Michael Matthay, MD

Director of the Critical Care Medicine Training
Associate Director of the Intensive Care Unit
Professor
Medicine
[email protected]
+1 415 819-2807

Dr. Matthay's overall focus is on improving clinical care of patients with acute respiratory failure from the acute respiratory distress syndrome and from sepsis. His research and clinical trials groups are very well funded by grants from the National Institute of Health. He also spends considerable time mentoring physicians and young faculty in career development and academic medicine.

Publications: 

A New Global Definition of Acute Respiratory Distress Syndrome.

American journal of respiratory and critical care medicine

Matthay MA, Arabi Y, Arroliga AC, Bernard G, Bersten AD, Brochard LJ, Calfee CS, Combes A, Daniel BM, Ferguson ND, Gong MN, Gotts JE, Herridge MS, Laffey JG, Liu KD, Machado FR, Martin TR, McAuley DF, Mercat A, Moss M, Mularski RA, Pesenti A, Qiu H, Ramakrishnan N, Ranieri M, Riviello ED, Rubin E, Slutsky A, Thompson BT, Twagirumugabe T, Ware LB, Wick KD

Exposure to ambient air pollutants and acute respiratory distress syndrome risk in sepsis.

Intensive care medicine

Reilly JP, Zhao Z, Shashaty MGS, Koyama T, Jones TK, Anderson BJ, Ittner CA, Dunn T, Miano TA, Oniyide O, Balmes JR, Matthay MA, Calfee CS, Christie JD, Meyer NJ, Ware LB

Clinical and biological heterogeneity of multisystem inflammatory syndrome in adults following SARS-CoV-2 infection: a case series.

Frontiers in medicine

Barth KE, Spottiswoode N, Hurabielle C, Subbaraj L, COMET Consortium, Calfee CS, Matthay MA, French S, Connolly A, Hewitt SM, Vannella KM, Barnett C, Langelier CR, Patterson S

Intravenous aviptadil and remdesivir for treatment of COVID-19-associated hypoxaemic respiratory failure in the USA (TESICO): a randomised, placebo-controlled trial.

The Lancet. Respiratory medicine

Brown SM, Barkauskas CE, Grund B, Sharma S, Phillips AN, Leither L, Peltan ID, Lanspa M, Gilstrap DL, Mourad A, Lane K, Beitler JR, Serra AL, Garcia I, Almasri E, Fayed M, Hubel K, Harris ES, Middleton EA, Barrios MAG, Mathews KS, Goel NN, Acquah S, Mosier J, Hypes C, Salvagio Campbell E, Khan A, Hough CL, Wilson JG, Levitt JE, Duggal A, Dugar S, Goodwin AJ, Terry C, Chen P, Torbati S, Iyer N, Sandkovsky US, Johnson NJ, Robinson BRH, Matthay MA, Aggarwal NR, Douglas IS, Casey JD, Hache-Marliere M, Georges Youssef J, Nkemdirim W, Leshnower B, Awan O, Pannu S, O'Mahony DS, Manian P, Awori Hayanga JW, Wortmann GW, Tomazini BM, Miller RF, Jensen JU, Murray DD, Bickell NA, Zatakia J, Burris S, Higgs ES, Natarajan V, Dewar RL, Schechner A, Kang N, Arenas-Pinto A, Hudson F, Ginde AA, Self WH, Rogers AJ, Oldmixon CF, Morin H, Sanchez A, Weintrob AC, Cavalcanti AB, Davis-Karim A, Engen N, Denning E, Taylor Thompson B, Gelijns AC, Kan V, Davey VJ, Lundgren JD, Babiker AG, Neaton JD, Lane HC, ACTIV-3b/Therapeutics for Severely Ill Inpatients with COVID-19 (TESICO) Study Group

ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies.

Intensive care medicine

Grasselli G, Calfee CS, Camporota L, Poole D, Amato MBP, Antonelli M, Arabi YM, Baroncelli F, Beitler JR, Bellani G, Bellingan G, Blackwood B, Bos LDJ, Brochard L, Brodie D, Burns KEA, Combes A, D'Arrigo S, De Backer D, Demoule A, Einav S, Fan E, Ferguson ND, Frat JP, Gattinoni L, Guérin C, Herridge MS, Hodgson C, Hough CL, Jaber S, Juffermans NP, Karagiannidis C, Kesecioglu J, Kwizera A, Laffey JG, Mancebo J, Matthay MA, McAuley DF, Mercat A, Meyer NJ, Moss M, Munshi L, Myatra SN, Ng Gong M, Papazian L, Patel BK, Pellegrini M, Perner A, Pesenti A, Piquilloud L, Qiu H, Ranieri MV, Riviello E, Slutsky AS, Stapleton RD, Summers C, Thompson TB, Valente Barbas CS, Villar J, Ware LB, Weiss B, Zampieri FG, Azoulay E, Cecconi M, European Society of Intensive Care Medicine Taskforce on ARDS

Early plasma angiopoietin-2 is prognostic for ARDS and mortality among critically ill patients with sepsis.

Critical care (London, England)

Rosenberger CM, Wick KD, Zhuo H, Wu N, Chen Y, Kapadia SB, Guimaraes A, Chang D, Choy DF, Chen H, Peck M, Sullivan KM, Ke S, Jauregui A, Leligdowicz A, Sinha P, Gomez AD, Kangelaris KN, Delucchi K, Liu KD, Calfee CS, Matthay MA, Hendrickson CM

Should We Add Fludrocortisone to Hydrocortisone for Treatment of Septic Shock?

JAMA internal medicine

Matthay MA, Dahabreh IJ, Thompson BT

Impaired alveolar macrophage 11β-hydroxysteroid dehydrogenase type 1 reductase activity contributes to increased pulmonary inflammation and mortality in sepsis-related ARDS.

Frontiers in immunology

Mahida RY, Lax S, Bassford CR, Scott A, Parekh D, Hardy RS, Naidu B, Matthay MA, Stewart PM, Cooper MC, Perkins GD, Thickett DR

Tight Glycemic Control, Inflammation, and the ICU: Evidence for Heterogeneous Treatment Effects in Two Randomized Controlled Trials.

American journal of respiratory and critical care medicine

Zinter MS, Markovic D, Asaro LA, Nadkarni VM, McQuillen PS, Sinha P, Matthay MA, Jeschke MG, Agus MSD, Sapru A

Effect of total cholesterol and statin therapy on mortality in ARDS patients: a secondary analysis of the SAILS and HARP-2 trials.

Critical care (London, England)

Pienkos SM, Moore AR, Guan J, Levitt JE, Matthay MA, Baron RM, Conlon J, McAuley DF, O'Kane CM, Rogers AJ

Association of SARS-CoV-2 nucleocapsid viral antigen and the receptor for advanced glycation end products with development of severe disease in patients presenting to the emergency department with COVID-19.

Frontiers in immunology

Matthay ZA, Fields AT, Wick KD, Jones C, Lane HC, Herrera K, Nu?ez-Garcia B, Gennatas E, Hendrickson CM, Kornblith AE, Matthay MA, Kornblith LZ, COVID-19 Associated Coagulopathy Inflammation Thrombosis (Co-ACIT) Study Group

Aerosolized nicotine from e-cigarettes alters gene expression, increases lung protein permeability, and impairs viral clearance in murine influenza infection.

Frontiers in immunology

Maishan M, Sarma A, Chun LF, Caldera S, Fang X, Abbott J, Christenson SA, Langelier CR, Calfee CS, Gotts JE, Matthay MA

Effects of the circulating environment of COVID-19 on platelet and neutrophil behavior.

Frontiers in immunology

Fields AT, Andraska EA, Kaltenmeier C, Matthay ZA, Herrera K, Nu?ez-Garcia B, Jones CM, Wick KD, Liu S, Luo JH, Yu YP, Matthay MA, Hendrickson CM, Bainton RJ, Barrett TJ, Berger JS, Neal MD, Kornblith LZ

Oxygen toxicity causes cyclic damage by destabilizing specific Fe-S cluster-containing protein complexes.

Molecular cell

Baik AH, Haribowo AG, Chen X, Queliconi BB, Barrios AM, Garg A, Maishan M, Campos AR, Matthay MA, Jain IH

SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants.

Stem cell reports

Hysenaj L, Little S, Kulhanek K, Magnen M, Bahl K, Gbenedio OM, Prinz M, Rodriguez L, Andersen C, Rao AA, Shen A, Lone JC, Lupin-Jimenez LC, Bonser LR, Serwas NK, Mick E, Khalid MM, Taha TY, Kumar R, Li JZ, Ding VW, Matsumoto S, Maishan M, Sreekumar B, Simoneau C, Nazarenko I, Tomlinson MG, Khan K, von Gottberg A, Sigal A, Looney MR, Fragiadakis GK, Jablons DM, Langelier CR, Matthay M, Krummel M, Erle DJ, Combes AJ, Sil A, Ott M, Kratz JR, Roose JP

Dysregulated lung stroma drives emphysema exacerbation by potentiating resident lymphocytes to suppress an epithelial stem cell reservoir.

Immunity

Wang C, Hyams B, Allen NC, Cautivo K, Monahan K, Zhou M, Dahlgren MW, Lizama CO, Matthay M, Wolters P, Molofsky AB, Peng T

Are circulating endothelial cells the next target for transcriptome-level pathway analysis in ARDS?

American journal of physiology. Lung cellular and molecular physiology

Costa Monteiro AC, Matthay MA

Myeloid Extracellular Vesicles: New Players in Indirect Lung Injury.

American journal of respiratory cell and molecular biology

Mahida RY, Matthay MA

Understanding the Role of Mesenchymal Stromal Cells in Treating COVID-19 Acute Respiratory Distress Syndrome.

American journal of respiratory and critical care medicine

O'Kane CM, Matthay MA

Mechanisms of impaired alveolar fluid clearance.

Anatomical record (Hoboken, N.J. : 2007)

Taenaka H, Matthay MA

Plasma metabolic profiling implicates dysregulated lipid metabolism and glycolytic shift in hyperinflammatory ARDS.

American journal of physiology. Lung cellular and molecular physiology

Alipanah-Lechner N, Neyton L, Mick E, Willmore A, Leligdowicz A, Contrepois K, Jauregui A, Zhuo H, Hendrickson C, Gomez A, Sinha P, Kangelaris KN, Liu KD, Matthay MA, Rogers AJ, Calfee CS

Chest x-ray imaging score is associated with severity of COVID-19 pneumonia: the MBrixia score.

Scientific reports

Jensen CM, Costa JC, N?rgaard JC, Zucco AG, Neesgaard B, Niemann CU, Ostrowski SR, Reekie J, Holten B, Kalhauge A, Matthay MA, Lundgren JD, Helleberg M, Moestrup KS

Association Between Shared Decision-Making During Family Meetings and Surrogates' Trust in Their ICU Physician.

Chest

Lincoln TE, Buddadhumaruk P, Arnold RM, Scheunemann LP, Ernecoff NC, Chang CH, Carson SS, Hough CL, Curtis JR, Anderson W, Steingrub J, Peterson MW, Lo B, Matthay MA, White DB

Reply to: SARS-CoV2 Endotheliopathy: Insights from Single Cell RNAseq.

American journal of respiratory and critical care medicine

Joffre J, Matthay MA, Hellman J

Integrated host-microbe plasma metagenomics for sepsis diagnosis in a prospective cohort of critically ill adults.

Nature microbiology

Kalantar KL, Neyton L, Abdelghany M, Mick E, Jauregui A, Caldera S, Serpa PH, Ghale R, Albright J, Sarma A, Tsitsiklis A, Leligdowicz A, Christenson SA, Liu K, Kangelaris KN, Hendrickson C, Sinha P, Gomez A, Neff N, Pisco A, Doernberg SB, Derisi JL, Matthay MA, Calfee CS, Langelier CR

COVID-19-Associated Lung Microvascular Endotheliopathy: A "From the Bench" Perspective.

American journal of respiratory and critical care medicine

Joffre J, Rodriguez L, Matthay ZA, Lloyd E, Fields AT, Bainton RJ, Kurien P, Sil A, Calfee CS, Woodruff PG, Erle DJ, Hendrickson C, Krummel MF, Langelier CR, Matthay MA, Kornblith LZ, Hellman J, COMET consortium and the Co-ACIT Study Group

Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung.

Science (New York, N.Y.)

Reyes NS, Krasilnikov M, Allen NC, Lee JY, Hyams B, Zhou M, Ravishankar S, Cassandras M, Wang C, Khan I, Matatia P, Johmura Y, Molofsky A, Matthay M, Nakanishi M, Sheppard D, Campisi J, Peng T

The prognostic value of early measures of the ventilatory ratio in the ARDS ROSE trial.

Critical care (London, England)

Monteiro ACC, Vangala S, Wick KD, Delucchi KL, Siegel ER, Thompson BT, Liu KD, Sapru A, Sinha P, Matthay MA, NHLBI PETAL Network

Plasma SARS-CoV-2 nucleocapsid antigen levels are associated with progression to severe disease in hospitalized COVID-19.

Critical care (London, England)

Wick KD, Leligdowicz A, Willmore A, Carrillo SA, Ghale R, Jauregui A, Chak SS, Nguyen V, Lee D, Jones C, Dewar R, Lane HC, Kangelaris KN, Hendrickson CM, Liu KD, Sinha P, Erle DJ, Langelier CR, Krummell MF, Woodruff PG, Calfee CS, Matthay MA, COMET Consortium

New Insights into Clinical and Mechanistic Heterogeneity of the Acute Respiratory Distress Syndrome: Summary of the Aspen Lung Conference 2021.

American journal of respiratory cell and molecular biology

Martin TR, Zemans RL, Ware LB, Schmidt EP, Riches DWH, Bastarache L, Calfee CS, Desai TJ, Herold S, Hough CL, Looney MR, Matthay MA, Meyer N, Parikh SM, Stevens T, Thompson BT

Opportunities for improved clinical trial designs in acute respiratory distress syndrome.

The Lancet. Respiratory medicine

Wick KD, Aggarwal NR, Curley MAQ, Fowler AA, Jaber S, Kostrubiec M, Lassau N, Laterre PF, Lebreton G, Levitt JE, Mebazaa A, Rubin E, Sinha P, Ware LB, Matthay MA

The Association of Baseline Plasma SARS-CoV-2 Nucleocapsid Antigen Level and Outcomes in Patients Hospitalized With COVID-19.

Annals of internal medicine

ACTIV-3/TICO Study Group, Rogers AJ, Wentworth D, Phillips A, Shaw-Saliba K, Dewar RL, Aggarwal NR, Babiker AG, Chang W, Dharan NJ, Davey VJ, Higgs ES, Gerry N, Ginde AA, Hayanga JWA, Highbarger H, Highbarger JL, Jain MK, Kan V, Kim K, Lallemand P, Leshnower BG, Lutaakome JK, Matthews G, Mourad A, Mylonakis E, Natarajan V, Padilla ML, Pandit LM, Paredes R, Pett S, Ramachandruni S, Rehman MT, Sherman BT, Files DC, Brown SM, Matthay MA, Thompson BT, Neaton JD, Lane HC, Lundgren JD

Pulse oximetry for the diagnosis and management of acute respiratory distress syndrome.

The Lancet. Respiratory medicine

Wick KD, Matthay MA, Ware LB

Efficacy and Safety of Ensovibep for Adults Hospitalized With COVID-19 : A Randomized Controlled Trial.

Annals of internal medicine

ACTIV-3/TICO Study Group, Barkauskas C, Mylonakis E, Poulakou G, Young BE, Vock DM, Siegel L, Engen N, Grandits G, Mosaly NR, Vekstein AM, Rogers R, Shehadeh F, Kaczynski M, Mylona EK, Syrigos KN, Rapti V, Lye DC, Hui DS, Leither L, Knowlton KU, Jain MK, Marines-Price R, Osuji A, Overcash JS, Kalomenidis I, Barmparessou Z, Waters M, Zepeda K, Chen P, Torbati S, Kiweewa F, Sebudde N, Almasri E, Hughes A, Bhagani SR, Rodger A, Sandkovsky U, Gottlieb RL, Nnakelu E, Trautner B, Menon V, Lutaakome J, Matthay M, Robinson P, Protopapas K, Koulouris N, Kimuli I, Baduashvili A, Braun DL, G?nthard HF, Ramachandruni S, Kidega R, Kim K, Hatlen TJ, Phillips AN, Murray DD, Jensen TO, Padilla ML, Accardi EX, Shaw-Saliba K, Dewar RL, Teitelbaum M, Natarajan V, Laverdure S, Highbarger HC, Rehman MT, Vogel S, Vall?e D, Crew P, Atri N, Schechner AJ, Pett S, Hudson F, Badrock J, Touloumi G, Brown SM, Self WH, North CM, Ginde AA, Chang CC, Kelleher A, Nagy-Agren S, Vasudeva S, Looney D, Nguyen HH, S?nchez A, Weintrob AC, Grund B, Sharma S, Reilly CS, Paredes R, Bednarska A, Gerry NP, Babiker AG, Davey VJ, Gelijns AC, Higgs ES, Kan V, Matthews G, Thompson BT, Legenne P, Chandra R, Lane HC, Neaton JD, Lundgren JD

NF-?B inhibitor alpha has a cross-variant role during SARS-CoV-2 infection in ACE2-overexpressing human airway organoids.

bioRxiv : the preprint server for biology

Simoneau CR, Chen PY, Xing GK, Khalid MM, Meyers NL, Hayashi JM, Taha TY, Leon KE, Ashuach T, Fontaine KA, Rodriguez L, Joehnk B, Walcott K, Vasudevan S, Fang X, Maishan M, Schultz S, Roose J, Matthay MA, Sil A, Arjomandi M, Yosef N, Ott M

Upcoming and urgent challenges in critical care research based on COVID-19 pandemic experience.

Anaesthesia, critical care & pain medicine

Verdonk F, Feyaerts D, Badenes R, Bastarache JA, Bouglé A, Ely W, Gaudilliere B, Howard C, Kotfis K, Lautrette A, Le Dorze M, Mankidy BJ, Matthay MA, Morgan CK, Mazeraud A, Patel BV, Pattnaik R, Reuter J, Schultz MJ, Sharshar T, Shrestha GS, Verdonk C, Ware LB, Pirracchio R, Jabaudon M

Use of pragmatic and explanatory trial designs in acute care research: lessons from COVID-19.

The Lancet. Respiratory medicine

Casey JD, Beskow LM, Brown J, Brown SM, Gayat É, Ng Gong M, Harhay MO, Jaber S, Jentzer JC, Laterre PF, Marshall JC, Matthay MA, Rice TW, Rosenberg Y, Turnbull AE, Ware LB, Self WH, Mebazaa A, Collins SP

Impact of E-Cigarette Aerosol on Primary Human Alveolar Epithelial Type 2 Cells.

American journal of physiology. Lung cellular and molecular physiology

Wick KD, Fang X, Maishan M, Matsumoto S, Spottiswoode N, Sarma A, Simoneau C, Khakoo M, Langelier C, Calfee CS, Gotts JE, Matthay MA

I-SPY COVID adaptive platform trial for COVID-19 acute respiratory failure: rationale, design and operations.

BMJ open

Files DC, Matthay MA, Calfee CS, Aggarwal NR, Asare AL, Beitler JR, Berger PA, Burnham EL, Cimino G, Coleman MH, Crippa A, Discacciati A, Gandotra S, Gibbs KW, Henderson PT, Ittner CAG, Jauregui A, Khan KT, Koff JL, Lang J, LaRose M, Levitt J, Lu R, McKeehan JD, Meyer NJ, Russell DW, Thomas KW, Eklund M, Esserman LJ, Liu KD, ISPY COVID Adaptive Platform Trial Network, undefined

Ventilatory Ratio is a Valuable Prognostic Indicator in an Observational Cohort of Patients With ARDS.

Respiratory care

Siegel ER, Zhuo H, Sinha P, Papolos AI, Ni SA, Vessel K, Belzer A, Minus EB, Calfee CS, Matthay MA, Wick KD

Importance of Catecholamine Signaling in the Development of Platelet Exhaustion after Traumatic Injury.

Journal of thrombosis and haemostasis : JTH

Matthay ZA, Fields AT, Nunez-Garcia B, Park JJ, Jones C, Leligdowicz A, Hendrickson CM, Callcut RA, Matthay MA, Kornblith LZ

Proceedings of the ISCT scientific signature series symposium, "sdvances in cell and gene therapies for lung diseases and critical illnesses": International society for cell & gene therapies, burlington VT, US, July 16, 2021.

Cytotherapy

Ting AE, Baker EK, Champagne J, Desai TJ, Dos Santos CC, Heijink IH, Itescu S, Blanc KL, Matthay MA, McAuley DF, McIntyre L, Mei SHJ, Parekkadan B, Rocco PRM, Sheridan J, Thébaud B, Weiss DJ

Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination.

Nature

Suryawanshi RK, Chen IP, Ma T, Syed AM, Brazer N, Saldhi P, Simoneau CR, Ciling A, Khalid MM, Sreekumar B, Chen PY, Kumar GR, Montano M, Gascon R, Tsou CL, Garcia-Knight MA, Sotomayor-Gonzalez A, Servellita V, Gliwa A, Nguyen J, Silva I, Milbes B, Kojima N, Hess V, Shacreaw M, Lopez L, Brobeck M, Turner F, Soveg FW, George AF, Fang X, Maishan M, Matthay M, Morris MK, Wadford D, Hanson C, Greene WC, Andino R, Spraggon L, Roan NR, Chiu CY, Doudna JA, Ott M

Immediate myeloid depot for SARS-CoV-2 in the human lung.

Research square

Looney M, Magnen M, You R, Rao A, Davis R, Rodriguez L, Simoneau C, Hysenaj L, Hu K, Love C, Woodruff P, Erle D, Hendrickson C, Calfee C, Matthay M, Roose J, Sil A, Ott M, Langelier C, Krummel M

Mesenchymal Stromal Cell Extracellular Vesicles - A New Approach for Preventing Bronchopulmonary Dysplasia?

American journal of respiratory and critical care medicine

Klinger JR, Matthay MA

Immediate myeloid depot for SARS-CoV-2 in the human lung.

bioRxiv : the preprint server for biology

Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, UCSF COMET Consortium, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR

RAGE has potential pathogenetic and prognostic value in non-intubated hospitalized patients with COVID-19.

JCI insight

Wick KD, Siegel L, Neaton JD, Oldmixon C, Lundgren J, Dewar RL, Lane HC, Thompson BT, Matthay MA

Extracorporeal Membrane Oxygenation for Respiratory Failure Related to COVID-19: A Nationwide Cohort Study.

Anesthesiology

Nesseler N, Fadel G, Mansour A, Para M, Falcoz PE, Mongardon N, Porto A, Bertier A, Levy B, Cadoz C, Guinot PG, Fouquet O, Fellahi JL, Ouattara A, Guihaire J, Ruggieri VG, Gaudard P, Labaste F, Clavier T, Brini K, Allou N, Lacroix C, Chommeloux J, Lebreton G, Matthay MA, Provenchere S, Flécher E, Vincentelli A, ECMOSARS Investigators

Transfusion-Related Acute Lung Injury: 36 years of Progress (1985-2021).

Annals of the American Thoracic Society

Toy P, Looney MR, Popovsky M, Palfi M, Berlin G, Chapman CE, Bolton-Maggs P, Matthay MA

Cigarette Smoke Exposure and ARDS in Sepsis: Epidemiology, Clinical Features, and Biologic Markers.

American journal of respiratory and critical care medicine

Moazed F, Hendrickson C, Jauregui A, Gotts J, Conroy A, Delucchi K, Zhuo H, Arambulo M, Vessel K, Ke S, Deiss T, Ni A, Leligdowicz A, Abbott J, Cohen MJ, Sinha P, Gomez A, Kangelaris K, Kornblith L, Matthay M, Benowitz N, Liu K, Calfee CS

Aerosolized Vitamin E Acetate Causes Oxidative Injury in Mice and in Alveolar Macrophages.

American journal of physiology. Lung cellular and molecular physiology

Matsumoto S, Traber MG, Leonard SW, Choi J, Fang X, Maishan M, Wick KD, Jones KD, Calfee CS, Gotts JE, Matthay MA

Pulmonary microbiome and gene expression signatures differentiate lung function in pediatric hematopoietic cell transplant candidates.

Science translational medicine

Zinter MS, Versluys AB, Lindemans CA, Mayday MY, Reyes G, Sunshine S, Chan M, Fiorino EK, Cancio M, Prevaes S, Sirota M, Matthay MA, Kharbanda S, Dvorak CC, Boelens JJ, DeRisi JL

CD14 Positive Extracellular Vesicles in Broncho-Alveolar Lavage Fluid as a New Biomarker of Acute Respiratory Distress Syndrome.

American journal of physiology. Lung cellular and molecular physiology

Mahida RY, Price J, Lugg ST, Li H, Parekh D, Scott A, Harrison P, Matthay MA, Thickett DR

Single Nucleotide Variant in FAS Associates With Organ Failure and Soluble Fas Cell Surface Death Receptor in Critical Illness.

Critical care medicine

Mikacenic C, Bhatraju P, Robinson-Cohen C, Kosamo S, Fohner AE, Dmyterko V, Long SA, Cerosaletti K, Calfee CS, Matthay MA, Walley KR, Russell JA, Christie JD, Meyer NJ, Christiani DC, Wurfel MM

A decoy mutant ACE2 designed to reduce COVID-19.

Trends in pharmacological sciences

Maishan M, Lim DL, Zimmerman GA, Matthay MA

Limited cross-variant immunity after infection with the SARS-CoV-2 Omicron variant without vaccination.

medRxiv : the preprint server for health sciences

Suryawanshi RK, Chen IP, Ma T, Syed AM, Simoneau CR, Ciling A, Khalid MM, Sreekumar B, Chen PY, George AF, Kumar GR, Montano M, Garcia-Knight MA, Brazer N, Saldhi P, Sotomayor-Gonzalez A, Servellita V, Gliwa A, Nguyen J, Silva I, Milbes B, Kojima N, Hess V, Shacreaw M, Lopez L, Brobeck M, Turner F, Soveg FW, Fang X, Maishan M, Matthay M, Morris MK, Wadford D, Hanson C, Greene WC, Andino R, Spraggon L, Roan NR, Chiu CY, Doudna J, Ott M

Update on the Features and Measurements of Experimental Acute Lung Injury in Animals: An Official American Thoracic Society Workshop Report.

American journal of respiratory cell and molecular biology

Kulkarni HS, Lee JS, Bastarache JA, Kuebler WM, Downey GP, Albaiceta GM, Altemeier WA, Artigas A, Bates JHT, Calfee CS, Dela Cruz CS, Dickson RP, Englert JA, Everitt JI, Fessler MB, Gelman AE, Gowdy KM, Groshong SD, Herold S, Homer RJ, Horowitz JC, Hsia CCW, Kurahashi K, Laubach VE, Looney MR, Lucas R, Mangalmurti NS, Manicone AM, Martin TR, Matalon S, Matthay MA, McAuley DF, McGrath-Morrow SA, Mizgerd JP, Montgomery SA, Moore BB, Noël A, Perlman CE, Reilly JP, Schmidt EP, Skerrett SJ, Suber TL, Summers C, Suratt BT, Takata M, Tuder R, Uhlig S, Witzenrath M, Zemans RL, Matute-Bello G

Functional Transcriptomic Studies of Immune Responses and Endotoxin Tolerance In early Human Sepsis.

Shock (Augusta, Ga.)

Leligdowicz A, Kamm J, Kalantar K, Jauregui A, Vessel K, Caldera S, Serpa PH, Abbott J, Fang X, Tian X, Prakash A, Kangelaris KN, Liu KD, Calfee CS, Langelier C, Matthay MA

Functional Outcomes and Morbidity in Pediatric Sepsis Survivors: A Tanzanian Experience.

Frontiers in pediatrics

Lau-Braunhut SA, Smith AM, Steurer MA, Murray BL, Sawe H, Matthay MA, Reynolds T, Kortz TB

Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis.

The Lancet. Respiratory medicine

Maddali MV, Churpek M, Pham T, Rezoagli E, Zhuo H, Zhao W, He J, Delucchi KL, Wang C, Wickersham N, McNeil JB, Jauregui A, Ke S, Vessel K, Gomez A, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Liu KD, Matthay MA, Ware LB, Laffey JG, Bellani G, Calfee CS, Sinha P, LUNG SAFE Investigators and the ESICM Trials Group

Mesenchymal stem/stromal cell-based therapies for severe viral pneumonia: therapeutic potential and challenges.

Intensive care medicine experimental

Masterson CH, Ceccato A, Artigas A, Dos Santos C, Rocco PR, Rolandsson Enes S, Weiss DJ, McAuley D, Matthay MA, English K, Curley GF, Laffey JG

Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells.

Nature cell biology

Kathiriya JJ, Wang C, Zhou M, Brumwell A, Cassandras M, Le Saux CJ, Cohen M, Alysandratos KD, Wang B, Wolters P, Matthay M, Kotton DN, Chapman HA, Peng T

Responses to a Neutralizing Monoclonal Antibody for Hospitalized Patients With COVID-19 According to Baseline Antibody and Antigen Levels : A Randomized Controlled Trial.

Annals of internal medicine

ACTIV-3/TICO Bamlanivimab Study Group, Lundgren JD, Grund B, Barkauskas CE, Holland TL, Gottlieb RL, Sandkovsky U, Brown SM, Knowlton KU, Self WH, Files DC, Jain MK, Benfield T, Bowdish ME, Leshnower BG, Baker JV, Jensen JU, Gardner EM, Ginde AA, Harris ES, Johansen IS, Markowitz N, Matthay MA, Østergaard L, Chang CC, Goodman AL, Chang W, Dewar RL, Gerry NP, Higgs ES, Highbarger H, Murray DD, Murray TA, Natarajan V, Paredes R, Parmar MKB, Phillips AN, Reilly C, Rupert AW, Sharma S, Shaw-Saliba K, Sherman BT, Teitelbaum M, Wentworth D, Cao H, Klekotka P, Babiker AG, Davey VJ, Gelijns AC, Kan VL, Polizzotto MN, Thompson BT, Lane HC, Neaton JD

Cell Therapy with the Cell or Without the Cell for Premature Infants? Time Will Tell.

American journal of respiratory and critical care medicine

Thébaud B, Matthay MA

Carbonic Anhydrase IX: Scaring Away the Grim Reaper in Acute Lung Injury?

American journal of respiratory cell and molecular biology

Leligdowicz A, Matthay MA

Delayed Presentation and Mortality in Children With Sepsis in a Public Tertiary Care Hospital in Tanzania.

Frontiers in pediatrics

Smith AM, Sawe HR, Matthay MA, Murray BL, Reynolds T, Kortz TB

Impaired antibacterial immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19.

medRxiv : the preprint server for health sciences

Tsitsiklis A, Zha BS, Byrne A, Devoe C, Levan S, Rackaityte E, Sunshine S, Mick E, Ghale R, Jauregui A, Sarma A, Neff N, Serpa PH, Deiss TJ, Kistler A, Carrillo S, Ansel KM, Leligdowicz A, Christenson S, Jones N, Wu B, Darmanis S, Matthay MA, Lynch SV, DeRisi JL, COMET Consortium+ , Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Rosenberg O, Calfee CS, Langelier CR

Promises and challenges of personalized medicine to guide ARDS therapy.

Critical care (London, England)

Wick KD, McAuley DF, Levitt JE, Beitler JR, Annane D, Riviello ED, Calfee CS, Matthay MA

Intravenous immunoglobulin therapy for COVID-19 ARDS.

The Lancet. Respiratory medicine

Wilfong EM, Matthay MA

Molecular programs of fibrotic change in aging human lung.

Nature communications

Lee S, Islam MN, Boostanpour K, Aran D, Jin G, Christenson S, Matthay MA, Eckalbar WL, DePianto DJ, Arron JR, Magee L, Bhattacharya S, Matsumoto R, Kubota M, Farber DL, Bhattacharya J, Wolters PJ, Bhattacharya M

Delayed angiopoietin-2 blockade reduces influenza-induced lung injury and improves survival in mice.

Physiological reports

Gotts JE, Maishan M, Chun L, Fang X, Han CY, Chiueh V, Khakoo AY, Lee T, Stolina M, Matthay MA

Beyond the Alveolar Epithelium: Plasma Soluble Receptor for Advanced Glycation End Products Is Associated With Oxygenation Impairment, Mortality, and Extrapulmonary Organ Failure in Children With Acute Respiratory Distress Syndrome.

Critical care medicine

Lim MJ, Zinter MS, Chen L, Wong KMY, Bhalla A, Gala K, Guglielmo M, Alkhouli M, Huard LL, Hanudel MR, Vangala S, Schwingshackl A, Matthay M, Sapru A

Environmental Factors.

Critical care clinics

Wick KD, Matthay MA

Preface.

Critical care clinics

Matthay MA, Liu KD

Assessment of Alveolar Macrophage Dysfunction Using an in vitro Model of Acute Respiratory Distress Syndrome.

Frontiers in medicine

Mahida RY, Scott A, Parekh D, Lugg ST, Belchamber KBR, Hardy RS, Matthay MA, Naidu B, Thickett DR

Therapeutic Effects of High Molecular Weight Hyaluronic Acid in Severe Pseudomonas Aeruginosa Pneumonia in Ex Vivo Perfused Human Lungs.

American journal of physiology. Lung cellular and molecular physiology

Zhang X, Sugita S, Liu A, Naito Y, Hwang W, Qiu H, Sakamoto A, Sawa T, Matthay MA, Lee JW

Acute Respiratory Distress Syndrome is associated with impaired alveolar macrophage efferocytosis.

The European respiratory journal

Mahida RY, Scott A, Parekh D, Lugg ST, Hardy RS, Lavery GG, Matthay MA, Naidu B, Perkins GD, Thickett DR

Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS.

Nature communications

Sarma A, Christenson SA, Byrne A, Mick E, Pisco AO, DeVoe C, Deiss T, Ghale R, Zha BS, Tsitsiklis A, Jauregui A, Moazed F, Detweiler AM, Spottiswoode N, Sinha P, Neff N, Tan M, Serpa PH, Willmore A, Ansel KM, Wilson JG, Leligdowicz A, Siegel ER, Sirota M, DeRisi JL, Matthay MA, COMET Consortium , Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Calfee CS, Langelier CR

Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19.

The New England journal of medicine

ATTACC Investigators , ACTIV-4a Investigators , REMAP-CAP Investigators , Lawler PR, Goligher EC, Berger JS, Neal MD, McVerry BJ, Nicolau JC, Gong MN, Carrier M, Rosenson RS, Reynolds HR, Turgeon AF, Escobedo J, Huang DT, Bradbury CA, Houston BL, Kornblith LZ, Kumar A, Kahn SR, Cushman M, McQuilten Z, Slutsky AS, Kim KS, Gordon AC, Kirwan BA, Brooks MM, Higgins AM, Lewis RJ, Lorenzi E, Berry SM, Berry LR, Angus DC, McArthur CJ, Webb SA, Farkouh ME, Hochman JS, Zarychanski R, Aday AW, Al-Beidh F, Annane D, Arabi YM, Aryal D, Baumann Kreuziger L, Beane A, Bhimani Z, Bihari S, Billett HH, Bond L, Bonten M, Brunkhorst F, Buxton M, Buzgau A, Castellucci LA, Chekuri S, Chen JT, Cheng AC, Chkhikvadze T, Coiffard B, Costantini TW, de Brouwer S, Derde LPG, Detry MA, Duggal A, Džavík V, Effron MB, Estcourt LJ, Everett BM, Fergusson DA, Fitzgerald M, Fowler RA, Galanaud JP, Galen BT, Gandotra S, García-Madrona S, Girard TD, Godoy LC, Goodman AL, Goossens H, Green C, Greenstein YY, Gross PL, Hamburg NM, Haniffa R, Hanna G, Hanna N, Hegde SM, Hendrickson CM, Hite RD, Hindenburg AA, Hope AA, Horowitz JM, Horvat CM, Hudock K, Hunt BJ, Husain M, Hyzy RC, Iyer VN, Jacobson JR, Jayakumar D, Keller NM, Khan A, Kim Y, Kindzelski AL, King AJ, Knudson MM, Kornblith AE, Krishnan V, Kutcher ME, Laffan MA, Lamontagne F, Le Gal G, Leeper CM, Leifer ES, Lim G, Lima FG, Linstrum K, Litton E, Lopez-Sendon J, Lopez-Sendon Moreno JL, Lother SA, Malhotra S, Marcos M, Saud Marinez A, Marshall JC, Marten N, Matthay MA, McAuley DF, McDonald EG, McGlothlin A, McGuinness SP, Middeldorp S, Montgomery SK, Moore SC, Morillo Guerrero R, Mouncey PR, Murthy S, Nair GB, Nair R, Nichol AD, Nunez-Garcia B, Pandey A, Park PK, Parke RL, Parker JC, Parnia S, Paul JD, Pérez González YS, Pompilio M, Prekker ME, Quigley JG, Rost NS, Rowan K, Santos FO, Santos M, Olombrada Santos M, Satterwhite L, Saunders CT, Schutgens REG, Seymour CW, Siegal DM, Silva DG, Shankar-Hari M, Sheehan JP, Singhal AB, Solvason D, Stanworth SJ, Tritschler T, Turner AM, van Bentum-Puijk W, van de Veerdonk FL, van Diepen S, Vazquez-Grande G, Wahid L, Wareham V, Wells BJ, Widmer RJ, Wilson JG, Yuriditsky E, Zampieri FG

Thrombomodulin is associated with increased mortality and organ failure in mechanically ventilated children with acute respiratory failure: biomarker analysis from a multicenter randomized controlled trial.

Critical care (London, England)

Monteiro ACC, Flori H, Dahmer MK, Sim MS, Quasney MW, Curley MAQ, Matthay MA, Sapru A, BALI Study Investigators of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Networ

Publisher Correction: Global absence and targeting of protective immune states in severe COVID-19.

Nature

Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Chew NW, Cleary SJ, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Im KW, Serwas NK, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, UCSF COMET Consortium , Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF

Plasma Metabolites in Early Sepsis Identify Distinct Clusters Defined by Plasma Lipids.

Critical care explorations

Rogers AJ, Leligdowicz A, Contrepois K, Jauregui A, Vessel K, Deiss TJ, Belzer A, Liu T, Lippi M, Ke S, Ross E, Zhou H, Hendrickson C, Gomez A, Sinha P, Kangelaris KN, Liu KD, Calfee CS, Matthay MA

Latent class analysis-derived subphenotypes are generalisable to observational cohorts of acute respiratory distress syndrome: a prospective study.

Thorax

Sinha P, Delucchi KL, Chen Y, Zhuo H, Abbott J, Wang C, Wickersham N, McNeil JB, Jauregui A, Ke S, Vessel K, Gomez A, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Liu KD, Matthay MA, Ware LB, Calfee CS

Mesenchymal stromal cells reduce evidence of lung injury in patients with ARDS.

JCI insight

Wick KD, Leligdowicz A, Zhuo H, Ware LB, Matthay MA

Readmission following both cardiac and non-cardiac acute dyspnoea is associated with a striking risk of death.

ESC heart failure

Cerlinskaite K, Mebazaa A, Cinotti R, Matthay M, Wussler DN, Gayat E, Juknevicius V, Kozhuharov N, Dinort J, Michou E, Gualandro DM, Paleviciute E, Alitoit-Marrote I, Kablucko D, Bagdonaite L, Balciunas M, Vaiciuliene D, Jonauskiene I, Motiejunaite J, Stašaitis K, Kukulskis A, Damalakas Š, Laucevicius A, Mueller C, Kavoliuniene A, Celutkiene J, GREAT network

SARS-CoV-2 infection studies in lung organoids identify TSPAN8 as novel mediator.

bioRxiv : the preprint server for biology

Hysenaj L, Little S, Kulhanek K, Gbenedio OM, Rodriguez L, Shen A, Lone JC, Lupin-Jimenez LC, Bonser LR, Serwas NK, Bahl K, Mick E, Li JZ, Ding VW, Matsumoto S, Maishan M, Simoneau C, Fragiadakis G, Jablons DM, Langelier CR, Matthay M, Ott M, Krummel M, Combes AJ, Sil A, Erle DJ, Kratz JR, Roose JP

Associations of D-Dimer on Admission and Clinical Features of COVID-19 Patients: A Systematic Review, Meta-Analysis, and Meta-Regression.

Frontiers in immunology

Zhao R, Su Z, Komissarov AA, Liu SL, Yi G, Idell S, Matthay MA, Ji HL

Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19.

Research square

Tsitsiklis A, Zha B, Byrne A, DeVoe C, Levan S, Rackaityte E, Sunshine S, Mick E, Ghale R, Jauregui A, Neff N, Sarma A, Serpa P, Deiss T, Kistler A, Carrillo S, Ansel KM, Leligdowicz A, Christenson S, Jones N, Wu B, Darmanis S, Matthay M, Lynch S, DeRisi J, Consortium C, Hendrickson C, Kangelaris K, Krummel M, Woodruff P, Erle D, Rosenberg O, Calfee C, Langelier C

Molecular Markers of Telomere Dysfunction and Senescence are Common Findings in the Usual Interstitial Pneumonia Pattern of Lung Fibrosis.

Histopathology

Lee JS, La J, Aziz S, Dobrinskikh E, Brownell R, Jones KD, Achtar-Zadeh N, Green G, Elicker BM, Golden JA, Matthay MA, Kukreja J, Schwartz DA, Wolters PJ

The ARREST Pneumonia (Arrest Respiratory Failure due to Pneumonia) Trial: Rationale and Design.

Annals of the American Thoracic Society

Levitt JE, Festic E, Desai M, Hedlin H, Mahaffey KW, Rogers AJ, Gajic O, Matthay MA

The Pulmonary Metatranscriptome Prior to Pediatric Hematopoietic Cell Transplantation Identifies Post-HCT Lung Injury.

Blood

Zinter MS, Lindemans C, Versluys B, Mayday MY, Sunshine S, Reyes G, Sirota M, Sapru A, Matthay MA, Kharbanda S, Dvorak CC, Boelens JJJ, DeRisi JL

Fibrinolytic niche is required for alveolar type 2 cell-mediated alveologenesis via a uPA-A6-CD44+-ENaC signal cascade.

Signal transduction and targeted therapy

Ali G, Zhang M, Zhao R, Jain KG, Chang J, Komatsu S, Zhou B, Liang J, Matthay MA, Ji HL

Global absence and targeting of protective immune states in severe COVID-19.

Nature

Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Chew NW, Cleary SJ, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Im KW, Serwas NK, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S

COVID-19 ARDS is characterized by a dysregulated host response that differs from cytokine storm and is modified by dexamethasone.

Research square

Sarma A, Christenson S, Mick E, Deiss T, DeVoe C, Pisco A, Ghale R, Jauregui A, Byrne A, Moazed F, Spottiswoode N, Sinha P, Zha B, Neff N, Tan M, Serpa PH, Ansel KM, Wilson J, Leligdowicz A, Seigel E, Sirota M, DeRisi J, Matthay M, Consortium C, Hendrickson C, Kangelaris K, Krummel M, Woodruff P, Erle D, Calfee C, Langelier C

The ABO Histo-Blood Group, endothelial activation, and acute respiratory distress syndrome risk in critical illness.

The Journal of clinical investigation

Reilly JP, Meyer NJ, Shashaty MG, Anderson BJ, Ittner C, Dunn TG, Lim B, Forker C, Bonk MP, Kotloff ED, Feng R, Cantu E, Mangalmurti NS, Calfee CS, Matthay MA, Mikacenic C, Walley KR, Russell JA, Christiani DC, Wurfel MM, Lanken PN, Reilly MP, Christie JD

A Neutrophil Subset Defined by Intracellular Olfactomedin 4 is Associated with Mortality in Sepsis.

American journal of physiology. Lung cellular and molecular physiology

Kangelaris KN, Clemens R, Fang X, Jauregui A, Liu T, Vessel K, Deiss T, Sinha P, Leligdowicz A, Liu KD, Zhuo H, Alder MN, Wong HR, Calfee CS, Lowell CA, Matthay MA

A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19.

The New England journal of medicine

Lundgren JD, Grund B, Barkauskas CE, Holland TL, Gottlieb RL, Sandkovsky U, Brown SM, Knowlton KU, Self WH, Files DC, Jain MK, Benfield T, Bowdish ME, Leshnower BG, Baker JV, Jensen JU, Gardner EM, Ginde AA, Harris ES, Johansen IS, Markowitz N, Matthay MA, Østergaard L, Chang CC, Davey VJ, Goodman A, Higgs ES, Murray DD, Murray TA, Paredes R, Parmar MKB, Phillips AN, Reilly C, Sharma S, Dewar RL, Teitelbaum M, Wentworth D, Cao H, Klekotka P, Babiker AG, Gelijns AC, Kan VL, Polizzotto MN, Thompson BT, Lane HC, Neaton JD

Biological Mechanisms of COVID-19 ARDS.

American journal of respiratory and critical care medicine

Matthay MA, Leligdowicz A, Liu KD

Corticosteroids, COVID-19 pneumonia and acute respiratory distress syndrome.

The Journal of clinical investigation

Matthay MA, Wick KD

Dose-Dependent Pulmonary Toxicity of Aerosolized Vitamin E Acetate.

American journal of respiratory cell and molecular biology

Matsumoto S, Fang X, Traber MG, Jones KD, Langelier C, Hayakawa Serpa P, Calfee CS, Matthay MA, Gotts JE

Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients With COVID-19: A Randomized Clinical Trial.

JAMA

Self WH, Semler MW, Leither LM, Casey JD, Angus DC, Brower RG, Chang SY, Collins SP, Eppensteiner JC, Filbin MR, Files DC, Gibbs KW, Ginde AA, Gong MN, Harrell FE, Hayden DL, Hough CL, Johnson NJ, Khan A, Lindsell CJ, Matthay MA, Moss M, Park PK, Rice TW, Robinson BRH, Schoenfeld DA, Shapiro NI, Steingrub JS, Ulysse CA, Weissman A, Yealy DM, Thompson BT, Brown SM

Alternative Tobacco Product Use in Critically Ill Patients.

International journal of environmental research and public health

Liu T, Deiss TJ, Lippi MW, Jauregui A, Vessel K, Ke S, Belzer A, Zhuo H, Kangelaris KN, Gomez AD, Matthay MA, Liu KD, Calfee CS

Phenotypes and personalized medicine in the acute respiratory distress syndrome.

Intensive care medicine

Matthay MA, Arabi YM, Siegel ER, Ware LB, Bos LDJ, Sinha P, Beitler JR, Wick KD, Curley MAQ, Constantin JM, Levitt JE, Calfee CS

Designing an ARDS trial for 2020 and beyond: focus on enrichment strategies.

Intensive care medicine

Ware LB, Matthay MA, Mebazaa A

Dexamethasone in hospitalised patients with COVID-19: addressing uncertainties.

The Lancet. Respiratory medicine

Matthay MA, Thompson BT

Global Absence and Targeting of Protective Immune States in Severe COVID-19.

bioRxiv : the preprint server for biology

Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Cleary SJ, Chew NW, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF

Global Absence and Targeting of Protective Immune States in Severe COVID-19.

Research square

Krummel M, Combes A, Courau T, Kuhn N, Hu K, Ray A, Chen W, Cleary S, Chew N, Kushnoor D, Reeder G, Shen A, Tsui J, Hiam K, Sandoval PM, Zhu W, Lee D, Sun Y, You R, Magnen M, Rodriguez L, Leligdowicz A, Zamecnik C, Loudermilk R, Wilson M, Ye C, Fragiadakis G, Looney M, Chan V, Ward A, Carrillo S, Matthay M, Erle D, Woodruff P, Langelier C, Kangelaris K, Hendrickson C, Calfee C, Rao A

Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung.

Nature cell biology

Cassandras M, Wang C, Kathiriya J, Tsukui T, Matatia P, Matthay M, Wolters P, Molofsky A, Sheppard D, Chapman H, Peng T

Using Best Subsets Regression to Identify Clinical Characteristics and Biomarkers Associated with Sepsis-Associated Acute Kidney Injury.

American journal of physiology. Renal physiology

Kwong YD, Mehta K, Miaskowski C, Zhuo H, Yee K, Jauregui A, Ke S, Deiss T, Abbott J, Kangelaris KN, Sinha P, Hendrickson CM, Gomez A, Leligdowicz A, Matthay MA, Calfee CS, Liu KD

Proinflammatory cytokines and ARDS pulmonary edema fluid induce CD40 on human mesenchymal stromal cells-A potential mechanism for immune modulation.

PloS one

Wilfong EM, Croze R, Fang X, Schwede M, Niemi E, López GY, Lee JW, Nakamura MC, Matthay MA

The endogenous capacity to produce proinflammatory mediators by the ex vivo human perfused lung.

Intensive care medicine experimental

Leligdowicz A, Ross JT, Nesseler N, Matthay MA

Monitoring Research Blood Sampling in Critically Ill Patients: Avoiding Iatrogenic Anemia.

American journal of respiratory and critical care medicine

Baron RM, Christman JW, Liu KD, Matthay MA, Self WH, McVerry BJ, Hite RD, Paine R, Wurfel MM, Shapiro NI, Adams PW, Schmidt EP, Ringwood N

Insufficient hyperfibrinolysis in COVID-19: a systematic review of thrombolysis based on meta-analysis and meta-regression.

medRxiv : the preprint server for health sciences

Ji HJ, Su Z, Zhao R, Komissarov AA, Yi G, Liu SL, Idell S, Matthay MA

Differential effects of the cystic fibrosis lung inflammatory environment on mesenchymal stromal cells.

American journal of physiology. Lung cellular and molecular physiology

Abreu SC, Hampton TH, Hoffman E, Dearborn J, Ashare A, Singh Sidhu K, Matthews DE, McKenna DH, Amiel E, Barua J, Krasnodembskaya A, English K, Mahon BP, Santos CD, Cruz FF, Chambers DC, Liu KD, Matthay MA, Cramer RA, Stanton BA, Rocco PRM, Wargo MJ, Weiss DJ, Rolandsson Enes S

NT-proBNP levels in the identification and classification of pulmonary transfusion reactions.

Transfusion

Roubinian NH, Chowdhury D, Hendrickson JE, Triulzi DJ, Gottschall JL, Looney MR, Matthay MA, Kor DJ, Brambilla D, Kleinman SH, Murphy EL

Is a "Cytokine Storm" Relevant to COVID-19?

JAMA internal medicine

Sinha P, Matthay MA, Calfee CS

Identifying Clinical Research Priorities in Adult Pulmonary and Critical Care: NHLBI Working Group Report.

American journal of respiratory and critical care medicine

Semler MW, Bernard GR, Aaron SD, Angus DC, Biros MH, Brower RG, Calfee CS, Colantuoni EA, Ferguson ND, Gong MN, Hopkins RO, Hough CL, Iwashyna TJ, Levy BD, Martin TR, Matthay MA, Mizgerd JP, Moss M, Needham DM, Self WH, Seymour CW, Stapleton RD, Thompson BT, Wunderink RG, Aggarwal NR, Reineck LA

Need for Additional Trials of Vitamin C for Sepsis.

JAMA

Files DC, Liu KD, Matthay M

Association of patient weight status with plasma surfactant protein D, a biomarker of alveolar epithelial injury, in children with acute respiratory failure.

Pediatric pulmonology

Ward SL, Dahmer MK, Weeks HM, Sapru A, Quasney MW, Curley MAQ, Liu KD, Matthay MA, Flori HR

Combined Mesenchymal Stromal Cell Therapy and ECMO in ARDS: A Controlled Experimental Study in Sheep.

American journal of respiratory and critical care medicine

Millar JE, Bartnikowski N, Passmore MR, Obonyo NG, Malfertheiner MV, von Bahr V, Redd MA, See Hoe L, Ki KK, Pedersen S, Boyle AJ, Baillie JK, Shekar K, Palpant N, Suen JY, Matthay MA, McAuley DF, Fraser JF

Extracellular Vesicles: A New Frontier for Research in Acute Respiratory Distress Syndrome.

American journal of respiratory cell and molecular biology

Mahida RY, Matsumoto S, Matthay MA

THE EX-VIVO PERFUSED HUMAN LUNG IS RESISTANT TO INJURY BY HIGH-DOSE S. PNEUMONIAE BACTEREMIA.

American journal of physiology. Lung cellular and molecular physiology

Ross JT, Nesseler N, Leligdowicz A, Zemans RL, Mahida RY, Minus E, Langelier C, Gotts JE, Matthay MA

Clinician Recognition of the Acute Respiratory Distress Syndrome: Risk Factors for Under-Recognition and Trends Over Time.

Critical care medicine

Schwede M, Lee RY, Zhuo H, Kangelaris KN, Jauregui A, Vessel K, Belzer A, Deiss T, Matthay MA, Liu KD, Calfee CS

Impact of Bilateral Infiltrates on Inflammatory Biomarker Levels and Clinical Outcomes of Children With Oxygenation Defect.

Critical care medicine

Kohne JG, Dahmer MK, Weeks HM, Kaciroti N, Quasney MW, Sapru A, Curley MAQ, Matthay M, Flori H

Plasmin improves blood-gas barrier function in oedematous lungs by cleaving epithelial sodium channels.

British journal of pharmacology

Zhao R, Ali G, Nie HG, Chang Y, Bhattarai D, Su X, Zhao X, Matthay MA, Ji HL

Patterns and Trends in Advance Care Planning Among Older Adults Who Received Intensive Care at the End of Life.

JAMA internal medicine

Block BL, Jeon SY, Sudore RL, Matthay MA, Boscardin WJ, Smith AK

The potential of lipid mediator networks as ocular surface therapeutics and biomarkers.

The ocular surface

Flitter BA, Fang X, Matthay MA, Gronert K

Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis.

Nature communications

Tsukui T, Sun KH, Wetter JB, Wilson-Kanamori JR, Hazelwood LA, Henderson NC, Adams TS, Schupp JC, Poli SD, Rosas IO, Kaminski N, Matthay MA, Wolters PJ, Sheppard D

Acute respiratory distress syndrome subphenotypes and therapy responsive traits among preclinical models: protocol for a systematic review and meta-analysis.

Respiratory research

Carla A, Pereira B, Boukail H, Audard J, Pinol-Domenech N, De Carvalho M, Blondonnet R, Zhai R, Morand D, Lambert C, Sapin V, Ware LB, Calfee CS, Bastarache JA, Laffey JG, Juffermans NP, Bos LD, Artigas A, Rocco PRM, Matthay MA, McAuley DF, Constantin JM, Jabaudon M

Gender Differences in Authorship of Critical Care Literature.

American journal of respiratory and critical care medicine

Vranas KC, Ouyang D, Lin AL, Slatore CG, Sullivan DR, Prasad Kerlin M, Liu KD, Baron RM, Calfee CS, Ware LB, Halpern S, Matthay MA, Herridge M, Mehta S, Rogers AJ

Elevated Plasmin(ogen) as a Common Risk Factor for COVID-19 Susceptibility.

Physiological reviews

Ji HL, Zhao R, Matalon S, Matthay MA

Acute respiratory distress syndrome-attributable mortality in critically ill patients with sepsis.

Intensive care medicine

Auriemma CL, Zhuo H, Delucchi K, Deiss T, Liu T, Jauregui A, Ke S, Vessel K, Lippi M, Seeley E, Kangelaris KN, Gomez A, Hendrickson C, Liu KD, Matthay MA, Ware LB, Calfee CS

Treatment for severe acute respiratory distress syndrome from COVID-19.

The Lancet. Respiratory medicine

Matthay MA, Aldrich JM, Gotts JE

Improved survival after lung transplantation for adults requiring preoperative invasive mechanical ventilation: A national cohort study.

The Journal of thoracic and cardiovascular surgery

Hamilton BCS, Dincheva GR, Matthay MA, Hays S, Singer JP, Brzezinski M, Kukreja J

Contemporary strategies to improve clinical trial design for critical care research: insights from the First Critical Care Clinical Trialists Workshop.

Intensive care medicine

Harhay MO, Casey JD, Clement M, Collins SP, Gayat É, Gong MN, Jaber S, Laterre PF, Marshall JC, Matthay MA, Monroe RE, Rice TW, Rubin E, Self WH, Mebazaa A

Peripheral Blood Leukocyte Telomere Length is Associated with Survival of Sepsis Patients.

The European respiratory journal

Liu S, Wang C, Green G, Zhuo H, Liu KD, Kangelaris KN, Gomez A, Jauregui A, Vessel K, Ke S, Hendrickson C, Matthay MA, Calfee CS, Ware LB, Wolters PJ

Plasma sRAGE Acts as Genetically Regulated Causal Intermediate in Sepsis-Associated ARDS.

American journal of respiratory and critical care medicine

Jones TK, Feng R, Kerchberger VE, Reilly JP, Anderson BJ, Shashaty MGS, Wang F, Dunn TG, Riley TR, Abbott J, Ittner CAG, Christiani DC, Mikacenic C, Wurfel MM, Ware LB, Calfee CS, Matthay MA, Christie JD, Meyer NJ

The authors reply.

Critical care medicine

Rogers AJ, Desai M, Matthay MA, Choi AM, Baron RM

Plasma sTNFR1 and IL8 for prognostic enrichment in sepsis trials: a prospective cohort study.

Critical care (London, England)

Anderson BJ, Calfee CS, Liu KD, Reilly JP, Kangelaris KN, Shashaty MGS, Lazaar AL, Bayliffe AI, Gallop RJ, Miano TA, Dunn TG, Johansson E, Abbott J, Jauregui A, Deiss T, Vessel K, Belzer A, Zhuo H, Matthay MA, Meyer NJ, Christie JD

The value of kinetic glomerular filtration rate estimation on medication dosing in acute kidney injury.

PloS one

Kwong YD, Chen S, Bouajram R, Li F, Matthay MA, Mehta KM, Glidden DV, Liu KD

Therapeutic Effects of Hyaluronic Acid in Bacterial Pneumonia in the Ex Vivo Perfused Human Lungs.

American journal of respiratory and critical care medicine

Liu A, Park JH, Zhang X, Sugita S, Naito Y, Lee JH, Kato H, Hao Q, Matthay MA, Lee JW

Proliferative regulation of alveolar epithelial type 2 progenitor cells by human Scnn1d gene.

Theranostics

Zhao R, Ali G, Chang J, Komatsu S, Tsukasaki Y, Nie HG, Chang Y, Zhang M, Liu Y, Jain K, Jung BG, Samten B, Jiang D, Liang J, Ikebe M, Matthay MA, Ji HL

Lung Inflammatory Environments Differentially Alter Mesenchymal Stromal Cell Behavior.

American journal of physiology. Lung cellular and molecular physiology

Abreu SC, Enes SR, Dearborn J, Goodwin M, Coffey A, Borg ZD, Dos Santos CC, Wargo MJ, Cruz FF, Loi R, DeSarno M, Ashikaga T, Antunes MA, Rocco PRM, Liu KD, Lee JW, Matthay MA, McKenna DH, Weiss DJ

Clinically Relevant Model of Pneumococcal Pneumonia, ARDS, and Non-Pulmonary Organ Dysfunction in Mice.

American journal of physiology. Lung cellular and molecular physiology

Gotts JE, Bernard O, Chun L, Croze RH, Ross JT, Nesseler N, Wu X, Abbott J, Fang X, Calfee CS, Matthay MA

Plasma total fibroblast growth factor 23 levels are associated with acute kidney injury and mortality in children with acute respiratory distress syndrome.

PloS one

Hanudel MR, Zinter MS, Chen L, Gala K, Lim M, Guglielmo M, Deshmukh T, Vangala S, Matthay M, Sapru A

A Multicenter Study of the Causes and Consequences of Optimistic Expectations About Prognosis by Surrogate Decision-Makers in ICUs.

Critical care medicine

White DB, Carson S, Anderson W, Steingrub J, Bird G, Curtis JR, Matthay M, Peterson M, Buddadhumaruk P, Shields AM, Ernecoff N, Shotsberger K, Weissfeld L, Chang CH, Pike F, Lo B, Hough CL

Association of Elevated Plasma Interleukin 18 Level With Increased Mortality in a Clinical Trial of Statin Treatment for Acute Respiratory Distress Syndrome.

Critical care medicine

Rogers AJ, Guan J, Trtchounian A, Hunninghake GM, Kaimal R, Desai M, Kozikowski LA, DeSouza L, Mogan S, Liu KD, Matthay MA, Steingrub J, Wheeler A, Yoon JH, Nakahira K, Choi AM, Baron RM

The ex vivo human lung: research value for translational science.

JCI insight

Ross JT, Nesseler N, Lee JW, Ware LB, Matthay MA

Pulmonary Dead Space Monitoring: Identifying Subjects With ARDS at Risk of Developing Right Ventricular Dysfunction.

Respiratory care

Papolos AI, Schiller NB, Belzer A, Zhuo H, Gotts JE, Bibby D, Calfee CS, Matthay MA

Pathogenesis of Acute Respiratory Distress Syndrome.

Seminars in respiratory and critical care medicine

Huppert LA, Matthay MA, Ware LB

Clinician-Family Communication About Patients' Values and Preferences in Intensive Care Units.

JAMA internal medicine

Scheunemann LP, Ernecoff NC, Buddadhumaruk P, Carson SS, Hough CL, Curtis JR, Anderson WG, Steingrub J, Lo B, Matthay M, Arnold RM, White DB

A prospective investigation of interleukin-8 levels in pediatric acute respiratory failure and acute respiratory distress syndrome.

Critical care (London, England)

Flori H, Sapru A, Quasney MW, Gildengorin G, Curley MAQ, Matthay MA, Dahmer MK

Identification of Acute Kidney Injury Sub-phenotypes with Differing Molecular Signatures and Response to Vasopressin Therapy.

American journal of respiratory and critical care medicine

Bhatraju PK, Zelnick LR, Herting J, Katz R, Mikacenic C, Kosamo S, Morrell ED, Robinson-Cohen C, Calfee CS, Christie JD, Liu KD, Matthay MA, Hahn WO, Dmyterko V, Slivinski NSJ, Russell JA, Walley KR, Christiani DC, Liles WC, Himmelfarb J, Wurfel MM

Positive Cumulative Fluid Balance Is Associated With Mortality in Pediatric Acute Respiratory Distress Syndrome in the Setting of Acute Kidney Injury.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Zinter MS, Spicer AC, Liu KD, Orwoll BE, Alkhouli MF, Brakeman PR, Calfee CS, Matthay MA, Sapru A

Precision medicine for cell therapy in acute respiratory distress syndrome - Authors' reply.

The Lancet. Respiratory medicine

Matthay MA, Zhuo H, Gotts JE, Liu KD, Calfee CS

The authors reply.

Critical care medicine

Fielding-Singh V, Matthay MA, Calfee CS

The authors reply.

Critical care medicine

Fielding-Singh V, Matthay MA, Calfee CS

Acute respiratory distress syndrome.

Nature reviews. Disease primers

Matthay MA, Zemans RL, Zimmerman GA, Arabi YM, Beitler JR, Mercat A, Herridge M, Randolph AG, Calfee CS

Heterogeneity in sepsis: new biological evidence with clinical applications.

Critical care (London, England)

Leligdowicz A, Matthay MA

AIMing Immunomodulation Therapy at Sepsis.

American journal of respiratory cell and molecular biology

Leligdowicz A, Matthay MA

Prospective Assessment of the Feasibility of a Trial of Low Tidal Volume Ventilation for Patients with Acute Respiratory Failure.

Annals of the American Thoracic Society

Lanspa MJ, Gong MN, Schoenfeld DA, Lee KT, Grissom CK, Hou PC, Serpa-Neto A, Brown SM, Iwashyna TJ, Yealy DM, Hough CL, Brower RG, Calfee CS, Hyzy RC, Matthay MA, Miller RR, Steingrub JS, Thompson BT, Miller CD, Clemmer TP, Hendey GW, Huang DT, Mathews KS, Qadir N, Tidswell M

Physiological Analysis and Clinical Performance of the Ventilatory Ratio in Acute Respiratory Distress Syndrome.

American journal of respiratory and critical care medicine

Sinha P, Calfee CS, Beitler JR, Soni N, Ho K, Matthay MA, Kallet RH

Early Plasma Matrix Metalloproteinase Profiles: A Novel Pathway in Pediatric Acute Respiratory Distress Syndrome.

American journal of respiratory and critical care medicine

Zinter MS, Delucchi KL, Kong MY, Orwoll BE, Spicer AS, Lim MJ, Alkhouli MF, Ratiu AE, McKenzie AV, McQuillen PS, Dvorak CC, Calfee CS, Matthay MA, Sapru A

ECMO in severe acute respiratory distress syndrome.

The Lancet. Respiratory medicine

Matthay MA

Low to Moderate Air Pollutant Exposure and Acute Respiratory Distress Syndrome after Severe Trauma.

American journal of respiratory and critical care medicine

Reilly JP, Zhao Z, Shashaty MGS, Koyama T, Christie JD, Lanken PN, Wang C, Balmes JR, Matthay MA, Calfee CS, Ware LB

Variability in Pediatric Ideal Body Weight Calculation: Implications for Lung-Protective Mechanical Ventilation Strategies in Pediatric Acute Respiratory Distress Syndrome.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Ward SL, Quinn CM, Steurer MA, Liu KD, Flori HR, Matthay MA

Integrating host response and unbiased microbe detection for lower respiratory tract infection diagnosis in critically ill adults.

Proceedings of the National Academy of Sciences of the United States of America

Langelier C, Kalantar KL, Moazed F, Wilson MR, Crawford ED, Deiss T, Belzer A, Bolourchi S, Caldera S, Fung M, Jauregui A, Malcolm K, Lyden A, Khan L, Vessel K, Quan J, Zinter M, Chiu CY, Chow ED, Wilson J, Miller S, Matthay MA, Pollard KS, Christenson S, Calfee CS, DeRisi JL

Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial.

The Lancet. Respiratory medicine

Matthay MA, Calfee CS, Zhuo H, Thompson BT, Wilson JG, Levitt JE, Rogers AJ, Gotts JE, Wiener-Kronish JP, Bajwa EK, Donahoe MP, McVerry BJ, Ortiz LA, Exline M, Christman JW, Abbott J, Delucchi KL, Caballero L, McMillan M, McKenna DH, Liu KD

Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis.

Intensive care medicine

Reilly JP, Wang F, Jones TK, Palakshappa JA, Anderson BJ, Shashaty MGS, Dunn TG, Johansson ED, Riley TR, Lim B, Abbott J, Ittner CAG, Cantu E, Lin X, Mikacenic C, Wurfel MM, Christiani DC, Calfee CS, Matthay MA, Christie JD, Feng R, Meyer NJ

Latent class analysis of ARDS subphenotypes: a secondary analysis of the statins for acutely injured lungs from sepsis (SAILS) study.

Intensive care medicine

Sinha P, Delucchi KL, Thompson BT, McAuley DF, Matthay MA, Calfee CS

Interleukin-1 Receptor Antagonist Is Associated With Pediatric Acute Respiratory Distress Syndrome and Worse Outcomes in Children With Acute Respiratory Failure.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Dahmer MK, Quasney MW, Sapru A, Gildengorin G, Curley MAQ, Matthay MA, Flori H

Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome.

The New England journal of medicine

Mi MY, Matthay MA, Morris AH

Assessment of industry data on pulmonary and immunosuppressive effects of IQOS.

Tobacco control

Moazed F, Chun L, Matthay MA, Calfee CS, Gotts J

Possible hepatotoxicity of IQOS.

Tobacco control

Chun L, Moazed F, Matthay M, Calfee C, Gotts J

Meta-Analysis of Preclinical Studies of Fibrinolytic Therapy for Acute Lung Injury.

Frontiers in immunology

Liu C, Ma Y, Su Z, Zhao R, Zhao X, Nie HG, Xu P, Zhu L, Zhang M, Li X, Zhang X, Matthay MA, Ji HL

Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial.

The Lancet. Respiratory medicine

Calfee CS, Delucchi KL, Sinha P, Matthay MA, Hackett J, Shankar-Hari M, McDowell C, Laffey JG, O'Kane CM, McAuley DF

Effect of Rosuvastatin on Acute Kidney Injury in Sepsis-Associated Acute Respiratory Distress Syndrome.

Canadian journal of kidney health and disease

Hsu RK, Truwit JD, Matthay MA, Levitt JE, Thompson BT, Liu KD

Plasma sRAGE is independently associated with increased mortality in ARDS: a meta-analysis of individual patient data.

Intensive care medicine

Jabaudon M, Blondonnet R, Pereira B, Cartin-Ceba R, Lichtenstern C, Mauri T, Determann RM, Drabek T, Hubmayr RD, Gajic O, Uhle F, Coppadoro A, Pesenti A, Schultz MJ, Ranieri MV, Brodska H, Mrozek S, Sapin V, Matthay MA, Constantin JM, Calfee CS

Human pulmonary endothelial cell permeability after exposure to LPS-stimulated leukocyte supernatants derived from patients with early sepsis.

American journal of physiology. Lung cellular and molecular physiology

Leligdowicz A, Chun LF, Jauregui A, Vessel K, Liu KD, Calfee CS, Matthay MA

Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype.

The Journal of clinical investigation

Wang C, Reyes de Mochel NS, Christenson SA, Cassandras M, Moon R, Brumwell AN, Byrnes LE, Li A, Yokosaki Y, Shan P, Sneddon JB, Jablons D, Lee PJ, Matthay MA, Chapman HA, Peng T

A psychometric study of the decisional conflict scale in surrogate decision makers.

Patient education and counseling

Pecanac KE, Brown RL, Steingrub J, Anderson W, Matthay MA, White DB

Secondary peritonitis: principles of diagnosis and intervention.

BMJ (Clinical research ed.)

Ross JT, Matthay MA, Harris HW

Severity scoring of lung oedema on the chest radiograph is associated with clinical outcomes in ARDS.

Thorax

Warren MA, Zhao Z, Koyama T, Bastarache JA, Shaver CM, Semler MW, Rice TW, Matthay MA, Calfee CS, Ware LB

Mesenchymal stromal cells and macrophages in sepsis: new insights.

The European respiratory journal

Kotas ME, Matthay MA

Contemporary Risk Factors and Outcomes of Transfusion-Associated Circulatory Overload.

Critical care medicine

Roubinian NH, Hendrickson JE, Triulzi DJ, Gottschall JL, Michalkiewicz M, Chowdhury D, Kor DJ, Looney MR, Matthay MA, Kleinman SH, Brambilla D, Murphy EL

Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice.

American journal of physiology. Lung cellular and molecular physiology

Gotts JE, Chun LF, Abbott J, Fang X, Takasaki N, Nishimura SL, Springer ML, Schick SF, Calfee CS, Matthay MA

Inhibiting Bruton's tyrosine kinase rescues mice from lethal influenza-induced acute lung injury.

American journal of physiology. Lung cellular and molecular physiology

Florence JM, Krupa A, Booshehri LM, Davis SA, Matthay MA, Kurdowska AK

Assessing Preventable Harms in the Intensive Care Unit: Data From a Tertiary Care Academic Medical Institution.

American journal of medical quality : the official journal of the American College of Medical Quality

Sung N, Aldrich JM, Shimabukuro DW, Matthay MA, Liu KD

Elevated donor plasminogen activator inhibitor-1 levels and the risk of primary graft dysfunction.

Clinical transplantation

Hamilton BCS, Dincheva GR, Zhuo H, Golden JA, Brzezinski M, Singer JP, Matthay MA, Kukreja J

The TLR4-PAR1 Axis Regulates Bone Marrow Mesenchymal Stromal Cell Survival and Therapeutic Capacity in Experimental Bacterial Pneumonia.

Stem cells (Dayton, Ohio)

Gupta N, Sinha R, Krasnodembskaya A, Xu X, Nizet V, Matthay MA, Griffin JH

Cell-based Therapy in Sepsis. A Step Closer.

American journal of respiratory and critical care medicine

Gotts JE, Matthay MA

Mesenchymal stem cell-derived extracellular vesicles attenuate pulmonary vascular permeability and lung injury induced by hemorrhagic shock and trauma.

The journal of trauma and acute care surgery

Potter DR, Miyazawa BY, Gibb SL, Deng X, Togaratti PP, Croze RH, Srivastava AK, Trivedi A, Matthay M, Holcomb JB, Schreiber MA, Pati S

Exosome-based Therapy for Bronchopulmonary Dysplasia.

American journal of respiratory and critical care medicine

Matthay MA, Abman SH

Rectal and Bladder Temperatures vs Forehead Core Temperatures Measured With SpotOn Monitoring System.

American journal of critical care : an official publication, American Association of Critical-Care Nurses

Schell-Chaple HM, Liu KD, Matthay MA, Puntillo KA

Clinical Presentation and Outcomes among Children with Sepsis Presenting to a Public Tertiary Hospital in Tanzania.

Frontiers in pediatrics

Kortz TB, Sawe HR, Murray B, Enanoria W, Matthay MA, Reynolds T

The Epithelial Sodium Channel Is a Modifier of the Long-Term Nonprogressive Phenotype Associated with F508del CFTR Mutations.

American journal of respiratory cell and molecular biology

Agrawal PB, Wang R, Li HL, Schmitz-Abe K, Simone-Roach C, Chen J, Shi J, Louie T, Sheng S, Towne MC, Brainson CF, Matthay MA, Kim CF, Bamshad M, Emond MJ, Gerard NP, Kleyman TR, Gerard C

ENaCs as Both Effectors and Regulators of MiRNAs in Lung Epithelial Development and Regeneration.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Ding Y, Zhao R, Zhao X, Matthay MA, Nie HG, Ji HL

Intratracheal instillation of alveolar type II cells enhances recovery from acute lung injury in rats.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

Guillamat-Prats R, Puig F, Camprubí-Rimblas M, Herrero R, Serrano-Mollar A, Gómez MN, Tijero J, Matthay MA, Blanch L, Artigas A

Cytokine Profiles of Severe Influenza Virus-Related Complications in Children.

Frontiers in immunology

Fiore-Gartland A, Panoskaltsis-Mortari A, Agan AA, Mistry AJ, Thomas PG, Matthay MA, Hertz T, Randolph AG

Reply to "Letter to the Editor: Pulmonary toxicity of electronic cigarettes: more doubts than certainties".

American journal of physiology. Lung cellular and molecular physiology

Chun LF, Moazed F, Calfee CS, Matthay MA, Gotts JE

Cigarette Smoke Exposure Worsens Endotoxin-Induced Lung Injury and Pulmonary Edema in Mice.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

Gotts JE, Abbott J, Fang X, Yanagisawa H, Takasaka N, Nishimura SL, Calfee CS, Matthay MA

Derivation and validation of a two-biomarker panel for diagnosis of ARDS in patients with severe traumatic injuries.

Trauma surgery & acute care open

Ware LB, Zhao Z, Koyama T, Brown RM, Semler MW, Janz DR, May AK, Fremont RD, Matthay MA, Cohen MJ, Calfee CS

Local lung hypoxia determines epithelial fate decisions during alveolar regeneration.

Nature cell biology

Xi Y, Kim T, Brumwell AN, Driver IH, Wei Y, Tan V, Jackson JR, Xu J, Lee DK, Gotts JE, Matthay MA, Shannon JM, Chapman HA, Vaughan AE

Epithelial Sodium Channel-a Mediates the Protective Effect of the TNF-Derived TIP Peptide in Pneumolysin-Induced Endothelial Barrier Dysfunction.

Frontiers in immunology

Czikora I, Alli AA, Sridhar S, Matthay MA, Pillich H, Hudel M, Berisha B, Gorshkov B, Romero MJ, Gonzales J, Wu G, Huo Y, Su Y, Verin AD, Fulton D, Chakraborty T, Eaton DC, Lucas R

Inhalation therapies in acute respiratory distress syndrome.

Annals of translational medicine

Artigas A, Camprubí-Rimblas M, Tantinyà N, Bringué J, Guillamat-Prats R, Matthay MA

External validation of a biomarker and clinical prediction model for hospital mortality in acute respiratory distress syndrome.

Intensive care medicine

Zhao Z, Wickersham N, Kangelaris KN, May AK, Bernard GR, Matthay MA, Calfee CS, Koyama T, Ware LB

Clinical trials in acute respiratory distress syndrome: challenges and opportunities.

The Lancet. Respiratory medicine

Matthay MA, McAuley DF, Ware LB

Pulmonary toxicity of e-cigarettes.

American journal of physiology. Lung cellular and molecular physiology

Chun LF, Moazed F, Calfee CS, Matthay MA, Gotts JE

Keratinocyte growth factor for the treatment of the acute respiratory distress syndrome (KARE): a randomised, double-blind, placebo-controlled phase 2 trial.

The Lancet. Respiratory medicine

McAuley DF, Cross LM, Hamid U, Gardner E, Elborn JS, Cullen KM, Dushianthan A, Grocott MP, Matthay MA, O'Kane CM

Understanding blood gas analysis.

Intensive care medicine

Gattinoni L, Pesenti A, Matthay M

Differentiating pulmonary transfusion reactions using recipient and transfusion factors.

Transfusion

Roubinian NH, Looney MR, Keating S, Kor DJ, Lowell CA, Gajic O, Hubmayr R, Gropper M, Koenigsberg M, Wilson GA, A Matthay M, Toy P, Murphy EL

Incorporating Inflammation into Mortality Risk in Pediatric Acute Respiratory Distress Syndrome.

Critical care medicine

Zinter MS, Orwoll BE, Spicer AC, Alkhouli MF, Calfee CS, Matthay MA, Sapru A

Randomized Clinical Trial of a Combination of an Inhaled Corticosteroid and Beta Agonist in Patients at Risk of Developing the Acute Respiratory Distress Syndrome.

Critical care medicine

Festic E, Carr GE, Cartin-Ceba R, Hinds RF, Banner-Goodspeed V, Bansal V, Asuni AT, Talmor D, Rajagopalan G, Frank RD, Gajic O, Matthay MA, Levitt JE

Validation of two multiplex platforms to quantify circulating markers of inflammation and endothelial injury in severe infection.

PloS one

Leligdowicz A, Conroy AL, Hawkes M, Zhong K, Lebovic G, Matthay MA, Kain KC

Profiling of ARDS pulmonary edema fluid identifies a metabolically distinct subset.

American journal of physiology. Lung cellular and molecular physiology

Rogers AJ, Contrepois K, Wu M, Zheng M, Peltz G, Ware LB, Matthay MA

Higher mini-BAL total protein concentration in early ARDS predicts faster resolution of lung injury measured by more ventilator-free days.

American journal of physiology. Lung cellular and molecular physiology

Hendrickson CM, Abbott J, Zhuo H, Liu KD, Calfee CS, Matthay MA

Protein biomarkers associated with primary graft dysfunction following lung transplantation.

American journal of physiology. Lung cellular and molecular physiology

Hamilton BC, Kukreja J, Ware LB, Matthay MA

Incidence and clinical characteristics of transfusion-associated circulatory overload using an active surveillance algorithm.

Vox sanguinis

Roubinian NH, Hendrickson JE, Triulzi DJ, Gottschall JL, Chowdhury D, Kor DJ, Looney MR, Matthay MA, Kleinman SH, Brambilla D, Murphy EL

Acute kidney injury subphenotypes based on creatinine trajectory identifies patients at increased risk of death.

Critical care (London, England)

Bhatraju PK, Mukherjee P, Robinson-Cohen C, O'Keefe GE, Frank AJ, Christie JD, Meyer NJ, Liu KD, Matthay MA, Calfee CS, Christiani DC, Himmelfarb J, Wurfel MM

Cathepsin L Helps to Defend Mice from Infection with Influenza A.

PloS one

Xu X, Greenland JR, Gotts JE, Matthay MA, Caughey GH

Challenges in predicting which patients will develop ARDS.

The Lancet. Respiratory medicine

Matthay MA

A Simple and Robust Bedside Model for Mortality Risk in Pediatric Patients With Acute Respiratory Distress Syndrome.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Spicer AC, Calfee CS, Zinter MS, Khemani RG, Lo VP, Alkhouli MF, Orwoll BE, Graciano AL, Boriosi JP, Howard JP, Flori HR, Matthay MA, Sapru A

Poor Adherence to Lung-Protective Mechanical Ventilation in Pediatric Acute Respiratory Distress Syndrome.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Ward SL, Quinn CM, Valentine SL, Sapru A, Curley MA, Willson DF, Liu KD, Matthay MA, Flori HR

IL1RL1 asthma risk variants regulate airway type 2 inflammation.

JCI insight

Gordon ED, Palandra J, Wesolowska-Andersen A, Ringel L, Rios CL, Lachowicz-Scroggins ME, Sharp LZ, Everman JL, MacLeod HJ, Lee JW, Mason RJ, Matthay MA, Sheldon RT, Peters MC, Nocka KH, Fahy JV, Seibold MA

The authors reply.

Critical care medicine

Kangelaris KN, Ware LB, Matthay MA, Calfee CS

The authors reply.

Critical care medicine

Kangelaris KN, Ware LB, Matthay MA, Calfee CS

miR-34 miRNAs Regulate Cellular Senescence in Type II Alveolar Epithelial Cells of Patients with Idiopathic Pulmonary Fibrosis.

PloS one

Disayabutr S, Kim EK, Cha SI, Green G, Naikawadi RP, Jones KD, Golden JA, Schroeder A, Matthay MA, Kukreja J, Erle DJ, Collard HR, Wolters PJ

Quantifying unintended exposure to high tidal volumes from breath stacking dyssynchrony in ARDS: the BREATHE criteria.

Intensive care medicine

Beitler JR, Sands SA, Loring SH, Owens RL, Malhotra A, Spragg RG, Matthay MA, Thompson BT, Talmor D

A new experimental model of acid- and endotoxin-induced acute lung injury in rats.

American journal of physiology. Lung cellular and molecular physiology

Puig F, Herrero R, Guillamat-Prats R, Gómez MN, Tijero J, Chimenti L, Stelmakh O, Blanch L, Serrano-Mollar A, Matthay MA, Artigas A

The acute respiratory distress syndrome following isolated severe traumatic brain injury.

The journal of trauma and acute care surgery

Hendrickson CM, Howard BM, Kornblith LZ, Conroy AS, Nelson MF, Zhuo H, Liu KD, Manley GT, Matthay MA, Calfee CS, Cohen MJ

Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome.

Critical care (London, England)

Sapru A, Liu KD, Wiemels J, Hansen H, Pawlikowska L, Poon A, Jorgenson E, Witte JS, Calfee CS, Ware LB, Matthay MA

Sepsis: pathophysiology and clinical management.

BMJ (Clinical research ed.)

Gotts JE, Matthay MA

Long-Term Ozone Exposure Increases the Risk of Developing the Acute Respiratory Distress Syndrome.

American journal of respiratory and critical care medicine

Ware LB, Zhao Z, Koyama T, May AK, Matthay MA, Lurmann FW, Balmes JR, Calfee CS

Mitochondrial Transfer via Tunneling Nanotubes is an Important Mechanism by Which Mesenchymal Stem Cells Enhance Macrophage Phagocytosis in the In Vitro and In Vivo Models of ARDS.

Stem cells (Dayton, Ohio)

Jackson MV, Morrison TJ, Doherty DF, McAuley DF, Matthay MA, Kissenpfennig A, O'Kane CM, Krasnodembskaya AD

Negative-Pressure Pulmonary Edema.

Chest

Bhattacharya M, Kallet RH, Ware LB, Matthay MA

Experts' opinion on management of hemodynamics in ARDS patients: focus on the effects of mechanical ventilation.

Intensive care medicine

Vieillard-Baron A, Matthay M, Teboul JL, Bein T, Schultz M, Magder S, Marini JJ

Diagnostic workup for ARDS patients.

Intensive care medicine

Papazian L, Calfee CS, Chiumello D, Luyt CE, Meyer NJ, Sekiguchi H, Matthay MA, Meduri GU

Human mesenchymal stromal cells reduce influenza A H5N1-associated acute lung injury in vitro and in vivo.

Proceedings of the National Academy of Sciences of the United States of America

Chan MC, Kuok DI, Leung CY, Hui KP, Valkenburg SA, Lau EH, Nicholls JM, Fang X, Guan Y, Lee JW, Chan RW, Webster RG, Matthay MA, Peiris JS

Key stakeholders' perceptions of the acceptability and usefulness of a tablet-based tool to improve communication and shared decision making in ICUs.

Journal of critical care

Ernecoff NC, Witteman HO, Chon K, Chen YI, Buddadhumaruk P, Chiarchiaro J, Shotsberger KJ, Shields AM, Myers BA, Hough CL, Carson SS, Lo B, Matthay MA, Anderson WG, Peterson MW, Steingrub JS, Arnold RM, White DB

Cigarette smokers have exaggerated alveolar barrier disruption in response to lipopolysaccharide inhalation.

Thorax

Moazed F, Burnham EL, Vandivier RW, O'Kane CM, Shyamsundar M, Hamid U, Abbott J, Thickett DR, Matthay MA, McAuley DF, Calfee CS

Acute cor pulmonale and the acute respiratory distress syndrome.

Intensive care medicine

Guérin C, Matthay MA

Timing of Intubation and Clinical Outcomes in Adults With Acute Respiratory Distress Syndrome.

Critical care medicine

Kangelaris KN, Ware LB, Wang CY, Janz DR, Zhuo H, Matthay MA, Calfee CS

Elevated soluble thrombomodulin is associated with organ failure and mortality in children with acute respiratory distress syndrome (ARDS): a prospective observational cohort study.

Critical care (London, England)

Orwoll BE, Spicer AC, Zinter MS, Alkhouli MF, Khemani RG, Flori HR, Neuhaus JM, Calfee CS, Matthay MA, Sapru A

Plasma angiopoietin-2 outperforms other markers of endothelial injury in prognosticating pediatric ARDS mortality.

American journal of physiology. Lung cellular and molecular physiology

Zinter MS, Spicer A, Orwoll BO, Alkhouli M, Dvorak CC, Calfee CS, Matthay MA, Sapru A

Cigarette Smoke Exposure and the Acute Respiratory Distress Syndrome.

Critical care medicine

Calfee CS, Matthay MA, Kangelaris KN, Siew ED, Janz DR, Bernard GR, May AK, Jacob P, Havel C, Benowitz NL, Ware LB

Therapeutic Effects of Human Mesenchymal Stem Cell-derived Microvesicles in Severe Pneumonia in Mice.

American journal of respiratory and critical care medicine

Monsel A, Zhu YG, Gennai S, Hao Q, Hu S, Rouby JJ, Rosenzwajg M, Matthay MA, Lee JW

Resolution of Alveolar Edema in Acute Respiratory Distress Syndrome. Physiology and Biology.

American journal of respiratory and critical care medicine

Matthay MA, Ware LB

Human Mesenchymal Stem (Stromal) Cells Promote the Resolution of Acute Lung Injury in Part through Lipoxin A4.

Journal of immunology (Baltimore, Md. : 1950)

Fang X, Abbott J, Cheng L, Colby JK, Lee JW, Levy BD, Matthay MA

Visualization of Fra-1/AP-1 activation during LPS-induced inflammatory lung injury using fluorescence optical imaging.

American journal of physiology. Lung cellular and molecular physiology

Rajasekaran S, Tamatam CR, Potteti HR, Raman V, Lee JW, Matthay MA, Mehta D, Reddy NM, Reddy SP

Distinct molecular phenotypes of direct vs indirect ARDS in single-center and multicenter studies.

Chest

Calfee CS, Janz DR, Bernard GR, May AK, Kangelaris KN, Matthay MA, Ware LB

Unexpected Role for Adaptive aßTh17 Cells in Acute Respiratory Distress Syndrome.

Journal of immunology (Baltimore, Md. : 1950)

Li JT, Melton AC, Su G, Hamm DE, LaFemina M, Howard J, Fang X, Bhat S, Huynh KM, O'Kane CM, Ingram RJ, Muir RR, McAuley DF, Matthay MA, Sheppard D

Saving lives with high-flow nasal oxygen.

The New England journal of medicine

Matthay MA

Estimating dead-space fraction for secondary analyses of acute respiratory distress syndrome clinical trials.

Critical care medicine

Beitler JR, Thompson BT, Matthay MA, Talmor D, Liu KD, Zhuo H, Hayden D, Spragg RG, Malhotra A

Microvesicles Derived From Human Mesenchymal Stem Cells Restore Alveolar Fluid Clearance in Human Lungs Rejected for Transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Gennai S, Monsel A, Hao Q, Park J, Matthay MA, Lee JW

Mesenchymal stem (stromal) cells for treatment of acute respiratory distress syndrome - authors' reply.

The Lancet. Respiratory medicine

Wilson J, McKenna D, Liu KD, Matthay MA

Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS.

American journal of physiology. Lung cellular and molecular physiology

Kangelaris KN, Prakash A, Liu KD, Aouizerat B, Woodruff PG, Erle DJ, Rogers A, Seeley EJ, Chu J, Liu T, Osterberg-Deiss T, Zhuo H, Matthay MA, Calfee CS

Erratum to: plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome.

Intensive care medicine

Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbott J, Matthay MA

Cytokines and clinical predictors in distinguishing pulmonary transfusion reactions.

Transfusion

Roubinian NH, Looney MR, Kor DJ, Lowell CA, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson GA, Matthay MA, Toy P, Murphy EL

Plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome.

Intensive care medicine

Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbott J, Abbot J, Matthay MA

A multicenter study of key stakeholders' perspectives on communicating with surrogates about prognosis in intensive care units.

Annals of the American Thoracic Society

Anderson WG, Cimino JW, Ernecoff NC, Ungar A, Shotsberger KJ, Pollice LA, Buddadhumaruk P, Carson SS, Curtis JR, Hough CL, Lo B, Matthay MA, Peterson MW, Steingrub JS, White DB

Protocolized sedation vs usual care in pediatric patients mechanically ventilated for acute respiratory failure: a randomized clinical trial.

JAMA

Curley MA, Wypij D, Watson RS, Grant MJ, Asaro LA, Cheifetz IM, Dodson BL, Franck LS, Gedeit RG, Angus DC, Matthay MA

Proteolytic regulation of epithelial sodium channels by urokinase plasminogen activator: cutting edge and cleavage sites.

The Journal of biological chemistry

Ji HL, Zhao R, Komissarov AA, Chang Y, Liu Y, Matthay MA

Body temperature and mortality in patients with acute respiratory distress syndrome.

American journal of critical care : an official publication, American Association of Critical-Care Nurses

Schell-Chaple HM, Puntillo KA, Matthay MA, Liu KD

Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury.

Nature

Vaughan AE, Brumwell AN, Xi Y, Gotts JE, Brownfield DG, Treutlein B, Tan K, Tan V, Liu FC, Looney MR, Matthay MA, Rock JR, Chapman HA

Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial.

The Lancet. Respiratory medicine

Wilson JG, Liu KD, Zhuo H, Caballero L, McMillan M, Fang X, Cosgrove K, Vojnik R, Calfee CS, Lee JW, Rogers AJ, Levitt J, Wiener-Kronish J, Bajwa EK, Leavitt A, McKenna D, Thompson BT, Matthay MA

Recipient clinical risk factors predominate in possible transfusion-related acute lung injury.

Transfusion

Toy P, Bacchetti P, Grimes B, Gajic O, Murphy EL, Winters JL, Gropper MA, Hubmayr RD, Matthay MA, Wilson G, Koenigsberg M, Lee DC, Hirschler NV, Lowell CA, Schuller RM, Gandhi MJ, Norris PJ, Mair DC, Sanchez Rosen R, Looney MR

Biology and pathology of fibroproliferation following the acute respiratory distress syndrome.

Intensive care medicine

Hendrickson CM, Crestani B, Matthay MA

Mesenchymal stem cells: mechanisms of potential therapeutic benefit in ARDS and sepsis.

The Lancet. Respiratory medicine

Walter J, Ware LB, Matthay MA

Heterogeneous gene expression signatures correspond to distinct lung pathologies and biomarkers of disease severity in idiopathic pulmonary fibrosis.

Thorax

DePianto DJ, Chandriani S, Abbas AR, Jia G, N'Diaye EN, Caplazi P, Kauder SE, Biswas S, Karnik SK, Ha C, Modrusan Z, Matthay MA, Kukreja J, Collard HR, Egen JG, Wolters PJ, Arron JR

A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation.

American journal of respiratory and critical care medicine

Czikora I, Alli A, Bao HF, Kaftan D, Sridhar S, Apell HJ, Gorshkov B, White R, Zimmermann A, Wendel A, Pauly-Evers M, Hamacher J, Garcia-Gabay I, Fischer B, Verin A, Bagi Z, Pittet JF, Shabbir W, Lemmens-Gruber R, Chakraborty T, Lazrak A, Matthay MA, Eaton DC, Lucas R

Prevalence and impact of active and passive cigarette smoking in acute respiratory distress syndrome.

Critical care medicine

Hsieh SJ, Zhuo H, Benowitz NL, Thompson BT, Liu KD, Matthay MA, Calfee CS

Is there a need for emerging drugs for the acute respiratory distress syndrome?

Expert opinion on emerging drugs

Fitzgerald M, McAuley DF, Matthay M

Donor smoking is associated with pulmonary edema, inflammation and epithelial dysfunction in ex vivo human donor lungs.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Ware LB, Lee JW, Wickersham N, Nguyen J, Matthay MA, Calfee CS

Silencing Bruton's tyrosine kinase in alveolar neutrophils protects mice from LPS/immune complex-induced acute lung injury.

American journal of physiology. Lung cellular and molecular physiology

Krupa A, Fol M, Rahman M, Stokes KY, Florence JM, Leskov IL, Khoretonenko MV, Matthay MA, Liu KD, Calfee CS, Tvinnereim A, Rosenfield GR, Kurdowska AK

Influenza causes prolonged disruption of the alveolar-capillary barrier in mice unresponsive to mesenchymal stem cell therapy.

American journal of physiology. Lung cellular and molecular physiology

Gotts JE, Abbott J, Matthay MA

Protective effect of Growth Hormone-Releasing Hormone agonist in bacterial toxin-induced pulmonary barrier dysfunction.

Frontiers in physiology

Czikora I, Sridhar S, Gorshkov B, Alieva IB, Kasa A, Gonzales J, Potapenko O, Umapathy NS, Pillich H, Rick FG, Block NL, Verin AD, Chakraborty T, Matthay MA, Schally AV, Lucas R

Design and implementation of the START (STem cells for ARDS Treatment) trial, a phase 1/2 trial of human mesenchymal stem/stromal cells for the treatment of moderate-severe acute respiratory distress syndrome.

Annals of intensive care

Liu KD, Wilson JG, Zhuo H, Caballero L, McMillan ML, Fang X, Cosgrove K, Calfee CS, Lee JW, Kangelaris KN, Gotts JE, Rogers AJ, Levitt JE, Wiener-Kronish JP, Delucchi KL, Leavitt AD, McKenna DH, Thompson BT, Matthay MA

Prospective study on the clinical course and outcomes in transfusion-related acute lung injury*.

Critical care medicine

Looney MR, Roubinian N, Gajic O, Gropper MA, Hubmayr RD, Lowell CA, Bacchetti P, Wilson G, Koenigsberg M, Lee DC, Wu P, Grimes B, Norris PJ, Murphy EL, Gandhi MJ, Winters JL, Mair DC, Schuller RM, Hirschler NV, Rosen RS, Matthay MA, Toy P

Translational studies in the ex vivo human lung.

Respiratory investigation

Sakuma T, Matthay MA

Keratinocyte growth factor promotes epithelial survival and resolution in a human model of lung injury.

American journal of respiratory and critical care medicine

Shyamsundar M, McAuley DF, Ingram RJ, Gibson DS, O'Kane D, McKeown ST, Edwards A, Taggart C, Elborn JS, Calfee CS, Matthay MA, O'Kane CM

Accumulation of BDCA1? dendritic cells in interstitial fibrotic lung diseases and Th2-high asthma.

PloS one

Greer AM, Matthay MA, Kukreja J, Bhakta NR, Nguyen CP, Wolters PJ, Woodruff PG, Fahy JV, Shin JS

Human mesenchymal stem cells reduce the severity of acute lung injury in a sheep model of bacterial pneumonia.

Thorax

Asmussen S, Ito H, Traber DL, Lee JW, Cox RA, Hawkins HK, McAuley DF, McKenna DH, Traber LD, Zhuo H, Wilson J, Herndon DN, Prough DS, Liu KD, Matthay MA, Enkhbaatar P

Resolution of pulmonary edema. Thirty years of progress.

American journal of respiratory and critical care medicine

Matthay MA

Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials.

The Lancet. Respiratory medicine

Calfee CS, Delucchi K, Parsons PE, Thompson BT, Ware LB, Matthay MA

Applying metabolomics to uncover novel biology in ARDS.

American journal of physiology. Lung cellular and molecular physiology

Rogers AJ, Matthay MA

Conditioned media from mesenchymal stromal cells restore sodium transport and preserve epithelial permeability in an in vitro model of acute alveolar injury.

American journal of physiology. Lung cellular and molecular physiology

Goolaerts A, Pellan-Randrianarison N, Larghero J, Vanneaux V, Uzunhan Y, Gille T, Dard N, Planès C, Matthay MA, Clerici C

A randomized trial of the effects of nebulized albuterol on pulmonary edema in brain-dead organ donors.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Ware LB, Landeck M, Koyama T, Zhao Z, Singer J, Kern R, Neidlinger N, Nguyen J, Johnson E, Janz DR, Bernard GR, Lee JW, Matthay MA

Is there still a role for the lung injury score in the era of the Berlin definition ARDS?

Annals of intensive care

Kangelaris KN, Calfee CS, May AK, Zhuo H, Matthay MA, Ware LB

Clinical grade allogeneic human mesenchymal stem cells restore alveolar fluid clearance in human lungs rejected for transplantation.

American journal of physiology. Lung cellular and molecular physiology

McAuley DF, Curley GF, Hamid UI, Laffey JG, Abbott J, McKenna DH, Fang X, Matthay MA, Lee JW

Mesenchymal stromal (stem) cell therapy: an emerging immunomodulatory strategy for the adjunctive treatment of sepsis.

American journal of respiratory and critical care medicine

Liles WC, Matthay MA, Dos Santos CC, Weiss DJ, Stewart DJ

Metabolomic derangements are associated with mortality in critically ill adult patients.

PloS one

Rogers AJ, McGeachie M, Baron RM, Gazourian L, Haspel JA, Nakahira K, Fredenburgh LE, Hunninghake GM, Raby BA, Matthay MA, Otero RM, Fowler VG, Rivers EP, Woods CW, Kingsmore S, Langley RJ, Choi AM

One-year mortality and predictors of death among hospital survivors of acute respiratory distress syndrome.

Intensive care medicine

Wang CY, Calfee CS, Paul DW, Janz DR, May AK, Zhuo H, Bernard GR, Matthay MA, Ware LB, Kangelaris KN

TGF-ß and lung fluid balance in ARDS.

Proceedings of the National Academy of Sciences of the United States of America

Frank JA, Matthay MA

Effect of simvastatin on physiological and biological outcomes in patients undergoing esophagectomy: a randomized placebo-controlled trial.

Annals of surgery

Shyamsundar M, McAuley DF, Shields MO, MacSweeney R, Duffy MJ, Johnston JR, McGuigan J, Backman JT, Calfee CS, Matthay MM, Griffiths MJ, McDowell C, Elborn SJ, O'Kane CM

Human mesenchymal stem cell microvesicles for treatment of Escherichia coli endotoxin-induced acute lung injury in mice.

Stem cells (Dayton, Ohio)

Zhu YG, Feng XM, Abbott J, Fang XH, Hao Q, Monsel A, Qu JM, Matthay MA, Lee JW

Treating ARDS: new hope for a tough problem.

The Lancet. Respiratory medicine

Gotts JE, Matthay MA

Cystic fibrosis epithelial cell and bacterial binding.

American journal of physiology. Lung cellular and molecular physiology

Engel J, Matthay M

Prognostic and diagnostic value of plasma soluble suppression of tumorigenicity-2 concentrations in acute respiratory distress syndrome.

Critical care medicine

Bajwa EK, Volk JA, Christiani DC, Harris RS, Matthay MA, Thompson BT, Januzzi JL

Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome.

Critical care (London, England)

Ware LB, Koyama T, Zhao Z, Janz DR, Wickersham N, Bernard GR, May AK, Calfee CS, Matthay MA

Acute cor pulmonale in ARDS.

Intensive care medicine

Vieillard-Baron A, Price LC, Matthay MA

Cell therapy for lung diseases. Report from an NIH-NHLBI workshop, November 13-14, 2012.

American journal of respiratory and critical care medicine

Matthay MA, Anversa P, Bhattacharya J, Burnett BK, Chapman HA, Hare JM, Hei DJ, Hoffman AM, Kourembanas S, McKenna DH, Ortiz LA, Ott HC, Tente W, Thébaud B, Trapnell BC, Weiss DJ, Yuan JX, Blaisdell CJ

Early acute lung injury: criteria for identifying lung injury prior to the need for positive pressure ventilation*.

Critical care medicine

Levitt JE, Calfee CS, Goldstein BA, Vojnik R, Matthay MA

Mesenchymal stem cells and idiopathic pulmonary fibrosis. Potential for clinical testing.

American journal of respiratory and critical care medicine

Toonkel RL, Hare JM, Matthay MA, Glassberg MK

Reply: idiopathic pulmonary fibrosis: a degenerative disease requiring a regenerative approach.

American journal of respiratory and critical care medicine

Glassberg MK, Hare JM, Toonkel RL, Matthay MA

Sugar administration is an effective adjunctive therapy in the treatment of Pseudomonas aeruginosa pneumonia.

American journal of physiology. Lung cellular and molecular physiology

Bucior I, Abbott J, Song Y, Matthay MA, Engel JN

The acute respiratory distress syndrome in 2013.

Translational respiratory medicine

Matthay MA, Song Y, Bai C, Jones KD

HMGB1 accelerates alveolar epithelial repair via an IL-1ß- and avß6 integrin-dependent activation of TGF-ß1.

PloS one

Pittet JF, Koh H, Fang X, Iles K, Christiaans S, Anjun N, Wagener BM, Park DW, Zmijewski JW, Matthay MA, Roux J

Plasma angiopoietin-2 predicts the onset of acute lung injury in critically ill patients.

American journal of respiratory and critical care medicine

Agrawal A, Matthay MA, Kangelaris KN, Stein J, Chu JC, Imp BM, Cortez A, Abbott J, Liu KD, Calfee CS

The Berlin definition of ARDS versus pathological evidence of diffuse alveolar damage.

American journal of respiratory and critical care medicine

Thompson BT, Matthay MA

The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases.

The Journal of clinical investigation

Katsumoto TR, Kudo M, Chen C, Sundaram A, Callahan EC, Zhu JW, Lin J, Rosen CE, Manz BN, Lee JW, Matthay MA, Huang X, Sheppard D, Weiss A

Therapeutic effects of human mesenchymal stem cells in ex vivo human lungs injured with live bacteria.

American journal of respiratory and critical care medicine

Lee JW, Krasnodembskaya A, McKenna DH, Song Y, Abbott J, Matthay MA

Noradrenergic neurons regulate monocyte trafficking and mortality during gram-negative peritonitis in mice.

Journal of immunology (Baltimore, Md. : 1950)

Seeley EJ, Barry SS, Narala S, Matthay MA, Wolters PJ

Calcium flux and endothelial dysfunction during acute lung injury: a STIMulating target for therapy.

The Journal of clinical investigation

Seeley EJ, Rosenberg P, Matthay MA

Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome.

Molecular medicine (Cambridge, Mass.)

Su X, Feng X, Terrando N, Yan Y, Chawla A, Koch LG, Britton SL, Matthay MA, Maze M

Activation of the heat shock response attenuates the interleukin 1ß-mediated inhibition of the amiloride-sensitive alveolar epithelial ion transport.

Shock (Augusta, Ga.)

Howard M, Roux J, Iles KE, Miyazawa B, Christiaans S, Anjum N, Dickinson DA, Goolaerts A, Matthay MA, Pittet JF

Risk factors and outcomes in transfusion-associated circulatory overload.

The American journal of medicine

Murphy EL, Kwaan N, Looney MR, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson G, Matthay M, Bacchetti P, Toy P

Cecal ligation model of sepsis in mice: new insights.

Critical care medicine

Bastarache JA, Matthay MA

Hyperoxic acute lung injury.

Respiratory care

Kallet RH, Matthay MA

Regulation and repair of the alveolar-capillary barrier in acute lung injury.

Annual review of physiology

Bhattacharya J, Matthay MA

IL-8 inhibits cAMP-stimulated alveolar epithelial fluid transport via a GRK2/PI3K-dependent mechanism.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Roux J, McNicholas CM, Carles M, Goolaerts A, Houseman BT, Dickinson DA, Iles KE, Ware LB, Matthay MA, Pittet JF

Novel aspects of urokinase function in the injured lung: role of a2-macroglobulin.

American journal of physiology. Lung cellular and molecular physiology

Komissarov AA, Stankowska D, Krupa A, Fudala R, Florova G, Florence J, Fol M, Allen TC, Idell S, Matthay MA, Kurdowska AK

Beta-adrenergic receptor polymorphisms and cardiac graft function in potential organ donors.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Khush KK, Pawlikowska L, Menza RL, Goldstein BA, Hayden V, Nguyen J, Kim H, Poon A, Sapru A, Matthay MA, Kwok PY, Young WL, Baxter-Lowe LA, Zaroff JG

Pathogenetic and predictive value of biomarkers in patients with ALI and lower severity of illness: results from two clinical trials.

American journal of physiology. Lung cellular and molecular physiology

Agrawal A, Zhuo H, Brady S, Levitt J, Steingrub J, Siegel MD, Soto G, Peterson MW, Chesnutt MS, Matthay MA, Liu KD

The acute respiratory distress syndrome.

The Journal of clinical investigation

Matthay MA, Ware LB, Zimmerman GA

The severity of shock is associated with impaired rates of net alveolar fluid clearance in clinical acute lung injury.

American journal of physiology. Lung cellular and molecular physiology

Zeyed YF, Bastarache JA, Matthay MA, Ware LB

Clinical evidence of early acute lung injury often precedes the diagnosis of ALI.

Journal of intensive care medicine

Rackley CR, Levitt JE, Zhuo H, Matthay MA, Calfee CS

Inflection points in sepsis biology: from local defense to systemic organ injury.

American journal of physiology. Lung cellular and molecular physiology

Seeley EJ, Matthay MA, Wolters PJ

Cell-based therapy for acute lung injury: are we there yet?

Anesthesiology

Lee JW, Zhu Y, Matthay MA

Plasma angiopoietin-2 in clinical acute lung injury: prognostic and pathogenetic significance.

Critical care medicine

Calfee CS, Gallagher D, Abbott J, Thompson BT, Matthay MA

The adenosine 2A receptor agonist GW328267C improves lung function after acute lung injury in rats.

American journal of physiology. Lung cellular and molecular physiology

Folkesson HG, Kuzenko SR, Lipson DA, Matthay MA, Simmons MA

Protein kinase C-a and arginase I mediate pneumolysin-induced pulmonary endothelial hyperpermeability.

American journal of respiratory cell and molecular biology

Lucas R, Yang G, Gorshkov BA, Zemskov EA, Sridhar S, Umapathy NS, Jezierska-Drutel A, Alieva IB, Leustik M, Hossain H, Fischer B, Catravas JD, Verin AD, Pittet JF, Caldwell RB, Mitchell TJ, Cederbaum SD, Fulton DJ, Matthay MA, Caldwell RW, Romero MJ, Chakraborty T

Multipotent stromal stem cells from human placenta demonstrate high therapeutic potential.

Stem cells translational medicine

Nazarov I, Lee JW, Soupene E, Etemad S, Knapik D, Green W, Bashkirova E, Fang X, Matthay MA, Kuypers FA, Serikov VB

IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute lung injury and pneumonia.

American journal of physiology. Lung cellular and molecular physiology

Bhattacharya M, Su G, Su X, Oses-Prieto JA, Li JT, Huang X, Hernandez H, Atakilit A, Burlingame AL, Matthay MA, Sheppard D

Progress in modelling acute lung injury in a pre-clinical mouse model.

The European respiratory journal

Matthay MA, Howard JP

Mesenchymal stem cells and the stem cell niche: a new chapter.

American journal of physiology. Lung cellular and molecular physiology

Gotts JE, Matthay MA

Human mesenchymal stem cells reduce mortality and bacteremia in gram-negative sepsis in mice in part by enhancing the phagocytic activity of blood monocytes.

American journal of physiology. Lung cellular and molecular physiology

Krasnodembskaya A, Samarani G, Song Y, Zhuo H, Su X, Lee JW, Gupta N, Petrini M, Matthay MA

Lung mast cell density defines a subpopulation of patients with idiopathic pulmonary fibrosis.

Histopathology

Cha SI, Chang CS, Kim EK, Lee JW, Matthay MA, Golden JA, Elicker BM, Jones K, Collard HR, Wolters PJ

The 4G/4G genotype of the PAI-1 (serpine-1) 4G/5G polymorphism is associated with decreased lung allograft utilization.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Sapru A, Zaroff JG, Pawlikowska L, Liu KD, Khush KK, Baxter-Lowe LA, Hayden V, Menza RL, Convery M, Lo V, Poon A, Kim H, Young WL, Kukreja J, Matthay MA

Comparison of chest radiograph scoring to lung weight as a quantitative index of pulmonary edema in organ donors.

Clinical transplantation

Ware LB, Neyrinck A, O'Neal HR, Lee JW, Landeck M, Johnson E, Calfee CS, Matthay MA

Anti-inflammatory effects of ß2 adrenergic receptor agonists in experimental acute lung injury.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Bosmann M, Grailer JJ, Zhu K, Matthay MA, Sarma JV, Zetoune FS, Ward PA

Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma.

PloS one

Christie JD, Wurfel MM, Feng R, O'Keefe GE, Bradfield J, Ware LB, Christiani DC, Calfee CS, Cohen MJ, Matthay M, Meyer NJ, Kim C, Li M, Akey J, Barnes KC, Sevransky J, Lanken PN, May AK, Aplenc R, Maloney JP, Hakonarson H

Agonist of growth hormone-releasing hormone reduces pneumolysin-induced pulmonary permeability edema.

Proceedings of the National Academy of Sciences of the United States of America

Lucas R, Sridhar S, Rick FG, Gorshkov B, Umapathy NS, Yang G, Oseghale A, Verin AD, Chakraborty T, Matthay MA, Zemskov EA, White R, Block NL, Schally AV

Mesenchymal stem cells enhance survival and bacterial clearance in murine Escherichia coli pneumonia.

Thorax

Gupta N, Krasnodembskaya A, Kapetanaki M, Mouded M, Tan X, Serikov V, Matthay MA

Altered lymphatics in an ovine model of congenital heart disease with increased pulmonary blood flow.

American journal of physiology. Lung cellular and molecular physiology

Datar SA, Johnson EG, Oishi PE, Johengen M, Tang E, Aramburo A, Barton J, Kuo HC, Bennett S, Xoinis K, Reel B, Kalkan G, Sajti E, Osorio O, Raff GW, Matthay MA, Fineman JR

The association between a Darc gene polymorphism and clinical outcomes in African American patients with acute lung injury.

Chest

Kangelaris KN, Sapru A, Calfee CS, Liu KD, Pawlikowska L, Witte JS, Vittinghoff E, Zhuo H, Auerbach AD, Ziv E, Matthay MA

A simple classification model for hospital mortality in patients with acute lung injury managed with lung protective ventilation.

Critical care medicine

Brown LM, Calfee CS, Matthay MA, Brower RG, Thompson BT, Checkley W

Acute kidney injury in patients with acute lung injury: impact of fluid accumulation on classification of acute kidney injury and associated outcomes.

Critical care medicine

Liu KD, Thompson BT, Ancukiewicz M, Steingrub JS, Douglas IS, Matthay MA, Wright P, Peterson MW, Rock P, Hyzy RC, Anzueto A, Truwit JD

Transfusion-related acute lung injury: incidence and risk factors.

Blood

Toy P, Gajic O, Bacchetti P, Looney MR, Gropper MA, Hubmayr R, Lowell CA, Norris PJ, Murphy EL, Weiskopf RB, Wilson G, Koenigsberg M, Lee D, Schuller R, Wu P, Grimes B, Gandhi MJ, Winters JL, Mair D, Hirschler N, Sanchez Rosen R, Matthay MA

Acute lung failure.

Seminars in respiratory and critical care medicine

Mac Sweeney R, McAuley DF, Matthay MA

Physiology, reductionism, and translational medicine: the right mix.

American journal of physiology. Lung cellular and molecular physiology

Pitt BR, Christman JW, Gunst SJ, Matthay MA, Stevens T, Ware LB

Claudin-4 levels are associated with intact alveolar fluid clearance in human lungs.

The American journal of pathology

Rokkam D, Lafemina MJ, Lee JW, Matthay MA, Frank JA

Advancing donor management research: design and implementation of a large, randomized, placebo-controlled trial.

Annals of intensive care

Ware LB, Koyama T, Billheimer D, Landeck M, Johnson E, Brady S, Bernard GR, Matthay MA

Concise review: Mesenchymal stem cells for acute lung injury: role of paracrine soluble factors.

Stem cells (Dayton, Ohio)

Lee JW, Fang X, Krasnodembskaya A, Howard JP, Matthay MA

Mesenchymal stem cells and acute lung injury.

Critical care clinics

Gotts JE, Matthay MA

An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals.

American journal of respiratory cell and molecular biology

Matute-Bello G, Downey G, Moore BB, Groshong SD, Matthay MA, Slutsky AS, Kuebler WM

Con: corticosteroids are not indicated for treatment of acute lung injury from H1N1 viral pneumonia.

American journal of respiratory and critical care medicine

Matthay MA, Liu KD

Alveolar epithelial cells express mesenchymal proteins in patients with idiopathic pulmonary fibrosis.

American journal of physiology. Lung cellular and molecular physiology

Marmai C, Sutherland RE, Kim KK, Dolganov GM, Fang X, Kim SS, Jiang S, Golden JA, Hoopes CW, Matthay MA, Chapman HA, Wolters PJ

Use of risk reclassification with multiple biomarkers improves mortality prediction in acute lung injury.

Critical care medicine

Calfee CS, Ware LB, Glidden DV, Eisner MD, Parsons PE, Thompson BT, Matthay MA

Active and passive cigarette smoking and acute lung injury after severe blunt trauma.

American journal of respiratory and critical care medicine

Calfee CS, Matthay MA, Eisner MD, Benowitz N, Call M, Pittet JF, Cohen MJ

Vascular pedicle width in acute lung injury: correlation with intravascular pressures and ability to discriminate fluid status.

Critical care (London, England)

Rice TW, Ware LB, Haponik EF, Chiles C, Wheeler AP, Bernard GR, Steingrub JS, Hite RD, Matthay MA, Wright P, Ely EW

Role of CFTR expressed by neutrophils in modulating acute lung inflammation and injury in mice.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]

Su X, Looney MR, Su HE, Lee JW, Song Y, Matthay MA

Informed consent in research to improve the number and quality of deceased donor organs.

Critical care medicine

Rey MM, Ware LB, Matthay MA, Bernard GR, McGuire AL, Caplan AL, Halpern SD

Single-nucleotide polymorphisms in the ß-adrenergic receptor genes are associated with lung allograft utilization.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

Sapru A, Pawlikowska L, Liu KD, Khush KK, Ann-Baxter-Lowe L, Hayden V, Menza RL, Convery M, Poon A, Landeck M, Zaroff JG, Matthay MA

Proteolytic release of the receptor for advanced glycation end products from in vitro and in situ alveolar epithelial cells.

American journal of physiology. Lung cellular and molecular physiology

Yamakawa N, Uchida T, Matthay MA, Makita K

Neuregulin-1-human epidermal receptor-2 signaling is a central regulator of pulmonary epithelial permeability and acute lung injury.

The Journal of biological chemistry

Finigan JH, Faress JA, Wilkinson E, Mishra RS, Nethery DE, Wyler D, Shatat M, Ware LB, Matthay MA, Mason R, Silver RF, Kern JA

Biomarkers increase detection of active smoking and secondhand smoke exposure in critically ill patients.

Critical care medicine

Hsieh SJ, Ware LB, Eisner MD, Yu L, Jacob P, Havel C, Goniewicz ML, Matthay MA, Benowitz NL, Calfee CS

The acute respiratory distress syndrome: pathogenesis and treatment.

Annual review of pathology

Matthay MA, Zemans RL

Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37.

Stem cells (Dayton, Ohio)

Krasnodembskaya A, Song Y, Fang X, Gupta N, Serikov V, Lee JW, Matthay MA

Stem cells in sepsis and acute lung injury.

Critical care medicine

Cribbs SK, Matthay MA, Martin GS

Priming with endotoxin increases acute lung injury in mice by enhancing the severity of lung endothelial injury.

Anatomical record (Hoboken, N.J. : 2007)

Lee JS, Su X, Rackley C, Matthay MA, Gupta N

Mesenchymal stem cells for acute lung injury: preclinical evidence.

Critical care medicine

Matthay MA, Goolaerts A, Howard JP, Lee JW

Therapeutic potential of mesenchymal stem cells for severe acute lung injury.

Chest

Matthay MA, Thompson BT, Read EJ, McKenna DH, Liu KD, Calfee CS, Lee JW

Thinking outside the box: Introduction.

Critical care medicine

Singer M, Matthay MA

The influence of race on the development of acute lung injury in trauma patients.

American journal of surgery

Brown LM, Kallet RH, Matthay MA, Dicker RA

Pathophysiology of transfusion-related acute lung injury.

Current opinion in hematology

Looney MR, Gilliss BM, Matthay MA

Ratio of angiopoietin-2 to angiopoietin-1 as a predictor of mortality in acute lung injury patients.

Critical care medicine

Ong T, McClintock DE, Kallet RH, Ware LB, Matthay MA, Liu KD

Assessing the quantity of pulmonary edema in critically ill children.

Critical care (London, England)

McAuley DF, Brown LM, Matthay MA

Advances and challenges in translating stem cell therapies for clinical diseases.

Translational research : the journal of laboratory and clinical medicine

Matthay MA

Alveolar fluid clearance is faster in women with acute lung injury compared to men.

Journal of critical care

Bastarache JA, Ong T, Matthay MA, Ware LB

Acute lung injury: epidemiology, pathogenesis, and treatment.

Journal of aerosol medicine and pulmonary drug delivery

Johnson ER, Matthay MA

Therapeutic strategies for severe acute lung injury.

Critical care medicine

Diaz JV, Brower R, Calfee CS, Matthay MA

Age-, sex-, and race-based differences among patients enrolled versus not enrolled in acute lung injury clinical trials.

Critical care medicine

Cooke CR, Erickson SE, Watkins TR, Matthay MA, Hudson LD, Rubenfeld GD

Plasma interleukin-8 is not an effective risk stratification tool for adults with vasopressor-dependent septic shock.

Critical care medicine

Calfee CS, Thompson BT, Parsons PE, Ware LB, Matthay MA, Wong HR

Update on acute lung injury and critical care medicine 2009.

American journal of respiratory and critical care medicine

Matthay MA, Idell S

Acute lung injury in patients with traumatic injuries: utility of a panel of biomarkers for diagnosis and pathogenesis.

The Journal of trauma

Fremont RD, Koyama T, Calfee CS, Wu W, Dossett LA, Bossert FR, Mitchell D, Wickersham N, Bernard GR, Matthay MA, May AK, Ware LB

Plasma biomarker profiles in acute exacerbation of idiopathic pulmonary fibrosis.

American journal of physiology. Lung cellular and molecular physiology

Collard HR, Calfee CS, Wolters PJ, Song JW, Hong SB, Brady S, Ishizaka A, Jones KD, King TE, Matthay MA, Kim DS

Regulated gene expression in cultured type II cells of adult human lung.

American journal of physiology. Lung cellular and molecular physiology

Ballard PL, Lee JW, Fang X, Chapin C, Allen L, Segal MR, Fischer H, Illek B, Gonzales LW, Kolla V, Matthay MA

Activation of the stress protein response inhibits the STAT1 signalling pathway and iNOS function in alveolar macrophages: role of Hsp90 and Hsp70.

Thorax

Howard M, Roux J, Lee H, Miyazawa B, Lee JW, Gartland B, Howard AJ, Matthay MA, Carles M, Pittet JF

Simulation of lung alveolar epithelial wound healing in vitro.

Journal of the Royal Society, Interface

Kim SH, Matthay MA, Mostov K, Hunt CA

Polymorphonuclear leukocytes mediate Staphylococcus aureus Panton-Valentine leukocidin-induced lung inflammation and injury.

Proceedings of the National Academy of Sciences of the United States of America

Diep BA, Chan L, Tattevin P, Kajikawa O, Martin TR, Basuino L, Mai TT, Marbach H, Braughton KR, Whitney AR, Gardner DJ, Fan X, Tseng CW, Liu GY, Badiou C, Etienne J, Lina G, Matthay MA, DeLeo FR, Chambers HF

Standards and recommendations for quantitative assessment of lung structure in research.

American journal of physiology. Lung cellular and molecular physiology

Matthay MA

Measuring the quantity of pulmonary edema in clinical lung injury.

Critical care medicine

Brown LM, Matthay MA

Thirty years of critical care medicine.

Critical care (London, England)

Vincent JL, Singer M, Marini JJ, Moreno R, Levy M, Matthay MA, Pinsky M, Rhodes A, Ferguson ND, Evans T, Annane D, Hall JB

Transforming growth factor beta1 inhibits cystic fibrosis transmembrane conductance regulator-dependent cAMP-stimulated alveolar epithelial fluid transport via a phosphatidylinositol 3-kinase-dependent mechanism.

The Journal of biological chemistry

Roux J, Carles M, Koh H, Goolaerts A, Ganter MT, Chesebro BB, Howard M, Houseman BT, Finkbeiner W, Shokat KM, Paquet AC, Matthay MA, Pittet JF

Mesenchymal stem cells for the prevention of bronchopulmonary dysplasia: delivering the secretome.

American journal of respiratory and critical care medicine

Abman SH, Matthay MA

Laminin gamma2 fragments are increased in the circulation of patients with early phase acute lung injury.

Intensive care medicine

Katayama M, Ishizaka A, Sakamoto M, Fujishima S, Sekiguchi K, Asano K, Betsuyaku T, Kotani T, Ware LB, Matthay MA, Hashimoto S

Early elevations in B-type natriuretic peptide levels are associated with poor clinical outcomes in pediatric acute lung injury.

Pediatric pulmonology

Reel B, Oishi PE, Hsu JH, Gildengorin G, Matthay MA, Fineman JR, Flori H

Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury.

Chest

Ware LB, Koyama T, Billheimer DD, Wu W, Bernard GR, Thompson BT, Brower RG, Standiford TJ, Martin TR, Matthay MA

Elevated PAI-1 is associated with poor clinical outcomes in pediatric patients with acute lung injury.

Intensive care medicine

Sapru A, Curley MA, Brady S, Matthay MA, Flori H

Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury.

The Journal of clinical investigation

Looney MR, Nguyen JX, Hu Y, Van Ziffle JA, Lowell CA, Matthay MA

Potential application of mesenchymal stem cells in acute lung injury.

Expert opinion on biological therapy

Lee JW, Gupta N, Serikov V, Matthay MA

Determining the aetiology of pulmonary oedema by the oedema fluid-to-plasma protein ratio.

The European respiratory journal

Ware LB, Fremont RD, Bastarache JA, Calfee CS, Matthay MA

Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung.

Proceedings of the National Academy of Sciences of the United States of America

Lee JW, Fang X, Gupta N, Serikov V, Matthay MA

Serotonin decreases alveolar epithelial fluid transport via a direct inhibition of the epithelial sodium channel.

American journal of respiratory cell and molecular biology

Goolaerts A, Roux J, Ganter MT, Shlyonsky V, Chraibi A, Stéphane R, Mies F, Matthay MA, Naeije R, Sariban-Sohraby S, Howard M, Pittet JF

Comparison of two non-bronchoscopic methods for evaluating inflammation in patients with acute hypoxaemic respiratory failure.

Critical care (London, England)

Colucci G, Domenighetti G, Della Bruna R, Bonilla J, Limoni C, Matthay MA, Martin TR

NADPH oxidase-1 plays a crucial role in hyperoxia-induced acute lung injury in mice.

American journal of respiratory and critical care medicine

Carnesecchi S, Deffert C, Pagano A, Garrido-Urbani S, Métrailler-Ruchonnet I, Schäppi M, Donati Y, Matthay MA, Krause KH, Barazzone Argiroffo C

Measurement of extravascular lung water using the single indicator method in patients: research and potential clinical value.

American journal of physiology. Lung cellular and molecular physiology

Brown LM, Liu KD, Matthay MA

Inhaled activated protein C: a novel therapy for acute lung injury?

Critical care (London, England)

Liu KD, Looney MR, Matthay MA

Protective mechanisms of activated protein C in severe inflammatory disorders.

British journal of pharmacology

Neyrinck AP, Liu KD, Howard JP, Matthay MA

4G/5G polymorphism of plasminogen activator inhibitor-1 gene is associated with mortality in intensive care unit patients with severe pneumonia.

Anesthesiology

Sapru A, Hansen H, Ajayi T, Brown R, Garcia O, Zhuo H, Wiemels J, Matthay MA, Wiener-Kronish J

Blood product transfusions and clinical outcomes in pediatric patients with acute lung injury.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Church GD, Matthay MA, Liu K, Milet M, Flori HR

Higher pulmonary dead space may predict prolonged mechanical ventilation after cardiac surgery.

Pediatric pulmonology

Ong T, Stuart-Killion RB, Daniel BM, Presnell LB, Zhuo H, Matthay MA, Liu KD

Recent trends in acute lung injury mortality: 1996-2005.

Critical care medicine

Erickson SE, Martin GS, Davis JL, Matthay MA, Eisner MD

Receptor for advanced glycation end-products (RAGE) is an indicator of direct lung injury in models of experimental lung injury.

American journal of physiology. Lung cellular and molecular physiology

Su X, Looney MR, Gupta N, Matthay MA

Neutrophil sandwiches injure the microcirculation.

Nature medicine

Looney MR, Matthay MA

Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers.

American journal of respiratory and critical care medicine

Shyamsundar M, McKeown ST, O'Kane CM, Craig TR, Brown V, Thickett DR, Matthay MA, Taggart CC, Backman JT, Elborn JS, McAuley DF

A computational approach to understand in vitro alveolar morphogenesis.

PloS one

Kim SH, Yu W, Mostov K, Matthay MA, Hunt CA

The pathogenetic and prognostic value of biologic markers in acute lung injury.

Journal of intensive care medicine

Levitt JE, Gould MK, Ware LB, Matthay MA

Racial and ethnic disparities in mortality from acute lung injury.

Critical care medicine

Erickson SE, Shlipak MG, Martin GS, Wheeler AP, Ancukiewicz M, Matthay MA, Eisner MD

Anti-chemokine autoantibody:chemokine immune complexes activate endothelial cells via IgG receptors.

American journal of respiratory cell and molecular biology

Krupa A, Fudala R, Stankowska D, Loyd T, Allen TC, Matthay MA, Gryczynski Z, Gryczynski I, Mettikolla YV, Kurdowska AK

Fatty acid transduction of nitric oxide signaling: nitrolinoleic acid mediates protective effects through regulation of the ERK pathway.

Free radical biology & medicine

Iles KE, Wright MM, Cole MP, Welty NE, Ware LB, Matthay MA, Schopfer FJ, Baker PR, Agarwal A, Freeman BA

Beyond fishing: the role of discovery proteomics in mechanistic lung research.

American journal of physiology. Lung cellular and molecular physiology

Ware LB, Matthay MA

Soluble intercellular adhesion molecule-1 and clinical outcomes in patients with acute lung injury.

Intensive care medicine

Calfee CS, Eisner MD, Parsons PE, Thompson BT, Conner ER, Matthay MA, Ware LB

Plasma receptor for advanced glycation end products and clinical outcomes in acute lung injury.

Thorax

Calfee CS, Ware LB, Eisner MD, Parsons PE, Thompson BT, Wickersham N, Matthay MA

Predictors of mortality in acute lung injury during the era of lung protective ventilation.

Thorax

Seeley E, McAuley DF, Eisner M, Miletin M, Matthay MA, Kallet RH

Randomized clinical trial of activated protein C for the treatment of acute lung injury.

American journal of respiratory and critical care medicine

Liu KD, Levitt J, Zhuo H, Kallet RH, Brady S, Steingrub J, Tidswell M, Siegel MD, Soto G, Peterson MW, Chesnutt MS, Phillips C, Weinacker A, Thompson BT, Eisner MD, Matthay MA

Alterations in the proteome of pulmonary alveolar type II cells in the rat after hepatic ischemia-reperfusion.

Critical care medicine

Hirsch J, Niemann CU, Hansen KC, Choi S, Su X, Frank JA, Fang X, Hirose R, Theodore P, Sapru A, Burlingame AL, Matthay MA

CD47 deficiency protects mice from lipopolysaccharide-induced acute lung injury and Escherichia coli pneumonia.

Journal of immunology (Baltimore, Md. : 1950)

Su X, Johansen M, Looney MR, Brown EJ, Matthay MA

Novel molecular strategy to prevent pulmonary edema.

Critical care medicine

Matthay MA, Berthiaume Y

Measurement of extravascular lung water in patients with pulmonary edema.

American journal of physiology. Lung cellular and molecular physiology

Matthay MA

Protein C as a surrogate end-point for clinical trials of sepsis.

Critical care (London, England)

Liu KD, Matthay MA

Treatment of acute lung injury: clinical and experimental studies.

Proceedings of the American Thoracic Society

Matthay MA

Biomarkers of inflammation, coagulation and fibrinolysis predict mortality in acute lung injury.

Critical care (London, England)

McClintock D, Zhuo H, Wickersham N, Matthay MA, Ware LB

A framework and mechanistically focused, in silico method for enabling rational translational research.

Summit on translational bioinformatics

Hunt CA, Baranzini S, Matthay MA, Park S

Intra-alveolar tissue factor pathway inhibitor is not sufficient to block tissue factor procoagulant activity.

American journal of physiology. Lung cellular and molecular physiology

Bastarache JA, Wang L, Wang Z, Albertine KH, Matthay MA, Ware LB

Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms.

Circulation research

Ganter MT, Roux J, Miyazawa B, Howard M, Frank JA, Su G, Sheppard D, Violette SM, Weinreb PH, Horan GS, Matthay MA, Pittet JF

Advances in critical care for the nephrologist: acute lung injury/ARDS.

Clinical journal of the American Society of Nephrology : CJASN

Liu KD, Matthay MA

Prostaglandin E2 mediates IL-1beta-related fibroblast mitogenic effects in acute lung injury through differential utilization of prostanoid receptors.

Journal of immunology (Baltimore, Md. : 1950)

White KE, Ding Q, Moore BB, Peters-Golden M, Ware LB, Matthay MA, Olman MA

Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury.

Critical care medicine

Liu KD, Glidden DV, Eisner MD, Parsons PE, Ware LB, Wheeler A, Korpak A, Thompson BT, Chertow GM, Matthay MA

Lung epithelial cells induce endodermal differentiation in mouse mesenchymal bone marrow stem cells by paracrine mechanism.

Tissue engineering

Popov BV, Serikov VB, Petrov NS, Izusova TV, Gupta N, Matthay MA

The role of protein C in sepsis.

Current infectious disease reports

Looney MR, Matthay MA

Trauma-associated lung injury differs clinically and biologically from acute lung injury due to other clinical disorders.

Critical care medicine

Calfee CS, Eisner MD, Ware LB, Thompson BT, Parsons PE, Wheeler AP, Korpak A, Matthay MA

Rac1 is required for reorientation of polarity and lumen formation through a PI 3-kinase-dependent pathway.

American journal of physiology. Renal physiology

Liu KD, Datta A, Yu W, Brakeman PR, Jou TS, Matthay MA, Mostov KE

Evidence of temporary airway epithelial repopulation and rare clonal formation by BM-derived cells following naphthalene injury in mice.

Anatomical record (Hoboken, N.J. : 2007)

Serikov VB, Popov B, Mikhailov VM, Gupta N, Matthay MA

Surfactant treatment of aspiration-induced lung injury in children.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Matthay MA, Taeusch W

Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice.

Journal of immunology (Baltimore, Md. : 1950)

Gupta N, Su X, Popov B, Lee JW, Serikov V, Matthay MA

Pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury/acute respiratory distress syndrome.

Critical care medicine

Ware LB, Matthay MA, Parsons PE, Thompson BT, Januzzi JL, Eisner MD

Workshop summary: phosgene-induced pulmonary toxicity revisited: appraisal of early and late markers of pulmonary injury from animal models with emphasis on human significance.

Inhalation toxicology

Pauluhn J, Carson A, Costa DL, Gordon T, Kodavanti U, Last JA, Matthay MA, Pinkerton KE, Sciuto AM

Plasma receptor for advanced glycation end-products predicts duration of ICU stay and mechanical ventilation in patients after lung transplantation.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

Calfee CS, Budev MM, Matthay MA, Church G, Brady S, Uchida T, Ishizaka A, Lara A, Ranes JL, deCamp MM, Arroliga AC

Pulmonary barriers to pneumonia and sepsis.

Nature medicine

Matthay MA, Su X

Acute lung injury edema fluid decreases net fluid transport across human alveolar epithelial type II cells.

The Journal of biological chemistry

Lee JW, Fang X, Dolganov G, Fremont RD, Bastarache JA, Ware LB, Matthay MA

Alveolar edema fluid clearance and acute lung injury.

Respiratory physiology & neurobiology

Berthiaume Y, Matthay MA

Anti-IL-8 autoantibody:IL-8 immune complexes suppress spontaneous apoptosis of neutrophils.

American journal of physiology. Lung cellular and molecular physiology

Fudala R, Krupa A, Matthay MA, Allen TC, Kurdowska AK

Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway?

Annals of surgery

Brohi K, Cohen MJ, Ganter MT, Matthay MA, Mackersie RC, Pittet JF

MAPK pathway mediates EGR-1-HSP70-dependent cigarette smoke-induced chemokine production.

American journal of physiology. Lung cellular and molecular physiology

Li CJ, Ning W, Matthay MA, Feghali-Bostwick CA, Choi AM

Genomics and proteomics of lung disease: conference summary.

American journal of physiology. Lung cellular and molecular physiology

Raj JU, Aliferis C, Caprioli RM, Cowley AW, Davies PF, Duncan MW, Erle DJ, Erzurum SC, Finn PW, Ischiropoulos H, Kaminski N, Kleeberger SR, Leikauf GD, Loyd JE, Martin TR, Matalon S, Moore JH, Quackenbush J, Sabo-Attwood T, Shapiro SD, Schnitzer JE, Schwartz DA, Schwiebert LM, Sheppard D, Ware LB, Weiss ST, Whitsett JA, Wurfel MM, Matthay MA

Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and rats.

American journal of respiratory cell and molecular biology

Su X, Lee JW, Matthay ZA, Mednick G, Uchida T, Fang X, Gupta N, Matthay MA

Postobstructive pulmonary edema: a case for hydrostatic mechanisms.

Chest

Fremont RD, Kallet RH, Matthay MA, Ware LB

Impact of low and high tidal volumes on the rat alveolar epithelial type II cell proteome.

American journal of respiratory and critical care medicine

Hirsch J, Hansen KC, Sapru A, Frank JA, Chalkley RJ, Fang X, Trinidad JC, Baker P, Burlingame AL, Matthay MA

The alveolar epithelium can initiate the extrinsic coagulation cascade through expression of tissue factor.

Thorax

Bastarache JA, Wang L, Geiser T, Wang Z, Albertine KH, Matthay MA, Ware LB

Physiological and biochemical markers of alveolar epithelial barrier dysfunction in perfused human lungs.

American journal of physiology. Lung cellular and molecular physiology

Frank JA, Briot R, Lee JW, Ishizaka A, Uchida T, Matthay MA

Early elevation of plasma von Willebrand factor antigen in pediatric acute lung injury is associated with an increased risk of death and prolonged mechanical ventilation.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Flori HR, Ware LB, Milet M, Matthay MA

Formation of cysts by alveolar type II cells in three-dimensional culture reveals a novel mechanism for epithelial morphogenesis.

Molecular biology of the cell

Yu W, Fang X, Ewald A, Wong K, Hunt CA, Werb Z, Matthay MA, Mostov K

Pulmonary artery catheter and fluid management in acute lung injury and the acute respiratory distress syndrome.

Clinics in chest medicine

Heresi GA, Arroliga AC, Wiedemann HP, Weidemann HP, Matthay MA

Cigarette smoke stimulates matrix metalloproteinase-2 activity via EGR-1 in human lung fibroblasts.

American journal of respiratory cell and molecular biology

Ning W, Dong Y, Sun J, Li C, Matthay MA, Feghali-Bostwick CA, Choi AM

Novel role of the human alveolar epithelium in regulating intra-alveolar coagulation.

American journal of respiratory cell and molecular biology

Wang L, Bastarache JA, Wickersham N, Fang X, Matthay MA, Ware LB

Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death.

Nature medicine

Bhandari V, Choo-Wing R, Lee CG, Zhu Z, Nedrelow JH, Chupp GL, Zhang X, Matthay MA, Ware LB, Homer RJ, Lee PJ, Geick A, de Fougerolles AR, Elias JA

Higher urine nitric oxide is associated with improved outcomes in patients with acute lung injury.

American journal of respiratory and critical care medicine

McClintock DE, Ware LB, Eisner MD, Wickersham N, Thompson BT, Matthay MA

Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier function.

American journal of respiratory cell and molecular biology

Su G, Hodnett M, Wu N, Atakilit A, Kosinski C, Godzich M, Huang XZ, Kim JK, Frank JA, Matthay MA, Sheppard D, Pittet JF

Protein permeability in lung injury: now in real time again?

Journal of applied physiology (Bethesda, Md. : 1985)

Lee JW, Matthay MA

Treatment of acute lung injury: historical perspective and potential future therapies.

Seminars in respiratory and critical care medicine

Levitt JE, Matthay MA

Alveolar macrophages contribute to alveolar barrier dysfunction in ventilator-induced lung injury.

American journal of physiology. Lung cellular and molecular physiology

Frank JA, Wray CM, McAuley DF, Schwendener R, Matthay MA

Activation of the stress protein response prevents the development of pulmonary edema by inhibiting VEGF cell signaling in a model of lung ischemia-reperfusion injury in rats.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Godzich M, Hodnett M, Frank JA, Su G, Pespeni M, Angel A, Howard MB, Matthay MA, Pittet JF

Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury.

The Journal of clinical investigation

Jenkins RG, Su X, Su G, Scotton CJ, Camerer E, Laurent GJ, Davis GE, Chambers RC, Matthay MA, Sheppard D

Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury.

The Journal of clinical investigation

Looney MR, Su X, Van Ziffle JA, Lowell CA, Matthay MA

Higher urine desmosine levels are associated with mortality in patients with acute lung injury.

American journal of physiology. Lung cellular and molecular physiology

McClintock DE, Starcher B, Eisner MD, Thompson BT, Hayden DL, Church GD, Matthay MA

Integrating acute lung injury and regulation of alveolar fluid clearance.

American journal of physiology. Lung cellular and molecular physiology

Guidot DM, Folkesson HG, Jain L, Sznajder JI, Pittet JF, Matthay MA

Evolving practices in critical care and potential implications for management of acute kidney injury.

Clinical journal of the American Society of Nephrology : CJASN

Liu KD, Matthay MA, Chertow GM

Extracellular heat shock protein 72 is a marker of the stress protein response in acute lung injury.

American journal of physiology. Lung cellular and molecular physiology

Ganter MT, Ware LB, Howard M, Roux J, Gartland B, Matthay MA, Fleshner M, Pittet JF

Airway epithelium, inflammation, and mechanisms of disease: A tribute to Carol B. Basbaum.

American journal of respiratory cell and molecular biology

Adler KB, Shapiro SD, Gallup M, Wu R, Randell SH, Holtzman MJ, Evans CM, Jacoby DB, Tesfaigzi Y, Rose MC, Mossman BT, Prince A, Reddy SP, Davis CW, Matthay MA

Animal models of transfusion-related acute lung injury.

Critical care medicine

Looney MR, Matthay MA

Pharmacotherapy of acute lung injury and the acute respiratory distress syndrome.

Journal of intensive care medicine

Cepkova M, Matthay MA

Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury.

American journal of physiology. Lung cellular and molecular physiology

Ware LB, Camerer E, Welty-Wolf K, Schultz MJ, Matthay MA

Perspectives, translational research, and letters to the editor.

American journal of physiology. Lung cellular and molecular physiology

Matthay MA, Christman JW, Pitt BR, Schwiebert LM, Stevens T, Ware LB

Alveolar epithelial ion and fluid transport: recent progress.

American journal of respiratory cell and molecular biology

Folkesson HG, Matthay MA

Clinical trial design--effect of prone positioning on clinical outcomes in infants and children with acute respiratory distress syndrome.

Journal of critical care

Curley MA, Arnold JH, Thompson JE, Fackler JC, Grant MJ, Fineman LD, Cvijanovich N, Barr FE, Molitor-Kirsch S, Steinhorn DM, Matthay MA, Hibberd PL

Stimulation of alveolar epithelial fluid clearance in human lungs by exogenous epinephrine.

Critical care medicine

Sakuma T, Gu X, Wang Z, Maeda S, Sugita M, Sagawa M, Osanai K, Toga H, Ware LB, Folkesson G, Matthay MA

Warm ischemia-induced alterations in oxidative and inflammatory proteins in hepatic Kupffer cells in rats.

Molecular & cellular proteomics : MCP

Hirsch J, Hansen KC, Choi S, Noh J, Hirose R, Roberts JP, Matthay MA, Burlingame AL, Maher JJ, Niemann CU

Receptor for advanced glycation end-products is a marker of type I cell injury in acute lung injury.

American journal of respiratory and critical care medicine

Uchida T, Shirasawa M, Ware LB, Kojima K, Hata Y, Makita K, Mednick G, Matthay ZA, Matthay MA

Beta-adrenergic agonist therapy as a potential treatment for acute lung injury.

American journal of respiratory and critical care medicine

Matthay MA, Abraham E

Clinical practice. Acute pulmonary edema.

The New England journal of medicine

Ware LB, Matthay MA

TNFalpha-induced long pentraxin PTX3 expression in human lung epithelial cells via JNK.

Journal of immunology (Baltimore, Md. : 1950)

Han B, Mura M, Andrade CF, Okutani D, Lodyga M, dos Santos CC, Keshavjee S, Matthay M, Liu M

Protective effect of endogenous beta-adrenergic tone on lung fluid balance in acute bacterial pneumonia in mice.

American journal of physiology. Lung cellular and molecular physiology

Su X, Robriquet L, Folkesson HG, Matthay MA

Congenital diaphragmatic hernia prevents absorption of distal air space fluid in late-gestation rat fetuses.

American journal of physiology. Lung cellular and molecular physiology

Folkesson HG, Chapin CJ, Beard LL, Ertsey R, Matthay MA, Kitterman JA

High prevalence of pulmonary arterial thrombi in donor lungs rejected for transplantation.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

Ware LB, Fang X, Wang Y, Babcock WD, Jones K, Matthay MA

Contribution of CFTR to apical-basolateral fluid transport in cultured human alveolar epithelial type II cells.

American journal of physiology. Lung cellular and molecular physiology

Fang X, Song Y, Hirsch J, Galietta LJ, Pedemonte N, Zemans RL, Dolganov G, Verkman AS, Matthay MA

Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms.

Journal of immunology (Baltimore, Md. : 1950)

Su X, Camerer E, Hamilton JR, Coughlin SR, Matthay MA

Leukotrienes in acute lung injury: a potential therapeutic target?

American journal of respiratory and critical care medicine

Frank JA, Matthay MA

Effect of prone positioning on clinical outcomes in children with acute lung injury: a randomized controlled trial.

JAMA

Curley MA, Hibberd PL, Fineman LD, Wypij D, Shih MC, Thompson JE, Grant MJ, Barr FE, Cvijanovich NZ, Sorce L, Luckett PM, Matthay MA, Arnold JH

VEGF levels in the alveolar compartment do not distinguish between ARDS and hydrostatic pulmonary oedema.

The European respiratory journal

Ware LB, Kaner RJ, Crystal RG, Schane R, Trivedi NN, McAuley D, Matthay MA

Recent advances in mechanical ventilation.

The American journal of medicine

Calfee CS, Matthay MA

Proteinase-activated receptor-1 mediates elastase-induced apoptosis of human lung epithelial cells.

American journal of respiratory cell and molecular biology

Suzuki T, Moraes TJ, Vachon E, Ginzberg HH, Huang TT, Matthay MA, Hollenberg MD, Marshall J, McCulloch CA, Abreu MT, Chow CW, Downey GP

Decreased expression of both the alpha1- and alpha2-subunits of the Na-K-ATPase reduces maximal alveolar epithelial fluid clearance.

American journal of physiology. Lung cellular and molecular physiology

Looney MR, Sartori C, Chakraborty S, James PF, Lingrel JB, Matthay MA

Critical care in AJRCCM 2004.

American journal of respiratory and critical care medicine

Angus D, Ishizaka A, Matthay M, Lemaire F, Macnee W, Abraham E

Interleukin-1beta decreases expression of the epithelial sodium channel alpha-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathway.

The Journal of biological chemistry

Roux J, Kawakatsu H, Gartland B, Pespeni M, Sheppard D, Matthay MA, Canessa CM, Pittet JF

In vitro and in vivo regulation of transepithelial lung alveolar sodium transport by serine proteases.

American journal of physiology. Lung cellular and molecular physiology

Planès C, Leyvraz C, Uchida T, Angelova MA, Vuagniaux G, Hummler E, Matthay M, Clerici C, Rossier B

Acute effects of tidal volume strategy on hemodynamics, fluid balance, and sedation in acute lung injury.

Critical care medicine

Cheng IW, Eisner MD, Thompson BT, Ware LB, Matthay MA

Alveolar epithelium: role in lung fluid balance and acute lung injury.

Proceedings of the American Thoracic Society

Matthay MA, Robriquet L, Fang X

Differential effects of sustained inflation recruitment maneuvers on alveolar epithelial and lung endothelial injury.

Critical care medicine

Frank JA, McAuley DF, Gutierrez JA, Daniel BM, Dobbs L, Matthay MA

Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury.

Critical care medicine

Parsons PE, Eisner MD, Thompson BT, Matthay MA, Ancukiewicz M, Bernard GR, Wheeler AP

Subglottic secretion drainage for preventing ventilator-associated pneumonia: a meta-analysis.

The American journal of medicine

Dezfulian C, Shojania K, Collard HR, Kim HM, Matthay MA, Saint S

Pediatric acute lung injury: prospective evaluation of risk factors associated with mortality.

American journal of respiratory and critical care medicine

Flori HR, Glidden DV, Rutherford GW, Matthay MA

Integrated control of lung fluid balance.

American journal of physiology. Lung cellular and molecular physiology

Mehta D, Bhattacharya J, Matthay MA, Malik AB

HO-1 induction restores c-AMP-dependent lung epithelial fluid transport following severe hemorrhage in rats.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Lee H, Pespeni M, Roux J, Dennery PA, Matthay MA, Pittet JF

Can nicotine treat sepsis?

Nature medicine

Matthay MA, Ware LB

Elevated plasma levels of soluble TNF receptors are associated with morbidity and mortality in patients with acute lung injury.

American journal of physiology. Lung cellular and molecular physiology

Parsons PE, Matthay MA, Ware LB, Eisner MD

Acute lung injury and acute respiratory distress syndrome in pregnancy.

Critical care clinics

Bandi VD, Munnur U, Matthay MA

Soluble MD-2 activity in plasma from patients with severe sepsis and septic shock.

Blood

Pugin J, Stern-Voeffray S, Daubeuf B, Matthay MA, Elson G, Dunn-Siegrist I

Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome.

The New England journal of medicine

Brower RG, Lanken PN, MacIntyre N, Matthay MA, Morris A, Ancukiewicz M, Schoenfeld D, Thompson BT

Coagulation-dependent mechanisms and asthma.

The Journal of clinical investigation

Matthay MA, Clements JA

Proteomics: current techniques and potential applications to lung disease.

American journal of physiology. Lung cellular and molecular physiology

Hirsch J, Hansen KC, Burlingame AL, Matthay MA

Transfusion-related acute lung injury: a review.

Chest

Looney MR, Gropper MA, Matthay MA

Significance of von Willebrand factor in septic and nonseptic patients with acute lung injury.

American journal of respiratory and critical care medicine

Ware LB, Eisner MD, Thompson BT, Parsons PE, Matthay MA

H(2)O(2) inhibits alveolar epithelial wound repair in vitro by induction of apoptosis.

American journal of physiology. Lung cellular and molecular physiology

Geiser T, Ishigaki M, van Leer C, Matthay MA, Broaddus VC

Mechanisms of alveolar protein clearance in the intact lung.

American journal of physiology. Lung cellular and molecular physiology

Hastings RH, Folkesson HG, Matthay MA

Diagnostic utility of B-type natriuretic peptide in patients with acute dyspnea or pleural effusions.

The American journal of medicine

Zemans RL, Chatterjee K, Matthay MA

Fluid transport across cultured rat alveolar epithelial cells: a novel in vitro system.

American journal of physiology. Lung cellular and molecular physiology

Fang X, Song Y, Zemans R, Hirsch J, Matthay MA

Malnutrition impairs alveolar fluid clearance in rat lungs.

American journal of physiology. Lung cellular and molecular physiology

Sakuma T, Zhao Y, Sugita M, Sagawa M, Toga H, Ishibashi T, Nishio M, Matthay MA

Pulmonary edema fluid from patients with early lung injury stimulates fibroblast proliferation through IL-1 beta-induced IL-6 expression.

Journal of immunology (Baltimore, Md. : 1950)

Olman MA, White KE, Ware LB, Simmons WL, Benveniste EN, Zhu S, Pugin J, Matthay MA

Look before you leap: how do intensivists improve care for critically ill patients?

The American journal of medicine

Gropper MA, Matthay MA

Proteomic analysis of pulmonary edema fluid and plasma in patients with acute lung injury.

American journal of physiology. Lung cellular and molecular physiology

Bowler RP, Duda B, Chan ED, Enghild JJ, Ware LB, Matthay MA, Duncan MW

Proinflammatory activity of anti-IL-8 autoantibody:IL-8 complexes in alveolar edema fluid from patients with acute lung injury.

American journal of physiology. Lung cellular and molecular physiology

Krupa A, Kato H, Matthay MA, Kurdowska AK

The ADP ribosyltransferase domain of Pseudomonas aeruginosa ExoT contributes to its biological activities.

Infection and immunity

Garrity-Ryan L, Shafikhani S, Balachandran P, Nguyen L, Oza J, Jakobsen T, Sargent J, Fang X, Cordwell S, Matthay MA, Engel JN

Cytokine-mediated inflammation in acute lung injury.

Cytokine & growth factor reviews

Goodman RB, Pugin J, Lee JS, Matthay MA

Pancreatitis-associated acute lung injury: new insights.

Chest

Pastor CM, Matthay MA, Frossard JL

Transforming growth factor-beta 1 regulates lung epithelial barrier function and fluid transport.

American journal of physiology. Lung cellular and molecular physiology

Clerici C, Matthay MA

Transgenic overexpression of granulocyte macrophage-colony stimulating factor in the lung prevents hyperoxic lung injury.

The American journal of pathology

Paine R, Wilcoxen SE, Morris SB, Sartori C, Baleeiro CE, Matthay MA, Christensen PJ

Effects of recruitment maneuvers in patients with acute lung injury and acute respiratory distress syndrome ventilated with high positive end-expiratory pressure.

Critical care medicine

Brower RG, Morris A, MacIntyre N, Matthay MA, Hayden D, Thompson T, Clemmer T, Lanken PN, Schoenfeld D

Effect of continuous hemofiltration on hemodynamics, lung inflammation and pulmonary edema in a canine model of acute lung injury.

Intensive care medicine

Su X, Bai C, Hong Q, Zhu D, He L, Wu J, Ding F, Fang X, Matthay MA

Acute lung injury and the acute respiratory distress syndrome.

Critical care clinics

Cheng IW, Matthay MA

Elevation of KL-6, a lung epithelial cell marker, in plasma and epithelial lining fluid in acute respiratory distress syndrome.

American journal of physiology. Lung cellular and molecular physiology

Ishizaka A, Matsuda T, Albertine KH, Koh H, Tasaka S, Hasegawa N, Kohno N, Kotani T, Morisaki H, Takeda J, Nakamura M, Fang X, Martin TR, Matthay MA, Hashimoto S

Pulmonary edema fluid antioxidants are depressed in acute lung injury.

Critical care medicine

Bowler RP, Velsor LW, Duda B, Chan ED, Abraham E, Ware LB, Matthay MA, Day BJ

Transforming growth factor-beta induces fibrosis in immune cell-depleted lungs.

American journal of physiology. Lung cellular and molecular physiology

Olman MA, Matthay MA

Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism.

The Journal of biological chemistry

Frank J, Roux J, Kawakatsu H, Su G, Dagenais A, Berthiaume Y, Howard M, Canessa CM, Fang X, Sheppard D, Matthay MA, Pittet JF

Functional identification of the alveolar edema reabsorption activity of murine tumor necrosis factor-alpha.

American journal of respiratory and critical care medicine

Elia N, Tapponnier M, Matthay MA, Hamacher J, Pache JC, Brundler MA, Totsch M, De Baetselier P, Fransen L, Fukuda N, Morel DR, Lucas R

Early elevation of plasma soluble intercellular adhesion molecule-1 in pediatric acute lung injury identifies patients at increased risk of death and prolonged mechanical ventilation.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Flori HR, Ware LB, Glidden D, Matthay MA

Protein C and thrombomodulin in human acute lung injury.

American journal of physiology. Lung cellular and molecular physiology

Ware LB, Fang X, Matthay MA

Elevated levels of plasminogen activator inhibitor-1 in pulmonary edema fluid are associated with mortality in acute lung injury.

American journal of physiology. Lung cellular and molecular physiology

Prabhakaran P, Ware LB, White KE, Cross MT, Matthay MA, Olman MA

Future research directions in acute lung injury: summary of a National Heart, Lung, and Blood Institute working group.

American journal of respiratory and critical care medicine

Matthay MA, Zimmerman GA, Esmon C, Bhattacharya J, Coller B, Doerschuk CM, Floros J, Gimbrone MA, Hoffman E, Hubmayr RD, Leppert M, Matalon S, Munford R, Parsons P, Slutsky AS, Tracey KJ, Ward P, Gail DB, Harabin AL

Therapeutic strategies to hasten the resolution of pulmonary edema.

Critical care medicine

Folkesson HG, Matthay MA

Prevention of ventilator-associated pneumonia: an evidence-based systematic review.

Annals of internal medicine

Collard HR, Saint S, Matthay MA

Keratinocyte growth factor promotes cell motility during alveolar epithelial repair in vitro.

Experimental cell research

Galiacy S, Planus E, Lepetit H, Féréol S, Laurent V, Ware L, Isabey D, Matthay M, Harf A, d'Ortho MP

High tidal volume ventilation induces NOS2 and impairs cAMP- dependent air space fluid clearance.

American journal of physiology. Lung cellular and molecular physiology

Frank JA, Pittet JF, Lee H, Godzich M, Matthay MA

Prognostic value of surfactant proteins A and D in patients with acute lung injury.

Critical care medicine

Cheng IW, Ware LB, Greene KE, Nuckton TJ, Eisner MD, Matthay MA

Meta-analysis of acute lung injury and acute respiratory distress syndrome trials.

American journal of respiratory and critical care medicine

Brower RG, Matthay M, Schoenfeld D

Alveolar epithelial fluid transport in acute lung injury: new insights.

The European respiratory journal

Sartori C, Matthay MA

Fas and fas ligand are up-regulated in pulmonary edema fluid and lung tissue of patients with acute lung injury and the acute respiratory distress syndrome.

The American journal of pathology

Albertine KH, Soulier MF, Wang Z, Ishizaka A, Hashimoto S, Zimmerman GA, Matthay MA, Ware LB

Hypoxia upregulates VEGF expression in alveolar epithelial cells in vitro and in vivo.

American journal of physiology. Lung cellular and molecular physiology

Pham I, Uchida T, Planes C, Ware LB, Kaner R, Matthay MA, Clerici C

Selected contribution: long-term effects of beta(2)-adrenergic receptor stimulation on alveolar fluid clearance in mice.

Journal of applied physiology (Bethesda, Md. : 1985)

Sartori C, Fang X, McGraw DW, Koch P, Snider ME, Folkesson HG, Matthay MA

Selected contribution: mechanisms that may stimulate the resolution of alveolar edema in the transplanted human lung.

Journal of applied physiology (Bethesda, Md. : 1985)

Ware LB, Fang X, Wang Y, Sakuma T, Hall TS, Matthay MA

Measuring microvascular blood flow in sepsis--a continuing challenge.

Lancet (London, England)

Ware LB, Matthay MA

Science review: mechanisms of ventilator-induced injury.

Critical care (London, England)

Frank JA, Matthay MA

Invited review: Active fluid clearance from the distal air spaces of the lung.

Journal of applied physiology (Bethesda, Md. : 1985)

Matthay MA, Clerici C, Saumon G

Ventilator-induced lung injury: in vivo and in vitro mechanisms.

American journal of physiology. Lung cellular and molecular physiology

Matthay MA, Bhattacharya S, Gaver D, Ware LB, Lim LH, Syrkina O, Eyal F, Hubmayr R

Pleural surface fluorescence measurement of Na+ and Cl- transport across the air space-capillary barrier.

Journal of applied physiology (Bethesda, Md. : 1985)

Jiang J, Song Y, Bai C, Koller BH, Matthay MA, Verkman AS

Assessment of lungs rejected for transplantation and implications for donor selection.

Lancet (London, England)

Ware LB, Wang Y, Fang X, Warnock M, Sakuma T, Hall TS, Matthay M

Evidence against aquaporin-1-dependent CO2 permeability in lung and kidney.

The Journal of physiology

Fang X, Yang B, Matthay MA, Verkman AS

Keratinocyte growth factor can enhance alveolar epithelial repair by nonmitogenic mechanisms.

American journal of physiology. Lung cellular and molecular physiology

Atabai K, Ishigaki M, Geiser T, Ueki I, Matthay MA, Ware LB

Lung epithelial fluid transport and the resolution of pulmonary edema.

Physiological reviews

Matthay MA, Folkesson HG, Clerici C

Enhancing the safety of critically ill patients by reducing urinary and central venous catheter-related infections.

American journal of respiratory and critical care medicine

Saint S, Savel RH, Matthay MA

Activity of pulmonary edema fluid interleukin-8 bound to alpha(2)-macroglobulin in patients with acute lung injury.

American journal of physiology. Lung cellular and molecular physiology

Kurdowska AK, Geiser TK, Alden SM, Dziadek BR, Noble JM, Nuckton TJ, Matthay MA

Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair.

American journal of physiology. Lung cellular and molecular physiology

Ware LB, Matthay MA

Pulmonary dead-space fraction as a risk factor for death in the acute respiratory distress syndrome.

The New England journal of medicine

Nuckton TJ, Alonso JA, Kallet RH, Daniel BM, Pittet JF, Eisner MD, Matthay MA

Airway pressures and early barotrauma in patients with acute lung injury and acute respiratory distress syndrome.

American journal of respiratory and critical care medicine

Eisner MD, Thompson BT, Schoenfeld D, Anzueto A, Matthay MA

Clinical Acute Lung Injury and Acute Respiratory Distress Syndrome.

Current treatment options in cardiovascular medicine

Matthay MA, Uchida T, Fang X

Distal air space epithelial fluid clearance in near-term rat fetuses is fast and requires endogenous catecholamines.

American journal of physiology. Lung cellular and molecular physiology

Folkesson HG, Matthay MA, Chapin CJ, Porta NF, Kitterman JA

Lidocaine induces a reversible decrease in alveolar epithelial fluid clearance in rats.

Anesthesiology

Laffon M, Jayr C, Barbry P, Wang Y, Folkesson HG, Pittet JF, Clerici C, Matthay MA

Novel role for CFTR in fluid absorption from the distal airspaces of the lung.

The Journal of general physiology

Fang X, Fukuda N, Barbry P, Sartori C, Verkman AS, Matthay MA

Low tidal volume reduces epithelial and endothelial injury in acid-injured rat lungs.

American journal of respiratory and critical care medicine

Frank JA, Gutierrez JA, Jones KD, Allen L, Dobbs L, Matthay MA

Stress preconditioning attenuates oxidative injury to the alveolar epithelium of the lung following haemorrhage in rats.

The Journal of physiology

Pittet JF, Lu LN, Geiser T, Lee H, Matthay MA, Welch WJ

Clinicians' approaches to mechanical ventilation in acute lung injury and ARDS.

Chest

Thompson BT, Hayden D, Matthay MA, Brower R, Parsons PE

Hypoxia reduces alveolar epithelial sodium and fluid transport in rats: reversal by beta-adrenergic agonist treatment.

American journal of respiratory cell and molecular biology

Vivona ML, Matthay M, Chabaud MB, Friedlander G, Clerici C

Keratinocyte growth factor reduces alveolar epithelial susceptibility to in vitro mechanical deformation.

American journal of physiology. Lung cellular and molecular physiology

Oswari J, Matthay MA, Margulies SS

Targeted transgenic expression of beta(2)-adrenergic receptors to type II cells increases alveolar fluid clearance.

American journal of physiology. Lung cellular and molecular physiology

McGraw DW, Fukuda N, James PF, Forbes SL, Woo AL, Lingrel JB, Witte DP, Matthay MA, Liggett SB

The Role of Protein C in Sepsis.

Current infectious disease reports

Looney MR, Matthay MA

Treatment of ARDS.

Chest

Brower RG, Ware LB, Berthiaume Y, Matthay MA

Efficacy of low tidal volume ventilation in patients with different clinical risk factors for acute lung injury and the acute respiratory distress syndrome.

American journal of respiratory and critical care medicine

Eisner MD, Thompson T, Hudson LD, Luce JM, Hayden D, Schoenfeld D, Matthay MA

Rapid alveolar epithelial fluid clearance following lung lavage in pulmonary alveolar proteinosis.

Chest

Chesnutt MS, Nuckton TJ, Golden J, Folkesson HG, Matthay MA

Mechanisms of TNF-alpha stimulation of amiloride-sensitive sodium transport across alveolar epithelium.

American journal of physiology. Lung cellular and molecular physiology

Fukuda N, Jayr C, Lazrak A, Wang Y, Lucas R, Matalon S, Matthay MA

Role of aquaporin water channels in airway fluid transport, humidification, and surface liquid hydration.

The Journal of general physiology

Song Y, Jayaraman S, Yang B, Matthay MA, Verkman AS

TGF-beta is a critical mediator of acute lung injury.

The Journal of clinical investigation

Pittet JF, Griffiths MJ, Geiser T, Kaminski N, Dalton SL, Huang X, Brown LA, Gotwals PJ, Koteliansky VE, Matthay MA, Sheppard D

Reactive nitrogen species inhibit alveolar epithelial fluid transport after hemorrhagic shock in rats.

Journal of immunology (Baltimore, Md. : 1950)

Pittet JF, Lu LN, Morris DG, Modelska K, Welch WJ, Carey HV, Roux J, Matthay MA

Pulmonary edema fluid from patients with acute lung injury augments in vitro alveolar epithelial repair by an IL-1beta-dependent mechanism.

American journal of respiratory and critical care medicine

Geiser T, Atabai K, Jarreau PH, Ware LB, Pugin J, Matthay MA

Contribution of amiloride-insensitive pathways to alveolar fluid clearance in adult rats.

Journal of applied physiology (Bethesda, Md. : 1985)

Norlin A, Lu LN, Guggino SE, Matthay MA, Folkesson HG

Pseudomonas aeruginosa ExoT inhibits in vitro lung epithelial wound repair.

Cellular microbiology

Geiser TK, Kazmierczak BI, Garrity-Ryan LK, Matthay MA, Engel JN

Alveolar epithelial transport. Basic science to clinical medicine.

American journal of respiratory and critical care medicine

Crandall ED, Matthay MA

Denopamine, a beta(1)-adrenergic agonist, increases alveolar fluid clearance in ex vivo rat and guinea pig lungs.

Journal of applied physiology (Bethesda, Md. : 1985)

Sakuma T, Tuchihara C, Ishigaki M, Osanai K, Nambu Y, Toga H, Takahashi K, Ohya N, Kurihara T, Matthay MA

Increased levels of nitrate and surfactant protein a nitration in the pulmonary edema fluid of patients with acute lung injury.

American journal of respiratory and critical care medicine

Zhu S, Ware LB, Geiser T, Matthay MA, Matalon S

Transepithelial sodium and water transport in the lung. Major player and novel therapeutic target in pulmonary edema.

Advances in experimental medicine and biology

Sartori C, Matthay MA, Scherrer U

Interleukin-1beta augments in vitro alveolar epithelial repair.

American journal of physiology. Lung cellular and molecular physiology

Geiser T, Jarreau PH, Atabai K, Matthay MA

Role of aquaporin water channels in pleural fluid dynamics.

American journal of physiology. Cell physiology

Song Y, Yang B, Matthay MA, Ma T, Verkman AS

Beta-adrenergic agonist therapy accelerates the resolution of hydrostatic pulmonary edema in sheep and rats.

Journal of applied physiology (Bethesda, Md. : 1985)

Frank JA, Wang Y, Osorio O, Matthay MA

Alveolar epithelial barrier. Role in lung fluid balance in clinical lung injury.

Clinics in chest medicine

Matthay MA, Fukuda N, Frank J, Kallet R, Daniel B, Sakuma T

Relationship of interstitial fluid volume to alveolar fluid clearance in mice: ventilated vs. in situ studies.

Journal of applied physiology (Bethesda, Md. : 1985)

Fukuda N, Folkesson HG, Matthay MA

Lung overexpression of the vascular endothelial growth factor gene induces pulmonary edema.

American journal of respiratory cell and molecular biology

Kaner RJ, Ladetto JV, Singh R, Fukuda N, Matthay MA, Crystal RG

Lung deflation impairs alveolar epithelial fluid transport in ischemic rabbit and rat lungs.

Transplantation

Sakuma T, Tsukano C, Ishigaki M, Nambu Y, Osanai K, Toga H, Takahashi K, Ohya N, Kurihara T, Nishio M, Matthay MA

The acute respiratory distress syndrome.

The New England journal of medicine

Ware LB, Matthay MA

Aquaporin water channels and lung physiology.

American journal of physiology. Lung cellular and molecular physiology

Verkman AS, Matthay MA, Song Y

Hypoxia regulates gene expression of alveolar epithelial transport proteins.

Journal of applied physiology (Bethesda, Md. : 1985)

Clerici C, Matthay MA

[Amiloride-sensitive sodium channel in the nephron and its activation by vasopressin].

Annales d'endocrinologie

Coscoy S, de Weille J, Lingueglia E, Fukuda N, Matthay M, Lazdunski M, Barbry P

Increased neutrophil numbers and IL-8 levels in airway secretions in acute severe asthma: Clinical and biologic significance.

American journal of respiratory and critical care medicine

Ordoñez CL, Shaughnessy TE, Matthay MA, Fahy JV

A novel alveolar type I cell-specific biochemical marker of human acute lung injury.

American journal of respiratory and critical care medicine

Newman V, Gonzalez RF, Matthay MA, Dobbs LG

Dexamethasone and thyroid hormone pretreatment upregulate alveolar epithelial fluid clearance in adult rats.

Journal of applied physiology (Bethesda, Md. : 1985)

Folkesson HG, Norlin A, Wang Y, Abedinpour P, Matthay MA

Carbon dioxide permeability of aquaporin-1 measured in erythrocytes and lung of aquaporin-1 null mice and in reconstituted proteoliposomes.

The Journal of biological chemistry

Yang B, Fukuda N, van Hoek A, Matthay MA, Ma T, Verkman AS

Consensus conference definitions for sepsis, septic shock, acute lung injury, and acute respiratory distress syndrome: time for a reevaluation.

Critical care medicine

Abraham E, Matthay MA, Dinarello CA, Vincent JL, Cohen J, Opal SM, Glauser M, Parsons P, Fisher CJ, Repine JE

Early expression of beta- and gamma-subunits of epithelial sodium channel during human airway development.

American journal of physiology. Lung cellular and molecular physiology

Gaillard D, Hinnrasky J, Coscoy S, Hofman P, Matthay MA, Puchelle E, Barbry P

Initial severity of metabolic acidosis predicts the development of acute lung injury in severely traumatized patients.

Critical care medicine

Eberhard LW, Morabito DJ, Matthay MA, Mackersie RC, Campbell AR, Marks JD, Alonso JA, Pittet JF

Lung fluid transport in aquaporin-5 knockout mice.

The Journal of clinical investigation

Ma T, Fukuda N, Song Y, Matthay MA, Verkman AS

Noninvasive ventilation for acute respiratory failure.

Journal of clinical monitoring and computing

Jasmer RM, Matthay MA

Health-related quality of life after acute lung injury.

Critical care medicine

Eisner MD, Matthay MA

Acid-induced lung injury. Protective effect of anti-interleukin-8 pretreatment on alveolar epithelial barrier function in rabbits.

American journal of respiratory and critical care medicine

Modelska K, Pittet JF, Folkesson HG, Courtney Broaddus V, Matthay MA

Alveolar epithelial fluid transport can be simultaneously upregulated by both KGF and beta-agonist therapy.

Journal of applied physiology (Bethesda, Md. : 1985)

Wang Y, Folkesson HG, Jayr C, Ware LB, Matthay MA

Interleukin-8 mediates injury from smoke inhalation to both the lung endothelial and the alveolar epithelial barriers in rabbits.

American journal of respiratory and critical care medicine

Laffon M, Pittet JF, Modelska K, Matthay MA, Young DM

Interobserver variability in applying a radiographic definition for ARDS.

Chest

Rubenfeld GD, Caldwell E, Granton J, Hudson LD, Matthay MA

Alveolar epithelial fluid transport and the resolution of clinically severe hydrostatic pulmonary edema.

Journal of applied physiology (Bethesda, Md. : 1985)

Verghese GM, Ware LB, Matthay BA, Matthay MA

The lectin-like domain of tumor necrosis factor-alpha increases membrane conductance in microvascular endothelial cells and peritoneal macrophages.

European journal of immunology

Hribar M, Bloc A, van der Goot FG, Fransen L, De Baetselier P, Grau GE, Bluethmann H, Matthay MA, Dunant Y, Pugin J, Lucas R

alpha-adrenergic blockade restores normal fluid transport capacity of alveolar epithelium after hemorrhagic shock.

The American journal of physiology

Laffon M, Lu LN, Modelska K, Matthay MA, Pittet JF

Indomethacin does not influence alveolar liquid clearance in anesthetized sheep or rats.

Experimental lung research

Berthiaume Y, Folkesson HG, Matthay MA

Oxidant-mediated lung injury in the acute respiratory distress syndrome.

Critical care medicine

Matthay MA, Geiser T, Matalon S, Ischiropoulos H

Acute pulmonary edema after lung transplantation: the pulmonary reimplantation response.

Chest

Khan SU, Salloum J, O'Donovan PB, Mascha EJ, Mehta AC, Matthay MA, Arroliga AC

Inhibition of beta-adrenergic-dependent alveolar epithelial clearance by oxidant mechanisms after hemorrhagic shock.

The American journal of physiology

Modelska K, Matthay MA, Brown LA, Deutch E, Lu LN, Pittet JF

Alveolar epithelial fluid transport capacity in reperfusion lung injury after lung transplantation.

American journal of respiratory and critical care medicine

Ware LB, Golden JA, Finkbeiner WE, Matthay MA

The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis.

Cell

Munger JS, Huang X, Kawakatsu H, Griffiths MJ, Dalton SL, Wu J, Pittet JF, Kaminski N, Garat C, Matthay MA, Rifkin DB, Sheppard D

Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice.

The Journal of clinical investigation

Bai C, Fukuda N, Song Y, Ma T, Matthay MA, Verkman AS

Alveolar epithelial fluid clearance persists in the presence of moderate left atrial hypertension in sheep.

Journal of applied physiology (Bethesda, Md. : 1985)

Campbell AR, Folkesson HG, Berthiaume Y, Gutkowska J, Suzuki S, Matthay MA

Ischemia-reperfusion lung injury in rabbits: mechanisms of injury and protection.

The American journal of physiology

Sakuma T, Takahashi K, Ohya N, Kajikawa O, Martin TR, Albertine KH, Matthay MA

Reduced osmotic water permeability of the peritoneal barrier in aquaporin-1 knockout mice.

The American journal of physiology

Yang B, Folkesson HG, Yang J, Matthay MA, Ma T, Verkman AS

Role of collagenase in mediating in vitro alveolar epithelial wound repair.

Journal of cell science

Planus E, Galiacy S, Matthay M, Laurent V, Gavrilovic J, Murphy G, Clérici C, Isabey D, Lafuma C, d'Ortho MP

Risk reduction in the intensive care unit.

The American journal of medicine

Saint S, Matthay MA

Alveolar epithelial fluid transport: basic mechanisms and clinical relevance.

Proceedings of the Association of American Physicians

Matthay MA, Flori HR, Conner ER, Ware LB

Pulmonary edema in obstetric patients is rapidly resolved except in the presence of infection or of nitroglycerin tocolysis after open fetal surgery.

American journal of obstetrics and gynecology

DiFederico EM, Burlingame JM, Kilpatrick SJ, Harrison M, Matthay MA

Upregulation of alveolar epithelial fluid transport after subacute lung injury in rats from bleomycin.

The American journal of physiology

Folkesson HG, Nitenberg G, Oliver BL, Jayr C, Albertine KH, Matthay MA

Hepatocyte growth factor and keratinocyte growth factor in the pulmonary edema fluid of patients with acute lung injury. Biologic and clinical significance.

American journal of respiratory and critical care medicine

Verghese GM, McCormick-Shannon K, Mason RJ, Matthay MA

Protective ventilation for the acute respiratory distress syndrome.

The New England journal of medicine

Parsons PE, Matthay M

A mouse model to test the in vivo efficacy of chemical chaperones.

Journal of pharmacological and toxicological methods

Bai C, Biwersi J, Verkman AS, Matthay MA

Evidence against a role of mouse, rat, and two cloned human t1alpha isoforms as a water channel or a regulator of aquaporin-type water channels.

American journal of respiratory cell and molecular biology

Ma T, Yang B, Matthay MA, Verkman AS

New in situ mouse model to quantify alveolar epithelial fluid clearance.

Journal of applied physiology (Bethesda, Md. : 1985)

Garat C, Carter EP, Matthay MA

The American-European Consensus Conference on ARDS, part 2. Ventilatory, pharmacologic, supportive therapy, study design strategies and issues related to recovery and remodeling.

Intensive care medicine

Artigas A, Bernard GR, Carlet J, Dreyfuss D, Gattinoni L, Hudson L, Lamy M, Marini JJ, Matthay MA, Pinsky MR, Spragg R, Suter PM

The American-European Consensus Conference on ARDS, part 2: Ventilatory, pharmacologic, supportive therapy, study design strategies, and issues related to recovery and remodeling. Acute respiratory distress syndrome.

American journal of respiratory and critical care medicine

Artigas A, Bernard GR, Carlet J, Dreyfuss D, Gattinoni L, Hudson L, Lamy M, Marini JJ, Matthay MA, Pinsky MR, Spragg R, Suter PM

Highly water-permeable type I alveolar epithelial cells confer high water permeability between the airspace and vasculature in rat lung.

Proceedings of the National Academy of Sciences of the United States of America

Dobbs LG, Gonzalez R, Matthay MA, Carter EP, Allen L, Verkman AS

Just say NO to inhaled nitric oxide for the acute respiratory distress syndrome.

Critical care medicine

Matthay MA, Pittet JF, Jayr C

Developmental changes in water permeability across the alveolar barrier in perinatal rabbit lung.

The Journal of clinical investigation

Carter EP, Umenishi F, Matthay MA, Verkman AS

Early detection of type III procollagen peptide in acute lung injury. Pathogenetic and prognostic significance.

American journal of respiratory and critical care medicine

Chesnutt AN, Matthay MA, Tibayan FA, Clark JG

Dobutamine increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation.

American journal of respiratory and critical care medicine

Tibayan FA, Chesnutt AN, Folkesson HG, Eandi J, Matthay MA

Upregulation of alveolar liquid clearance after fluid resuscitation for hemorrhagic shock in rats.

The American journal of physiology

Modelska K, Matthay MA, McElroy MC, Pittet JF

Inhibition of CD18 or CD11b attenuates acute lung injury after acid instillation in rabbits.

Journal of applied physiology (Bethesda, Md. : 1985)

Folkesson HG, Matthay MA

Protein tyrosine phosphatases mediate cell readhesion in alveolar epithelial cells mechanically separated from in vitro matrix.

American journal of respiratory cell and molecular biology

Oliver BL, Garat C, Pytela R, Matthay MA

Biological markers of acute lung injury: prognostic and pathogenetic significance.

American journal of respiratory and critical care medicine

Pittet JF, Mackersie RC, Martin TR, Matthay MA

Beta-adrenergic agonist stimulated alveolar fluid clearance in ex vivo human and rat lungs.

American journal of respiratory and critical care medicine

Sakuma T, Folkesson HG, Suzuki S, Okaniwa G, Fujimura S, Matthay MA

Acute bacterial pneumonia in rats increases alveolar epithelial fluid clearance by a tumor necrosis factor-alpha-dependent mechanism.

The Journal of clinical investigation

Rezaiguia S, Garat C, Delclaux C, Meignan M, Fleury J, Legrand P, Matthay MA, Jayr C

Increased alveolar fluid clearance following thoracotomy: report of a case and results of an analysis.

Surgery today

Sakuma T, Usuda K, Handa M, Okaniwa G, Nakada T, Fujimura S, Matthay MA

Sharp increase in rat lung water channel expression in the perinatal period.

American journal of respiratory cell and molecular biology

Umenishi F, Carter EP, Yang B, Oliver B, Matthay MA, Verkman AS

Soluble and insoluble fibronectin increases alveolar epithelial wound healing in vitro.

The American journal of physiology

Garat C, Kheradmand F, Albertine KH, Folkesson HG, Matthay MA

Anti-IL-8 autoantibodies in alveolar fluid from patients with the adult respiratory distress syndrome.

Journal of immunology (Baltimore, Md. : 1950)

Kurdowska A, Miller EJ, Noble JM, Baughman RP, Matthay MA, Brelsford WG, Cohen AB

Acid aspiration induced lung injury. New insights and therapeutic options.

American journal of respiratory and critical care medicine

Matthay MA, Rosen GD

Alveolar liquid clearance is increased by endogenous catecholamines in hemorrhagic shock in rats.

Journal of applied physiology (Bethesda, Md. : 1985)

Pittet JF, Brenner TJ, Modelska K, Matthay MA

Transforming growth factor-alpha increases alveolar liquid clearance in anesthetized ventilated rats.

The American journal of physiology

Folkesson HG, Pittet JF, Nitenberg G, Matthay MA

The acute respiratory distress syndrome.

The New England journal of medicine

Matthay MA

Alveolar epithelial clearance of protein.

Journal of applied physiology (Bethesda, Md. : 1985)

Folkesson HG, Matthay MA, Weström BR, Kim KJ, Karlsson BW, Hastings RH