Michael Matthay, MD

Director of the Critical Care Medicine Training
Associate Director of the Intensive Care Unit
Professor
Medicine
+1 415 353-1206

Michael A. Matthay, MD is a Professor of Medicine and Anesthesia at the University of California at San Francisco and a Senior Associate at the Cardiovascular Research Institute. He is Director of the Critical Care Medicine Training in the Department of Medicine and Associate Director of the Intensive Care Unit. He received his AB from Harvard University in 1969 and his MD from the University of Pennsylvania School of Medicine in 1973. Dr. Matthay received clinical training in Internal Medicine at the University of Colorado from 1973-76 and in Pulmonary and Critical Care Medicine from the University of California at San Francisco from 1977-78. He also received research training from the Cardiovascular Physiology Laboratory, University of Colorado in 1976 and the Cardiovascular Research Institute from 1978-79.

Michael Matthay was selected in 2006 by the UCSF Academic Senate as the recipient of the Sixth Annual Distinguished Clinical Research Lectureshi, by the American Physiological Society and the Respiration Section for the Julius Comroe Jr Award in 2009, and by the University of Paris in 20011 with an Honorary Degree (Honora Causa).

Dr. Matthay is currently the Principal Investigator of a NIH/NHLBI-sponsored phase 1/2 clinical trial of mesenchymal stem (stromal) cells for the treatment of Acute Respiratory Distress Syndrome (START). Details of the trial may be found at the following website: http://stemcellsards.ucsf.edu.

Publications: 

Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome.

The New England journal of medicine

Mi MY, Matthay MA, Morris AH

Assessment of industry data on pulmonary and immunosuppressive effects of IQOS.

Tobacco control

Moazed F, Chun L, Matthay MA, Calfee CS, Gotts J

Possible hepatotoxicity of IQOS.

Tobacco control

Chun L, Moazed F, Matthay M, Calfee C, Gotts J

Meta-Analysis of Preclinical Studies of Fibrinolytic Therapy for Acute Lung Injury.

Frontiers in immunology

Liu C, Ma Y, Su Z, Zhao R, Zhao X, Nie HG, Xu P, Zhu L, Zhang M, Li X, Zhang X, Matthay MA, Ji HL

Early Plasma Matrix Metalloproteinase Profiles: A Novel Pathway in Pediatric Acute Respiratory Distress Syndrome.

American journal of respiratory and critical care medicine

Zinter MS, Delucchi KL, Kong MY, Orwoll BE, Spicer AS, Lim MJ, Alkhouli MF, Ratiu AE, McKenzie AV, McQuillen PS, Dvorak CC, Calfee CS, Matthay MA, Sapru A

Interleukin-1 Receptor Antagonist Is Associated With Pediatric Acute Respiratory Distress Syndrome and Worse Outcomes in Children With Acute Respiratory Failure.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Dahmer MK, Quasney MW, Sapru A, Gildengorin G, Curley MAQ, Matthay MA, Flori H

Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial.

The Lancet. Respiratory medicine

Calfee CS, Delucchi KL, Sinha P, Matthay MA, Hackett J, Shankar-Hari M, McDowell C, Laffey JG, O'Kane CM, McAuley DF

Effect of Rosuvastatin on Acute Kidney Injury in Sepsis-Associated Acute Respiratory Distress Syndrome.

Canadian journal of kidney health and disease

Hsu RK, Truwit JD, Matthay MA, Levitt JE, Thompson BT, Liu KD

Low to Moderate Air Pollutant Exposure and Acute Respiratory Distress Syndrome after Severe Trauma.

American journal of respiratory and critical care medicine

Reilly JP, Zhao Z, Shashaty MGS, Koyama T, Christie JD, Lanken PN, Wang C, Balmes JR, Matthay MA, Calfee CS, Ware LB

Plasma sRAGE is independently associated with increased mortality in ARDS: a meta-analysis of individual patient data.

Intensive care medicine

Jabaudon M, Blondonnet R, Pereira B, Cartin-Ceba R, Lichtenstern C, Mauri T, Determann RM, Drabek T, Hubmayr RD, Gajic O, Uhle F, Coppadoro A, Pesenti A, Schultz MJ, Ranieri MV, Brodska H, Mrozek S, Sapin V, Matthay MA, Constantin JM, Calfee CS

Human pulmonary endothelial cell permeability after exposure to LPS-stimulated leukocyte supernatants derived from patients with early sepsis.

American journal of physiology. Lung cellular and molecular physiology

Leligdowicz A, Chun LF, Jauregui A, Vessel K, Liu KD, Calfee CS, Matthay MA

Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype.

The Journal of clinical investigation

Wang C, Reyes de Mochel NS, Christenson SA, Cassandras M, Moon R, Brumwell AN, Byrnes LE, Li A, Yokosaki Y, Shan P, Sneddon JB, Jablons D, Lee PJ, Matthay MA, Chapman HA, Peng T

Secondary peritonitis: principles of diagnosis and intervention.

BMJ (Clinical research ed.)

Ross JT, Matthay MA, Harris HW

Severity scoring of lung oedema on the chest radiograph is associated with clinical outcomes in ARDS.

Thorax

Warren MA, Zhao Z, Koyama T, Bastarache JA, Shaver CM, Semler MW, Rice TW, Matthay MA, Calfee CS, Ware LB

Contemporary Risk Factors and Outcomes of Transfusion-Associated Circulatory Overload.

Critical care medicine

Roubinian NH, Hendrickson JE, Triulzi DJ, Gottschall JL, Michalkiewicz M, Chowdhury D, Kor DJ, Looney MR, Matthay MA, Kleinman SH, Brambilla D, Murphy EL

Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice.

American journal of physiology. Lung cellular and molecular physiology

Gotts JE, Chun LF, Abbott J, Fang X, Takasaki N, Nishimura SL, Springer ML, Schick SF, Calfee CS, Matthay MA

Assessing Preventable Harms in the Intensive Care Unit: Data From a Tertiary Care Academic Medical Institution.

American journal of medical quality : the official journal of the American College of Medical Quality

Sung N, Aldrich JM, Shimabukuro DW, Matthay MA, Liu KD

Cell-based Therapy in Sepsis. A Step Closer.

American journal of respiratory and critical care medicine

Gotts JE, Matthay MA

Mesenchymal stem cell-derived extracellular vesicles attenuate pulmonary vascular permeability and lung injury induced by hemorrhagic shock and trauma.

The journal of trauma and acute care surgery

Potter DR, Miyazawa BY, Gibb SL, Deng X, Togaratti PP, Croze RH, Srivastava AK, Trivedi A, Matthay M, Holcomb JB, Schreiber MA, Pati S

Elevated donor plasminogen activator inhibitor-1 levels and the risk of primary graft dysfunction.

Clinical transplantation

Hamilton BCS, Dincheva GR, Zhuo H, Golden JA, Brzezinski M, Singer JP, Matthay MA, Kukreja J

Exosome-based Therapy for Bronchopulmonary Dysplasia.

American journal of respiratory and critical care medicine

Matthay MA, Abman SH

Rectal and Bladder Temperatures vs Forehead Core Temperatures Measured With SpotOn Monitoring System.

American journal of critical care : an official publication, American Association of Critical-Care Nurses

Schell-Chaple HM, Liu KD, Matthay MA, Puntillo KA

Clinical Presentation and Outcomes among Children with Sepsis Presenting to a Public Tertiary Hospital in Tanzania.

Frontiers in pediatrics

Kortz TB, Sawe HR, Murray B, Enanoria W, Matthay MA, Reynolds T

The Epithelial Sodium Channel Is a Modifier of the Long-Term Nonprogressive Phenotype Associated with F508del CFTR Mutations.

American journal of respiratory cell and molecular biology

Agrawal PB, Wang R, Li HL, Schmitz-Abe K, Simone-Roach C, Chen J, Shi J, Louie T, Sheng S, Towne MC, Brainson CF, Matthay MA, Kim CF, Bamshad M, Emond MJ, Gerard NP, Kleyman TR, Gerard C

Intratracheal instillation of alveolar type II cells enhances recovery from acute lung injury in rats.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

Guillamat-Prats R, Puig F, Camprubí-Rimblas M, Herrero R, Serrano-Mollar A, Gómez MN, Tijero J, Matthay MA, Blanch L, Artigas A

Reply to "Letter to the Editor: Pulmonary toxicity of electronic cigarettes: more doubts than certainties".

American journal of physiology. Lung cellular and molecular physiology

Chun LF, Moazed F, Calfee CS, Matthay MA, Gotts JE

Cigarette Smoke Exposure Worsens Endotoxin-Induced Lung Injury and Pulmonary Edema in Mice.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

Gotts JE, Abbott J, Fang X, Yanagisawa H, Takasaka N, Nishimura SL, Calfee CS, Matthay MA

Derivation and validation of a two-biomarker panel for diagnosis of ARDS in patients with severe traumatic injuries.

Trauma surgery & acute care open

Ware LB, Zhao Z, Koyama T, Brown RM, Semler MW, Janz DR, May AK, Fremont RD, Matthay MA, Cohen MJ, Calfee CS

Local lung hypoxia determines epithelial fate decisions during alveolar regeneration.

Nature cell biology

Xi Y, Kim T, Brumwell AN, Driver IH, Wei Y, Tan V, Jackson JR, Xu J, Lee DK, Gotts JE, Matthay MA, Shannon JM, Chapman HA, Vaughan AE

Inhalation therapies in acute respiratory distress syndrome.

Annals of translational medicine

Artigas A, Camprubí-Rimblas M, Tantinyà N, Bringué J, Guillamat-Prats R, Matthay MA

External validation of a biomarker and clinical prediction model for hospital mortality in acute respiratory distress syndrome.

Intensive care medicine

Zhao Z, Wickersham N, Kangelaris KN, May AK, Bernard GR, Matthay MA, Calfee CS, Koyama T, Ware LB

Clinical trials in acute respiratory distress syndrome: challenges and opportunities.

The Lancet. Respiratory medicine

Matthay MA, McAuley DF, Ware LB

Pulmonary toxicity of e-cigarettes.

American journal of physiology. Lung cellular and molecular physiology

Chun LF, Moazed F, Calfee CS, Matthay MA, Gotts JE

Keratinocyte growth factor for the treatment of the acute respiratory distress syndrome (KARE): a randomised, double-blind, placebo-controlled phase 2 trial.

The Lancet. Respiratory medicine

McAuley DF, Cross LM, Hamid U, Gardner E, Elborn JS, Cullen KM, Dushianthan A, Grocott MP, Matthay MA, O'Kane CM

Incorporating Inflammation into Mortality Risk in Pediatric Acute Respiratory Distress Syndrome.

Critical care medicine

Zinter MS, Orwoll BE, Spicer AC, Alkhouli MF, Calfee CS, Matthay MA, Sapru A

Randomized Clinical Trial of a Combination of an Inhaled Corticosteroid and Beta Agonist in Patients at Risk of Developing the Acute Respiratory Distress Syndrome.

Critical care medicine

Festic E, Carr GE, Cartin-Ceba R, Hinds RF, Banner-Goodspeed V, Bansal V, Asuni AT, Talmor D, Rajagopalan G, Frank RD, Gajic O, Matthay MA, Levitt JE

Profiling of ARDS pulmonary edema fluid identifies a metabolically distinct subset.

American journal of physiology. Lung cellular and molecular physiology

Rogers AJ, Contrepois K, Wu M, Zheng M, Peltz G, Ware LB, Matthay MA

Higher mini-BAL total protein concentration in early ARDS predicts faster resolution of lung injury measured by more ventilator-free days.

American journal of physiology. Lung cellular and molecular physiology

Hendrickson CM, Abbott J, Zhuo H, Liu KD, Calfee CS, Matthay MA

Acute kidney injury subphenotypes based on creatinine trajectory identifies patients at increased risk of death.

Critical care (London, England)

Bhatraju PK, Mukherjee P, Robinson-Cohen C, O'Keefe GE, Frank AJ, Christie JD, Meyer NJ, Liu KD, Matthay MA, Calfee CS, Christiani DC, Himmelfarb J, Wurfel MM

Cathepsin L Helps to Defend Mice from Infection with Influenza A.

PloS one

Xu X, Greenland JR, Gotts JE, Matthay MA, Caughey GH

Challenges in predicting which patients will develop ARDS.

The Lancet. Respiratory medicine

Matthay MA

A Simple and Robust Bedside Model for Mortality Risk in Pediatric Patients With Acute Respiratory Distress Syndrome.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Spicer AC, Calfee CS, Zinter MS, Khemani RG, Lo VP, Alkhouli MF, Orwoll BE, Graciano AL, Boriosi JP, Howard JP, Flori HR, Matthay MA, Sapru A

Poor Adherence to Lung-Protective Mechanical Ventilation in Pediatric Acute Respiratory Distress Syndrome.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Ward SL, Quinn CM, Valentine SL, Sapru A, Curley MA, Willson DF, Liu KD, Matthay MA, Flori HR

IL1RL1 asthma risk variants regulate airway type 2 inflammation.

JCI insight

Gordon ED, Palandra J, Wesolowska-Andersen A, Ringel L, Rios CL, Lachowicz-Scroggins ME, Sharp LZ, Everman JL, MacLeod HJ, Lee JW, Mason RJ, Matthay MA, Sheldon RT, Peters MC, Nocka KH, Fahy JV, Seibold MA

The authors reply.

Critical care medicine

Kangelaris KN, Ware LB, Matthay MA, Calfee CS

The authors reply.

Critical care medicine

Kangelaris KN, Ware LB, Matthay MA, Calfee CS

miR-34 miRNAs Regulate Cellular Senescence in Type II Alveolar Epithelial Cells of Patients with Idiopathic Pulmonary Fibrosis.

PloS one

Disayabutr S, Kim EK, Cha SI, Green G, Naikawadi RP, Jones KD, Golden JA, Schroeder A, Matthay MA, Kukreja J, Erle DJ, Collard HR, Wolters PJ

Quantifying unintended exposure to high tidal volumes from breath stacking dyssynchrony in ARDS: the BREATHE criteria.

Intensive care medicine

Beitler JR, Sands SA, Loring SH, Owens RL, Malhotra A, Spragg RG, Matthay MA, Thompson BT, Talmor D

The acute respiratory distress syndrome following isolated severe traumatic brain injury.

The journal of trauma and acute care surgery

Hendrickson CM, Howard BM, Kornblith LZ, Conroy AS, Nelson MF, Zhuo H, Liu KD, Manley GT, Matthay MA, Calfee CS, Cohen MJ

Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome.

Critical care (London, England)

Sapru A, Liu KD, Wiemels J, Hansen H, Pawlikowska L, Poon A, Jorgenson E, Witte JS, Calfee CS, Ware LB, Matthay MA

Sepsis: pathophysiology and clinical management.

BMJ (Clinical research ed.)

Gotts JE, Matthay MA

Long-Term Ozone Exposure Increases the Risk of Developing the Acute Respiratory Distress Syndrome.

American journal of respiratory and critical care medicine

Ware LB, Zhao Z, Koyama T, May AK, Matthay MA, Lurmann FW, Balmes JR, Calfee CS

Mitochondrial Transfer via Tunneling Nanotubes is an Important Mechanism by Which Mesenchymal Stem Cells Enhance Macrophage Phagocytosis in the In Vitro and In Vivo Models of ARDS.

Stem cells (Dayton, Ohio)

Jackson MV, Morrison TJ, Doherty DF, McAuley DF, Matthay MA, Kissenpfennig A, O'Kane CM, Krasnodembskaya AD

Negative-Pressure Pulmonary Edema.

Chest

Bhattacharya M, Kallet RH, Ware LB, Matthay MA

Diagnostic workup for ARDS patients.

Intensive care medicine

Papazian L, Calfee CS, Chiumello D, Luyt CE, Meyer NJ, Sekiguchi H, Matthay MA, Meduri GU

Human mesenchymal stromal cells reduce influenza A H5N1-associated acute lung injury in vitro and in vivo.

Proceedings of the National Academy of Sciences of the United States of America

Chan MC, Kuok DI, Leung CY, Hui KP, Valkenburg SA, Lau EH, Nicholls JM, Fang X, Guan Y, Lee JW, Chan RW, Webster RG, Matthay MA, Peiris JS

Cigarette smokers have exaggerated alveolar barrier disruption in response to lipopolysaccharide inhalation.

Thorax

Moazed F, Burnham EL, Vandivier RW, O'Kane CM, Shyamsundar M, Hamid U, Abbott J, Thickett DR, Matthay MA, McAuley DF, Calfee CS

Acute cor pulmonale and the acute respiratory distress syndrome.

Intensive care medicine

Guérin C, Matthay MA

Timing of Intubation and Clinical Outcomes in Adults With Acute Respiratory Distress Syndrome.

Critical care medicine

Kangelaris KN, Ware LB, Wang CY, Janz DR, Zhuo H, Matthay MA, Calfee CS

Elevated soluble thrombomodulin is associated with organ failure and mortality in children with acute respiratory distress syndrome (ARDS): a prospective observational cohort study.

Critical care (London, England)

Orwoll BE, Spicer AC, Zinter MS, Alkhouli MF, Khemani RG, Flori HR, Neuhaus JM, Calfee CS, Matthay MA, Sapru A

Plasma angiopoietin-2 outperforms other markers of endothelial injury in prognosticating pediatric ARDS mortality.

American journal of physiology. Lung cellular and molecular physiology

Zinter MS, Spicer A, Orwoll BO, Alkhouli M, Dvorak CC, Calfee CS, Matthay MA, Sapru A

Cigarette Smoke Exposure and the Acute Respiratory Distress Syndrome.

Critical care medicine

Calfee CS, Matthay MA, Kangelaris KN, Siew ED, Janz DR, Bernard GR, May AK, Jacob P, Havel C, Benowitz NL, Ware LB

Therapeutic Effects of Human Mesenchymal Stem Cell-derived Microvesicles in Severe Pneumonia in Mice.

American journal of respiratory and critical care medicine

Monsel A, Zhu YG, Gennai S, Hao Q, Hu S, Rouby JJ, Rosenzwajg M, Matthay MA, Lee JW

Resolution of Alveolar Edema in Acute Respiratory Distress Syndrome. Physiology and Biology.

American journal of respiratory and critical care medicine

Matthay MA, Ware LB

Human Mesenchymal Stem (Stromal) Cells Promote the Resolution of Acute Lung Injury in Part through Lipoxin A4.

Journal of immunology (Baltimore, Md. : 1950)

Fang X, Abbott J, Cheng L, Colby JK, Lee JW, Levy BD, Matthay MA

Visualization of Fra-1/AP-1 activation during LPS-induced inflammatory lung injury using fluorescence optical imaging.

American journal of physiology. Lung cellular and molecular physiology

Rajasekaran S, Tamatam CR, Potteti HR, Raman V, Lee JW, Matthay MA, Mehta D, Reddy NM, Reddy SP

Distinct molecular phenotypes of direct vs indirect ARDS in single-center and multicenter studies.

Chest

Calfee CS, Janz DR, Bernard GR, May AK, Kangelaris KN, Matthay MA, Ware LB

Unexpected Role for Adaptive aßTh17 Cells in Acute Respiratory Distress Syndrome.

Journal of immunology (Baltimore, Md. : 1950)

Li JT, Melton AC, Su G, Hamm DE, LaFemina M, Howard J, Fang X, Bhat S, Huynh KM, O'Kane CM, Ingram RJ, Muir RR, McAuley DF, Matthay MA, Sheppard D

Saving lives with high-flow nasal oxygen.

The New England journal of medicine

Matthay MA

Estimating dead-space fraction for secondary analyses of acute respiratory distress syndrome clinical trials.

Critical care medicine

Beitler JR, Thompson BT, Matthay MA, Talmor D, Liu KD, Zhuo H, Hayden D, Spragg RG, Malhotra A

Mesenchymal stem (stromal) cells for treatment of acute respiratory distress syndrome - authors' reply.

The Lancet. Respiratory medicine

Wilson J, McKenna D, Liu KD, Matthay MA

Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS.

American journal of physiology. Lung cellular and molecular physiology

Kangelaris KN, Prakash A, Liu KD, Aouizerat B, Woodruff PG, Erle DJ, Rogers A, Seeley EJ, Chu J, Liu T, Osterberg-Deiss T, Zhuo H, Matthay MA, Calfee CS

Erratum to: plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome.

Intensive care medicine

Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbott J, Matthay MA

Cytokines and clinical predictors in distinguishing pulmonary transfusion reactions.

Transfusion

Roubinian NH, Looney MR, Kor DJ, Lowell CA, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson GA, Matthay MA, Toy P, Murphy EL

Plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome.

Intensive care medicine

Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbott J, Abbot J, Matthay MA

Body temperature and mortality in patients with acute respiratory distress syndrome.

American journal of critical care : an official publication, American Association of Critical-Care Nurses

Schell-Chaple HM, Puntillo KA, Matthay MA, Liu KD

Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury.

Nature

Vaughan AE, Brumwell AN, Xi Y, Gotts JE, Brownfield DG, Treutlein B, Tan K, Tan V, Liu FC, Looney MR, Matthay MA, Rock JR, Chapman HA

Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial.

The Lancet. Respiratory medicine

Wilson JG, Liu KD, Zhuo H, Caballero L, McMillan M, Fang X, Cosgrove K, Vojnik R, Calfee CS, Lee JW, Rogers AJ, Levitt J, Wiener-Kronish J, Bajwa EK, Leavitt A, McKenna D, Thompson BT, Matthay MA

Recipient clinical risk factors predominate in possible transfusion-related acute lung injury.

Transfusion

Toy P, Bacchetti P, Grimes B, Gajic O, Murphy EL, Winters JL, Gropper MA, Hubmayr RD, Matthay MA, Wilson G, Koenigsberg M, Lee DC, Hirschler NV, Lowell CA, Schuller RM, Gandhi MJ, Norris PJ, Mair DC, Sanchez Rosen R, Looney MR

Biology and pathology of fibroproliferation following the acute respiratory distress syndrome.

Intensive care medicine

Hendrickson CM, Crestani B, Matthay MA

Mesenchymal stem cells: mechanisms of potential therapeutic benefit in ARDS and sepsis.

The Lancet. Respiratory medicine

Walter J, Ware LB, Matthay MA

Heterogeneous gene expression signatures correspond to distinct lung pathologies and biomarkers of disease severity in idiopathic pulmonary fibrosis.

Thorax

DePianto DJ, Chandriani S, Abbas AR, Jia G, N'Diaye EN, Caplazi P, Kauder SE, Biswas S, Karnik SK, Ha C, Modrusan Z, Matthay MA, Kukreja J, Collard HR, Egen JG, Wolters PJ, Arron JR

A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation.

American journal of respiratory and critical care medicine

Czikora I, Alli A, Bao HF, Kaftan D, Sridhar S, Apell HJ, Gorshkov B, White R, Zimmermann A, Wendel A, Pauly-Evers M, Hamacher J, Garcia-Gabay I, Fischer B, Verin A, Bagi Z, Pittet JF, Shabbir W, Lemmens-Gruber R, Chakraborty T, Lazrak A, Matthay MA, Eaton DC, Lucas R

Prevalence and impact of active and passive cigarette smoking in acute respiratory distress syndrome.

Critical care medicine

Hsieh SJ, Zhuo H, Benowitz NL, Thompson BT, Liu KD, Matthay MA, Calfee CS

Is there a need for emerging drugs for the acute respiratory distress syndrome?

Expert opinion on emerging drugs

Fitzgerald M, McAuley DF, Matthay M

Silencing Bruton's tyrosine kinase in alveolar neutrophils protects mice from LPS/immune complex-induced acute lung injury.

American journal of physiology. Lung cellular and molecular physiology

Krupa A, Fol M, Rahman M, Stokes KY, Florence JM, Leskov IL, Khoretonenko MV, Matthay MA, Liu KD, Calfee CS, Tvinnereim A, Rosenfield GR, Kurdowska AK

Influenza causes prolonged disruption of the alveolar-capillary barrier in mice unresponsive to mesenchymal stem cell therapy.

American journal of physiology. Lung cellular and molecular physiology

Gotts JE, Abbott J, Matthay MA

Design and implementation of the START (STem cells for ARDS Treatment) trial, a phase 1/2 trial of human mesenchymal stem/stromal cells for the treatment of moderate-severe acute respiratory distress syndrome.

Annals of intensive care

Liu KD, Wilson JG, Zhuo H, Caballero L, McMillan ML, Fang X, Cosgrove K, Calfee CS, Lee JW, Kangelaris KN, Gotts JE, Rogers AJ, Levitt JE, Wiener-Kronish JP, Delucchi KL, Leavitt AD, McKenna DH, Thompson BT, Matthay MA

Prospective study on the clinical course and outcomes in transfusion-related acute lung injury*.

Critical care medicine

Looney MR, Roubinian N, Gajic O, Gropper MA, Hubmayr RD, Lowell CA, Bacchetti P, Wilson G, Koenigsberg M, Lee DC, Wu P, Grimes B, Norris PJ, Murphy EL, Gandhi MJ, Winters JL, Mair DC, Schuller RM, Hirschler NV, Rosen RS, Matthay MA, Toy P

Keratinocyte growth factor promotes epithelial survival and resolution in a human model of lung injury.

American journal of respiratory and critical care medicine

Shyamsundar M, McAuley DF, Ingram RJ, Gibson DS, O'Kane D, McKeown ST, Edwards A, Taggart C, Elborn JS, Calfee CS, Matthay MA, O'Kane CM

Accumulation of BDCA1? dendritic cells in interstitial fibrotic lung diseases and Th2-high asthma.

PloS one

Greer AM, Matthay MA, Kukreja J, Bhakta NR, Nguyen CP, Wolters PJ, Woodruff PG, Fahy JV, Shin JS

Human mesenchymal stem cells reduce the severity of acute lung injury in a sheep model of bacterial pneumonia.

Thorax

Asmussen S, Ito H, Traber DL, Lee JW, Cox RA, Hawkins HK, McAuley DF, McKenna DH, Traber LD, Zhuo H, Wilson J, Herndon DN, Prough DS, Liu KD, Matthay MA, Enkhbaatar P

Resolution of pulmonary edema. Thirty years of progress.

American journal of respiratory and critical care medicine

Matthay MA

Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials.

The Lancet. Respiratory medicine

Calfee CS, Delucchi K, Parsons PE, Thompson BT, Ware LB, Matthay MA

Conditioned media from mesenchymal stromal cells restore sodium transport and preserve epithelial permeability in an in vitro model of acute alveolar injury.

American journal of physiology. Lung cellular and molecular physiology

Goolaerts A, Pellan-Randrianarison N, Larghero J, Vanneaux V, Uzunhan Y, Gille T, Dard N, Planès C, Matthay MA, Clerici C

Is there still a role for the lung injury score in the era of the Berlin definition ARDS?

Annals of intensive care

Kangelaris KN, Calfee CS, May AK, Zhuo H, Matthay MA, Ware LB

Mesenchymal stromal (stem) cell therapy: an emerging immunomodulatory strategy for the adjunctive treatment of sepsis.

American journal of respiratory and critical care medicine

Liles WC, Matthay MA, Dos Santos CC, Weiss DJ, Stewart DJ

One-year mortality and predictors of death among hospital survivors of acute respiratory distress syndrome.

Intensive care medicine

Wang CY, Calfee CS, Paul DW, Janz DR, May AK, Zhuo H, Bernard GR, Matthay MA, Ware LB, Kangelaris KN

TGF-ß and lung fluid balance in ARDS.

Proceedings of the National Academy of Sciences of the United States of America

Frank JA, Matthay MA

Human mesenchymal stem cell microvesicles for treatment of Escherichia coli endotoxin-induced acute lung injury in mice.

Stem cells (Dayton, Ohio)

Zhu YG, Feng XM, Abbott J, Fang XH, Hao Q, Monsel A, Qu JM, Matthay MA, Lee JW

Treating ARDS: new hope for a tough problem.

The Lancet. Respiratory medicine

Gotts JE, Matthay MA

Cystic fibrosis epithelial cell and bacterial binding.

American journal of physiology. Lung cellular and molecular physiology

Engel J, Matthay M

Prognostic and diagnostic value of plasma soluble suppression of tumorigenicity-2 concentrations in acute respiratory distress syndrome.

Critical care medicine

Bajwa EK, Volk JA, Christiani DC, Harris RS, Matthay MA, Thompson BT, Januzzi JL

Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome.

Critical care (London, England)

Ware LB, Koyama T, Zhao Z, Janz DR, Wickersham N, Bernard GR, May AK, Calfee CS, Matthay MA

Cell therapy for lung diseases. Report from an NIH-NHLBI workshop, November 13-14, 2012.

American journal of respiratory and critical care medicine

Matthay MA, Anversa P, Bhattacharya J, Burnett BK, Chapman HA, Hare JM, Hei DJ, Hoffman AM, Kourembanas S, McKenna DH, Ortiz LA, Ott HC, Tente W, Thébaud B, Trapnell BC, Weiss DJ, Yuan JX, Blaisdell CJ

Early acute lung injury: criteria for identifying lung injury prior to the need for positive pressure ventilation*.

Critical care medicine

Levitt JE, Calfee CS, Goldstein BA, Vojnik R, Matthay MA

Mesenchymal stem cells and idiopathic pulmonary fibrosis. Potential for clinical testing.

American journal of respiratory and critical care medicine

Toonkel RL, Hare JM, Matthay MA, Glassberg MK

Reply: idiopathic pulmonary fibrosis: a degenerative disease requiring a regenerative approach.

American journal of respiratory and critical care medicine

Glassberg MK, Hare JM, Toonkel RL, Matthay MA

Sugar administration is an effective adjunctive therapy in the treatment of Pseudomonas aeruginosa pneumonia.

American journal of physiology. Lung cellular and molecular physiology

Bucior I, Abbott J, Song Y, Matthay MA, Engel JN

The acute respiratory distress syndrome in 2013.

Translational respiratory medicine

Matthay MA, Song Y, Bai C, Jones KD

Plasma angiopoietin-2 predicts the onset of acute lung injury in critically ill patients.

American journal of respiratory and critical care medicine

Agrawal A, Matthay MA, Kangelaris KN, Stein J, Chu JC, Imp BM, Cortez A, Abbott J, Liu KD, Calfee CS

The Berlin definition of ARDS versus pathological evidence of diffuse alveolar damage.

American journal of respiratory and critical care medicine

Thompson BT, Matthay MA

The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases.

The Journal of clinical investigation

Katsumoto TR, Kudo M, Chen C, Sundaram A, Callahan EC, Zhu JW, Lin J, Rosen CE, Manz BN, Lee JW, Matthay MA, Huang X, Sheppard D, Weiss A

Therapeutic effects of human mesenchymal stem cells in ex vivo human lungs injured with live bacteria.

American journal of respiratory and critical care medicine

Lee JW, Krasnodembskaya A, McKenna DH, Song Y, Abbott J, Matthay MA

Noradrenergic neurons regulate monocyte trafficking and mortality during gram-negative peritonitis in mice.

Journal of immunology (Baltimore, Md. : 1950)

Seeley EJ, Barry SS, Narala S, Matthay MA, Wolters PJ

Calcium flux and endothelial dysfunction during acute lung injury: a STIMulating target for therapy.

The Journal of clinical investigation

Seeley EJ, Rosenberg P, Matthay MA

Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome.

Molecular medicine (Cambridge, Mass.)

Su X, Feng X, Terrando N, Yan Y, Chawla A, Koch LG, Britton SL, Matthay MA, Maze M

Activation of the heat shock response attenuates the interleukin 1ß-mediated inhibition of the amiloride-sensitive alveolar epithelial ion transport.

Shock (Augusta, Ga.)

Howard M, Roux J, Iles KE, Miyazawa B, Christiaans S, Anjum N, Dickinson DA, Goolaerts A, Matthay MA, Pittet JF

Risk factors and outcomes in transfusion-associated circulatory overload.

The American journal of medicine

Murphy EL, Kwaan N, Looney MR, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson G, Matthay M, Bacchetti P, Toy P

Cecal ligation model of sepsis in mice: new insights.

Critical care medicine

Bastarache JA, Matthay MA

Hyperoxic acute lung injury.

Respiratory care

Kallet RH, Matthay MA

Regulation and repair of the alveolar-capillary barrier in acute lung injury.

Annual review of physiology

Bhattacharya J, Matthay MA

IL-8 inhibits cAMP-stimulated alveolar epithelial fluid transport via a GRK2/PI3K-dependent mechanism.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Roux J, McNicholas CM, Carles M, Goolaerts A, Houseman BT, Dickinson DA, Iles KE, Ware LB, Matthay MA, Pittet JF

Novel aspects of urokinase function in the injured lung: role of a2-macroglobulin.

American journal of physiology. Lung cellular and molecular physiology

Komissarov AA, Stankowska D, Krupa A, Fudala R, Florova G, Florence J, Fol M, Allen TC, Idell S, Matthay MA, Kurdowska AK

Pathogenetic and predictive value of biomarkers in patients with ALI and lower severity of illness: results from two clinical trials.

American journal of physiology. Lung cellular and molecular physiology

Agrawal A, Zhuo H, Brady S, Levitt J, Steingrub J, Siegel MD, Soto G, Peterson MW, Chesnutt MS, Matthay MA, Liu KD

The acute respiratory distress syndrome.

The Journal of clinical investigation

Matthay MA, Ware LB, Zimmerman GA

The severity of shock is associated with impaired rates of net alveolar fluid clearance in clinical acute lung injury.

American journal of physiology. Lung cellular and molecular physiology

Zeyed YF, Bastarache JA, Matthay MA, Ware LB

Clinical evidence of early acute lung injury often precedes the diagnosis of ALI.

Journal of intensive care medicine

Rackley CR, Levitt JE, Zhuo H, Matthay MA, Calfee CS

Inflection points in sepsis biology: from local defense to systemic organ injury.

American journal of physiology. Lung cellular and molecular physiology

Seeley EJ, Matthay MA, Wolters PJ

Cell-based therapy for acute lung injury: are we there yet?

Anesthesiology

Lee JW, Zhu Y, Matthay MA

Plasma angiopoietin-2 in clinical acute lung injury: prognostic and pathogenetic significance.

Critical care medicine

Calfee CS, Gallagher D, Abbott J, Thompson BT, Matthay MA

Protein kinase C-a and arginase I mediate pneumolysin-induced pulmonary endothelial hyperpermeability.

American journal of respiratory cell and molecular biology

Lucas R, Yang G, Gorshkov BA, Zemskov EA, Sridhar S, Umapathy NS, Jezierska-Drutel A, Alieva IB, Leustik M, Hossain H, Fischer B, Catravas JD, Verin AD, Pittet JF, Caldwell RB, Mitchell TJ, Cederbaum SD, Fulton DJ, Matthay MA, Caldwell RW, Romero MJ, Chakraborty T

Multipotent stromal stem cells from human placenta demonstrate high therapeutic potential.

Stem cells translational medicine

Nazarov I, Lee JW, Soupene E, Etemad S, Knapik D, Green W, Bashkirova E, Fang X, Matthay MA, Kuypers FA, Serikov VB

Progress in modelling acute lung injury in a pre-clinical mouse model.

The European respiratory journal

Matthay MA, Howard JP

Mesenchymal stem cells and the stem cell niche: a new chapter.

American journal of physiology. Lung cellular and molecular physiology

Gotts JE, Matthay MA

Human mesenchymal stem cells reduce mortality and bacteremia in gram-negative sepsis in mice in part by enhancing the phagocytic activity of blood monocytes.

American journal of physiology. Lung cellular and molecular physiology

Krasnodembskaya A, Samarani G, Song Y, Zhuo H, Su X, Lee JW, Gupta N, Petrini M, Matthay MA

Lung mast cell density defines a subpopulation of patients with idiopathic pulmonary fibrosis.

Histopathology

Cha SI, Chang CS, Kim EK, Lee JW, Matthay MA, Golden JA, Elicker BM, Jones K, Collard HR, Wolters PJ

Comparison of chest radiograph scoring to lung weight as a quantitative index of pulmonary edema in organ donors.

Clinical transplantation

Ware LB, Neyrinck A, O'Neal HR, Lee JW, Landeck M, Johnson E, Calfee CS, Matthay MA

Anti-inflammatory effects of ß2 adrenergic receptor agonists in experimental acute lung injury.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Bosmann M, Grailer JJ, Zhu K, Matthay MA, Sarma JV, Zetoune FS, Ward PA

Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma.

PloS one

Christie JD, Wurfel MM, Feng R, O'Keefe GE, Bradfield J, Ware LB, Christiani DC, Calfee CS, Cohen MJ, Matthay M, Meyer NJ, Kim C, Li M, Akey J, Barnes KC, Sevransky J, Lanken PN, May AK, Aplenc R, Maloney JP, Hakonarson H

Mesenchymal stem cells enhance survival and bacterial clearance in murine Escherichia coli pneumonia.

Thorax

Gupta N, Krasnodembskaya A, Kapetanaki M, Mouded M, Tan X, Serikov V, Matthay MA

The association between a Darc gene polymorphism and clinical outcomes in African American patients with acute lung injury.

Chest

Kangelaris KN, Sapru A, Calfee CS, Liu KD, Pawlikowska L, Witte JS, Vittinghoff E, Zhuo H, Auerbach AD, Ziv E, Matthay MA

A simple classification model for hospital mortality in patients with acute lung injury managed with lung protective ventilation.

Critical care medicine

Brown LM, Calfee CS, Matthay MA, Brower RG, Thompson BT, Checkley W

Acute kidney injury in patients with acute lung injury: impact of fluid accumulation on classification of acute kidney injury and associated outcomes.

Critical care medicine

Liu KD, Thompson BT, Ancukiewicz M, Steingrub JS, Douglas IS, Matthay MA, Wright P, Peterson MW, Rock P, Hyzy RC, Anzueto A, Truwit JD

Transfusion-related acute lung injury: incidence and risk factors.

Blood

Toy P, Gajic O, Bacchetti P, Looney MR, Gropper MA, Hubmayr R, Lowell CA, Norris PJ, Murphy EL, Weiskopf RB, Wilson G, Koenigsberg M, Lee D, Schuller R, Wu P, Grimes B, Gandhi MJ, Winters JL, Mair D, Hirschler N, Sanchez Rosen R, Matthay MA

Acute lung failure.

Seminars in respiratory and critical care medicine

Mac Sweeney R, McAuley DF, Matthay MA

Claudin-4 levels are associated with intact alveolar fluid clearance in human lungs.

The American journal of pathology

Rokkam D, Lafemina MJ, Lee JW, Matthay MA, Frank JA

Advancing donor management research: design and implementation of a large, randomized, placebo-controlled trial.

Annals of intensive care

Ware LB, Koyama T, Billheimer D, Landeck M, Johnson E, Brady S, Bernard GR, Matthay MA

Concise review: Mesenchymal stem cells for acute lung injury: role of paracrine soluble factors.

Stem cells (Dayton, Ohio)

Lee JW, Fang X, Krasnodembskaya A, Howard JP, Matthay MA

Mesenchymal stem cells and acute lung injury.

Critical care clinics

Gotts JE, Matthay MA

An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals.

American journal of respiratory cell and molecular biology

Matute-Bello G, Downey G, Moore BB, Groshong SD, Matthay MA, Slutsky AS, Kuebler WM

Con: corticosteroids are not indicated for treatment of acute lung injury from H1N1 viral pneumonia.

American journal of respiratory and critical care medicine

Matthay MA, Liu KD

Alveolar epithelial cells express mesenchymal proteins in patients with idiopathic pulmonary fibrosis.

American journal of physiology. Lung cellular and molecular physiology

Marmai C, Sutherland RE, Kim KK, Dolganov GM, Fang X, Kim SS, Jiang S, Golden JA, Hoopes CW, Matthay MA, Chapman HA, Wolters PJ

Use of risk reclassification with multiple biomarkers improves mortality prediction in acute lung injury.

Critical care medicine

Calfee CS, Ware LB, Glidden DV, Eisner MD, Parsons PE, Thompson BT, Matthay MA

Active and passive cigarette smoking and acute lung injury after severe blunt trauma.

American journal of respiratory and critical care medicine

Calfee CS, Matthay MA, Eisner MD, Benowitz N, Call M, Pittet JF, Cohen MJ

Vascular pedicle width in acute lung injury: correlation with intravascular pressures and ability to discriminate fluid status.

Critical care (London, England)

Rice TW, Ware LB, Haponik EF, Chiles C, Wheeler AP, Bernard GR, Steingrub JS, Hite RD, Matthay MA, Wright P, Ely EW

Role of CFTR expressed by neutrophils in modulating acute lung inflammation and injury in mice.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]

Su X, Looney MR, Su HE, Lee JW, Song Y, Matthay MA

Informed consent in research to improve the number and quality of deceased donor organs.

Critical care medicine

Rey MM, Ware LB, Matthay MA, Bernard GR, McGuire AL, Caplan AL, Halpern SD

Single-nucleotide polymorphisms in the ß-adrenergic receptor genes are associated with lung allograft utilization.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

Sapru A, Pawlikowska L, Liu KD, Khush KK, Ann-Baxter-Lowe L, Hayden V, Menza RL, Convery M, Poon A, Landeck M, Zaroff JG, Matthay MA

Proteolytic release of the receptor for advanced glycation end products from in vitro and in situ alveolar epithelial cells.

American journal of physiology. Lung cellular and molecular physiology

Yamakawa N, Uchida T, Matthay MA, Makita K

Neuregulin-1-human epidermal receptor-2 signaling is a central regulator of pulmonary epithelial permeability and acute lung injury.

The Journal of biological chemistry

Finigan JH, Faress JA, Wilkinson E, Mishra RS, Nethery DE, Wyler D, Shatat M, Ware LB, Matthay MA, Mason R, Silver RF, Kern JA

Biomarkers increase detection of active smoking and secondhand smoke exposure in critically ill patients.

Critical care medicine

Hsieh SJ, Ware LB, Eisner MD, Yu L, Jacob P, Havel C, Goniewicz ML, Matthay MA, Benowitz NL, Calfee CS

The acute respiratory distress syndrome: pathogenesis and treatment.

Annual review of pathology

Matthay MA, Zemans RL

Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37.

Stem cells (Dayton, Ohio)

Krasnodembskaya A, Song Y, Fang X, Gupta N, Serikov V, Lee JW, Matthay MA

Stem cells in sepsis and acute lung injury.

Critical care medicine

Cribbs SK, Matthay MA, Martin GS

Priming with endotoxin increases acute lung injury in mice by enhancing the severity of lung endothelial injury.

Anatomical record (Hoboken, N.J. : 2007)

Lee JS, Su X, Rackley C, Matthay MA, Gupta N

Mesenchymal stem cells for acute lung injury: preclinical evidence.

Critical care medicine

Matthay MA, Goolaerts A, Howard JP, Lee JW

Therapeutic potential of mesenchymal stem cells for severe acute lung injury.

Chest

Matthay MA, Thompson BT, Read EJ, McKenna DH, Liu KD, Calfee CS, Lee JW

Thinking outside the box: Introduction.

Critical care medicine

Singer M, Matthay MA

The influence of race on the development of acute lung injury in trauma patients.

American journal of surgery

Brown LM, Kallet RH, Matthay MA, Dicker RA

Pathophysiology of transfusion-related acute lung injury.

Current opinion in hematology

Looney MR, Gilliss BM, Matthay MA

Ratio of angiopoietin-2 to angiopoietin-1 as a predictor of mortality in acute lung injury patients.

Critical care medicine

Ong T, McClintock DE, Kallet RH, Ware LB, Matthay MA, Liu KD

Assessing the quantity of pulmonary edema in critically ill children.

Critical care (London, England)

McAuley DF, Brown LM, Matthay MA

Advances and challenges in translating stem cell therapies for clinical diseases.

Translational research : the journal of laboratory and clinical medicine

Matthay MA

Alveolar fluid clearance is faster in women with acute lung injury compared to men.

Journal of critical care

Bastarache JA, Ong T, Matthay MA, Ware LB

Acute lung injury: epidemiology, pathogenesis, and treatment.

Journal of aerosol medicine and pulmonary drug delivery

Johnson ER, Matthay MA

Therapeutic strategies for severe acute lung injury.

Critical care medicine

Diaz JV, Brower R, Calfee CS, Matthay MA

Age-, sex-, and race-based differences among patients enrolled versus not enrolled in acute lung injury clinical trials.

Critical care medicine

Cooke CR, Erickson SE, Watkins TR, Matthay MA, Hudson LD, Rubenfeld GD

Plasma interleukin-8 is not an effective risk stratification tool for adults with vasopressor-dependent septic shock.

Critical care medicine

Calfee CS, Thompson BT, Parsons PE, Ware LB, Matthay MA, Wong HR

Update on acute lung injury and critical care medicine 2009.

American journal of respiratory and critical care medicine

Matthay MA, Idell S

Acute lung injury in patients with traumatic injuries: utility of a panel of biomarkers for diagnosis and pathogenesis.

The Journal of trauma

Fremont RD, Koyama T, Calfee CS, Wu W, Dossett LA, Bossert FR, Mitchell D, Wickersham N, Bernard GR, Matthay MA, May AK, Ware LB

Plasma biomarker profiles in acute exacerbation of idiopathic pulmonary fibrosis.

American journal of physiology. Lung cellular and molecular physiology

Collard HR, Calfee CS, Wolters PJ, Song JW, Hong SB, Brady S, Ishizaka A, Jones KD, King TE, Matthay MA, Kim DS

Regulated gene expression in cultured type II cells of adult human lung.

American journal of physiology. Lung cellular and molecular physiology

Ballard PL, Lee JW, Fang X, Chapin C, Allen L, Segal MR, Fischer H, Illek B, Gonzales LW, Kolla V, Matthay MA

Activation of the stress protein response inhibits the STAT1 signalling pathway and iNOS function in alveolar macrophages: role of Hsp90 and Hsp70.

Thorax

Howard M, Roux J, Lee H, Miyazawa B, Lee JW, Gartland B, Howard AJ, Matthay MA, Carles M, Pittet JF

Polymorphonuclear leukocytes mediate Staphylococcus aureus Panton-Valentine leukocidin-induced lung inflammation and injury.

Proceedings of the National Academy of Sciences of the United States of America

Diep BA, Chan L, Tattevin P, Kajikawa O, Martin TR, Basuino L, Mai TT, Marbach H, Braughton KR, Whitney AR, Gardner DJ, Fan X, Tseng CW, Liu GY, Badiou C, Etienne J, Lina G, Matthay MA, DeLeo FR, Chambers HF

Measuring the quantity of pulmonary edema in clinical lung injury.

Critical care medicine

Brown LM, Matthay MA

Thirty years of critical care medicine.

Critical care (London, England)

Vincent JL, Singer M, Marini JJ, Moreno R, Levy M, Matthay MA, Pinsky M, Rhodes A, Ferguson ND, Evans T, Annane D, Hall JB

Transforming growth factor beta1 inhibits cystic fibrosis transmembrane conductance regulator-dependent cAMP-stimulated alveolar epithelial fluid transport via a phosphatidylinositol 3-kinase-dependent mechanism.

The Journal of biological chemistry

Roux J, Carles M, Koh H, Goolaerts A, Ganter MT, Chesebro BB, Howard M, Houseman BT, Finkbeiner W, Shokat KM, Paquet AC, Matthay MA, Pittet JF

Mesenchymal stem cells for the prevention of bronchopulmonary dysplasia: delivering the secretome.

American journal of respiratory and critical care medicine

Abman SH, Matthay MA

Laminin gamma2 fragments are increased in the circulation of patients with early phase acute lung injury.

Intensive care medicine

Katayama M, Ishizaka A, Sakamoto M, Fujishima S, Sekiguchi K, Asano K, Betsuyaku T, Kotani T, Ware LB, Matthay MA, Hashimoto S

Early elevations in B-type natriuretic peptide levels are associated with poor clinical outcomes in pediatric acute lung injury.

Pediatric pulmonology

Reel B, Oishi PE, Hsu JH, Gildengorin G, Matthay MA, Fineman JR, Flori H

Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury.

Chest

Ware LB, Koyama T, Billheimer DD, Wu W, Bernard GR, Thompson BT, Brower RG, Standiford TJ, Martin TR, Matthay MA

Elevated PAI-1 is associated with poor clinical outcomes in pediatric patients with acute lung injury.

Intensive care medicine

Sapru A, Curley MA, Brady S, Matthay MA, Flori H

Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury.

The Journal of clinical investigation

Looney MR, Nguyen JX, Hu Y, Van Ziffle JA, Lowell CA, Matthay MA

Potential application of mesenchymal stem cells in acute lung injury.

Expert opinion on biological therapy

Lee JW, Gupta N, Serikov V, Matthay MA

Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung.

Proceedings of the National Academy of Sciences of the United States of America

Lee JW, Fang X, Gupta N, Serikov V, Matthay MA

Serotonin decreases alveolar epithelial fluid transport via a direct inhibition of the epithelial sodium channel.

American journal of respiratory cell and molecular biology

Goolaerts A, Roux J, Ganter MT, Shlyonsky V, Chraibi A, Stéphane R, Mies F, Matthay MA, Naeije R, Sariban-Sohraby S, Howard M, Pittet JF

Comparison of two non-bronchoscopic methods for evaluating inflammation in patients with acute hypoxaemic respiratory failure.

Critical care (London, England)

Colucci G, Domenighetti G, Della Bruna R, Bonilla J, Limoni C, Matthay MA, Martin TR

NADPH oxidase-1 plays a crucial role in hyperoxia-induced acute lung injury in mice.

American journal of respiratory and critical care medicine

Carnesecchi S, Deffert C, Pagano A, Garrido-Urbani S, Métrailler-Ruchonnet I, Schäppi M, Donati Y, Matthay MA, Krause KH, Barazzone Argiroffo C

Measurement of extravascular lung water using the single indicator method in patients: research and potential clinical value.

American journal of physiology. Lung cellular and molecular physiology

Brown LM, Liu KD, Matthay MA

Inhaled activated protein C: a novel therapy for acute lung injury?

Critical care (London, England)

Liu KD, Looney MR, Matthay MA

Protective mechanisms of activated protein C in severe inflammatory disorders.

British journal of pharmacology

Neyrinck AP, Liu KD, Howard JP, Matthay MA

4G/5G polymorphism of plasminogen activator inhibitor-1 gene is associated with mortality in intensive care unit patients with severe pneumonia.

Anesthesiology

Sapru A, Hansen H, Ajayi T, Brown R, Garcia O, Zhuo H, Wiemels J, Matthay MA, Wiener-Kronish J

Blood product transfusions and clinical outcomes in pediatric patients with acute lung injury.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Church GD, Matthay MA, Liu K, Milet M, Flori HR

Higher pulmonary dead space may predict prolonged mechanical ventilation after cardiac surgery.

Pediatric pulmonology

Ong T, Stuart-Killion RB, Daniel BM, Presnell LB, Zhuo H, Matthay MA, Liu KD

Recent trends in acute lung injury mortality: 1996-2005.

Critical care medicine

Erickson SE, Martin GS, Davis JL, Matthay MA, Eisner MD

Receptor for advanced glycation end-products (RAGE) is an indicator of direct lung injury in models of experimental lung injury.

American journal of physiology. Lung cellular and molecular physiology

Su X, Looney MR, Gupta N, Matthay MA

Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers.

American journal of respiratory and critical care medicine

Shyamsundar M, McKeown ST, O'Kane CM, Craig TR, Brown V, Thickett DR, Matthay MA, Taggart CC, Backman JT, Elborn JS, McAuley DF

The pathogenetic and prognostic value of biologic markers in acute lung injury.

Journal of intensive care medicine

Levitt JE, Gould MK, Ware LB, Matthay MA

Racial and ethnic disparities in mortality from acute lung injury.

Critical care medicine

Erickson SE, Shlipak MG, Martin GS, Wheeler AP, Ancukiewicz M, Matthay MA, Eisner MD

Anti-chemokine autoantibody:chemokine immune complexes activate endothelial cells via IgG receptors.

American journal of respiratory cell and molecular biology

Krupa A, Fudala R, Stankowska D, Loyd T, Allen TC, Matthay MA, Gryczynski Z, Gryczynski I, Mettikolla YV, Kurdowska AK

Fatty acid transduction of nitric oxide signaling: nitrolinoleic acid mediates protective effects through regulation of the ERK pathway.

Free radical biology & medicine

Iles KE, Wright MM, Cole MP, Welty NE, Ware LB, Matthay MA, Schopfer FJ, Baker PR, Agarwal A, Freeman BA

Beyond fishing: the role of discovery proteomics in mechanistic lung research.

American journal of physiology. Lung cellular and molecular physiology

Ware LB, Matthay MA

Soluble intercellular adhesion molecule-1 and clinical outcomes in patients with acute lung injury.

Intensive care medicine

Calfee CS, Eisner MD, Parsons PE, Thompson BT, Conner ER, Matthay MA, Ware LB

Randomized clinical trial of activated protein C for the treatment of acute lung injury.

American journal of respiratory and critical care medicine

Liu KD, Levitt J, Zhuo H, Kallet RH, Brady S, Steingrub J, Tidswell M, Siegel MD, Soto G, Peterson MW, Chesnutt MS, Phillips C, Weinacker A, Thompson BT, Eisner MD, Matthay MA

Alterations in the proteome of pulmonary alveolar type II cells in the rat after hepatic ischemia-reperfusion.

Critical care medicine

Hirsch J, Niemann CU, Hansen KC, Choi S, Su X, Frank JA, Fang X, Hirose R, Theodore P, Sapru A, Burlingame AL, Matthay MA

CD47 deficiency protects mice from lipopolysaccharide-induced acute lung injury and Escherichia coli pneumonia.

Journal of immunology (Baltimore, Md. : 1950)

Su X, Johansen M, Looney MR, Brown EJ, Matthay MA

Novel molecular strategy to prevent pulmonary edema.

Critical care medicine

Matthay MA, Berthiaume Y

Measurement of extravascular lung water in patients with pulmonary edema.

American journal of physiology. Lung cellular and molecular physiology

Matthay MA

Protein C as a surrogate end-point for clinical trials of sepsis.

Critical care (London, England)

Liu KD, Matthay MA

Treatment of acute lung injury: clinical and experimental studies.

Proceedings of the American Thoracic Society

Matthay MA

Biomarkers of inflammation, coagulation and fibrinolysis predict mortality in acute lung injury.

Critical care (London, England)

McClintock D, Zhuo H, Wickersham N, Matthay MA, Ware LB

Intra-alveolar tissue factor pathway inhibitor is not sufficient to block tissue factor procoagulant activity.

American journal of physiology. Lung cellular and molecular physiology

Bastarache JA, Wang L, Wang Z, Albertine KH, Matthay MA, Ware LB

Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms.

Circulation research

Ganter MT, Roux J, Miyazawa B, Howard M, Frank JA, Su G, Sheppard D, Violette SM, Weinreb PH, Horan GS, Matthay MA, Pittet JF

Advances in critical care for the nephrologist: acute lung injury/ARDS.

Clinical journal of the American Society of Nephrology : CJASN

Liu KD, Matthay MA

Prostaglandin E2 mediates IL-1beta-related fibroblast mitogenic effects in acute lung injury through differential utilization of prostanoid receptors.

Journal of immunology (Baltimore, Md. : 1950)

White KE, Ding Q, Moore BB, Peters-Golden M, Ware LB, Matthay MA, Olman MA

Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury.

Critical care medicine

Liu KD, Glidden DV, Eisner MD, Parsons PE, Ware LB, Wheeler A, Korpak A, Thompson BT, Chertow GM, Matthay MA

Lung epithelial cells induce endodermal differentiation in mouse mesenchymal bone marrow stem cells by paracrine mechanism.

Tissue engineering

Popov BV, Serikov VB, Petrov NS, Izusova TV, Gupta N, Matthay MA

The role of protein C in sepsis.

Current infectious disease reports

Looney MR, Matthay MA

Trauma-associated lung injury differs clinically and biologically from acute lung injury due to other clinical disorders.

Critical care medicine

Calfee CS, Eisner MD, Ware LB, Thompson BT, Parsons PE, Wheeler AP, Korpak A, Matthay MA

Rac1 is required for reorientation of polarity and lumen formation through a PI 3-kinase-dependent pathway.

American journal of physiology. Renal physiology

Liu KD, Datta A, Yu W, Brakeman PR, Jou TS, Matthay MA, Mostov KE

Evidence of temporary airway epithelial repopulation and rare clonal formation by BM-derived cells following naphthalene injury in mice.

Anatomical record (Hoboken, N.J. : 2007)

Serikov VB, Popov B, Mikhailov VM, Gupta N, Matthay MA

Surfactant treatment of aspiration-induced lung injury in children.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Matthay MA, Taeusch W

Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice.

Journal of immunology (Baltimore, Md. : 1950)

Gupta N, Su X, Popov B, Lee JW, Serikov V, Matthay MA

Pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury/acute respiratory distress syndrome.

Critical care medicine

Ware LB, Matthay MA, Parsons PE, Thompson BT, Januzzi JL, Eisner MD

Plasma receptor for advanced glycation end-products predicts duration of ICU stay and mechanical ventilation in patients after lung transplantation.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

Calfee CS, Budev MM, Matthay MA, Church G, Brady S, Uchida T, Ishizaka A, Lara A, Ranes JL, deCamp MM, Arroliga AC

Acute lung injury edema fluid decreases net fluid transport across human alveolar epithelial type II cells.

The Journal of biological chemistry

Lee JW, Fang X, Dolganov G, Fremont RD, Bastarache JA, Ware LB, Matthay MA

Alveolar edema fluid clearance and acute lung injury.

Respiratory physiology & neurobiology

Berthiaume Y, Matthay MA

Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway?

Annals of surgery

Brohi K, Cohen MJ, Ganter MT, Matthay MA, Mackersie RC, Pittet JF

Genomics and proteomics of lung disease: conference summary.

American journal of physiology. Lung cellular and molecular physiology

Raj JU, Aliferis C, Caprioli RM, Cowley AW, Davies PF, Duncan MW, Erle DJ, Erzurum SC, Finn PW, Ischiropoulos H, Kaminski N, Kleeberger SR, Leikauf GD, Loyd JE, Martin TR, Matalon S, Moore JH, Quackenbush J, Sabo-Attwood T, Shapiro SD, Schnitzer JE, Schwartz DA, Schwiebert LM, Sheppard D, Ware LB, Weiss ST, Whitsett JA, Wurfel MM, Matthay MA

Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and rats.

American journal of respiratory cell and molecular biology

Su X, Lee JW, Matthay ZA, Mednick G, Uchida T, Fang X, Gupta N, Matthay MA

Postobstructive pulmonary edema: a case for hydrostatic mechanisms.

Chest

Fremont RD, Kallet RH, Matthay MA, Ware LB

Impact of low and high tidal volumes on the rat alveolar epithelial type II cell proteome.

American journal of respiratory and critical care medicine

Hirsch J, Hansen KC, Sapru A, Frank JA, Chalkley RJ, Fang X, Trinidad JC, Baker P, Burlingame AL, Matthay MA

The alveolar epithelium can initiate the extrinsic coagulation cascade through expression of tissue factor.

Thorax

Bastarache JA, Wang L, Geiser T, Wang Z, Albertine KH, Matthay MA, Ware LB

Physiological and biochemical markers of alveolar epithelial barrier dysfunction in perfused human lungs.

American journal of physiology. Lung cellular and molecular physiology

Frank JA, Briot R, Lee JW, Ishizaka A, Uchida T, Matthay MA

Early elevation of plasma von Willebrand factor antigen in pediatric acute lung injury is associated with an increased risk of death and prolonged mechanical ventilation.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Flori HR, Ware LB, Milet M, Matthay MA

Formation of cysts by alveolar type II cells in three-dimensional culture reveals a novel mechanism for epithelial morphogenesis.

Molecular biology of the cell

Yu W, Fang X, Ewald A, Wong K, Hunt CA, Werb Z, Matthay MA, Mostov K

Pulmonary artery catheter and fluid management in acute lung injury and the acute respiratory distress syndrome.

Clinics in chest medicine

Heresi GA, Arroliga AC, Wiedemann HP, Weidemann HP, Matthay MA

Cigarette smoke stimulates matrix metalloproteinase-2 activity via EGR-1 in human lung fibroblasts.

American journal of respiratory cell and molecular biology

Ning W, Dong Y, Sun J, Li C, Matthay MA, Feghali-Bostwick CA, Choi AM

Novel role of the human alveolar epithelium in regulating intra-alveolar coagulation.

American journal of respiratory cell and molecular biology

Wang L, Bastarache JA, Wickersham N, Fang X, Matthay MA, Ware LB

Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death.

Nature medicine

Bhandari V, Choo-Wing R, Lee CG, Zhu Z, Nedrelow JH, Chupp GL, Zhang X, Matthay MA, Ware LB, Homer RJ, Lee PJ, Geick A, de Fougerolles AR, Elias JA

Higher urine nitric oxide is associated with improved outcomes in patients with acute lung injury.

American journal of respiratory and critical care medicine

McClintock DE, Ware LB, Eisner MD, Wickersham N, Thompson BT, Matthay MA

Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier function.

American journal of respiratory cell and molecular biology

Su G, Hodnett M, Wu N, Atakilit A, Kosinski C, Godzich M, Huang XZ, Kim JK, Frank JA, Matthay MA, Sheppard D, Pittet JF

Protein permeability in lung injury: now in real time again?

Journal of applied physiology (Bethesda, Md. : 1985)

Lee JW, Matthay MA

Treatment of acute lung injury: historical perspective and potential future therapies.

Seminars in respiratory and critical care medicine

Levitt JE, Matthay MA

Alveolar macrophages contribute to alveolar barrier dysfunction in ventilator-induced lung injury.

American journal of physiology. Lung cellular and molecular physiology

Frank JA, Wray CM, McAuley DF, Schwendener R, Matthay MA

Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury.

The Journal of clinical investigation

Jenkins RG, Su X, Su G, Scotton CJ, Camerer E, Laurent GJ, Davis GE, Chambers RC, Matthay MA, Sheppard D

Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury.

The Journal of clinical investigation

Looney MR, Su X, Van Ziffle JA, Lowell CA, Matthay MA

Higher urine desmosine levels are associated with mortality in patients with acute lung injury.

American journal of physiology. Lung cellular and molecular physiology

McClintock DE, Starcher B, Eisner MD, Thompson BT, Hayden DL, Church GD, Matthay MA

Evolving practices in critical care and potential implications for management of acute kidney injury.

Clinical journal of the American Society of Nephrology : CJASN

Liu KD, Matthay MA, Chertow GM

Extracellular heat shock protein 72 is a marker of the stress protein response in acute lung injury.

American journal of physiology. Lung cellular and molecular physiology

Ganter MT, Ware LB, Howard M, Roux J, Gartland B, Matthay MA, Fleshner M, Pittet JF

Airway epithelium, inflammation, and mechanisms of disease: A tribute to Carol B. Basbaum.

American journal of respiratory cell and molecular biology

Adler KB, Shapiro SD, Gallup M, Wu R, Randell SH, Holtzman MJ, Evans CM, Jacoby DB, Tesfaigzi Y, Rose MC, Mossman BT, Prince A, Reddy SP, Davis CW, Matthay MA

Animal models of transfusion-related acute lung injury.

Critical care medicine

Looney MR, Matthay MA

Pharmacotherapy of acute lung injury and the acute respiratory distress syndrome.

Journal of intensive care medicine

Cepkova M, Matthay MA

Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury.

American journal of physiology. Lung cellular and molecular physiology

Ware LB, Camerer E, Welty-Wolf K, Schultz MJ, Matthay MA

Perspectives, translational research, and letters to the editor.

American journal of physiology. Lung cellular and molecular physiology

Matthay MA, Christman JW, Pitt BR, Schwiebert LM, Stevens T, Ware LB

Alveolar epithelial ion and fluid transport: recent progress.

American journal of respiratory cell and molecular biology

Folkesson HG, Matthay MA

Clinical trial design--effect of prone positioning on clinical outcomes in infants and children with acute respiratory distress syndrome.

Journal of critical care

Curley MA, Arnold JH, Thompson JE, Fackler JC, Grant MJ, Fineman LD, Cvijanovich N, Barr FE, Molitor-Kirsch S, Steinhorn DM, Matthay MA, Hibberd PL

Stimulation of alveolar epithelial fluid clearance in human lungs by exogenous epinephrine.

Critical care medicine

Sakuma T, Gu X, Wang Z, Maeda S, Sugita M, Sagawa M, Osanai K, Toga H, Ware LB, Folkesson G, Matthay MA

Receptor for advanced glycation end-products is a marker of type I cell injury in acute lung injury.

American journal of respiratory and critical care medicine

Uchida T, Shirasawa M, Ware LB, Kojima K, Hata Y, Makita K, Mednick G, Matthay ZA, Matthay MA

Beta-adrenergic agonist therapy as a potential treatment for acute lung injury.

American journal of respiratory and critical care medicine

Matthay MA, Abraham E

Clinical practice. Acute pulmonary edema.

The New England journal of medicine

Ware LB, Matthay MA

Protective effect of endogenous beta-adrenergic tone on lung fluid balance in acute bacterial pneumonia in mice.

American journal of physiology. Lung cellular and molecular physiology

Su X, Robriquet L, Folkesson HG, Matthay MA

High prevalence of pulmonary arterial thrombi in donor lungs rejected for transplantation.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

Ware LB, Fang X, Wang Y, Babcock WD, Jones K, Matthay MA

Contribution of CFTR to apical-basolateral fluid transport in cultured human alveolar epithelial type II cells.

American journal of physiology. Lung cellular and molecular physiology

Fang X, Song Y, Hirsch J, Galietta LJ, Pedemonte N, Zemans RL, Dolganov G, Verkman AS, Matthay MA

Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms.

Journal of immunology (Baltimore, Md. : 1950)

Su X, Camerer E, Hamilton JR, Coughlin SR, Matthay MA

Leukotrienes in acute lung injury: a potential therapeutic target?

American journal of respiratory and critical care medicine

Frank JA, Matthay MA

Effect of prone positioning on clinical outcomes in children with acute lung injury: a randomized controlled trial.

JAMA

Curley MA, Hibberd PL, Fineman LD, Wypij D, Shih MC, Thompson JE, Grant MJ, Barr FE, Cvijanovich NZ, Sorce L, Luckett PM, Matthay MA, Arnold JH

Recent advances in mechanical ventilation.

The American journal of medicine

Calfee CS, Matthay MA

Proteinase-activated receptor-1 mediates elastase-induced apoptosis of human lung epithelial cells.

American journal of respiratory cell and molecular biology

Suzuki T, Moraes TJ, Vachon E, Ginzberg HH, Huang TT, Matthay MA, Hollenberg MD, Marshall J, McCulloch CA, Abreu MT, Chow CW, Downey GP

Decreased expression of both the alpha1- and alpha2-subunits of the Na-K-ATPase reduces maximal alveolar epithelial fluid clearance.

American journal of physiology. Lung cellular and molecular physiology

Looney MR, Sartori C, Chakraborty S, James PF, Lingrel JB, Matthay MA

Critical care in AJRCCM 2004.

American journal of respiratory and critical care medicine

Angus D, Ishizaka A, Matthay M, Lemaire F, Macnee W, Abraham E

Interleukin-1beta decreases expression of the epithelial sodium channel alpha-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathway.

The Journal of biological chemistry

Roux J, Kawakatsu H, Gartland B, Pespeni M, Sheppard D, Matthay MA, Canessa CM, Pittet JF

Acute effects of tidal volume strategy on hemodynamics, fluid balance, and sedation in acute lung injury.

Critical care medicine

Cheng IW, Eisner MD, Thompson BT, Ware LB, Matthay MA

Alveolar epithelium: role in lung fluid balance and acute lung injury.

Proceedings of the American Thoracic Society

Matthay MA, Robriquet L, Fang X

Differential effects of sustained inflation recruitment maneuvers on alveolar epithelial and lung endothelial injury.

Critical care medicine

Frank JA, McAuley DF, Gutierrez JA, Daniel BM, Dobbs L, Matthay MA

Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury.

Critical care medicine

Parsons PE, Eisner MD, Thompson BT, Matthay MA, Ancukiewicz M, Bernard GR, Wheeler AP

Pediatric acute lung injury: prospective evaluation of risk factors associated with mortality.

American journal of respiratory and critical care medicine

Flori HR, Glidden DV, Rutherford GW, Matthay MA

Can nicotine treat sepsis?

Nature medicine

Matthay MA, Ware LB

Elevated plasma levels of soluble TNF receptors are associated with morbidity and mortality in patients with acute lung injury.

American journal of physiology. Lung cellular and molecular physiology

Parsons PE, Matthay MA, Ware LB, Eisner MD

Acute lung injury and acute respiratory distress syndrome in pregnancy.

Critical care clinics

Bandi VD, Munnur U, Matthay MA

Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome.

The New England journal of medicine

Brower RG, Lanken PN, MacIntyre N, Matthay MA, Morris A, Ancukiewicz M, Schoenfeld D, Thompson BT

Coagulation-dependent mechanisms and asthma.

The Journal of clinical investigation

Matthay MA, Clements JA

Proteomics: current techniques and potential applications to lung disease.

American journal of physiology. Lung cellular and molecular physiology

Hirsch J, Hansen KC, Burlingame AL, Matthay MA

Transfusion-related acute lung injury: a review.

Chest

Looney MR, Gropper MA, Matthay MA

Significance of von Willebrand factor in septic and nonseptic patients with acute lung injury.

American journal of respiratory and critical care medicine

Ware LB, Eisner MD, Thompson BT, Parsons PE, Matthay MA

H(2)O(2) inhibits alveolar epithelial wound repair in vitro by induction of apoptosis.

American journal of physiology. Lung cellular and molecular physiology

Geiser T, Ishigaki M, van Leer C, Matthay MA, Broaddus VC

Mechanisms of alveolar protein clearance in the intact lung.

American journal of physiology. Lung cellular and molecular physiology

Hastings RH, Folkesson HG, Matthay MA

Diagnostic utility of B-type natriuretic peptide in patients with acute dyspnea or pleural effusions.

The American journal of medicine

Zemans RL, Chatterjee K, Matthay MA

Fluid transport across cultured rat alveolar epithelial cells: a novel in vitro system.

American journal of physiology. Lung cellular and molecular physiology

Fang X, Song Y, Zemans R, Hirsch J, Matthay MA

Pulmonary edema fluid from patients with early lung injury stimulates fibroblast proliferation through IL-1 beta-induced IL-6 expression.

Journal of immunology (Baltimore, Md. : 1950)

Olman MA, White KE, Ware LB, Simmons WL, Benveniste EN, Zhu S, Pugin J, Matthay MA

Proteomic analysis of pulmonary edema fluid and plasma in patients with acute lung injury.

American journal of physiology. Lung cellular and molecular physiology

Bowler RP, Duda B, Chan ED, Enghild JJ, Ware LB, Matthay MA, Duncan MW

Proinflammatory activity of anti-IL-8 autoantibody:IL-8 complexes in alveolar edema fluid from patients with acute lung injury.

American journal of physiology. Lung cellular and molecular physiology

Krupa A, Kato H, Matthay MA, Kurdowska AK

Cytokine-mediated inflammation in acute lung injury.

Cytokine & growth factor reviews

Goodman RB, Pugin J, Lee JS, Matthay MA

Pancreatitis-associated acute lung injury: new insights.

Chest

Pastor CM, Matthay MA, Frossard JL

Effects of recruitment maneuvers in patients with acute lung injury and acute respiratory distress syndrome ventilated with high positive end-expiratory pressure.

Critical care medicine

Brower RG, Morris A, MacIntyre N, Matthay MA, Hayden D, Thompson T, Clemmer T, Lanken PN, Schoenfeld D

Effect of continuous hemofiltration on hemodynamics, lung inflammation and pulmonary edema in a canine model of acute lung injury.

Intensive care medicine

Su X, Bai C, Hong Q, Zhu D, He L, Wu J, Ding F, Fang X, Matthay MA

Acute lung injury and the acute respiratory distress syndrome.

Critical care clinics

Cheng IW, Matthay MA

Elevation of KL-6, a lung epithelial cell marker, in plasma and epithelial lining fluid in acute respiratory distress syndrome.

American journal of physiology. Lung cellular and molecular physiology

Ishizaka A, Matsuda T, Albertine KH, Koh H, Tasaka S, Hasegawa N, Kohno N, Kotani T, Morisaki H, Takeda J, Nakamura M, Fang X, Martin TR, Matthay MA, Hashimoto S

Pulmonary edema fluid antioxidants are depressed in acute lung injury.

Critical care medicine

Bowler RP, Velsor LW, Duda B, Chan ED, Abraham E, Ware LB, Matthay MA, Day BJ

Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism.

The Journal of biological chemistry

Frank J, Roux J, Kawakatsu H, Su G, Dagenais A, Berthiaume Y, Howard M, Canessa CM, Fang X, Sheppard D, Matthay MA, Pittet JF

Functional identification of the alveolar edema reabsorption activity of murine tumor necrosis factor-alpha.

American journal of respiratory and critical care medicine

Elia N, Tapponnier M, Matthay MA, Hamacher J, Pache JC, Brundler MA, Totsch M, De Baetselier P, Fransen L, Fukuda N, Morel DR, Lucas R

Early elevation of plasma soluble intercellular adhesion molecule-1 in pediatric acute lung injury identifies patients at increased risk of death and prolonged mechanical ventilation.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Flori HR, Ware LB, Glidden D, Matthay MA

Protein C and thrombomodulin in human acute lung injury.

American journal of physiology. Lung cellular and molecular physiology

Ware LB, Fang X, Matthay MA

Elevated levels of plasminogen activator inhibitor-1 in pulmonary edema fluid are associated with mortality in acute lung injury.

American journal of physiology. Lung cellular and molecular physiology

Prabhakaran P, Ware LB, White KE, Cross MT, Matthay MA, Olman MA

Future research directions in acute lung injury: summary of a National Heart, Lung, and Blood Institute working group.

American journal of respiratory and critical care medicine

Matthay MA, Zimmerman GA, Esmon C, Bhattacharya J, Coller B, Doerschuk CM, Floros J, Gimbrone MA, Hoffman E, Hubmayr RD, Leppert M, Matalon S, Munford R, Parsons P, Slutsky AS, Tracey KJ, Ward P, Gail DB, Harabin AL

Therapeutic strategies to hasten the resolution of pulmonary edema.

Critical care medicine

Folkesson HG, Matthay MA

Keratinocyte growth factor promotes cell motility during alveolar epithelial repair in vitro.

Experimental cell research

Galiacy S, Planus E, Lepetit H, Féréol S, Laurent V, Ware L, Isabey D, Matthay M, Harf A, d'Ortho MP

High tidal volume ventilation induces NOS2 and impairs cAMP- dependent air space fluid clearance.

American journal of physiology. Lung cellular and molecular physiology

Frank JA, Pittet JF, Lee H, Godzich M, Matthay MA

Prognostic value of surfactant proteins A and D in patients with acute lung injury.

Critical care medicine

Cheng IW, Ware LB, Greene KE, Nuckton TJ, Eisner MD, Matthay MA

Meta-analysis of acute lung injury and acute respiratory distress syndrome trials.

American journal of respiratory and critical care medicine

Brower RG, Matthay M, Schoenfeld D

Fas and fas ligand are up-regulated in pulmonary edema fluid and lung tissue of patients with acute lung injury and the acute respiratory distress syndrome.

The American journal of pathology

Albertine KH, Soulier MF, Wang Z, Ishizaka A, Hashimoto S, Zimmerman GA, Matthay MA, Ware LB

Hypoxia upregulates VEGF expression in alveolar epithelial cells in vitro and in vivo.

American journal of physiology. Lung cellular and molecular physiology

Pham I, Uchida T, Planes C, Ware LB, Kaner R, Matthay MA, Clerici C

Selected contribution: mechanisms that may stimulate the resolution of alveolar edema in the transplanted human lung.

Journal of applied physiology (Bethesda, Md. : 1985)

Ware LB, Fang X, Wang Y, Sakuma T, Hall TS, Matthay MA

Measuring microvascular blood flow in sepsis--a continuing challenge.

Lancet (London, England)

Ware LB, Matthay MA

Science review: mechanisms of ventilator-induced injury.

Critical care (London, England)

Frank JA, Matthay MA

Invited review: Active fluid clearance from the distal air spaces of the lung.

Journal of applied physiology (Bethesda, Md. : 1985)

Matthay MA, Clerici C, Saumon G

Ventilator-induced lung injury: in vivo and in vitro mechanisms.

American journal of physiology. Lung cellular and molecular physiology

Matthay MA, Bhattacharya S, Gaver D, Ware LB, Lim LH, Syrkina O, Eyal F, Hubmayr R

Pleural surface fluorescence measurement of Na+ and Cl- transport across the air space-capillary barrier.

Journal of applied physiology (Bethesda, Md. : 1985)

Jiang J, Song Y, Bai C, Koller BH, Matthay MA, Verkman AS

Assessment of lungs rejected for transplantation and implications for donor selection.

Lancet (London, England)

Ware LB, Wang Y, Fang X, Warnock M, Sakuma T, Hall TS, Matthay M

Evidence against aquaporin-1-dependent CO2 permeability in lung and kidney.

The Journal of physiology

Fang X, Yang B, Matthay MA, Verkman AS

Keratinocyte growth factor can enhance alveolar epithelial repair by nonmitogenic mechanisms.

American journal of physiology. Lung cellular and molecular physiology

Atabai K, Ishigaki M, Geiser T, Ueki I, Matthay MA, Ware LB

Lung epithelial fluid transport and the resolution of pulmonary edema.

Physiological reviews

Matthay MA, Folkesson HG, Clerici C

Enhancing the safety of critically ill patients by reducing urinary and central venous catheter-related infections.

American journal of respiratory and critical care medicine

Saint S, Savel RH, Matthay MA

Activity of pulmonary edema fluid interleukin-8 bound to alpha(2)-macroglobulin in patients with acute lung injury.

American journal of physiology. Lung cellular and molecular physiology

Kurdowska AK, Geiser TK, Alden SM, Dziadek BR, Noble JM, Nuckton TJ, Matthay MA

Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair.

American journal of physiology. Lung cellular and molecular physiology

Ware LB, Matthay MA

Pulmonary dead-space fraction as a risk factor for death in the acute respiratory distress syndrome.

The New England journal of medicine

Nuckton TJ, Alonso JA, Kallet RH, Daniel BM, Pittet JF, Eisner MD, Matthay MA

Airway pressures and early barotrauma in patients with acute lung injury and acute respiratory distress syndrome.

American journal of respiratory and critical care medicine

Eisner MD, Thompson BT, Schoenfeld D, Anzueto A, Matthay MA

Clinical Acute Lung Injury and Acute Respiratory Distress Syndrome.

Current treatment options in cardiovascular medicine

Matthay MA, Uchida T, Fang X

Lidocaine induces a reversible decrease in alveolar epithelial fluid clearance in rats.

Anesthesiology

Laffon M, Jayr C, Barbry P, Wang Y, Folkesson HG, Pittet JF, Clerici C, Matthay MA

Low tidal volume reduces epithelial and endothelial injury in acid-injured rat lungs.

American journal of respiratory and critical care medicine

Frank JA, Gutierrez JA, Jones KD, Allen L, Dobbs L, Matthay MA

The Role of Protein C in Sepsis.

Current infectious disease reports

Looney MR, Matthay MA