticate, and manage disease burden.

I have dedicated my efforts to (1) investigate the biology of airway immune cells using inhalational exposure to ozone in humans as a model of lung injury simulating exacerbation in chronic lung disease, and (2) characterize the cardiopulmonary abnormalities in a cohort of individuals with history of prolonged heavy exposure to secondhand tobacco smoke as a model of occult chronic obstructive lung disease.

Publications: 

Radiographic Lung Volumes Predict Progression to COPD in Smokers with Preserved Spirometry in SPIROMICS.

The European respiratory journal

Arjomandi M, Zeng S, Barjaktarevic I, Barr RG, Bleecker ER, Bowler RP, Buhr RG, Criner GJ, Comellas AP, Cooper CB, Couper DJ, Curtis JL, Dransfield MT, Han MK, Hansel NN, Hoffman EA, Kaner RJ, Kanner RE, Krishnan JA, Paine R, Peters SP, Rennard SI, Woodruff PG

Ozone effects on blood biomarkers of systemic inflammation, oxidative stress, endothelial function, and thrombosis: The Multicenter Ozone Study in oldEr Subjects (MOSES).

PloS one

Balmes JR, Arjomandi M, Bromberg PA, Costantini MG, Dagincourt N, Hazucha MJ, Hollenbeck-Pringle D, Rich DQ, Stark P, Frampton MW

Back to the Box: Using Lung Volumes to Predict Susceptibility to Develop Chronic Obstructive Pulmonary Disease among Smokers.

Annals of the American Thoracic Society

Siyang Zeng, Andrea Tham, Bruce Bos, Joan Jin, Mehrdad Arjomandi

Inflammatory Phenotypes Associated with Chronic Obstructive Pulmonary Disease Increase Susceptibility to Exacerbation. Lessons from Single Cell Analysis of Lung Macrophages.

Annals of the American Thoracic Society

Sreelakshmi Vasudevan, Joshua Vasquez, Wenxuan Chen, Siyang Zeng, Mehrdad Arjomandi

Analytical validation of a novel multi-analyte plasma test for lung nodule characterization

Biomedical research and reviews. 2018 November 23; 2.

Trivedi NN, Brown JK, Rubenstein T, Rostykus AD, Fish AL, Heng Y, Luis C, Alice J, Sandy K, Bhavin P, Sidhu M, Vuong D, Wang S, Beggs M, Wu AH, Arjomandi M

Risk assessment for indeterminate pulmonary nodules using a novel, plasma-protein based biomarker assay. Biomedical research and clinical practice

Biomedical research and clinical practice

Trivedi NN, Arjomandi M, Brown JK, Rubenstein T, Rostykus AD, Esposito S, Axler E, Beggs M, Yu H, Carbonell L, Juang A, Kamer S, Patel B, Wang S, Fish AL, Haddad Z, Wu AH

Lung volume indices predict morbidity in smokers with preserved spirometry.

Thorax

Zeng S, Tham A, Bos B, Jin J, Giang B, Arjomandi M

Cardiovascular function and ozone exposure: The Multicenter Ozone Study in oldEr Subjects (MOSES).

Environment international

Rich DQ, Balmes JR, Frampton MW, Zareba W, Stark P, Arjomandi M, Hazucha MJ, Costantini MG, Ganz P, Hollenbeck-Pringle D, Dagincourt N, Bromberg PA

Marijuana Use, Respiratory Symptoms, and Pulmonary Function: A Systematic Review and Meta-analysis.

Annals of internal medicine

Ghasemiesfe M, Ravi D, Vali M, Korenstein D, Arjomandi M, Frank J, Austin PC, Keyhani S

Stability of Frequency of Severe Chronic Obstructive Pulmonary Disease Exacerbations and Health Care Utilization in Clinical Populations.

Chronic obstructive pulmonary diseases (Miami, Fla.)

Blagev DP, Collingridge DS, Rea S, Press VG, Churpek MM, Carey K, Mularski RA, Zeng S, Arjomandi M

The Laboratory-Based Intermountain Validated Exacerbation (LIVE) Score Identifies Chronic Obstructive Pulmonary Disease Patients at High Mortality Risk.

Frontiers in medicine

Blagev DP, Collingridge DS, Rea S, Horne BD, Press VG, Churpek MM, Carey KA, Mularski RA, Zeng S, Arjomandi M

Respiratory Responses to Ozone Exposure: The Multicenter Ozone Study in oldEr Subjects (MOSES).

American journal of respiratory and critical care medicine

Arjomandi M, Balmes JR, Frampton MW, Bromberg P, Rich DQ, Stark P, Alexis NE, Costantini M, Hollenbeck-Pringle D, Dagincourt N, Hazucha MJ

Lung volumes identify an at-risk group in persons with prolonged secondhand tobacco smoke exposure but without overt airflow obstruction.

BMJ open respiratory research

Arjomandi M, Zeng S, Geerts J, Stiner RK, Bos B, van Koeverden I, Keene J, Elicker B, Blanc PD, Gold WM

Multicenter Ozone Study in oldEr Subjects (MOSES): Part 1. Effects of Exposure to Low Concentrations of Ozone on Respiratory and Cardiovascular Outcomes

Health Effect Institute: Research Report

Mark W Frampton, John R Balmes, Philip A Bromberg, Paul Stark, Mehrdad Arjomandi, Milan J Hazucha, David Q Rich, Danielle Hollenbeck-Pringle, Nicholas Dagincourt, Neil Alexis, Peter Ganz, Wojciech Zareba, Maria G Costantini

Asthma-COPD Overlap Syndrome- an Underdiagnosed Phenotype in Heavy Smokers.

Journal of Allergy and Clinical Immunology

Miren Guenechea-Sola, Sarah Dalton, Jeroen Geerts, Siyang Zeng, Mehrdad Arjomandi

Inflammatory and repair pathways induced in human bronchoalveolar lavage cells with ozone inhalation.

PloS one

Leroy P, Tham A, Wong H, Tenney R, Chen C, Stiner R, Balmes JR, Paquet AC, Arjomandi M

Exposure to medium and high ambient levels of ozone causes adverse systemic inflammatory and cardiac autonomic effects.

American journal of physiology. Heart and circulatory physiology

Arjomandi M, Wong H, Donde A, Frelinger J, Dalton S, Ching W, Power K, Balmes JR

Ozone inhalation leads to a dose-dependent increase of cytogenetic damage in human lymphocytes.

Environmental and molecular mutagenesis

Holland N, Davé V, Venkat S, Wong H, Donde A, Balmes JR, Arjomandi M

IQGAP1-dependent scaffold suppresses RhoA and inhibits airway smooth muscle contraction.

The Journal of clinical investigation

Bhattacharya M, Sundaram A, Kudo M, Farmer J, Ganesan P, Khalifeh-Soltani A, Arjomandi M, Atabai K, Huang X, Sheppard D

Hidden Costs of Climate Change: Contribution of Ozone to Human Diseases

Proceedings of the American Association for the Advancement of Science. Proceedings of the U.S.-Iran Symposium on Air Pollution in Megacities.

Mfge8 suppresses airway hyperresponsiveness in asthma by regulating smooth muscle contraction.

Proceedings of the National Academy of Sciences of the United States of America

Kudo M, Khalifeh Soltani SM, Sakuma SA, McKleroy W, Lee TH, Woodruff PG, Lee JW, Huang K, Chen C, Arjomandi M, Huang X, Atabai K

Oxidative Injury Due to Inhalation of Ozone Causes Dose-Dependent Cytogenetic Damage in Peripheral Blood Lymphocytes.

Annals of the American Thoracic Society

Mehrdad Arjomandi, Subha Venkat, Hofer Wong, Aneesh Donde, John Balmes, Nina Holland

Effects of exercise on systemic inflammatory, coagulatory, and cardiac autonomic parameters in an inhalational exposure study.

Journal of occupational and environmental medicine

Donde A, Wong H, Frelinger J, Power K, Balmes JR, Arjomandi M

Polymorphism in Osteopontin Gene (SPP1) Is Associated with Asthma and Related Phenotypes in a Puerto Rican Population.

Pediatric allergy, immunology, and pulmonology

Arjomandi M, Galanter JM, Choudhry S, Eng C, Hu D, Beckman K, Chapela R, Rodríguez-Santana JR, Rodríguez-Cintrón W, Ford J, Avila PC, Burchard EG

Secreted osteopontin is highly polymerized in human airways and fragmented in asthmatic airway secretions.

PloS one

Arjomandi M, Frelinger J, Donde A, Wong H, Yellamilli A, Raymond W

PAI-1 is an essential component of the pulmonary host response during Pseudomonas aeruginosa pneumonia in mice.

Thorax

Goolaerts A, Lafargue M, Song Y, Miyazawa B, Arjomandi M, Carlès M, Roux J, Howard M, Parks DA, Iles KE, Pittet JF

Low prevalence of chronic beryllium disease among workers at a nuclear weapons research and development facility.

Journal of occupational and environmental medicine

Arjomandi M, Seward J, Gotway MB, Nishimura S, Fulton GP, Thundiyil J, King TE, Harber P, Balmes JR

Pulmonary function abnormalities in never-smoking flight attendants exposed to secondhand tobacco smoke in the aircraft cabin.

Journal of occupational and environmental medicine

Arjomandi M, Haight T, Redberg R, Gold WM

Is there an association between lifetime cumulative exposure and acute pulmonary responses to ozone?

Journal of occupational and environmental medicine

Arjomandi M, Tager IB, Bastaki M, Chen C, Holland N, Balmes JR

Effects of chronic and acute ozone exposure on lipid peroxidation and antioxidant capacity in healthy young adults.

Environmental health perspectives

Chen C, Arjomandi M, Balmes J, Tager I, Holland N

Effects of antioxidant enzyme polymorphisms on ozone-induced lung function changes.

The European respiratory journal

Chen C, Arjomandi M, Tager IB, Holland N, Balmes JR

Effects of nitrogen dioxide on allergic airway responses in subjects with asthma.

Journal of occupational and environmental medicine

Witten A, Solomon C, Abbritti E, Arjomandi M, Zhai W, Kleinman M, Balmes J

Sputum induction and bronchoscopy for assessment of ozone-induced airway inflammation in asthma.

Chest

Arjomandi M, Schmidlin I, Girling P, Boylen K, Ferrando R, Balmes J

Repeated exposure to ozone increases alveolar macrophage recruitment into asthmatic airways.

American journal of respiratory and critical care medicine

Arjomandi M, Witten A, Abbritti E, Reintjes K, Schmidlin I, Zhai W, Solomon C, Balmes J

Arginine restores nitric oxide activity and inhibits monocyte accumulation after vascular injury in hypercholesterolemic rabbits.

Journal of the American College of Cardiology

Wang BY, Candipan RC, Arjomandi M, Hsiun PT, Tsao PS, Cooke JP

Effects of immunosuppressants FK506 and rapamycin on the heterooligomeric form of the progesterone receptor.

The Journal of steroid biochemistry and molecular biology

Renoir JM, Le Bihan S, Mercier-Bodard C, Gold A, Arjomandi M, Radanyi C, Baulieu EE