THS Publications

Critical Reviews on THS

Jacob P 3rd, Benowitz NL, Destaillats H, Gundel LA, Hang B, Martins-Green M, Matt G, Quintana P, Samet JM, Schick SF, Talbot P, Aquilina N, Hovell MF, Mao J-H, Whitehead T (2016) Thirdhand Smoke: New Evidence, Challenges, and Future Directions. Chemical Research in Toxicology 2017, 30(1):270–294. doi:10.1021/acs.chemrestox.6b00343.

Matt GE, Quintana PJE, Destaillats H, Gundel LA, Sleiman M, Singer BC, Jacob P 3rd, Benowitz N, Winickoff J, Rehan V, Talbot P, Schick S, Samet J, Wang Y, Hang B, Martins-Green M, Pankow J, Hovell M (2011) Thirdhand tobacco smoke: emerging evidence and arguments for a multidisciplinary research agenda.  Environ Health Perspectives, 2011, 119:1218-1226. doi:10.1289/ehp.1103500.

THS Chemistry & Indoor Environmental Fate

Bahl V, Jacob P 3rd, Havel C, Schick SF, Talbot P (2014) Thirdhand Cigarette Smoke: Factors Affecting Exposure and Remediation. PLoS One 9(10):e108258. doi:10.1371/journal.pone.0108258.

Gundel LA, Destaillats H (2012) Aerosol chemistry and physics: An indoor perspective. In Aerosols handbook: Measurements, dosimetry and health effects, 2ndEdition, Editors: L. S. Ruzer and N.H. Harley, CRC Press, Boca Raton, FL. [ISBN: 9781439855102].

Jacob P 3rd, Aquilina N, Havel C, Yu L, Yturralde O, Benowitz N (In Preparation) Determination of Tobacco Alkaloids, Tobacco-Specific Nitrosamines, and PAHs in House Dust and Airborne Particulate Matter.

Jacob P 3rd, Goniewicz ML, Havel C, Schick CF, Benowitz NL (2013) Nicotelline: A Proposed Biomarker and Environmental Tracer for Particulate Matter Derived from Tobacco Smoke. Chem Res Toxicol 18(26):1615-31. doi:10.1021/tx400094y.

Matt GE, Bernert JT, Hovell, M.F. (2008) Measuring secondhand smoke exposure in children: an ecological measurement approach. Journal of Pediatric Psychology 33(2):156-175doi:10.1093/jpepsy/jsm123.

Petrick L, Destaillats H, Zouev I, Sabach S, Dubowski Y (2010) Sorption, desorption and surface oxidative fate of nicotine. Physical Chemistry Chemical Physics2010, 12:10356-10364. doi:10.1039/C002643C.

Petrick L, Sleiman M, Dubowski Y, Gundel LA, Destaillats H (2011) Tobacco smoke aging in the presence of ozone: A room-sized chamber study. Atmospheric Environment 45:4959-4965. doi:10.1016/j.atmosenv.2011.05.076.

Schick SF, Farraro KF, Perrino C, Sleiman M, van de Vossenberg G, Trinh MP, Hammond SK, Jenkins BM, Balmes JR (2014) Thirdhand cigarette smoke in an experimental chamber: evidence of surface deposition of nicotine, nitrosamines and polycyclic aromatic hydrocarbons and de novo formation of NNK. Tob Control23(2):152-158. doi:10.1136/tobaccocontrol-2012-050915.

Sleiman M, Gundel LA, Pankow JF, Jacob P 3rd, Singer BC, Destaillats H (2010) Formation of carcinogens indoors by surface-mediated reactions of nicotine with nitrous acid, leading to potential thirdhand smoke hazards. Proceedings of the National Academy of Sciences USA 107:6576-6581. doi:10.1073/pnas.0912820107.

Sleiman M, Destaillats H, Gundel LA (2013) Solid-phase supported profluorescent nitroxide probe for the determination of aerosol-borne reactive oxygen species. Talanta 2013, 116:1033-1039. doi:10.1016/j.talanta.2013.08.024.

Sleiman M, Destaillats H, Smith JD, Liu C, Ahmed M, Wilson KR, Gundel LA (2010) Secondary organic aerosol formation from ozone-initiated reactions with nicotine and secondhand tobacco smoke. Atmospheric Environment 44:4191-4198. doi:10.1016/j.atmosenv.2010.07.023.

Sleiman M, Logue JM, Luo W, Pankow JF, Gundel LA, Destaillats H (2014) Inhalable constituents of thirdhand tobacco smoke: Chemical characterization and health impact considerations. Environ. Sci. Technol 48:13093-13101. doi:10.1021/es5036333.

Sleiman M, Logue JM, Montesinos VN, Russell ML, Litter MI, Gundel LA, Destaillats H (2016) Emissions from electronic cigarettes: Key parameters affecting the release of harmful chemicals.  Environ Sci Technol 2016, 50(17):9644–9651. doi:10.1021/acs.est.6b01741.

Sleiman M, Maddalena RL, Gundel LA, Destaillats H (2009) Rapid and sensitive gas chromatography ion-trap mass spectrometry method for the determination of tobacco-specific N-nitrosamines in secondhand smoke. J. Chromatography A 1216:7899-7905. doi:10.1016/j.chroma.2009.09.020.


Biochemistry and Biology of THS

Adhami N, Shelley R, Starck SR, Flores C, and Martins Green M (2016) A health threat to bystanders living in the homes of smokers: How smoke toxins deposited on surfaces can cause insulin resistance. PLoS ONE 11(3): e0149510. doi:10.1371/journal.pone.0153382.

Bahl V, Johnson K, Phandthong G, Zahedi A, Schick SF, Talbot P (2016) Thirdhand Cigarette Smoke Causes Stress-Induced Mitochondrial Hyperfusion and Alters the Transcriptional Profile of Stem Cells. Toxicological Sciences 153:55-69. doi:10.1093/toxsci/kfw102.

Bahl V, Shim HJ, Jacob P 3rd, Dias K, Schick S, Talbot P (2015) Thirdhand Smoke: Chemical Dynamics, Cytotoxicity, and Genotoxicity in Outdoor and Indoor Environments. Toxicology In Vitro 32:220-231. doi:10.1016/j.tiv.2015.12.007.

Bahl V, Weng N, Schick S, Sleiman M, Whitehead J, Ibarra A, Talbot P (2016) Cytotoxicity of Thirdhand Smoke and Identification of Acrolein as a Volatile Thirdhand Smoke Chemical That Inhibits Cell Proliferation. Toxicological Sciences 150: 234-246. doi:10.1093/toxsci/kfv327.

Guan BX, Bhanu B, Talbot P, Lin S (2014) Bio-driven cell region detection in human embryonic stem cell assay. IEEE/ACM Transactions on Computational Biology and Bioinformatics May-June 2014, pp 604-611. doi:10.1109/TCBB.2014.2306836.

Hang B, Sarker AH, Havel C, Saha S, Hazra TK, Schick S, Jacob P 3rd, Rehan VK, Chenna A, Sharan D, Sleiman M, Destaillats H, Gundel LA (2013) Thirdhand smoke causes DNA damage in human cells. Mutagenesis 28:381-391. doi:10.1093/mutage/get013.

Hang B, Snijders AM, Huang Y, Schick SF, Wang P, Xia Y, Havel C, Jacob P 3rd, Benowitz N, Destaillats H, Gundel LA, Mao JH (2017) Early exposure to thirdhand cigarette smoke affects body mass and the development of immunity in mice. Scientific Reports 7:41915. doi:10.1038/srep41915.

Hang B, Wang P, Zhao Y, Sarker A, Chenna A, Xia Y, Snijders AM, Mao JH (2017) Adverse Health Effects of Thirdhand Smoke: From Cell to Animal Models. Int J Mol Sci. Apr 28;18(5). pii: E932. doi:10.3390/ijms18050932.

Sarker AH, Chatterjee A, Williams M, Lin S, Havel C, Jacob P 3rd, Boldogh I, Hazra TK, Talbot P, and Hang B (2014) NEIL2 protects against oxidative DNA damage induced by sidestream smoke in human cells. PLoS ONE Mar 3; 9(3):e90261. doi:10.1371/journal.pone.0090261.

Pinnameni K, Sievers RE, Sharma R, Selchau AM, Gutierrez G, Nordsiek EJ, Su R, An S, Chen Q, Wan X, Derakhshandeh R, Aschbacher K, Heiss C, Glantz SA, Schick SF, Springer ML (2014) Brief Exposure to Secondhand Smoke Reversibly Impairs Endothelial Vasodilatory Function. Nicotine Tob Res 16:584-90. doi:10.1093/ntr/ntt189.

Xu B, Chen M, Yao M, et al. (2015) Metabolomics reveals metabolic changes in male reproductive cells exposed to thirdhand smoke. Scientific Reports 5:15512. doi:10.1038/srep15512.


Field Studies and Interventions

Apelberg BJ, Hepp LM, Avila-Tang E, Gundel AL, Hammond SK, Hovell MF, Hyland A, Klepeis NE, Madsen C, Navas-Acien A, Repace J, Samet JM, Breysse PN (2013) Environmental monitoring of secondhand smoke exposure. Tob Control May;22(3):147-55. doi:10.1136/tobaccocontrol-2011-050301.

Fortmann AL, Romero RA, Sklar MS, Pham V, Zakarian J, Quintana PJE, Chatfield D, Matt GE (2010) Residual tobacco smoke in used cars: futile efforts and persistent pollutants.  Nicotine Tob Res. 12(10):1029-1036. doi:10.1093/ntr/ntq144.

Hoh E, Hunt RN, Quintana PJ, Zakarian JM, Chatfield DA, Wittry BC, Rodriguez E, Matt GE (2012) Environmental tobacco smoke as a source of polycyclic aromatic hydrocarbons in settled household dust. Environ Sci Technol 46(7):4174-83. doi:10.1021/es300267g.

Hovell MF, Adams MA, Hofstetter CR, Martínez-Donate AP, González-Pérez GJ, Rovniak LS, Boman-Davis MS (2014) Complete Home Smoking Bans and Antitobacco Contingencies: A Natural Experiment. Nicotine Tob Res. 16(2), 186-196. doi:10.1093/ntr/ntt130. 

Hovell MF, Hughes SC (2009) The behavioral ecology of secondhand smoke exposure: A pathway to complete tobacco control. Nicotine Tob Res 11:1254-64. doi:10.1093/ntr/ntp133.

Hovell MF, Lessov-Schlaggar CN, Ding D (2011) Smokefree Community Policies Promote Home Smoking Bans Unknown Mechanisms and Opportunities for Preventive Medicine. Am J Prev Med 2011, 41(6):650-652. doi:10.1016/j.amepre.2011.09.015.

Kassem NO, Daffa RM, Liles S, Jackson SR, Kassem NO, Younis MA, Mehta S, Chen M, Jacob P 3rd, Carmella SG, Chatfield DA, Benowitz NL, Matt GE, Hecht SS, Hovell MF (2014) Children's Exposure to Secondhand and Thirdhand Smoke Carcinogens and Toxicants in Homes of Hookah Smokers. Nicotine Tob Res2014 Jul, 16(7):961-75. doi:10.1093/ntr/ntu016.

Kassem NOF, Kassem NO, Jackson SR, Liles S, Daffa RM, Zarth AT, Younis MA, Carmella SG, Hofstetter CR, Chatfield DA, Matt GE, Hecht SS, Hovell MF (2014)  Benzene Uptake in Hookah Smokers and Non-smokers Attending Hookah Social Events: Regulatory Implications. Cancer Epidemiol Biomarkers Prev.  Published Online First November 21, 2014. doi:10.1158/1055-9965.EPI-14-0576.

Klepeis NE, SC Hughes, RD Edwards, T Allen, M Johnson, Z Chowdhury, KR Smith, M Boman-Davis1, J Bellettiere, MF Hovell (2014) Promoting Smoke-Free Homes: A Novel Behavioral Intervention Using Real-Time Audio-Visual Feedback on Airborne Particle Levels. PLoS ONE 8(8) e73251. doi:10.1371/journal.pone.0073251.

Mahabee-Gittens EM, Merianos AL, Matt GE (2017) Preliminary evidence that high levels of nicotine on children's hands may contribute to overall tobacco smoke exposure. Tob Control Epub 2017/04/01. doi:10.1136/tobaccocontrol-2016-053602. 

Matt GE, Fortmann AL, Quintana PJE, Zakarian JM, Romero RA, Chatfield DA, Hoh, E, Hovell MF (2013) Towards smoke-free rental cars: an evaluation of voluntary smoking restrictions in California. Tob Control 22(3): 201-7. doi:10.1136/tobaccocontrol-2011-050231.

Matt G E, Romero R, Ma D, Quintana PJE, Hovell MF, Donohue M, Messer K, Salem S, Aguilar M, Boland J, Cullimore J, Crane M, Junke J, Tassinario P, Timmermann V, Wong K, Chatfield D (2008) Tobacco use and asking prices of used cars: prevalence, costs, and new opportunities for changing smoking behavior. Tobacco Induced Diseases 4: 2. doi:10.1186/1617-9625-4-2. 

Matt GE, Quintana PJE, Fortmann AL, Zakarian JM, Galaviz, VE, Chatfield DA, Hoh, E, Hovell MF, Winston C (2014) Thirdhand smoke and exposure in California hotels: non-smoking rooms fail to protect non-smoking hotel guests from tobacco smoke exposure. Tob Control 23(3):264 - 272. doi:10.1136/tobaccocontrol-2012-050824.

Matt GE, Quintana PJE, Hovell MF, Bernert JT, Song S, Ashley D, Novianti N, Juarez T, Floro J, Gehrman C, Garcia M, Larson S (2004)  Households Contaminated by environmental tobacco smoke: sources of infant exposures. Tobacco Control 13:29-37. doi:10.1136/tc.2003.003889.

Matt GE, Quintana PJE, Hovell MF, Chatfield D, Ma DS, Romero R, Uribe, A (2008) Residual Tobacco Smoke Pollution in Used Cars for Sale: Air, Dust, and Surfaces. Nicotine & Tobacco Research 10(9):1467-1475. doi:10.1080/14622200802279898.

Matt GE, Quintana PJE, Zakarian JM, Fortmann AL, Chatfield DA, Hoh E, Uribe AM, Hovell MF (2011) When smokers move out and nonsmokers move in: Residential thirdhand smoke pollution and exposure. Tobacco Control 20(1):e1. doi:10.1136/tc.2010.037382. 

Matt GE, Quintana PJE, Zakarian JM, Hoh E, Hovell MF, Mahabee-Gittens M, Watanabe K, Datuin K, Vue C, Chatfield DA (2016) When smokers quit: exposure to nicotine and carcinogens persists from thirdhand smoke pollution. Tob Control Epub 2016/09/23. doi:10.1136/tobaccocontrol-2016-053119. 

Northrup TF, Khan AM, Jacob P 3rd, Benowitz NL, Hoh E, Hovell MF, Matt GE, Stotts AL (2015) Thirdhand smoke contamination in hospital settings: assessing exposure risk for vulnerable paediatric patients. Tobacco Control 2016, 25: 619-623. doi:10.1136/tobaccocontrol-2015-052506.

Northrup TF, Matt GE, Hovell MF, Khan AM, Stotts AL (2016) Thirdhand Smoke in the Homes of Medically Fragile Children: Assessing the Impact of Indoor Smoking Levels and Smoking Bans. Nicotine Tob Res 18(5):1290-1298. doi:10.1093/ntr/ntv174.

Quintana PJ, Matt GE, Chatfield DA, Zakarian JM, Fortmann AL, Hoh E (2013) Wipe sampling for nicotine as a marker of thirdhand tobacco smoke contamination on surfaces in homes, cars, and hotels. Nicotine Tob Res 15(9):1555-63. doi:10.1093/ntr/ntt014.

Whitehead TP, Havel C, Metayer C, Benowitz NL, Jacob P 3rd (2015) Tobacco alkaloids and tobacco-specific nitrosamines in dust from homes of smokeless tobacco users, active smokers, and nontobacco users. Chem Res Toxicol 28(5):1007-14. doi :10.1021/acs.chemrestox.5b00040.

Winickoff JP, Friebely J, Tanski SE, Sherrod C, Matt GE, Hovell MF, McMillen RC (2009) Beliefs about the health effects of “thirdhand” smoke and home smoking bans. Pediatrics 123(1):e74-e79. doi:10.1542/peds.2008-2184.



Northrup TF, Jacob P 3rd, Benowitz NL, Ho E, Quintana PJ, Hovell MF, Matt GE, Stotts AL (2016) Thirdhand Smoke: State of the Science and a Call for Policy Expansion. Public Health Rep 131(2): 233-238. doi:10.1177/003335491613100206.

Samet JM, Chanson D, Wipfli H (2015) The challenges of limiting exposure to THS in vulnerable populations. Curr. Environ. Health Rep. 2(3) 215-225. doi:10.1007/s4057201500601.


Preclinical and Clinical Research

Adhami N, Chen Y, and Martins-Green M. (2017) Biomarkers of Disease Can Be Detected as Early as Four Weeks After Initiation of Exposure to Third Hand Smoke. In Press.

Adhami N, Shelley R, Starck SR, Flores C, and Martins Green M (2016) A health threat to bystanders living in the homes of smokers: How smoke toxins deposited on surfaces can cause insulin resistance. PLoS ONE 11(3): e0149510. doi:10.1371/journal.pone.0153382.

Dhall S, Alamat R, Castro A, Sarker AH, Mao J-H, Chan A, Hang B, Martins-Green M (2016) Tobacco Toxins Deposited on Surfaces (Third Hand Smoke) Impair Wound Healing. Clinical Sciences 130:1269-1284. doi:10.1042/CS20160236.

Flores C, Adhami N, Martins-Green M (2016) THS Toxins Induce Hepatic Steatosis by Altering Oxidative Stress and SIRT1 Levels. J Clin Toxicol 6:318. doi:10.4172/2161-0495.1000318.

Flores, C., M. Martins-Green (2017). The role of fatty acid metabolism in THS-induced hepatic steatosis. In press.

Karim ZA, Alshbool FZ, Vemana HP, Adhami N, Dhall S, Lin OA, Espinosa EVP, Martins-Green M, Khasawneh FT (2015) Third Hand Smoke: Impact on Hemostasis and Thrombogenesis.  J Cardiovasc Pharmacol 2015, 66(2):177-82. doi:10.1097/FJC.0000000000000260.

Martins-Green M, Frankos M, Adhami N, Valdez M, Goodwin B, Lyubovitsky J, Dhall S, Garcia M, Egiebor I, Martinez B, Green HW, Havel C, Yu L, Liles S, Matt G, Destaillats H, Sleiman M, Gundel LA, Benowitz N, Jacob P 3rd, Hovell M, Winickoff M, Curras-Collazo M (2014) Cigarette smoke toxins deposited on surfaces: Implications for human health. PLoS ONE 9(1): e86391. doi:10.1371/journal.pone.0086391.