Tobacco Center Faculty Blog

February 5, 2020

Stanton A. Glantz, PhD

My colleague Michael Matthay, a Professor of Medicine, Associate Director of the UCSF Intensive Care Unit, and an expert in mouse studies submitted this public comment to FDA. The tracking number is 1k4-9et5-a588  and a PDF of the comment is available here.


PMIs’ mouse study demonstrates increased morbidity and mortality in mice exposed to IQOS aerosol, and PMI’s December 20, 2019 response to FDA’s Request for Information fails to show otherwise


Michael A. Matthay, MD

University of California San Francisco TCORS


Docket Number: FDA-2017-D-3001


February 3, 2020


February 3, 2020

Stanton A. Glantz, PhD

Rebecca Evans-Polce and colleagues just published “Trends in E-Cigarette, Cigarette, Cigar, and Smokeless Tobacco Use Among US Adolescent Cohorts, 2014-2018” in American Journal of Public Health.  They used data from the National Youth Tobacco Survey fro 2014-2018, the years in which e-cigarette use really took off, to assess the age at which kids started using e-cigarettes, cigarettes, smokeless tobacco, and cigars.  They found that the age of initiation for cigarettes, smokeless, and cigars did not change over these 5 years, but that the age initiation for e-cigarettes dropped. 

In 2014, 8.8% of lifetime e-cigarette users had started by age 14; in 2018 this fraction had increased to 28.6%.

This result adds to the overwhelming case that e-cigarette use is an epidemic with kids and highlights the need to continue to press for bans on the sale of all flavored tobacco products, including e-cigarettes, and also stopping the sale of all e-cigarettes that have not been approved as “appropriate for the protection of public health” by the FDA.

This is also more evidence that the FDA’s “enforcement policy” that exempts popular new disposable and refillable e-cigarettes is likely to fail to have much impact on youth use.  It needs to be comprehensive.

Here is the abstract:

February 3, 2020

Stanton A. Glantz, PhD

The public health debate and FDA frame for evaluating e-cigs, heated tobacco products, and other new products has been over whether they were an “off ramp from cigarettes” or whether they were a less dangerous alterative to cigarettes.

That’s not how the tobacco companies think about these products.  The see them as alternatives to quitting entirely.

At the UCSF Tobacco Center’s annual “It’s About a Billion Lives” symposium last week, Professor Dorie Apollonio gave a brilliant history of the industry’s alternative products going back over 100 years, to the invention of the Bonsack cigarette manufacturing machine.

The tobacco companies have known for over 100 years that people were concerned about the health dangers of smoking and working to quit smoking.  All these new products have been developed as an alternative to quitting so that the companies could hold on to customers.

“Harm reduction” and “continuum of risk” ideas were developed as marketing and policy messages to promote these alternatives to quitting completely.