The Identification of Molecular Sub-phenotypes of Asthma and COPD

These studies are funded by: 1) An R01 grant  from the National Heart, Lung and Blood Institute at the National Institutes of Health. The grant is entitled “Molecular Phenotyping of Asthma” (R01 HL-095372) which has applied genomic analyses to airway samples from patients with asthma to distinguish Th2-driven and non-Th2-driven sub-phenotypes of asthma that have distinct clinical, pathological and treatment-related characteristics. 2) A seven-year NIH contract to apply similar methods to study chronic obstructive pulmonary disease (COPD) as part of the NHLBI Spiromics Project (N01 HR-08-08). The goal of the Spiromics project is to identify molecular phenotypes of COPD and to develop intermediate outcome measures for clinical trials.